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Marina Cuchel, MD, PhD

Marina Cuchel, MD, PhD

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Research Associate Professor of Medicine
Department: Medicine

Contact information
Institute for Translational Medicine and Therapeutics
8039 Maloney Building
3600 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-7188
Fax: (215) 615-6520
MD (Medicine)
Universita' degli Studi di Milano, Milan, Italy, 1987.
Specialist (Geriatric Medicine)
Universita' degli Studi di Milano, Milan, Italy, 1991.
PhD (Pathophysiology of Aging)
Universita' degli Studi di Milano, Milan, Italy, 1998.
MS (Translational Research)
University of Pennsylvania School of Medicine, 2008.
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Description of Research Expertise

Dr. Cuchel is interested in the study of mechanisms regulating the metabolism of lipid and lipoproteins, with particular attention to HDL and reverse cholesterol transport, using two parallel approaches: animal models and well-defined human monogenic disorders. She is also interested in early phase development of novel therapeutic strategies for the treatment of rare genetic disorders of lipid metabolism and for the enhancement of reverse cholesterol transport.

Selected Publications

Herzog Eva, Pragst Ingo, Waelchli Marcel, Gille Andreas, Schenk Sabrina, Mueller-Cohrs Jochen, Diditchenko Svetlana, Zanoni Paolo, Cuchel Marina, Seubert Andreas, Rader Daniel J, Wright Samuel D: Reconstituted high-density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component. Journal of applied toxicology : JAT Dec 2015.

Blom D, Averna M, Meagher E, Theron H du T, Sirtori C, Hegele R, Shah P, Gaudet D, Stefanutti C, Vigna G, Foulds P, Bloedon L, Rader D, Cuchel M. : Long-term efficacy and safety of lomitapide for the treatment of homozygous familial hypercholesterolemia: Results of the Phase 3 Extension Trial. AHA Scientific Sessions in press, November 2015 Notes: Poster Presentation.

Millar John S, Cuchel Marina: ApoA-I-Directed Therapies for the Management of Atherosclerosis. Current atherosclerosis reports 17(10): 539, Oct 2015.

Iqbal Jahangir, Walsh Meghan T, Hammad Samar M, Cuchel Marina, Tarugi Patrizia, Hegele Robert A, Davidson Nicholas O, Rader Daniel J, Klein Richard L, Hussain M Mahmood: Microsomal triglyceride transfer protein transfers and determines plasma concentrations of ceramide and sphingomyelin, but not glycosylceramide. The Journal of biological chemistry Sep 2015.

Rickels Michael R, Cuchel Marina: Response to Comment on Rickels et al. Loss-of-Function Mutations in ABCA1 and Enhanced β-Cell Secretory Capacity in Young Adults. Diabetes 2015;64:193-199. Diabetes 64(9): e27, Sep 2015.

Bi Xin, Vitali Cecilia, Cuchel Marina: ABCA1 and Inflammation: From Animal Models to Humans. Arteriosclerosis, thrombosis, and vascular biology 35(7): 1551-3, Jul 2015.

Zhang Hanrui, Xue Chenyi, Shah Rhia, Bermingham Kate, Hinkle Christine C, Li Wenjun, Rodrigues Amrith, Tabita-Martinez Jennifer, Millar John S, Cuchel Marina, Pashos Evanthia E, Liu Ying, Yan Ruilan, Yang Wenli, Gosai Sager J, VanDorn Daniel, Chou Stella T, Gregory Brian D, Morrisey Edward E, Li Mingyao, Rader Daniel J, Reilly Muredach P: Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease. Circulation research 117(1): 17-28, Jun 2015.

Agarwala Anandita P, Rodrigues Amrith, Risman Marjorie, McCoy Mary, Trindade Kevin, Qu Liming, Cuchel Marina, Billheimer Jeffrey, Rader Daniel J: High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients With Very High HDL Cholesterol and Coronary Disease. Arteriosclerosis, thrombosis, and vascular biology 35(6): 1515-9, Jun 2015.

Stefanutti C, Blom D J, Averna M R, Meagher E A, Theron H dT, Marais A D, Hegele R A, Sirtori C R, Shah P K, Gaudet D, Vigna G B, Sachais B S, Di Giacomo S, du Plessis A M E, Bloedon L T, Balser J, Rader D J, Cuchel M: The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - a post-hoc analysis of a Phase 3, single-arm, open-label trial. Atherosclerosis 240(2): 408-14, Jun 2015.

Wiegman Albert, Gidding Samuel S, Watts Gerald F, Chapman M John, Ginsberg Henry N, Cuchel Marina, Ose Leiv, Averna Maurizio, Boileau Catherine, Borén Jan, Bruckert Eric, Catapano Alberico L, Defesche Joep C, Descamps Olivier S, Hegele Robert A, Hovingh G Kees, Humphries Steve E, Kovanen Petri T, Kuivenhoven Jan Albert, Masana Luis, Nordestgaard Børge G, Pajukanta Päivi, Parhofer Klaus G, Raal Frederick J, Ray Kausik K, Santos Raul D, Stalenhoef Anton F H, Steinhagen-Thiessen Elisabeth, Stroes Erik S, Taskinen Marja-Riitta, Tybjærg-Hansen Anne, Wiklund Olov: Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. European heart journal 36(36): 2425-37, May 2015.

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Last updated: 12/31/2016
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