Publications | Zhu Lab | Perelman School of Medicine at the University of Pennsylvania

Nitric oxide promotes rapid development of motility to accelerate biofilm dispersal in Vibrio cholerae

Proc Natl Acad Sci U S A. 2025 Dec 9;122(49):e2526864122. Authors: Esteves NC, Tao R, Pu Q, Banerjee A, Mathijssen AJTM, Zhu J.

Diet modulates Vibrio cholerae colonization and competitive outcomes with the gut microbiota

Cell Host Microbe. 2025 Dec 10;33(12):2085-2099.e5. Authors: Liu R, Zhang Y, Ge S, Cho JY, Esteves NC, Zhu J, Hsiao A.

Music exposure enhances resistance to Salmonella infection by promoting healthy gut microbiota

Microbiol Spectr. 2025;13(5):e0237724. Authors: Zhu CY, Byun H, Do EA, Zhang Y, Tanchoco E, Beld J, Hsiao A, Zhu J.

In Vivo Nitrosative Stress-Induced Expression of a Photolyase Promotes Vibrio cholerae Environmental Blue Light Resistance

Mol Microbiol. 2025;123(4):295-304. Authors: Banerjee A, Byun H, Hrycko AJ, Pu Q, Brockett MR, Esteves NC, Miller JR, Li Q, Ma AT, Zhu J.

An exploration of mechanisms underlying Desemzia incerta colonization resistance to methicillin-resistant Staphylococcus aureus on the skin

mSphere. 2024;9(3):e0063623. Authors: Wei M, Knight SAB, Fazelinia H, Spruce L, Roof J, Chu E, Kim DY, Bhanap P, Walsh J, Flowers L, Zhu J, Grice EA.

An Intestinal Bacillus velezensis Isolate Displays Broad-Spectrum Antibacterial Activity and Prevents Infection of Both Gram-Positive and Gram-Negative Pathogens In Vivo

J Bacteriol. 2023;205(6):e0013323. Authors: Byun H, Brockett MR, Pu Q, Hrycko AJ, Beld J, Zhu J.

S-Nitrosylation of the virulence regulator AphB promotes Vibrio cholerae pathogenesis

PLoS Pathog. 2022;18(6):e1010581. Authors: Chen J, Byun H, She Q, Liu Z, Ruggeberg KG, Pu Q, Jung IJ, Zhu D, Brockett MR, Hsiao A, Zhu J.

A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling

Proc Natl Acad Sci U S A. 2022;119(11):e2121180119. Authors: Chen J, Byun H, Liu R, Jung IJ, Pu Q, Zhu CY, Tanchoco E, Alavi S, Degnan PH, Ma AT, Roggiani M, Beld J, Goulian M, Hsiao A, Zhu J.

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Thiol-based functional mimicry of phosphorylation of the two-component system response regulator ArcA promotes pathogenesis in enteric pathogens

Cell Rep. 2021;37(12):110147. Authors: Zhou Y, Pu Q, Chen J, Hao G, Gao R, Ali A, Hsiao A, Stock AM, Goulian M, Zhu J.

Phosphatidic acid-mediated binding and mammalian cell internalization of the Vibrio cholerae cytotoxin MakA

PLoS Pathog. 2021 Mar;17(3):e1009414. Authors: Nadeem A, Alam A, Toh E, Myint SL, Ur Rehman Z, Liu T, Bally M, Arnqvist A, Wang H, Zhu J, Persson K, Uhlin BE, Wai SN.

Effects of Regulatory Network Organization and Environment on PmrD Connector Activity and Polymyxin Resistance in Klebsiella pneumoniae and Escherichia coli

Antimicrob Agents Chemother. 2021 Feb 17;65(3). Authors: Chen AI, Albicoro FJ, Zhu J, Goulian M.

Pathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions

Virulence. 2020;11(1):1582-1599. Authors: Hsiao A, Zhu J.

Siderophore piracy enhances Vibrio cholerae environmental survival and pathogenesis

Microbiology (Reading). 2020 Nov;166(11):1038-1046. Authors: Byun H, Jung IJ, Chen J, Larios Valencia J, Zhu J.

Colistin-resistance-mediated bacterial surface modification sensitizes phage infection

Antimicrob Agents Chemother. 2019;63(12).e01609-19 Authors: Hao G, Chen AI, Liu M, Zhou H, Egan M, Yang X, Kan B, Wang H, Goulian M, Zhu J.

CitAB Two-Component System-Regulated Citrate Utilization Contributes to Vibrio cholerae Competitiveness with the Gut Microbiota

Infect Immun. 2019;87(3).e00746-18. Authors: Liu M, Hao G, Li Z, Zhou Y, Garcia-Sillas R, Li J, Wang H, Kan B, Zhu J.

Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution

Nat Microbiol. 2019;4(1):97-111. Authors: Song D., et al.

Hypermutation-induced in vivo oxidative stress resistance enhances Vibrio cholerae host adaptation

PLoS Pathog. 2018;14(10):e1007413. Authors: Wang H, Xing X, Wang J, Pang B, Liu M, Larios-Valencia J, Liu T, Liu G, Xie S, Hao G, Liu Z, Kan B, Zhu J.

OxyR2 Modulates OxyR1 Activity and Vibrio cholerae Oxidative Stress Response

Infect Immun. 2017;85(4).e00929-16.

