My laboratory based research focuses on developing strategies of improving the radiation response, using agents that modify the tumor microenvironment and alter cellular signaling. In particular we have focused on the PI3K/mTOR pathway, which is upregulated in many human cancers. Our research suggest that inhibition of this pathway can increase the intrinsic sensitivity of tumor cells to radiation and also decrease tumor oxygenation.
My clinical research focuses on using hypofractionated radiation to potentiate the action of immune checkpoint inhibitors in patient with metastatic solid tumors including melanoma, non small-lung cancer, and breast cancer.
Gandhi SJ, Minn A, Vonderheide RH, Wherry EJ, Hahn SM, Maity A: Awakening the immune system with radiation: Optimal dose and fractionation. Cancer letters Mar 2015.
Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Vonderheide RH, Minn AJ: Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature Mar 2015.
Cerniglia GJ, Dey S, Gallagher-Colombo SM, Daurio N, Tuttle S, Busch TM, Lin A, Esipova TV, Vinogradov SA, Koumenis C, Maity A: PI3K/Akt inhibition decreases oxygen consumption In tumor cells by phosphorylating and inactivating pyruvate dehydrogenase PDH E1α subunit. Proceedings of the american association for cancer research annual meeting 2015 Notes: poster presentation at 106th annual meeting, American Association for Cancer Research.
Rech AJ, Twyman-Saint Victor C, Maity A, Rengan R, Pauken KE, Stelekati E, Benci J, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma D, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Minn AJ, Vonderheide RH: Radiation and dual immune checkpoint blockade overcome tumor resistance and distinctly improve immunity. Proceedings of the american association for cancer research annual meeting 2015 Notes: oral presentation at 106th annual meeting, American Association for Cancer Research, Philadelphia, PA.
Welsh JW, Seyedin SN, Cortez MA, Maity A, Hahn SM: Galectin-1 and immune suppression during radiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research 20(24): 6230-2, Dec 2014.
Alonso-Basanta M, Fang P, Maity A, Hahn SM, Lustig RA, Dorsey JF: A Phase I Study of Nelfinavir Concurrent with Temozolomide and Radiotherapy in Patients with Glioblastoma Multiforme. Journal of Neurooncology 116(2): 365-72, Jan 2014.
Thompson RF, Maity A: Radiotherapy and the tumor microenvironment: mutual influence and clinical implications. Advances in Experimental Medicine and Biology 772: 147-65, 2014.
George J. Cerniglia, Souvik Dey, Shannon M. Gallagher-Colombo, Natalie Daurio, Stephen Tuttle, Theresa M. Busch, Alexander Lin, Tatiana V. Esipova, Sergei A. Vinogradov, Constantinos Koumenis, Amit Maity: The PI3K/mTOR pathway regulates oxygen metabolism via pyruvate dehydrogenase (PDH)-E1α phosphorylation. International journal of radiation oncology, biology, physics
2014 Notes: poster presentation at 56th meeting of American Society for Therapeutic Radiology and Oncology
Damek-Poprawa M, Both S, Wright A C, Maity A, Akintoye SQ: Onset of mandible and tibia osteoradionecrosis - a comparative pilot study in the rat. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 115(2): 201-11, Feb 2013.
George J. Cerniglia,
Shannon M. Gallagher-Colombo,
Theresa M. Busch,
Stephen W. Tuttle,
Cameron J. Koch,
Amit Maity: Targeting the PI3K/mTOR pathway decreases oxygen consumption and reduces tumor hypoxia International journal of radiation oncology, biology, physics 2013 Notes: accepted for Poster Discussion Session presentation at 55th meeting of American Society for Therapeutic Radiology and Oncology
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Last updated: 05/13/2015
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