Max B. Kelz, MD PhD

faculty photo
Associate Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Graduate Group Affiliations

Contact information
3620 Hamilton Walk,
John Morgan Building - Room 334
Philadelphia, PA 19104
Office: 215 573-8208
Fax: 215 349-5078
Lab: 215 898-8929
MS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
BS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
PhD (Neuroscience)
Yale University, 1999.
MD (Medicine)
Yale University, 2000.
Permanent link

Description of Research Expertise

Molecular Mechanisms of Anesthetic Action
Neurobiology of Sleep Wake Regulation
Mouse Genetics
Molecular Biology
Anesthetic pharmacology

Selected Publications

Drobish JK, Kelz MB, DiPuppo P, Cook-Sather SD: Case report: Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient. Anesthesia & Analgesia Case Reports in press, 2015.

McCarren HS, Chalifoux MR, Han B, Moore JT, Meng QC, Baron-Hionis N, Sedigh-Sarvestani M, Contreras D, Beck SG, Kelz MB: α2-Adrenergic Stimulation of the VLPO Destabilizes the Anesthetic State. Journal of Neuroscience 34(49): 16385-96, Dec 2014.

Han B, McCarren HS, O'Neill D, Kelz MB: Distinctive Recruitment of Endogenous Sleep-promoting Neurons by Volatile Anesthetics and a Nonimmobilizer. Anesthesiology 121(5): 999-1009, Nov 2014.

Deutschman CS, Raj NR, McGuire EO, Kelz MB: Orexinergic Activity Modulates Altered Vital Signs and Pituitary Hormone Secretion in Experimental Sepsis. Critical Care Medicine 41(11): e368-75, Nov 2013.

McCarren HS, Moore JT, Kelz MB: Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention JoVE 80: e51079, October 2013.

Joiner WJ, Friedman EB, Hung H-T, Koh K, Sowcik M, Sehgal A, Kelz MB: Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genetics 9(9): e1003605, September 2013 Notes: Published with an editorial by Sanders RD and Maze M: Take Off, Landing, and Fly Anesthesia PLoS Genetics 9(9): e1003788, 2013.

Newman J, Blake K, Fennema J, Harris D, Shanks A, Avidan MS, Kelz MB, Mashour GA. : Incidence, risk factors and outcomes of postoperative coma: an observational study of 858,606 patients. European Journal of Anesthesiology 30(8): 476-82, Aug 2013.

Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA: Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. Journal of Neuroscience 33(17): 7264-73, April 2013.

Weiser BP, Kelz MB, Eckenhoff RG: In vivo activation of azi-propofol prolongs anesthesia and reveals synaptic targets. J Biol Chem 288(2): 1279-85, Jan 2013.

Hu FY, Hanna GM, Wei H, Mardini F, Thomas SA, Wyner AJ, Kelz MB: Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine ß-hydroxylase knockout mice. Anesthesiology 117(5): 1006-17, November 2012 Notes: Published with an accompanying an Editorial, Sanders RD and Maze M, Anesthesiology 2012; 117:945-7.

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Last updated: 12/17/2014
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