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Roberto Dominguez, Ph.D.

Roberto Dominguez, Ph.D.

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Professor of Physiology
Department: Physiology
Graduate Group Affiliations

Contact information
Department of Physiology
Perelman School of Medicine
University of Pennsylvania
728 Clinical Research Bldg
415 Curie Blvd
Philadelphia, PA 19104-6085
Office: 215-573-4559
Fax: 215-573-2273
M.S. (Theoretical Physics & Mathematics)
Faculty of Physics, Odessa State University (former USSR), 1987.
Ph.D. (Protein Crystallography and Biochemistry)
Pasteur Institute and Paris-Sud University, Paris, France, 1996.
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Description of Research Expertise

Structural Biology of the Actin Cytoskeleton

The actin cytoskeleton plays an essential role in multiple cellular functions, including cytokinesis, vesicular trafficking and the maintenance of cell shape and polarity. To accomplish these functions, the cytoskeleton undergoes constant remodeling into various forms of structural and functional networks, such as lamellipodia, filopodia, stress fibers and focal adhesions. Remodeling of the cytoskeleton is a tightly regulated process, involving hundreds of actin-binding and signaling proteins. The main focus of the research in our lab is to understand the molecular basis for how protein-protein interaction networks bring together cytoskeleton scaffolding, nucleation, elongation, and signaling proteins to accomplish specific cellular functions.

Our primary research tool is protein X-ray crystallography. The atomic “snapshots” resulting from the X-ray crystal structures of proteins provide a wealth of knowledge, but lack information about the dynamic aspects of protein-protein interactions. To obtain this kind of information we also use a host of other approaches, including mutagenesis, bio-informatics, biophysical and biochemical methods.
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Last updated: 06/27/2014
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