My laboratory based research focuses on developing strategies of improving the radiation response, using agents that modify the tumor microenvironment and alter cellular signaling. In particular we have focused on the PI3K/mTOR pathway, which is upregulated in many human cancers. Our research suggest that inhibition of this pathway can increase the intrinsic sensitivity of tumor cells to radiation and also decrease tumor oxygenation.
Alonso-Basanta M, Fang P, Maity A, Hahn SM, Lustig RA, Dorsey JF: A Phase I Study of Nelfinavir Concurrent with Temozolomide and Radiotherapy in Patients with Glioblastoma Multiforme. Journal of Neurooncology 116(2): 365-72, Jan 2014.
Thompson RF, Maity A: Radiotherapy and the tumor microenvironment: mutual influence and clinical implications. Advances in Experimental Medicine and Biology 772: 147-65, 2014.
George J. Cerniglia, Souvik Dey, Shannon M. Gallagher-Colombo, Natalie Daurio, Stephen Tuttle, Theresa M. Busch, Alexander Lin, Tatiana V. Esipova, Sergei A. Vinogradov, Constantinos Koumenis, Amit Maity: The PI3K/mTOR pathway regulates oxygen metabolism via pyruvate dehydrogenase (PDH)-E1α phosphorylation. International journal of radiation oncology, biology, physics
2014 Notes: poster presentation at 56th meeting of American Society for Therapeutic Radiology and Oncology
Damek-Poprawa M, Both S, Wright A C, Maity A, Akintoye SQ: Onset of mandible and tibia osteoradionecrosis - a comparative pilot study in the rat. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 115(2): 201-11, Feb 2013.
George J. Cerniglia,
Shannon M. Gallagher-Colombo,
Theresa M. Busch,
Stephen W. Tuttle,
Cameron J. Koch,
Amit Maity: Targeting the PI3K/mTOR pathway decreases oxygen consumption and reduces tumor hypoxia International journal of radiation oncology, biology, physics 2013 Notes: accepted for Poster Discussion Session presentation at 55th meeting of American Society for Therapeutic Radiology and Oncology
George J. Cerniglia, Natalie Daurio, Shannon M. Gallagher-Colombo, Theresa M. Busch, Stephen W. Tuttle, Cameron J. Koch, Alexander Lin, Constantinos Koumenis, Amit Maity,: Agents that target the PI3K/mTOR pathway decrease oxygen consumption and reduce tumor hypoxia Proceedings of the american association for cancer research annual meeting 2013 Notes: poster presentation at 104th annual meeting, American Association for Cancer Research.
Rengan R, Mick R, Pryma D, Rosen MA, Lin L, Maity A, Evans TL, Stevenson JP, Langer CJ, Kucharczuk J, Friedberg J, Prendergast S, Sharkoski T, Hahn SM : A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer: a report of toxicities and clinical response. Journal of Thoracic Oncology 7(4): 709-15, Apr 2012
Volz E, Gabriel P, Bergendahl WH, Maity A, Hahn S: Improving safety culture through incident reporting. International journal of radiation oncology, biology, physics 84(3): S100-S101, 2012 Notes: oral presentation at 54th meeting of American Society for Therapeutic Radiology and Oncology
Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C.
: ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. Journal of Clinical Investigation 122(12): 4621-34, Dec 3 2012.
Cerniglia GJ, Karar J, Tyagi S, Christofidou-Solomidou M, Rengan R, Koumenis C, Maity A: Inhibition of autophagy as a strategy to augument radiosensitization by the dual PI3K/mTOR inhibitor NVP-BEZ235. Molecular pharmacology 82(6): 1230-40, Dec 2012.
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Last updated: 11/20/2014
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