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Melpo Christofidou-Solomidou, PhD
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Adjunct Professor of Medicine (Pulmonary, Allergy and Critical Care)
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Director, Pulmonary Morphology Core Laboratory, University of Pennsylvania Perelman School of Medicine
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IACUC Committee Member, University of Pennsylvania
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Investigator Member, Center of Excellence in Environmental Toxicology, University of Pennsylvania Perelman School of Medicine
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Investigator Member, Abramson Cancer Center, University of Pennsylvania
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Founder and Chair, Scientific Advisory Board, LignaMed, LLC, LignaMed, LLC, an upstart company in collaboration with the University of Pennsylvania Penn Center for Innovation
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Co-Founder, JT-MeSh Diagnostics, LLC
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Department: Medicine
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Contact information
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University of Pennsylvania, Department of Medicine
35 Pulmonary, Allergy and Critical Care Division
1b 3450 Hamilton Walk,
51 Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
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35 Pulmonary, Allergy and Critical Care Division
1b 3450 Hamilton Walk,
51 Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
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Office: (215) 573-9917
34 Fax: (215) 746-0376
34 Lab: (215)-573-9848
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34 Fax: (215) 746-0376
34 Lab: (215)-573-9848
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Email:
melpo@mail.med.upenn.edu
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melpo@mail.med.upenn.edu
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Publications
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Links
af Search PubMed for articles
ab Synthetic flaxseed derivative helps heart function in septic mice
14f Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
14c Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
ed The Penn-CHOP Lung Biology Institute (LBI) aims to address the critical demand for better treatment options for both adult and pediatric lung diseases.
19c ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors 2 b
13f Temple University Researchers Show Synthetic Flaxseed-Derived Antioxidant Improves Heart Function in Mice with Sepsis, Alleviating Cardiac Complications
c4 Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
1cf The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
d5 Researchers show synthetic flaxseed derivative helps heart function in septic mice
b5 This Inexpensive Omega-3 Source can Protect Against Radiation
9f Protect Yourself from Radiation with Flaxseeds
b4 The little seed that can protect you from radiation damage
115 LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
9b Radiotherapy damage may be prevented by Flaxseed
154 LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
15e LignaMed Announces Publication of Data on Lead Candidate LGM2605 Demonstrating Protective Effect on Airway Hyperreactivity in Asthma
8f Primary Work Website
a5 Penn Lung Center Faculty profile
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af Search PubMed for articles
ab Synthetic flaxseed derivative helps heart function in septic mice
14f Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
14c Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
ed The Penn-CHOP Lung Biology Institute (LBI) aims to address the critical demand for better treatment options for both adult and pediatric lung diseases.
19c ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors 2 b
13f Temple University Researchers Show Synthetic Flaxseed-Derived Antioxidant Improves Heart Function in Mice with Sepsis, Alleviating Cardiac Complications
c4 Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
1cf The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
d5 Researchers show synthetic flaxseed derivative helps heart function in septic mice
b5 This Inexpensive Omega-3 Source can Protect Against Radiation
9f Protect Yourself from Radiation with Flaxseeds
b4 The little seed that can protect you from radiation damage
115 LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
9b Radiotherapy damage may be prevented by Flaxseed
154 LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
15e LignaMed Announces Publication of Data on Lead Candidate LGM2605 Demonstrating Protective Effect on Airway Hyperreactivity in Asthma
8f Primary Work Website
a5 Penn Lung Center Faculty profile
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Education:
21 9 B.S. 14 (Biology) c
5b State University of New York at Stony Brook, Long Island, New York, 1983.
21 9 M.S. 19 (Cell Biology) c
50 Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
21 a Ph.D. 19 (Cell Biology) c
50 Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
21 7 ML 1a (Master in Law) c
48 University of Pennsylvania, Carey School of Law, 2022.
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Permanent link21 9 B.S. 14 (Biology) c
5b State University of New York at Stony Brook, Long Island, New York, 1983.
21 9 M.S. 19 (Cell Biology) c
50 Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
21 a Ph.D. 19 (Cell Biology) c
50 Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
21 7 ML 1a (Master in Law) c
48 University of Pennsylvania, Carey School of Law, 2022.
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Description of Research Expertise
30c The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.26 29
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15e Thomas J. Goodwin and Melpo Christofidou-Solomidou: Editorial to the Special Issue: “Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment” Int J Mol Sci. MDPI (eds.). 23(12): 6466, June 2022.
