Marina Cuchel, MD, PhD

faculty photo
Research Associate Professor of Medicine
Department: Medicine

Contact information
Institute for Translational Medicine and Therapeutics
8039 Maloney Building
3600 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-7188
Fax: (215) 615-6520
Education:
MD (Medicine)
Universita' degli Studi di Milano, Milan, Italy, 1987.
Specialist (Geriatric Medicine)
Universita' degli Studi di Milano, Milan, Italy, 1991.
PhD (Pathophysiology of Aging)
Universita' degli Studi di Milano, Milan, Italy, 1998.
MS (Translational Research)
University of Pennsylvania School of Medicine, 2008.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Dr. Cuchel is interested in the study of mechanisms regulating the metabolism of lipid and lipoproteins, with particular attention to HDL and reverse cholesterol transport, using two parallel approaches: animal models and well-defined human monogenic disorders. She is also interested in early phase development of novel therapeutic strategies for the treatment of rare genetic disorders of lipid metabolism and for the enhancement of reverse cholesterol transport.

Selected Publications

Blom Dirk J, Averna Maurizio R, Meagher Emma A, du Toit Theron Hendrik, Sirtori Cesare R, Hegele Robert A, Shah Prediman K, Gaudet Daniel, Stefanutti Claudia, Vigna Giovanni B, Larrey Dominique, Bloedon LeAnne T, Foulds Pamela, Rader Daniel J, Cuchel Marina: Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia. Circulation 136(3): 332-335, Jul 2017.

Liu Ying, Conlon Donna M, Bi Xin, Slovik Katherine J, Shi Jianting, Edelstein Hailey I, Millar John S, Javaheri Ali, Cuchel Marina, Pashos Evanthia E, Iqbal Jahangir, Hussain M Mahmood, Hegele Robert A, Yang Wenli, Duncan Stephen A, Rader Daniel J, Morrisey Edward E: Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress. Cell reports 19(7): 1456-1466, May 2017.

Bi Xin, Pashos Evanthia E, Cuchel Marina, Lyssenko Nicholas N, Hernandez Mayda, Picataggi Antonino, McParland James, Yang Wenli, Liu Ying, Yan Ruilan, Yu Christopher, DerOhannessian Stephanie L, Phillips Michael C, Morrisey Edward E, Duncan Stephen A, Rader Daniel J: ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion. EBioMedicine 18: 139-145, Apr 2017.

Cuchel Marina, Raper Anna C, Conlon Donna M, Pryma Daniel A, Freifelder Richard H, Poria Rahul, Cromley Debra, Li Xiaoyu, Dunbar Richard L, French Benjamin, Qu Liming, Farver William, Su Ching-Chiang, Lund-Katz Sissel, Baer Amanda, Ruotolo Giacomo, Akerblad Peter, Ryan Carol S, Xiao Lan, Kirchgessner Todd G, Millar John S, Billheimer Jeffrey T, Rader Daniel J: A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans. Journal of lipid research 58(4): 752-762, Apr 2017.

Ajufo Ezim, Cuchel Marina: Improving the yield of genetic testing in familial hypercholesterolaemia. European heart journal 38(8): 574-576, Feb 2017.

Sheikh Saba, Gudipaty Lalitha, De Leon Diva D, Hadjiliadis Denis, Kubrak Christina, Rosenfeld Nora K, Nyirjesy Sarah C, Peleckis Amy J, Malik Saloni, Stefanovski Darko, Cuchel Marina, Rubenstein Ronald C, Kelly Andrea, Rickels Michael R: Reduced β-Cell Secretory Capacity in Pancreatic-Insufficient, but Not Pancreatic-Sufficient, Cystic Fibrosis Despite Normal Glucose Tolerance. Diabetes 66(1): 134-144, Jan 2017.

Gaudet Daniel, Gipe Daniel A, Pordy Robert, Ahmad Zahid, Cuchel Marina, Shah Prediman K, Chyu Kuang-Yuh, Sasiela William J, Chan Kuo-Chen, Brisson Diane, Khoury Etienne, Banerjee Poulabi, Gusarova Viktoria, Gromada Jesper, Stahl Neil, Yancopoulos George D, Hovingh G Kees: ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia. The New England journal of medicine 377(3): 296-297, 07 2017.

Santos Raul D, Gidding Samuel S, Hegele Robert A, Cuchel Marina A, Barter Philip J, Watts Gerald F, Baum Seth J, Catapano Alberico L, Chapman M John, Defesche Joep C, Folco Emanuela, Freiberger Tomas, Genest Jacques, Hovingh G Kees, Harada-Shiba Mariko, Humphries Steve E, Jackson Ann S, Mata Pedro, Moriarty Patrick M, Raal Frederick J, Al-Rasadi Khalid, Ray Kausik K, Reiner Zelijko, Sijbrands Eric J G, Yamashita Shizuya: Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel. The lancet. Diabetes & endocrinology 4(10): 850-61, Oct 2016.

Ajufo Ezim, Cuchel Marina: Recent Developments in Gene Therapy for Homozygous Familial Hypercholesterolemia. Current atherosclerosis reports 18(5): 22, May 2016.

Zanoni Paolo, Khetarpal Sumeet A, Larach Daniel B, Hancock-Cerutti William F, Millar John S, Cuchel Marina, DerOhannessian Stephanie, Kontush Anatol, Surendran Praveen, Saleheen Danish, Trompet Stella, Jukema J Wouter, De Craen Anton, Deloukas Panos, Sattar Naveed, Ford Ian, Packard Chris, Majumder Abdullah al Shafi, Alam Dewan S, Di Angelantonio Emanuele, Abecasis Goncalo, Chowdhury Rajiv, Erdmann Jeanette, Nordestgaard Børge G, Nielsen Sune F, Tybjærg-Hansen Anne, Schmidt Ruth Frikke, Kuulasmaa Kari, Liu Dajiang J, Perola Markus, Blankenberg Stefan, Salomaa Veikko, Männistö Satu, Amouyel Philippe, Arveiler Dominique, Ferrieres Jean, Müller-Nurasyid Martina, Ferrario Marco, Kee Frank, Willer Cristen J, Samani Nilesh, Schunkert Heribert, Butterworth Adam S, Howson Joanna M M, Peloso Gina M, Stitziel Nathan O, Danesh John, Kathiresan Sekar, Rader Daniel J: Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science (New York, N.Y.) 351(6278): 1166-71, Mar 2016.

back to top
Last updated: 08/03/2017
The Trustees of the University of Pennsylvania