Amit Maity, MD, PhD
Amit Maity, MD, PhD
Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology
Contact information
2 PCAM West
3400 Civic Center Blvd.
Philadelphia, PA 19104
3400 Civic Center Blvd.
Philadelphia, PA 19104
Office: 2156622712
Fax: 2153498952
Fax: 2153498952
Email:
maity@uphs.upenn.edu
maity@uphs.upenn.edu
Publications
Education:
MD (Medicine)
Boston University, 1985.
BA (Mathematics)
Boston University, 1985.
PhD (Pathology)
University of Pennsylvania, 1995.
Permanent linkMD (Medicine)
Boston University, 1985.
BA (Mathematics)
Boston University, 1985.
PhD (Pathology)
University of Pennsylvania, 1995.
Description of Research Expertise
My laboratory based research focuses on developing strategies of improving the radiation response, using agents that modify the tumor microenvironment and alter cellular signaling. In particular we have focused on the PI3K/mTOR pathway, which is upregulated in many human cancers. Our research suggest that inhibition of this pathway can increase the intrinsic sensitivity of tumor cells to radiation and also decrease tumor oxygenation.Selected Publications
Rengan R, Mick R, Pryma D, Rosen MA, Lin L, Maity A, Evans TL, Stevenson JP, Langer CJ, Kucharczuk J, Friedberg J, Prendergast S, Sharkoski T, Hahn SM : A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer: a report of toxicities and clinical response. Journal of thoracic oncology 7(4): 709-15, April 2012Marotta A, Karar J, Jenkins W T, Kumanova M, Jenkins K W, Tobias J W, Baldwin D, Hatzigeorgiou A, Alexiou P, Evans S M, Alarcon R, Maity A*, Koch C*, Koumenis C*: In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection. Cancer research 71(3): 779-89, Feb 2011 Notes: *joint corresponding authors.
Cerniglia G J, Pore N, Tsai J H, Schultz S, Mick R, Choe R, Xing Z, Durduran T, Yodh A G, Evans S M, Koch C J, Hahn S M, Quon H, Sehgal C M, Lee W M F, Maity A: Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PloS one 4(8): e6539, Aug 2009.
Gupta A K, Lee J H, Wilke W W, Quon H, Smith G, Maity A, Buatti J M, Spitz D R: Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT. International journal of radiation oncology, biology, physics 74(3): 928-33, Jul 2009.
Shinohara E T, Maity A, Jha N, Lustig R A: Sirolimus as a potential radiosensitizer in squamous cell cancer of the head and neck. Head & neck 31(3): 406-11, Mar 2009.
Curry J M, Eubank T D, Roberts R D, Wang Y, Pore N, Maity A, Marsh C B: M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo. PloS one 3(10): e3405, Oct 2008.
Tuttle S W, Maity A, Oprysko P R, Kachur A V, Ayene I S, Biaglow J E, Koch C J: Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia. The journal of biological chemistry 282(51): 36790-6, Dec 2007.
Kao G D, Jiang Z, Fernandes A M, Gupta A K, Maity A: Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. The journal of biological chemistry 282(29): 21206-12, Jul 2007.
Shu H-K G, Sall W F, Maity A, Tochner Z A, Janss A J, Belasco J B, Rorke-Adams L B, Phillips P C, Sutton L N, Fisher M J: Childhood intracranial ependymoma: twenty-year experience from a single institution. Cancer 110(2): 432-41, Jul 2007.
Jiang Z, Pore N, Cerniglia G J, Mick R, Georgescu M-M, Bernhard E J, Hahn S M, Gupta A K, Maity A: Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir. Cancer research 67(9): 4467-73, May 2007.
Pore N, Jiang Z, Gupta A, Cerniglia G, Kao G D, Maity A: EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Cancer research 66(6): 3197-204, Mar 2006.