Perelman School of Medicine at the University of Pennsylvania

Penn Institute for Immunology

David C. Fajgenbaum

faculty photo
Research Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania (HUP)
Division of Medical Genetics
5th Floor Silverstein, Suite S05094
3400 Spruce Street
Philadelphia, PA 19104
Fax: 877-991-9674
Lab: 215-614-0936
BS (Human Sciences with Distinction, Magna Cum Laude)
Georgetown University, Washington, DC, 2007.
MSc (Public Health)
University of Oxford, Oxford, UK, 2008.
MD (Medicine)
University of Pennsylvania Perelman School of Medicine, 2013.
MBA (Health Care Management Program)
Wharton School of Business, University of Pennsylvania, 2015.
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Description of Other Expertise

David Fajgenbaum, MD, MBA, MSc, is an Assistant Professor of Medicine in the Division of Translational Medicine & Human Genetics at the University of Pennsylvania, the Co-Founder & Executive Director of the Castleman Disease Collaborative Network (CDCN), and Associate Director, Patient Impact of the University of Pennsylvania's Orphan Disease Center. Dr. Fajgenbaum is also a member of Forbes Magazine's 2015 30 Under 30 Healthcare list, Senior Fellow of the Leonard Davis Institute for Health Economics, and Fellow of the College of Physicians of Philadelphia.

Dr. Fajgenbaum co-founded the CDCN in 2012 to accelerate research and treatments for Castleman disease through global collaboration, strategic investment in high impact research, and patient engagement. His research has initiated a paradigm shift in how doctors research and treat Castleman disease. Dr. Fajgenbaum is working to create a blueprint for accelerating research for many more diseases.

Dr. Fajgenbaum is also the Co-Founder and former Board Chair of the National Students of AMF Support Network, a non-profit organization dedicated to supporting grieving college students. AMF has reached 3,000+ students on 200+ college campuses nationwide. He recently co-authored "We Get It," a book for grieving college students and those who wish to support them.

Dr. Fajgenbaum’s work has been highlighted by the New York Times, Science, Today Show, Reader's Digest, Everylife Foundation (2016 RareVoice: Federal Advocacy Award from Rare Disease Legislative Advocates), Global Genes (2015 RARE Champion of Hope: Science award by Global Genes), and the University of Colorado (2013 Distinguished Service Award). Dr. Fajgenbaum completed his MBA at Wharton, where he was awarded the Joseph Wharton Award, Core Value Leadership Award, Kissick Scholarship, Eilers Award, Mandel Fellowship, and Commencement Speaker. Dr. Fajgenbaum earned his MD from the Raymond & Ruth Perelman School of Medicine at the University of Pennsylvania, where he was a 21st Century Gamble Scholar. He studied for an MSc in Public Health from the University of Oxford as the 2007 Joseph L. Allbritton Scholar. He received a BS in Human Sciences with Distinction from Georgetown University, where he was USA Today Academic All-USA First Team.

Description of Research Expertise

Dr. Fajgenbaum holds expertise related to Castleman disease and other hematologic, oncologic and inflammatory diseases. He is also an expert regarding orphan and hematology/oncology drug development, translational research, health care/social entrepreneurship, health policy/public health, bereavement, college student mental health and non-profit development.

Selected Publications

Frits van Rhee & David C. Fajgenbaum: Ask the Hematologists: What are your treatment approaches to Castleman disease with the advent of anti–interleukin-6 therapy? The Hematologist: ASH News and Reports. 12(2): 4-5, 2015.

David C. Fajgenbaum: A Rare Disease That Picked the Wrong Family: Fighting Back to Help a Loved One and as a Tool for Actively Coping. A review of Rare, a documentary video produced directed by Maren Grainger-Monsen and Nicole Newnham. 56 minutes. 2012. Palo Alto, CA: Stanford University Center for Biomedical Ethics. Death Studies. 39(10): 673-6, 2015.

Heather Servaty-Seib & David C. Fajgenbaum: We Get It: Voices of Grieving College Students and Young Adults. Jessica Kingsley Publishers. Jessica Kingsley Publishers, 2015.

David C. Fajgenbaum, Amy Liu, Jason Ruth, Chris Nabel, Brian Finkelman, Razelle Kurzrock, Frits van Rhee, Arthur Rubenstein : HHV-8-Negative, Idiopathic Multicentric Castleman Disease (iMCD): A Description of Clinical Features and Therapeutic Options through a Systematic Literature Review. Blood (ASH Annual Meeting Abstracts). 124:Abstract 4861, 2014.

David C. Fajgenbaum, Frits van Rhee, Chris Nabel: HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy. Blood. 123: 2924-2933, 2014.

David C. Fajgenbaum, Frits van Rhee, Adnan Nasir, Misha Rosenbach, Jason Reutter: Eruptive Cherry Hemangiomatosis associated with Multicentric Castleman’s Disease: A Case Report and possible Mechanism. JAMA Dermatology. 149(2): 204-208, 2013.

David C. Fajgenbaum & Lisa Fajgenbaum: Death and Loss in the Future as it Relates to Young Adults and National Students of AMF. The ADEC Forum. 39(2): 1, 2013.

David C. Fajgenbaum: National Students of AMF: Peer Support and Service as Therapeutic Supports Among Grieving College Students. The ADEC Forum. 38(2): 24-38, 2012.

David C. Fajgenbaum, Ben Chesson, Robin Lanzi: Building a Network of Grief Support on College Campuses: A National Grassroots Initiative. The Journal of College Student Psychotherapy. 26(2): 99-120, 2012.

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Last updated: 01/31/2018
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