Marina Cuchel, MD, PhD

faculty photo
Research Associate Professor of Medicine
Department: Medicine

Contact information
Institute for Translational Medicine and Therapeutics
8039 Maloney Building
3600 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-7188
Fax: (215) 615-6520
Education:
MD (Medicine)
Universita' degli Studi di Milano, Milan, Italy, 1987.
Specialist (Geriatric Medicine)
Universita' degli Studi di Milano, Milan, Italy, 1991.
PhD (Pathophysiology of Aging)
Universita' degli Studi di Milano, Milan, Italy, 1998.
MS (Translational Research)
University of Pennsylvania School of Medicine, 2008.
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Description of Research Expertise

Dr. Cuchel is interested in the study of mechanisms regulating the metabolism of lipid and lipoproteins, using two parallel approaches: animal models and well-defined human monogenic disorders. She is also interested in early phase development of novel therapeutic strategies for the treatment of rare genetic disorders of lipid metabolism and for the enhancement of reverse cholesterol transport.

Selected Publications

Millar John S, Cuchel Marina: Cholesterol metabolism in humans: a review of methods and comparison of results. Current opinion in lipidology Nov 2017.

Hancock-Cerutti William, Lhomme Marie, Dauteuille Carolane, Lecocq Sora, Chapman M John, Rader Daniel J, Kontush Anatol, Cuchel Marina: Paradoxical coronary artery disease in humans with hyperalphalipoproteinemia is associated with distinct differences in the high-density lipoprotein phosphosphingolipidome. Journal of clinical lipidology 11(5): 1192-1200.e3, Sep - Oct 2017.

Khetarpal Sumeet A, Zeng Xuemei, Millar John S, Vitali Cecilia, Somasundara Amritha Varshini Hanasoge, Zanoni Paolo, Landro James A, Barucci Nicole, Zavadoski William J, Sun Zhiyuan, de Haard Hans, Toth Ildik├│ V, Peloso Gina M, Natarajan Pradeep, Cuchel Marina, Lund-Katz Sissel, Phillips Michael C, Tall Alan R, Kathiresan Sekar, DaSilva-Jardine Paul, Yates Nathan A, Rader Daniel J: A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nature medicine 23(9): 1086-1094, Sep 2017.

Gaudet Daniel, Gipe Daniel A, Pordy Robert, Ahmad Zahid, Cuchel Marina, Shah Prediman K, Chyu Kuang-Yuh, Sasiela William J, Chan Kuo-Chen, Brisson Diane, Khoury Etienne, Banerjee Poulabi, Gusarova Viktoria, Gromada Jesper, Stahl Neil, Yancopoulos George D, Hovingh G Kees: ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia. The New England journal of medicine 377(3): 296-297, Jul 2017.

Blom Dirk J, Averna Maurizio R, Meagher Emma A, du Toit Theron Hendrik, Sirtori Cesare R, Hegele Robert A, Shah Prediman K, Gaudet Daniel, Stefanutti Claudia, Vigna Giovanni B, Larrey Dominique, Bloedon LeAnne T, Foulds Pamela, Rader Daniel J, Cuchel Marina: Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia. Circulation 136(3): 332-335, Jul 2017.

Liu Ying, Conlon Donna M, Bi Xin, Slovik Katherine J, Shi Jianting, Edelstein Hailey I, Millar John S, Javaheri Ali, Cuchel Marina, Pashos Evanthia E, Iqbal Jahangir, Hussain M Mahmood, Hegele Robert A, Yang Wenli, Duncan Stephen A, Rader Daniel J, Morrisey Edward E: Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress. Cell reports 19(7): 1456-1466, May 2017.

Bi Xin, Pashos Evanthia E, Cuchel Marina, Lyssenko Nicholas N, Hernandez Mayda, Picataggi Antonino, McParland James, Yang Wenli, Liu Ying, Yan Ruilan, Yu Christopher, DerOhannessian Stephanie L, Phillips Michael C, Morrisey Edward E, Duncan Stephen A, Rader Daniel J: ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion. EBioMedicine 18: 139-145, Apr 2017.

Cuchel Marina, Raper Anna C, Conlon Donna M, Pryma Daniel A, Freifelder Richard H, Poria Rahul, Cromley Debra, Li Xiaoyu, Dunbar Richard L, French Benjamin, Qu Liming, Farver William, Su Ching-Chiang, Lund-Katz Sissel, Baer Amanda, Ruotolo Giacomo, Akerblad Peter, Ryan Carol S, Xiao Lan, Kirchgessner Todd G, Millar John S, Billheimer Jeffrey T, Rader Daniel J: A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans. Journal of lipid research 58(4): 752-762, Apr 2017.

Ajufo Ezim, Cuchel Marina: Improving the yield of genetic testing in familial hypercholesterolaemia. European heart journal 38(8): 574-576, Feb 2017.

Sheikh Saba, Gudipaty Lalitha, De Leon Diva D, Hadjiliadis Denis, Kubrak Christina, Rosenfeld Nora K, Nyirjesy Sarah C, Peleckis Amy J, Malik Saloni, Stefanovski Darko, Cuchel Marina, Rubenstein Ronald C, Kelly Andrea, Rickels Michael R: Reduced ╬▓-Cell Secretory Capacity in Pancreatic-Insufficient, but Not Pancreatic-Sufficient, Cystic Fibrosis Despite Normal Glucose Tolerance. Diabetes 66(1): 134-144, Jan 2017.

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Last updated: 12/19/2017
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