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Tomas S. Aleman, MD

Tomas S. Aleman, MD

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Assistant Professor of Ophthalmology at the Hospital of the University of Pennsylvania
Department: Ophthalmology

Contact information
Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
Office: 215-662-9981
Fax: 215-662-9388
Education:
B.S. (Sciences (High Honors))
F. Engels Vocational Schools, 1982.
M.D. (Medicine)
University of Havana (High Honors), 1988.
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Description of Research Expertise

Dr. Aleman has extensive expertise in the study of hereditary retinal degenerations. He is part of the Retinal Degeneration Center at Scheie Eye Institute. His research expertise includes state-of-the-art psychophysical, electrophysiological and imaging studies in patients and animal models of the human disease. Most of the studies in which Dr. Aleman is an investigator are aimed to lead patients with these incurable retinal degenerations into clinical trials. The macular pigment is a carotenoid complex proposed to have a protective role in the human central retina. With the long-term goal of finding ways to prevent central vision loss in retinal degenerative diseases, Dr. Aleman has studied macular pigment levels and the response to supplementation with lutein in patients with inherited retinal disorders.

Clinical Trials
Dr. Aleman is an investigator in an upcoming gene therapy trial for Leber’s congenital amaurosis, the most severe form of inherited retinal degeneration.

Key Words
Hereditary Retinal Degenerations, retinitis pigmentosa, macular disorders, optical coherence tomography, electroretinogram

Description of Clinical Expertise

Dr. Aleman cares for patients with hereditary retinal degenerations at the Center for Hereditary Retinal Degenerations at Scheie Eye Institute. He has been also responsible for all clinical electrophysiological investigations within this department, which provides this service to a large number of specialists in the region.

Description of Other Expertise

Fluent in Spanish

Selected Publications

Aleman TS, Brodie F, Garvin C, Gewaily DY, Ficicioglu CH, Mills MD, Forbes BJ, Maguire AM, Davidson SL: Retinal structure in cobalamin C disease: mechanistic and therapeutic implications. Ophthalmic Genetics 2014 Notes: in press.

Aleman TS, Garrity ST, Brucker AJ.: Retinal structure in vitamin A deficiency as explored with multimodal imaging. Doc. Ophthalmol. 127: 239-43, 2013.

Jacobson SG, Cideciyan AV, Ratnakaram R, Heon E, Schwartz SB, Roman AJ, Peden MC, Aleman TS, Boye SL, Sumaroka A, Conlon TJ, Calcedo R, Pang JJ, Erger KE, Olivares MB, Mullins CL, Swider M, Kaushal S, Feuer WJ, Iannaccone A, Fishman GA, Stone EM, Byrne BJ, Hauswirth WW. : Gene therapy for Leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Arch Ophthalmol. 130: 9-24, 2012

Dinculescu A, Estreicher J, Zenteno JC, Aleman TS, Schwartz SB, Huang WC, Roman AJ, Sumaroka A, Li Q, Deng WT, Min SH, Chiodo VA, Neeley A, Liu X, Shu X, Matias-Florentino M, Buentello-Volante B, Boye SL, Cideciyan AV, Hauswirth WW, Jacobson SG. : Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept Hum Gene Ther 23 : 367-376, 2012.

Moran AM, Aleman TS, Gausas RE, Fogt F. : Traumatic arteriovenous fistula of the superficial temporal artery: a histopathologic report Ophthal Plast Reconstr Surg. 2012.

Cideciyan AV, Swider M, Aleman TS, Feuer WJ, Schwartz SB, Russell RC, Steinberg JD, Stone EM, Jacobson SG : Macular function in macular degenerations: repeatability of microperimetry as a potential outcome measure for ABCA4-associated retinopathy trials Invest Ophthalmol Vis Sci. 53: 841-852, 2012.

Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Román AJ, Deng WT, Swider M, Aleman TS, Boye SL, Genini S, Swaroop A, Hauswirth WW, Jacobson SG, Aguirre GD : Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proc Natl Acad Sci U S A. 109 : 2132-2137, 2012.

Aleman TS, Tapino PJ, Brucker AJ : Evidence of Recurrent microvascular occlusions associated with acute branch retinal artery occlusion demonstrated with SD-OCT. Retina 32 : 1687-1688, 2012.

Lopes VS, Gibbs D, Libby R, Aleman TS, Welch DL, Lillo C, Jacobson SG, Roxana RA, Radu A, Steel KP, Williams DS: The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65. Hum Mol Genet 20: 2560-2570, 2011.

Shu X; Luhmann U, Aleman TS, Barker SE, Lennon A, Tulloch B, Chen M, Xu H, Jacobson SG, Ali R, Wright A: Characterisation of a C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration. PLoS One. 6: e27433, 2011.

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Last updated: 05/01/2014
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