1e
19
1
49
2
2
18
1b
1d
18
36
60
1d
2 29
1d
25
Roberto Dominguez, Ph.D.
88
60
William Maul Measey Presidential Professor of Physiology II
7
61
Department: Physiology
4
1
23
1f
Graduate Group Affiliations
8
a
b
1d
46
Contact information
46
4
3
3
1d
46
Department of Physiology
23 Perelman School of Medicine
22 University of Pennsylvania
22 728 Clinical Research Bldg
36 415 Curie Blvd
Philadelphia, PA 19104-6085
26
23 Perelman School of Medicine
22 University of Pennsylvania
22 728 Clinical Research Bldg
36 415 Curie Blvd
Philadelphia, PA 19104-6085
2e
Office: 215-573-4559
32 Fax: 215-573-2273
24
9f
12
32 Fax: 215-573-2273
24
18
Publications
23 a
3
2
29
23 a
Links
cc Search PubMed for articles
5c Dominguez Lab
77 Physiology Department
79 BMB Graduate Group
c
4
b
1f
cc Search PubMed for articles
5c Dominguez Lab
77 Physiology Department
79 BMB Graduate Group
c
13
Education:
21 a M.S. 2e (Theoretical Physics & Mathematics) c
52 Faculty of Physics, Odessa State University (former USSR), 1987.
21 a Ph.D. 35 (Protein Crystallography and Biochemistry) c
52 Pasteur Institute and Paris-Sud University, Paris, France, 1996.
c
3
3
3
3
8d
Permanent link21 a M.S. 2e (Theoretical Physics & Mathematics) c
52 Faculty of Physics, Odessa State University (former USSR), 1987.
21 a Ph.D. 35 (Protein Crystallography and Biochemistry) c
52 Pasteur Institute and Paris-Sud University, Paris, France, 1996.
c
2 29
21
1e
1d
24
5e
8
13f Cytoskeletal proteins control a myriad of fundamental cellular activities, including cell locomotion, intracellular transport, endo- and exocytosis. Dysfunction of cytoskeletal components is often associated with devastating diseases, such as cancer and several muscular, immune and neurodegenerative disorders.
8
2a5 Cytoskeletal proteins often form large functional assemblies, and additionally associate with cellular membranes. Therefore, our goal is to study their structures and activities within the context of such protein-protein and protein-membrane interaction networks. An important tool in our research is X-ray crystallography. The atomic “snapshots” resulting from crystal structures provide a wealth of knowledge, but lack information about the dynamic aspects of protein function. To obtain this kind of information we use a host of other approaches, including molecular biology, bioinformatics, biophysical methods (ITC, MALS, FRET, TIRF, Cryo-EM), and cell biology.
26 7 1d 1f
27
Description of Research Expertise
160 My laboratory studies the proteins that control the actin cytoskeleton and cytoskeleton-membrane connections, as well as the signaling cascades that regulate their activities. We use a broad spectrum of experimental approaches, spanning structural biology, biochemistry and cell biology, allowing us to correlate structure to function.8
13f Cytoskeletal proteins control a myriad of fundamental cellular activities, including cell locomotion, intracellular transport, endo- and exocytosis. Dysfunction of cytoskeletal components is often associated with devastating diseases, such as cancer and several muscular, immune and neurodegenerative disorders.
8
2a5 Cytoskeletal proteins often form large functional assemblies, and additionally associate with cellular membranes. Therefore, our goal is to study their structures and activities within the context of such protein-protein and protein-membrane interaction networks. An important tool in our research is X-ray crystallography. The atomic “snapshots” resulting from crystal structures provide a wealth of knowledge, but lack information about the dynamic aspects of protein function. To obtain this kind of information we use a host of other approaches, including molecular biology, bioinformatics, biophysical methods (ITC, MALS, FRET, TIRF, Cryo-EM), and cell biology.
26 7 1d 1f