Kathleen E. Sullivan, MD PHD
Kathleen E. Sullivan, MD PhD
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
Division of Allergy and Immunology
Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: (215) 590-1697
Fax: 267-426-0363
Fax: 267-426-0363
Email:
sullivak@mail.med.upenn.edu
sullivak@mail.med.upenn.edu
Publications
Education:
B.A., M.A. (Biophysics)
Johns Hopkins University, 1980.
Ph.D. (Immunology & Biochemistry)
University of California at San Francisco, 1988.
M.D.
University of California at San Francisco, 1988.
Permanent linkB.A., M.A. (Biophysics)
Johns Hopkins University, 1980.
Ph.D. (Immunology & Biochemistry)
University of California at San Francisco, 1988.
M.D.
University of California at San Francisco, 1988.
Description of Research Expertise
Research Interests:The etiopathogenesis of lupus and the regulation of genes involved in inflammation.
Research Summary:
We are interested in genes that control inflammation and specifically in the role of these genes in inflammatory disorders such as systemic lupus erythematosus (SLE) and Crohn's disease. Over-expression of TNF is a characteristic of most inflammatory diseases and anti-TNF antibody treatment is a valuable strategy. By understanding the regulation of TNF expression, we hope to develop strategies which would allow resetting of the TNF locus such that production is normalized.
A variety of techniques are used in the lab to understand the genetics of SLE. Chromatin immunoprecipitation is used to define the epigenetic status of a given locus and micrococcal nuclease is used to define nucleosome positions. Additional studies of chromatin as a dynamic modulator of gene expression are planned and we will continue to define the variables that are important in the development of lupus.
The Pathogenesis of Influenza
Research Summary:
We have studied protection from influenza and are evaluating proteins involved in viral entry.
Description of Clinical Expertise
Primary ImmunodeficienciesSelected Publications
Heltzer, M. L., Coffin, S. E., Maurer, K., Bagashev, A., Zhang, Z., Orange, J. O., Sullivan, K. E. : Immune dysregulation in severe influenza. Journal of Leukocyte Biology (85), 1036-1043, 2009.Grant, S.F.A, Petri, M., Bradfield, J. P., Kim, C. E., Santa, E., Annaiah, K., Frackelton, E. C., Glessner, J. T., Otiento, F. G., Shaner, J. L., Smith, R. M., Eckert, A. W., Chiavacci, R. M., Imielinski, M., Sullivan, K. E., Hakonarson, H. : Association of the BANK1 R61H variant with systemic lupus erythematosus in Americans of European and African ancestry. Application of Clin Genet. (2), 1-5, 2009.
Garrett, S., Dietzmann-Maurer, K., Song, L., Sullivan, K. E. : Polarization of primary human monocytes by IFN-γ induces chromatin changes and recruits RNA Pol II to the TNF-α promoter. J. Immunol. (180), 5257-66, 2008.
Yong, P. L., Russo, P., Sullivan, K. E. : Use of sirolimus in IPEX and IPEX-like children. J. Clin. Immunol. (28), 581-587, 2008.
Garrett, S., Fitzgerald, M.C., Sullivan, K. E. : LPS and Poly I:C induce chromatin modifications at a novel upstream region of the IL-23 p19 promoter. Inflammation(31), 235-246, 2008.
Liu, S., Abrams, D, Baldassano, R. N., Sullivan, K. E. : Prevalence of chronic granulomatous disease in pediatric patients diagnosed with Crohn’s disease. Inflamm. Bowel Dis (14), 727-8, 2008.
Heltzer, M. L., Choi, J., Ochs, H. D., Sullivan, K. E., Torgerson, T. R., Ernst, L. M. : A potential screening tool of IPEX syndrome. Ped. Dev. Pathol. (109), 98-105, 2007.
Onigbanjo, MT, Orange, JS, Perez, EE, Sullivan, KE. : Hypogamaglobulinemia in a pediatric tertiary care setting. Clin Imm (125), 52-59, 2007.
Sediva, A, Smith, C I E, Asplund, A C, Hadac, J, Janda, A, Zeman, J, Hansikova, H, Dvorakova, L, Mrazova, L, Velbri, S, Koehler, C, Roesch, K, Sullivan, K E, Futatani, T, Ochs, H D. : Contiguous X-chromosome deletion syndrome encompassing the BTK, TIMM8A, TAF7L and DRP2 genes. J. Clin. Immunol.(27), 640-6, 2007.
Kobrynski, L.J., Sullivan, K.E. : Velocardiofacial syndrome, DiGeroge syndrome: the chromosome 22q11.2 deletion syndrome. Lancet (370), 1443-52, 2007.