Long Description for Fractionated Photofrin-Mediated Photodynamic Therapy

The figure consists of two main parts: a schematic diagram on the left and a graph on the right, both related to a treatment plan involving light exposure. Schematic Diagram (Left Side) The schematic illustrates a treatment plan design for "fractionated treatment," which involves varying the illumination time of light fractions. The diagram shows a timeline with three distinct phases: Light on (1st fraction): This phase delivers X% of the total light fluence (a measure of light energy per unit area). Dark interval (2 hours): A 2-hour period with 0% of the total light fluence, indicating no light exposure. Light on (2nd fraction): This phase delivers Y% of the total light fluence, completing the treatment cycle. The values of X and Y depend on the specific treatment scheme, meaning the proportions of light delivered in each fraction can vary. Graph (Right Side) The graph plots the LCR (likely a measure like Local Control Rate) on the y-axis against [ROS]rx (in mM) on the x-axis, which represents the concentration of reactive oxygen species (ROS) at a specific point, possibly related to the treatment's effect. The x-axis ranges from 0 to 1.5 mM, and the y-axis ranges from 0 to 1. Two curves are shown, each representing a different treatment approach: One fraction (solid black line): This curve shows the LCR as a function of ROS concentration for a single light fraction. Data points for this curve are marked with various shapes (triangles, stars, diamonds). Two fractions (dashed blue line): This curve represents the LCR for the two-fraction treatment (as described in the schematic. Data points are marked with similar shapes as the one-fraction curve.