Max B. Kelz, MD PhD

faculty photo
Associate Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Graduate Group Affiliations

Contact information
3620 Hamilton Walk,
John Morgan Building - Room 334
Philadelphia, PA 19104
Office: 215 573-8208
Fax: 215 349-5078
Lab: 215 898-8929
Education:
MS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
BS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
PhD (Neuroscience)
Yale University, 1999.
MD (Medicine)
Yale University, 2000.
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Description of Research Expertise

Molecular Mechanisms of Anesthetic Action
Neurobiology of Sleep Wake Regulation
Mouse Genetics
Molecular Biology
Anesthetic pharmacology

Selected Publications

Drobish JK, Kelz MB, DiPuppo P, Cook-Sather SD: Case report: Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient. Anesthesia & Analgesia Case Reports in press, 2015.

McCarren HS, Chalifoux MR, Han B, Moore JT, Meng QC, Baron-Hionis N, Sedigh-Sarvestani M, Contreras D, Beck SG, Kelz MB: α2-Adrenergic Stimulation of the VLPO Destabilizes the Anesthetic State. Journal of Neuroscience 34(49): 16385-96, Dec 2014.

Han B, McCarren HS, O'Neill D, Kelz MB: Distinctive Recruitment of Endogenous Sleep-promoting Neurons by Volatile Anesthetics and a Nonimmobilizer. Anesthesiology 121(5): 999-1009, Nov 2014.

Deutschman CS, Raj NR, McGuire EO, Kelz MB: Orexinergic Activity Modulates Altered Vital Signs and Pituitary Hormone Secretion in Experimental Sepsis. Critical Care Medicine 41(11): e368-75, Nov 2013.

McCarren HS, Moore JT, Kelz MB: Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention JoVE 80: e51079, October 2013.

Joiner WJ, Friedman EB, Hung H-T, Koh K, Sowcik M, Sehgal A, Kelz MB: Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genetics 9(9): e1003605, September 2013 Notes: Published with an editorial by Sanders RD and Maze M: Take Off, Landing, and Fly Anesthesia PLoS Genetics 9(9): e1003788, 2013.

Newman J, Blake K, Fennema J, Harris D, Shanks A, Avidan MS, Kelz MB, Mashour GA. : Incidence, risk factors and outcomes of postoperative coma: an observational study of 858,606 patients. European Journal of Anesthesiology 30(8): 476-82, Aug 2013.

Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA: Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. Journal of Neuroscience 33(17): 7264-73, April 2013.

Weiser BP, Kelz MB, Eckenhoff RG: In vivo activation of azi-propofol prolongs anesthesia and reveals synaptic targets. J Biol Chem 288(2): 1279-85, Jan 2013.

Hu FY, Hanna GM, Wei H, Mardini F, Thomas SA, Wyner AJ, Kelz MB: Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine ß-hydroxylase knockout mice. Anesthesiology 117(5): 1006-17, November 2012 Notes: Published with an accompanying an Editorial, Sanders RD and Maze M, Anesthesiology 2012; 117:945-7.

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Last updated: 12/17/2014
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