Partner Research Centers:

Center for Neurodegenerative Disease Research

Kurt R Brunden

faculty photo
Research Professor of Pathology and Laboratory Medicine
Director or Drug Discovery, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA
Department: Pathology and Laboratory Medicine

Contact information
Center for Neurodegenerative Disease Research
University of Pennsylvania
3600 Spruce St.
3rd Floor Maloney Bldg.
Philadelphia, PA 19104
Office: 215-615-5262
B.S. (Biology/Health Chemistry)
Western Michigan University, 1980.
Ph.D. (Biochemistry)
Purdue University, 1985.
Post-Graduate Training
Post-docotoral fellow, Mayo Clinic and Foundation, 1985-1987.
Instructor and Research Assoc., Mayo Clinic and Foundation, 1988-1988.
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Description of Research Expertise

Dr. Brunden oversees research programs directed towards the identification of therapeutic targets and treatments for Alzheimer's, Parkinson's and other neurodegenerative diseases.

Selected Publications

Makani V, Zhang B, Han H, Yao Y, Lassalas P, Lou K, Paterson I, Lee VM-Y, Trojanowski JQ, Ballatore C, Smith AB III and Brunden KR : Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathol. Comm. In press, 2016.

Kovalevich J, Cornec A-S, Yao Y, James M, Crowe A, Lee VM-Y, Trojanowski JQ, Smith AB III, Ballatore C and Brunden KR : Characterization of brain-penetrant pyrimidine-containing molecules with differential microtubule-stabilizing activities developed as potential therapeutic agents for Alzheimer’s disease and related tauopathies. J. Pharm. Exp. Therap. 357: 432-450, 2016.

Guo JL, Buist A, Soares A, Callaerts K, Calafate S, Stevenaert F, Daniels JP, Zoll BE, Crowe A, Brunden KR, Moechers D and Lee V-MY: The dynamics and turnover of tau aggregates in cultured cells: insights into therapies for tauopathies. J. Biol. Chem. 291: 13175-13193, 2016.

Herbst-Robinson KJ, Liu L, James M, Yao Y, Xie SX and Brunden KR : Inflammatory eicosanoids increase amyloid precursor protein expression via activation of multiple neuronal receptors. Scientific Reports 5: 18286, 2015.

Sankaranaraynan S, Barten D, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Kennan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, Barrezueta N, Polson C, Wes P, Rangan V, Cacace A, Albright CF, Meredith J, Trojanowski JQ, Lee V-MY, Brunden KR* and Ahlijanian M* (*Co-corresponding authors): Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PlosONE 10: e0125614, 2015.

Peeraer E, Bottelbergs A, Van Kolen K, Stancu IC, Vasconcelos B, Mahieu M, Duytschaever H, Ver Donck L, Torremans A, Sluydts E, Van Acker N, Kemp JA, Mercken, M, Brunden KR, Trojanowski JQ, Dewachter I; Lee VM and Moechers D: Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiol. Dis. 73: 83-95, 2015.

Cornec A-S, James M, Kovalevich J, Trojanowski JQ, Lee VM-Y, Smith AB III, Ballatore C and Brunden KR: Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine. Bioorg. Med. Chem. Lett. in press, 2015.

65. Lou K, Yao Y, Hoye A, James M, Cornec A, Hyde E, Gay B, Lee VM-Y, Trojanowski JQ, Smith AB III, Brunden KR* and Ballatore C* (*Co-corresponding authors): Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer’s disease and related tauopathies. J. Med. Chem. 57: 6116-27, 2014.

66. Wang X, Liu L, Huang L, Herbst-Robinson K, Cornec A, James M, Sugiyama S, Bassetto M, Brancale A, Trojanowski JQ, Lee VM-Y, Smith AB III, Brunden KR* and Ballatore C* (*Co-corresponding authors): Potent, long-acting cyclopentane-1,3-dione thromboxane (A2) receptor antagonists. ACS Med. Chem. Lett. 5: 1015-20, 2014.

Ballatore C, Gay B, Huang L, Herbst-Robinson K, James M, Trojanowski JQ, Lee VM-Y, Brunden KR and Smith AB III : Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group. Bioorg. Med. Chem. Lett. 24: 4171-75, 2014.

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Last updated: 09/26/2016
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