Melpo Christofidou-Solomidou, PhD
Melpo Christofidou-Solomidou, PhD
Research Professor of Medicine
Department: Medicine
Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Office: (215) 573-9917
Fax: (215) 746-0376
Lab: (215)-573-9848
Fax: (215) 746-0376
Lab: (215)-573-9848
Email:
melpo@mail.med.upenn.edu
melpo@mail.med.upenn.edu
Links
Penn Lung Center Faculty profile
Primary Work Website
LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors
Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
5. Radiotherapy damage may be prevented by Flaxseed
4. This Inexpensive Omega-3 Source can Protect Against Radiation
2. Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
6. The little seed that can protect you from radiation damage
3. Protect Yourself from Radiation with Flaxseeds
Penn Lung Center Faculty profile
Primary Work Website
LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors
Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
5. Radiotherapy damage may be prevented by Flaxseed
4. This Inexpensive Omega-3 Source can Protect Against Radiation
2. Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
6. The little seed that can protect you from radiation damage
3. Protect Yourself from Radiation with Flaxseeds
Education:
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Permanent linkB.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Description of Research Expertise
The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.Selected Publications
Shireen Chikara, Kaitlin Lindsey, Harsharan Dhillon, Sujan Mamidi, Jeffrey Kittilson, Christofidou-Solomidou M, and Katie M. Reindl: Enterolactone induces G1-phase cell cycle arrest in non-small cell lung cancer cells. Nutrition and Cancer 69(4): 652-662, MAY 2017.Shireen Chikara, Kaitlin Lindsey, Pawel Borowicz, Melpo Christofidou-Solomidou and Katie Reindl: Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines. BMC Complementary and Alternative Medicine 17(1): 30, JAN 2017.
Ralph A. Pietrofesa, Anastasia Velalopoulou, Stacey L. Lehman, Evguenia Arguiri, Pantelis Solomides, Cameron J. Koch, Om P. Mishra, Constantinos Koumenis, Thomas J. Goodwin, Melpo Christofidou-Solomidou: Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel. International Journal of Molecular Science. MDPI (eds.). 17(6), June 2016.
Salamatipour A, Mohanty SK, Pietrofesa RA, Vann D, Christofidou-Solomidou M, and Willenbring JK: Effect of dry and wet grinding conditions on toxicity of chrysotile asbestos. Environmental Science and Technology Letters 3(7): 270-274, June 2016.
Vladimir V. Shuvaev, Silvia Muro, Evguenia Arguiri3 Makan Khoshnejad, Samira Tliba, Christofidou-Solomidou M, and Vladimir R. Muzykantov: Size and targeting to PECAM vs ICAM control endothelial delivery, internalization and protective effect of multimolecular SOD conjugates. Journal of Controlled Release 16: pp. 115-12, MAY 2016.
Om P. Mishra, Anatoliy V. Popov, Ralph Pietrofesa and Christofidou- Solomidou M: Gamma-Irradiation Produces Active Chlorine Species (ACS) in Physiological Solutions: Secoisolariciresinol Diglucoside (SDG) Scavenges ACS - A Novel Mechanism of DNA Radioprotection. Biochimica et Biophysica Acta (BBA). Elsevier Press, 1860(9): 1884-1897, MAY 2016.
Ming-Hui Fan, Qiang Zhu, Hui-Hua Li, Hyun-Jeong Ra, Sonali Majumdar, Daniel H. Madsen, Christofidou-Solomidou M, David W. Speicher, Sergey L. Leikin, Carol Feghali-Bostwick, Ellen Pure: Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from the Lung in Mice. Journal of Biological Chemistry 291(15): 8070-89, April 2016.
Makan Khoshnejad, Vladimir V. Shuvaev, Katherine W. Pulsipher, Chuanyun Dai, Elizabeth D. Hood, Evguenia Arguiri, Melpo Christofidou-Solomidou, Ivan J. Dmochowski, Colin F. Greineder and Vladimir R. Muzykantov: Vascular accessibility of endothelial targeted Ferritin Nanoparticles. Bioconjugate Chemistry 27(3): 628-37, MAR 2016.
Yuwaraj Kadariya, Craig W. Menges, Jacqueline Talarchek, Qi Cai, Andres J. Klein-Szanto, Ralph Pietrofesa Christofidou-Solomidou M, Mitchell Cheung, Brooke T. Mossman, Arti Shukla, and Joseph R. Testa: Inflammation-related IL-1beta/IL-1R Signaling promotes the development of Asbestos-Induced Malignant Mesothelioma. Cancer Prevention Research 9(5): 406-142016, March 2016.
Pietrofesa RA, Velalopoulou A, Albelda SM, and Christofidou-Solomidou M: Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605). International Journal of Molecular Sciences 17(3): 322, February 2016.