My laboratory based research focuses on developing strategies of improving the radiation response, using agents that modify the tumor microenvironment and alter cellular signaling. In particular we have focused on the PI3K/mTOR pathway, which is upregulated in many human cancers. Our research suggest that inhibition of this pathway can increase the intrinsic sensitivity of tumor cells to radiation and also decrease tumor oxygenation.
Damek-Poprawa M, Both S, Wright A C, Maity A, Akintoye SQ: Onset of mandible and tibia osteoradionecrosis - a comparative pilot study in the rat. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 115(2): 201-11, Feb 2013.
Rengan R, Mick R, Pryma D, Rosen MA, Lin L, Maity A, Evans TL, Stevenson JP, Langer CJ, Kucharczuk J, Friedberg J, Prendergast S, Sharkoski T, Hahn SM : A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer: a report of toxicities and clinical response. Journal of Thoracic Oncology 7(4): 709-15, Apr 2012
Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C.
: ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. Journal of Clinical Investigation 122(12): 4621-34, Dec 3 2012.
Cerniglia GJ, Karar J, Tyagi S, Christofidou-Solomidou M, Rengan R, Koumenis C, Maity A: Inhibition of autophagy as a strategy to augument radiosensitization by the dual PI3K/mTOR inhibitor NVP-BEZ235. Molecular pharmacology 82(6): 1230-40, Dec 2012.
Karar J, Cerniglia GJ, Lindsten T, Koumenis C, Maity A: Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia. Cancer biology & therapy 13(11): 1102-11, Sep 2012.
Marotta A, Karar J, Jenkins W T, Kumanova M, Jenkins K W, Tobias J W, Baldwin D, Hatzigeorgiou A, Alexiou P, Evans S M, Alarcon R, Maity A*, Koch C*, Koumenis C*: In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection. Cancer research 71(3): 779-89, Feb 2011 Notes: *joint corresponding authors.
Cerniglia G J, Pore N, Tsai J H, Schultz S, Mick R, Choe R, Xing Z, Durduran T, Yodh A G, Evans S M, Koch C J, Hahn S M, Quon H, Sehgal C M, Lee W M F, Maity A: Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PloS one 4(8): e6539, Aug 2009.
Gupta A K, Lee J H, Wilke W W, Quon H, Smith G, Maity A, Buatti J M, Spitz D R: Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT. International journal of radiation oncology, biology, physics 74(3): 928-33, Jul 2009.
Shinohara E T, Maity A, Jha N, Lustig R A: Sirolimus as a potential radiosensitizer in squamous cell cancer of the head and neck. Head & neck 31(3): 406-11, Mar 2009.
Curry J M, Eubank T D, Roberts R D, Wang Y, Pore N, Maity A, Marsh C B: M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo. PloS one 3(10): e3405, Oct 2008.
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Last updated: 01/23/2014
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