A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis

Cell. 2017;168(1-2):172-185.e15. Authors: Bartlett TM, Bratton BP, Duvshani A, Miguel A, Sheng Y, Martin NR, Nguyen JP, Persat A, Desmarais SM, VanNieuwenhze MS, Huang KC, Zhu J, Shaevitz JW, Gitai Z. A

Calcium Enhances Bile Salt-Dependent Virulence Activation in Vibrio cholerae

Infect Immun. 2017;85(1).e00707-16 202a Authors: Hay AJ, Yang M, Xia X, Liu Z, Hammons J, Fenical W, Zhu J.

Plant nodulation inducers enhance horizontal gene transfer of Azorhizobium caulinodans symbiosis island

Proc Natl Acad Sci U S A. 2016;113(48):13875-13880. Authors: Ling J, Wang H, Wu P, Li T, Tang Y, Naseer N, Zheng H, Masson-Boivin C, Zhong Z, Zhu J.

Thiol-based switch mechanism of virulence regulator AphB modulates oxidative stress response in Vibrio cholerae

Mol Microbiol. 2016;102(5):939-949. Authors: Liu Z, Wang H, Zhou Z, Sheng Y, Naseer N, Kan B, Zhu J.

Differential Thiol-Based Switches Jump-Start Vibrio cholerae Pathogenesis

Cell Rep. 2016;14(2):347-54. Authors: Liu Z, Wang H, Zhou Z, Naseer N, Xiang F, Kan B, Goulian M, Zhu J.

Dual Zinc Transporter Systems in Vibrio cholerae Promote Competitive Advantages over Gut Microbiome

Infect Immun. 2015;83(10):3902-8. Authors: Sheng Y, Fan F, Jensen O, Zhong Z, Kan B, Wang H, Zhu J.

"Quorum Non-Sensing": Social Cheating and Deception in Vibrio cholerae

Appl Environ Microbiol. 2015;81(11):3856-62. Authors: Katzianer DS, Wang H, Carey RM, Zhu J.

Microbiota talks cholera out of the gut

Cell Host Microbe. 2014;16(5):549-50. Authors: Hay AJ, Zhu J.

Host intestinal signal-promoted biofilm dispersal induces Vibrio cholerae colonization

Infect Immun. 2015;83(1):317-23. Authors: Hay AJ, Zhu J.

A high-throughput small-molecule screen to identify a novel chemical inhibitor of Clostridium difficile

Int J Antimicrob Agents. 2014;44(1):69-73. Authors: Katzianer DS, Yano T, Rubin H, Zhu J.

Escherichia coli isolate for studying colonization of the mouse intestine and its application to two-component signaling knockouts

J Bacteriol. 2014;196(9):1723-32. Authors: Lasaro M, Liu Z, Bishar R, Kelly K, Chattopadhyay S, Paul S, Sokurenko E, Zhu J, Goulian M.

Enhanced interaction of Vibrio cholerae virulence regulators TcpP and ToxR under oxygen-limiting conditions

Infect Immun. 2014;82(4):1676-82. Authors: Fan F, Liu Z, Jabeen N, Birdwell LD, Zhu J, Kan B.

Efficient responses to host and bacterial signals during Vibrio cholerae colonization

Gut Microbes. 2014;5(1):120-8. Authors: Rothenbacher FP, Zhu J.

A novel protein protects bacterial iron-dependent metabolism from nitric oxide

J Bacteriol. 2013;195(20):4702-8. 203c Authors: Stern AM, Liu B, Bakken LR, Shapleigh JP, Zhu J.

Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence

Proc Natl Acad Sci U S A. 2013;110(6):2348-53. Authors: Yang M, Liu Z, Hughes C, Stern AM, Wang H, Zhong Z, Kan B, Fenical W, Zhu J.

The NorR regulon is critical for Vibrio cholerae resistance to nitric oxide and sustained colonization of the intestines

mBio. 2012;3(2):e00013-12. Authors: Stern AM, Hay AJ, Liu Z, Desland FA, Zhang J, Zhong Z, Zhu J.

The Prevalence of Functional Quorum-Sensing Systems in Recently Emerged Vibrio cholerae Toxigenic Strains

Environ Microbiol Rep. 2011;3(2):218-222. Authors: Wang Y, Wang H, Cui Z, Chen H, Zhong Z, Kan B, Zhu J.

Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB

Proc Natl Acad Sci U S A. 2011;108(2):810-5. Authors: Liu Z, Yang M, Peterfreund GL, Tsou AM, Selamoglu N, Daldal F, Zhong Z, Kan B, Zhu J.

Regulatory targets of quorum sensing in Vibrio cholerae: evidence for two distinct HapR-binding motifs

Nucleic Acids Res. 2009,37(8):2747-56. Authors: Tsou AM, Cai T, Liu Z, Zhu J, Kulkarni RV.

Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing.

Proc Natl Acad Sci U S A. 2008;105(28):9769-74. Authors: Liu Z, Miyashiro T, Tsou A, Hsiao A, Goulian M, Zhu J.

Vibrio cholerae virulence regulator-coordinated evasion of host immunity.

Proc Natl Acad Sci U S A. 2006;103(39):14542-7. Authors: Hsiao A, Liu Z, Joelsson A, Zhu J.