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Marina Cuchel, MD, PhD

Marina Cuchel, MD, PhD

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Research Assistant Professor of Medicine
Department: Medicine

Contact information
Institute for Translational Medicine and Therapeutics
8039 Maloney Building
3600 Spruce Street
Philadelphia, PA 19104
Office: (215) 746-2834
Fax: (215) 615-6520
Education:
MD (Medicine)
Universita' degli Studi di Milano, Milan, Italy, 1987.
Specialist (Geriatric Medicine)
Universita' degli Studi di Milano, Milan, Italy, 1991.
PhD (Pathophysiology of Aging)
Universita' degli Studi di Milano, Milan, Italy, 1998.
MS (Translational Research)
University of Pennsylvania School of Medicine, 2008.
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Description of Research Expertise

Dr. Cuchel is interested in the study of mechanisms regulating the metabolism of lipid and lipoproteins, with particular attention to HDL and reverse cholesterol transport, using two parallel approaches: animal models and well-defined human monogenic disorders. She is also interested in early phase development of novel therapeutic strategies for the treatment of rare genetic disorders of lipid metabolism and for the enhancement of reverse cholesterol transport.

Selected Publications

Cuchel M: Mutations in ABCA1 are associated with enhanced Beta-Cell Secretory capacity in Humans. 82nd European Atherosclerosis Society Congress Jun 2014 Notes: Oral Presentation.

Gudipaty L, Rosenfeld NK, Fuller C, Cuchel M, Rickels MR: Impaired β-Cell secretory capacity in non obese compared to obese early Type 2 Diabetes and healthy controls. ICE/ENDO 2014 Meeting Jun 2014 Notes: Oral Presentation.

Anthanont P, Millar JS, Billheimer J, Cuchel M, Rader DJ, Schaefer EJ: A Novel Apolipoprotein A-I Truncation (ApoA-IMytilene) Associated with Decreased ApoA-I Production and Cholesterol Efflux. ICE/ENDO 2014 Meeting Jun 2014 Notes: Poster Presentation.

Gudipaty L, Rosenfeld N, Kubrak C, Peleckis A, Malik S, Cuchel M, De Leon DD, Hadjiliadis D, Rubenstein RC, Rickels MR, Kelly A: Characterization of Insulin Secretion in Postpubertal Adolescents and Adults with Cystic Fibrosis--Preliminary Results. ICE/ENDO 2014 Meeting Jun 2014 Notes: Oral Presenation.

Hancock-Cerutti W, Zanoni P, Lhomme M, Lecocq S, Dauteuille C, Larach D, Chapman J, Cuchel M, Rader DJ, Kontush A: A deleterious mutation in SCARB1 significantly alters HDL level, composition and biological function in humans. 82nd European Atherosclerosis Society Congress May 2014 Notes: Moderated Poster Presentation.

Hancock-Cerutti W, Lhomme M, Dauteuille C, Lecocq S, Chapman J, Rader DJ, Kontush A, Cuchel M: In hyperalphalipoproteinemic subjects, the presence of coronary artery disease is associated with marked changes in the HDL phosphosphingolipidome. 82nd European Atherosclerosis Society Congress May-June 2014 Notes: Moderated Poster Presentation.

Zanoni P, Larach D, Khetarpal S, Hancock-Cerutti WF, Peloso G, Rodrigues A, Tohyama J, Billheimer JR, Kathiresan S, Cuchel M, Rader DJ: A Loss-of-Function Mutation in SCARB1 Severely Impairs SR-BI Processing and Activity in Humans. 82nd European Atherosclerosis Society Congress May-June 2014 Notes: Oral Presentation.

Tricoci P, D’Andrea DM, Gurbel P, Cuchel M, Winston B, Schott R, Weiss R, Michael Blazing, David Corteville, Alison Bailey, Dominick J Angiolillo, Penelope Dalitz, Shelley Myles-Di Mauro, Charles Shear, John H Alexander: Safety and Tolerability of CSL112 in Subjects With Stable Atherothrombotic Disease: Results From a Phase 2a, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Study. 2013 AHA Scientific Sessions. Circulation 128(22 Supplement ): A18589, Nov 2013 Notes: Oral Presentation.

Cuchel M, Blom DJ, Averna MR, Meagher EA, Du H, Theron T, Sirtori CR, Hegele RA, Shah PK, Gaudet D, Stefanutti C, Vigna GB, di Ferrara U, Bloedon LT, Rader DJ, HoFH Lomitapide Study Investigators : Sustained LDL-C Lowering and Stable Hepatic Fat Levels in Patients With Homozygous Familial Hypercholesterolemia Treated With the Microsomal Triglyceride Transfer Protein Inhibitor, Lomitapide: Results of an Ongoing Long-Term Extension Study. 2013 AHA Scientific Sessions Circulation 128(22 Supplement ): A16516, Nov 2013 Notes: Poster Presentation.

Agarwala A, Billheimer J, Rodrigues A, Risman M, McCoy M, Cuchel M, Rader DJ : HDL Phospholipid is Associated With Coronary Artery Disease (CAD) in Individuals with HDL-C. Above the 90th Percentile Who Develop (CAD). 2013 AHA Scientific Sessions, Dallas TX Circulation 128(22 Supplement ), Nov 2013 Notes: Poster Presentation.

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Last updated: 04/15/2014
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