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Tomas S. Aleman, MD

Tomas S. Aleman, MD

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Associate Professor of Ophthalmology at the Hospital of the University of Pennsylvania
Department: Ophthalmology

Contact information
Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
Office: 215-614-4100
Fax: 215-615-0527
B.S. (Sciences (High Honors))
F. Engels Vocational Schools, 1982.
M.D. (Medicine)
University of Havana (High Honors), 1988.
Permanent link
Perelman School of Medicine > Faculty > Search

Description of Research Expertise

Dr. Aleman has extensive expertise in the study of hereditary retinal degenerations. He is part of the Retinal Degeneration Center at Scheie Eye Institute and the CAROT center of the Department of Ophthalmology of the University of Pennsylvania. His research expertise includes state-of-the-art psychophysical, electrophysiological and imaging studies in patients and animal models of the human disease. Most of the studies in which Dr. Aleman is an investigator are aimed to lead patients with these incurable retinal degenerations into clinical trials as well as in the detailed characterization of patients, both children and adults, with these conditions.

Clinical Trials
Dr. Aleman is a co-principal investigator in an ongoing gene therapy trial for choroideremia.

Key Words
Hereditary Retinal Degenerations, retinitis pigmentosa, choroideremia, cone rod dystrophy, optical coherence tomography, electroretinogram

Description of Clinical Expertise

Dr. Aleman cares for children and adults with retinal degenerations, hereditary or acquired, at the Center for Hereditary Retinal Degenerations at Scheie Eye Institute and at the Perelman Center for Advanced Medicine. He is the co-principal investigator of a gene therapy trial for choroideremia. He is also responsible for all clinical electrophysiological investigations within this department, which provides this service to a large number of specialists in the region.

Description of Other Expertise

Fluent in Spanish

Selected Publications

Matsui R, McGuigan III DB, Gruzensky ML, Aleman TS, Schwartz SB, Sumaroka A, Koenekoop RK, Cideciyan AV, Jacobson SG: SPATA7: Evolving phenotype from cone-rod dystrophy to retinitis pigmentosa. Ophthalmic genetics 37(3): 333-8, Sep 2016 Notes: Epub 2016 Feb

Fuerst NM, Serrano L, Han G, Morgan JIW, Maguire AMM, Leroy BP, Kim BJ, Aleman TS. 2016; 30:1-8.: Detailed functional and structural phenotype of Bietti crystalline dystrophy associated with mutations in CYP4V2 complicated by choroidal neovascularization. Ophthalmic Genetics 30: 1-8, Mar 2016 Notes: Epub ahead of print.

Bonafede L Ficicioglu CH, Serrano L, Han G, Morgan JIW, Mills MD, Forbes BJ, Davidson SL, Binenbaum G, Kaplan PB, Nichols CW, Verloo P, Leroy BP, Maguire AM, Aleman TS. : Cobalamin C deficiency shows a Rapidly Progressing Maculopathy with severe photoreceptor and ganglion cell loss. Invest Ophthalmol Vis Sci. 56(13): 7875-87, Dec 2015.

Swanson J, Xu W, Aleman TS, Mitchell B, Wes A, Chen SS, Bender L, Heuer G, Katowitz W, Bartlett S, Taylor J. : Optical coherence tomography can detect intracranial hypertension in young children with craniosynostosis. Plast Reconstr Surg. 136((4 Suppl)): 39, Oct 2015.

Brodie FL, Charlson ES, Aleman TS, Salvo RT, Lau MK, Farren ND, Engelhard SB, Pistilli M, Brucker AJ. : Obstructive sleep apnea and central serous chorioretinopathy. Retina 35(2), Feb 2015.

Aleman TS, Huang J, Garrity ST, Carter SB, Aleman WD, Ying G, Tamhankar MA.: Relationship between optic nerve appearance and retinal nerve fiber thickness as explored with spectral domain optical coherence tomography. Trans Vis Sci Tech 3(6): 4, Nov 2014.

Aleman TS, Brodie F, Garvin C, Gewaily DY, Ficicioglu CH, Mills MD, Forbes BJ, Maguire AM, Davidson SL: Retinal structure in cobalamin C disease: mechanistic and therapeutic implications. Ophthalmic Genetics Feb 2014 Notes: E Pub ahead of print.

Aleman TS, Garrity ST, Brucker AJ.: Retinal structure in vitamin A deficiency as explored with multimodal imaging. Doc. Ophthalmol. 127(3): 239-43, Dec 2013.

Moran AM, Aleman TS, Gausas RE, Fogt F. : Traumatic arteriovenous fistula of the superficial temporal artery: a histopathologic report Ophthal Plast Reconstr Surg. 29(5): 126-8, Sep-Oct 2013.

Jacobson SG, Cideciyan AV, Ratnakaram R, Heon E, Schwartz SB, Roman AJ, Peden MC, Aleman TS, Boye SL, Sumaroka A, Conlon TJ, Calcedo R, Pang JJ, Erger KE, Olivares MB, Mullins CL, Swider M, Kaushal S, Feuer WJ, Iannaccone A, Fishman GA, Stone EM, Byrne BJ, Hauswirth WW. : Gene therapy for Leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Arch Ophthalmol. 130(1): 9-24, Jan 2012

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Last updated: 07/26/2016
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