My laboratory based research focuses on developing strategies of improving the radiation response, using agents that modify the tumor microenvironment and alter cellular signaling. In particular we have focused on the PI3K/mTOR pathway, which is upregulated in many human cancers. Our research suggest that inhibition of this pathway can increase the intrinsic sensitivity of tumor cells to radiation and also decrease tumor oxygenation.
Gandhi Saumil J, Minn Andy, Vonderheide Robert H, Wherry E John, Hahn Stephen M, Maity Amit: Awakening the immune system with radiation: Optimal dose and fractionation. Cancer letters Mar 2015.
Twyman-Saint Victor Christina, Rech Andrew J, Maity Amit, Rengan Ramesh, Pauken Kristen E, Stelekati Erietta, Benci Joseph L, Xu Bihui, Dada Hannah, Odorizzi Pamela M, Herati Ramin S, Mansfield Kathleen D, Patsch Dana, Amaravadi Ravi K, Schuchter Lynn M, Ishwaran Hemant, Mick Rosemarie, Pryma Daniel A, Xu Xiaowei, Feldman Michael D, Gangadhar Tara C, Hahn Stephen M, Wherry E John, Vonderheide Robert H, Minn Andy J: Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature Mar 2015.
Welsh James W, Seyedin Steven N, Cortez Maria Angelica, Maity Amit, Hahn Stephen M: Galectin-1 and immune suppression during radiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research 20(24): 6230-2, Dec 2014.
Alonso-Basanta M, Fang P, Maity A, Hahn SM, Lustig RA, Dorsey JF: A Phase I Study of Nelfinavir Concurrent with Temozolomide and Radiotherapy in Patients with Glioblastoma Multiforme. Journal of Neurooncology 116(2): 365-72, Jan 2014.
Thompson RF, Maity A: Radiotherapy and the tumor microenvironment: mutual influence and clinical implications. Advances in Experimental Medicine and Biology 772: 147-65, 2014.
George J. Cerniglia, Souvik Dey, Shannon M. Gallagher-Colombo, Natalie Daurio, Stephen Tuttle, Theresa M. Busch, Alexander Lin, Tatiana V. Esipova, Sergei A. Vinogradov, Constantinos Koumenis, Amit Maity: The PI3K/mTOR pathway regulates oxygen metabolism via pyruvate dehydrogenase (PDH)-E1α phosphorylation. International journal of radiation oncology, biology, physics
2014 Notes: poster presentation at 56th meeting of American Society for Therapeutic Radiology and Oncology
Damek-Poprawa M, Both S, Wright A C, Maity A, Akintoye SQ: Onset of mandible and tibia osteoradionecrosis - a comparative pilot study in the rat. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 115(2): 201-11, Feb 2013.
George J. Cerniglia,
Shannon M. Gallagher-Colombo,
Theresa M. Busch,
Stephen W. Tuttle,
Cameron J. Koch,
Amit Maity: Targeting the PI3K/mTOR pathway decreases oxygen consumption and reduces tumor hypoxia International journal of radiation oncology, biology, physics 2013 Notes: accepted for Poster Discussion Session presentation at 55th meeting of American Society for Therapeutic Radiology and Oncology
George J. Cerniglia, Natalie Daurio, Shannon M. Gallagher-Colombo, Theresa M. Busch, Stephen W. Tuttle, Cameron J. Koch, Alexander Lin, Constantinos Koumenis, Amit Maity,: Agents that target the PI3K/mTOR pathway decrease oxygen consumption and reduce tumor hypoxia Proceedings of the american association for cancer research annual meeting 2013 Notes: poster presentation at 104th annual meeting, American Association for Cancer Research.
Rengan R, Mick R, Pryma D, Rosen MA, Lin L, Maity A, Evans TL, Stevenson JP, Langer CJ, Kucharczuk J, Friedberg J, Prendergast S, Sharkoski T, Hahn SM : A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer: a report of toxicities and clinical response. Journal of Thoracic Oncology 7(4): 709-15, Apr 2012
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Last updated: 04/12/2015
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