188 106. Lim TL, Pietrofesa RA, Arguiri E, Koumenis C, Feigenberg S, Simone CB, Rengan R, Cengel K, Levin WP, Christofidou-Solomidou M, and Berman AT: Phase II Trial of Flaxseed to Prevent Acute Complications of Chemoradiation for Lung Cance. The Journal of Alternative and Complementary Medicine 27(10): 824-831, OCT 2021.
141 Reagan Badger, Kyewon Park, Ralph A Pietrofesa, Melpo Christofidou-Solomidou, Kinta M Serve : Late Inflammation Induced by Asbestiform Fibers in Mice Is Ameliorated by a Small Molecule Synthetic Lignan. Int J Mol Sci. MDPI, 22(20): 10982, OCT 2021.
1ee Ralph A Pietrofesa, Kyewon Park, Om P Mishra, Darrah Johnson-McDaniel, Jacob W Myerson, Vladimir V Shuvaev, Evguenia Arguiri, Shampa Chatterjee, Ganesh S Moorthy, Athena Zuppa, Wei-Ting Hwang, Melpo Christofidou-Solomidou : Copper Oxide Nanoparticle-Induced Acute Inflammatory Response and Injury in Murine Lung Is Ameliorated by Synthetic Secoisolariciresinol Diglucoside (LGM2605). Int J Mol Sci 22(17): 9477, AUG 2021.
1b9 Anuradha Dhingra, Rachel C Sharp, Taewan J Kim, Anatoliy V Popov, Gui-Shuang Ying, Ralph Pietrofesa, Kyewon Park, Christofidou-Solomidou M, Kathleen Boesze-Battaglia: Assessment of a small molecule synthetic lignan in enhancing oxidative balance and decreasing lipid accumulation in human retinal pigment epithelia. Int J Mol Sci. IJMS (eds.). 22(11): 5764, June 2021.
184 Anuradha Dhingra, Rachel C Sharp, Taewan Kim, Anatoliy V Popov, Gui-Shuang Ying, Ralph A Pietrofesa, Kyewon Park, Melpo Christofidou-Solomidou, Kathleen Boesze-Battaglia: Assessment of a Small Molecule Synthetic Lignan in Enhancing Oxidative Balance and Decreasing Lipid Accumulation in Human Retinal Pigment Epithelia. Int J Mol Sci 2c 22(11): 5764, MAY 2021.
2a3 Ioannis D. Kyriazis, Matthew Hoffman, Lea Gaignebetb; Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D. Bannister, Melpo Christofidou-Solomidou, Shin-ichi Oka, Junichi Sadoshima, PhD, Walter J. Koch, Ira J. Goldberg, Vincent W. Yang, Agnieszka B. Bialkowska, Georgios Kararigas, Konstantinos Drosatos: KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. Circulation Research. Council on Basic Cardiovascular Sciences of the American Heart Association (eds.). Wolters Kluwer Health/Lippincott Williams & Wilkins, 128(3): 335-357, FEB 2021.
14b Christofidou-Solomidou M, Sielecki T, Chatterjee S: Endothelial Signaling in Vascular Dysfunction and Disease: Chapter 13: Effects of space radiation on the endovasculature: implications for human deep space exploration. Elsevier Press-Book chapter DEC 2020.
183 Sonia Kartha, Christine L. Weisshaar, Ralph A. Pietrofesa, Melpo Christofidou-Solomidou and Beth A. Winkelstein: Synthetic Secoisolariciresinol Diglucoside Attenuates Established Pain, Oxidative Stress and Neuroinflammation in a Rodent Model of Painful Radiculopathy. Antioxidants. MDPI (eds.). 9: 1209, Nov 2020.
