Max B. Kelz, MD PhD

faculty photo
Associate Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Graduate Group Affiliations

Contact information
3620 Hamilton Walk,
John Morgan Building - Room 334
Philadelphia, PA 19104
Office: 215 662-3713
Fax: 215 349-5078
Education:
MS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
BS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
PhD (Neuroscience)
Yale University, 1999.
MD (Medicine)
Yale University, 2000.
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Description of Research Expertise

Molecular Mechanisms of Anesthetic Action
Neurobiology of Sleep Wake Regulation
Mouse Genetics
Molecular Biology
Anesthetic pharmacology

Selected Publications

Deutschman CS, Raj NR, McGuire EO, Kelz MB: Orexinergic Activity Modulates Altered Vital Signs and Pituitary Hormone Secretion in Experimental Sepsis. Critical Care Medicine 41(11): e368-75, Nov 2013.

McCarren HS, Moore JT, Kelz MB: Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention JoVE 80: e51079, October 2013.

Joiner WJ, Friedman EB, Hung H-T, Koh K, Sowcik M, Sehgal A, Kelz MB: Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genetics 9(9): e1003605, September 2013 Notes: Published with an editorial by Sanders RD and Maze M: Take Off, Landing, and Fly Anesthesia PLoS Genetics 9(9): e1003788, 2013.

Newman J, Blake K, Fennema J, Harris D, Shanks A, Avidan MS, Kelz MB, Mashour GA. : Incidence, risk factors and outcomes of postoperative coma: an observational study of 858,606 patients. European Journal of Anesthesiology 30(8): 476-82, Aug 2013.

Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA: Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. Journal of Neuroscience 33(17): 7264-73, April 2013.

Weiser BP, Kelz MB, Eckenhoff RG: In vivo activation of azi-propofol prolongs anesthesia and reveals synaptic targets. J Biol Chem 288(2): 1279-85, Jan 2013.

Hu FY, Hanna GM, Wei H, Mardini F, Thomas SA, Wyner AJ, Kelz MB: Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine ß-hydroxylase knockout mice. Anesthesiology 117(5): 1006-17, November 2012 Notes: Published with an accompanying an Editorial, Sanders RD and Maze M, Anesthesiology 2012; 117:945-7.

Moore JT, Chen J, Han B, Meng Q-C, Veasey SC, Beck SG, Kelz MB: Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis. Current Biology 22: 2008-16, November 2012 Notes: Published with an editorial by Solt Current Biology 2012 22:R918-9. Publication was the subject of a Nature News and Views http://www.nature.com/nature/journal/v491/n7422/full/491046a.html?WT.ec_id=NATURE-20121101.

Li RQ, McKinstry AR, Moore JT, Caltagarone BM, Eckenhoff MF, Eckenhoff RG, Kelz MB: Is hydrogen sulfide induced suspended animation general anesthesia? JPET 341(3): 735-42, June 2012.

Pick J, Chen Y, Moore JT, Sun Y, Wyner AJ, Friedman EB, Kelz MB: Rapid eye movement sleep debt accrues in mice exposed to volatile anesthetics. Anesthesiology 115(4): 702-712, Oct 2011 Notes: Accompanied by an editorial: Anesthesiology 2011 115(4)683-4. PMID 21829133.

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Last updated: 12/18/2013
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