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Melpo Christofidou-Solomidou, PhD

Melpo Christofidou-Solomidou, PhD

faculty photo
Research Professor of Medicine
Department: Medicine

Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Office: (215) 573-9917
Fax: (215) 746-0376
Lab: (215)-573-9848
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
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Perelman School of Medicine > Faculty > Search

Description of Research Expertise

The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.

Selected Publications

Ralph A. Pietrofesa, Anastasia Velalopoulou, Stacey L. Lehman, Evguenia Arguiri, Pantelis Solomides, Cameron J. Koch, Om P. Mishra, Constantinos Koumenis, Thomas J. Goodwin, Melpo Christofidou-Solomidou: Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel. International Journal of Molecular Science. MDPI (eds.). 17(6), June 2016.

Salamatipour A, Mohanty SK, Pietrofesa RA, Vann D, Christofidou-Solomidou M, and Willenbring JK: Asbestos fiber preparation methods affect fiber toxicity. Environmental Science and Technology Letters In Press, June 2016.

Vladimir V. Shuvaev, Silvia Muro, Evguenia Arguiri3 Makan Khoshnejad, Samira Tliba, Christofidou-Solomidou M, and Vladimir R. Muzykantov: Size and targeting to PECAM vs ICAM control endothelial delivery, internalization and protective effect of multimolecular SOD conjugates. Journal of Controlled Release 16, MAY 2016.

Om P. Mishra, Anatoliy V. Popov, Ralph Pietrofesa and Christofidou- Solomidou M: Gamma-Irradiation Produces Active Chlorine Species (ACS) in Physiological Solutions: Secoisolariciresinol Diglucoside (SDG) Scavenges ACS - A Novel Mechanism of DNA Radioprotection. Biochimica et Biophysica Acta (BBA). Elsevier Press, 1860: 1884-1897, MAY 2016.

Makan Khoshnejad, Vladimir V. Shuvaev, Katherine W. Pulsipher, Chuanyun Dai, Elizabeth D. Hood, Evguenia Arguiri, Melpo Christofidou-Solomidou, Ivan J. Dmochowski, Colin F. Greineder and Vladimir R. Muzykantov: Vascular Accessibility of Endothelial Targeted Ferritin Nanoparticles. Bioconjugate Chemistry 6(27): 628-37, MAR 2016.

Yuwaraj Kadariya, Craig W. Menges, Jacqueline Talarchek, Qi Cai, Andres J. Klein-Szanto, Ralph Pietrofesa Christofidou-Solomidou M, Mitchell Cheung, Brooke T. Mossman, Arti Shukla, and Joseph R. Testa: Inflammation-related IL-1/IL-1R Signaling promotes the development of Asbestos-Induced Malignant Mesothelioma. Cancer Prevention Research In Press, March 2016.

Pietrofesa RA, Velalopoulou A, Albelda SM, and Christofidou-Solomidou M: Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605). International Journal of Molecular Sciences In Press, February 2016.

Shireen Chikara, Kaitlin Lindsey, Harsharan Dhillon, Sujan Mamidi, Jeffrey Kittilson, Christofidou-Solomidou M, and Katie M. Reindl: Enterolactone induces G1-phase cell cycle arrest in non-small cell lung cancer cells. Journal of Nutrition In Review 2016.

Pietrofesa RA, Velalopoulou A, Menges CW, Testa JR, Hwang WT, Albelda SM, and Christofidou-Solomidou M: Flaxseed Lignans Enriched in Secoisolariciresinol Diglucoside (SDG) Prevent Incidence of Mesothelioma in a Murine Model of Accelerated Asbestos-Induced Mesothelioma. Carcinogenesis In Prep 2016.

Ralph A. Pietrofesa, Anastasia Velalopoulou, Evguenia Arguiri, Raymond Luke, Om P. Mishra, Wei-Ting-Whang, Steven M. Albelda and Melpo Christofidou-Solomidou: The Flaxseed Lignan Secoisolariciresinol Diglucoside (SDG) Inhibit Asbestos-Induced Inflammasome activation. Cancer Prevention Research In Review 2016.

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Last updated: 10/13/2016
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