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Selected Publications
ef Ralph A. Pietrofesa, Shampa Chatterjee, Yuwaraj Kadariya, Joseph R. Testa, Steven M. Albelda and Melpo Christofidou-Solomidou: Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents 3c Asbestos-Induced Inflammation and Genotoxic Cell Damage in 7d Human Mesothelial Cells. International Journal of Molecular Sciences. MDPI, 23(17): 10085, SEPT 2022.15e Thomas J. Goodwin and Melpo Christofidou-Solomidou: Editorial to the Special Issue: “Dysregulation of Human Molecular and Metabolic Mechanisms Resulting in Oxidative Stress and Damage Generation in the Space Environment” Int J Mol Sci. MDPI (eds.). 23(12): 6466, June 2022.
188 106. Lim TL, Pietrofesa RA, Arguiri E, Koumenis C, Feigenberg S, Simone CB, Rengan R, Cengel K, Levin WP, Christofidou-Solomidou M, and Berman AT: Phase II Trial of Flaxseed to Prevent Acute Complications of Chemoradiation for Lung Cance. The Journal of Alternative and Complementary Medicine 27(10): 824-831, OCT 2021.
141 Reagan Badger, Kyewon Park, Ralph A Pietrofesa, Melpo Christofidou-Solomidou, Kinta M Serve : Late Inflammation Induced by Asbestiform Fibers in Mice Is Ameliorated by a Small Molecule Synthetic Lignan. Int J Mol Sci. MDPI, 22(20): 10982, OCT 2021.
1ee Ralph A Pietrofesa, Kyewon Park, Om P Mishra, Darrah Johnson-McDaniel, Jacob W Myerson, Vladimir V Shuvaev, Evguenia Arguiri, Shampa Chatterjee, Ganesh S Moorthy, Athena Zuppa, Wei-Ting Hwang, Melpo Christofidou-Solomidou : Copper Oxide Nanoparticle-Induced Acute Inflammatory Response and Injury in Murine Lung Is Ameliorated by Synthetic Secoisolariciresinol Diglucoside (LGM2605). Int J Mol Sci 22(17): 9477, AUG 2021.
1b9 Anuradha Dhingra, Rachel C Sharp, Taewan J Kim, Anatoliy V Popov, Gui-Shuang Ying, Ralph Pietrofesa, Kyewon Park, Christofidou-Solomidou M, Kathleen Boesze-Battaglia: Assessment of a small molecule synthetic lignan in enhancing oxidative balance and decreasing lipid accumulation in human retinal pigment epithelia. Int J Mol Sci. IJMS (eds.). 22(11): 5764, June 2021.
184 Anuradha Dhingra, Rachel C Sharp, Taewan Kim, Anatoliy V Popov, Gui-Shuang Ying, Ralph A Pietrofesa, Kyewon Park, Melpo Christofidou-Solomidou, Kathleen Boesze-Battaglia: Assessment of a Small Molecule Synthetic Lignan in Enhancing Oxidative Balance and Decreasing Lipid Accumulation in Human Retinal Pigment Epithelia. Int J Mol Sci 2c 22(11): 5764, MAY 2021.
2a3 Ioannis D. Kyriazis, Matthew Hoffman, Lea Gaignebetb; Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D. Bannister, Melpo Christofidou-Solomidou, Shin-ichi Oka, Junichi Sadoshima, PhD, Walter J. Koch, Ira J. Goldberg, Vincent W. Yang, Agnieszka B. Bialkowska, Georgios Kararigas, Konstantinos Drosatos: KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. Circulation Research. Council on Basic Cardiovascular Sciences of the American Heart Association (eds.). Wolters Kluwer Health/Lippincott Williams & Wilkins, 128(3): 335-357, FEB 2021.
14b Christofidou-Solomidou M, Sielecki T, Chatterjee S: Endothelial Signaling in Vascular Dysfunction and Disease: Chapter 13: Effects of space radiation on the endovasculature: implications for human deep space exploration. Elsevier Press-Book chapter DEC 2020.
183 Sonia Kartha, Christine L. Weisshaar, Ralph A. Pietrofesa, Melpo Christofidou-Solomidou and Beth A. Winkelstein: Synthetic Secoisolariciresinol Diglucoside Attenuates Established Pain, Oxidative Stress and Neuroinflammation in a Rodent Model of Painful Radiculopathy. Antioxidants. MDPI (eds.). 9: 1209, Nov 2020.
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