Melpo Christofidou-Solomidou, PhD
Research Professor of Medicine
Department: Medicine
Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Office: (215) 573-9917
Fax: (215) 746-0376
Lab: (215)-573-9848
Fax: (215) 746-0376
Lab: (215)-573-9848
Email:
melpo@mail.med.upenn.edu
melpo@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Penn Lung Center Faculty profile
2. Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors
3. Protect Yourself from Radiation with Flaxseeds
Researchers show synthetic flaxseed derivative helps heart function in septic mice
LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
Primary Work Website
5. Radiotherapy damage may be prevented by Flaxseed
LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
6. The little seed that can protect you from radiation damage
Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
4. This Inexpensive Omega-3 Source can Protect Against Radiation
Synthetic flaxseed derivative helps heart function in septic mice
Synthetic flaxseed derivative helps heart function in septic mice
Temple University Researchers Show Synthetic Flaxseed-Derived Antioxidant Improves Heart Function in Mice with Sepsis, Alleviating Cardiac Complications
Search PubMed for articles
Penn Lung Center Faculty profile
2. Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors
3. Protect Yourself from Radiation with Flaxseeds
Researchers show synthetic flaxseed derivative helps heart function in septic mice
LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
Primary Work Website
5. Radiotherapy damage may be prevented by Flaxseed
LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
6. The little seed that can protect you from radiation damage
Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
4. This Inexpensive Omega-3 Source can Protect Against Radiation
Synthetic flaxseed derivative helps heart function in septic mice
Synthetic flaxseed derivative helps heart function in septic mice
Temple University Researchers Show Synthetic Flaxseed-Derived Antioxidant Improves Heart Function in Mice with Sepsis, Alleviating Cardiac Complications
Education:
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Permanent linkB.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Description of Research Expertise
The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.Selected Publications
Ioannis D. Kyriazis, Matthew Hoffman, Lea Gaignebetb; Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D. Bannister, Melpo Christofidou-Solomidou, Shin-ichi Oka, Junichi Sadoshima, PhD, Walter J. Koch, Ira J. Goldberg, Vincent W. Yang, Agnieszka B. Bialkowska, Georgios Kararigas, Konstantinos Drosatos: FOXO1 induces cardiomyocyte-KLF5, which drives oxidative stress and diabetic cardiomyopathy. Circulation Research. Council on Basic Cardiovascular Sciences of the American Heart Association (eds.). Wolters Kluwer Health/Lippincott Williams & Wilkins, DEC 2020.Christofidou-Solomidou M, Sielecki T, Chatterjee S: Endothelial Signaling in Vascular Dysfunction and Disease: Chapter 13: Effects of space radiation on the endovasculature: implications for human deep space exploration. Elsevier Press-Book chapter DEC 2020.
Sonia Kartha, Christine L. Weisshaar, Ralph A. Pietrofesa, Melpo Christofidou-Solomidou and Beth A. Winkelstein: Synthetic Secoisolariciresinol Diglucoside Attenuates Established Pain, Oxidative Stress and Neuroinflammation in a Rodent Model of Painful Radiculopathy. Antioxidants. MDPI (eds.). 9: 1209, Nov 2020.
Mishra OP, Popov AV, Pietrofesa RA, Hwang WT, Andrake M, Nakamaru-Ogiso E, Christofidou-Solomidou M: Radiation activates myeloperoxidase (MPO) to generate active chlorine species (ACS) via a dephosphorylation mechanism - inhibitory effect of LGM2605. Biochim Biophys Acta Gen Subj. 1862(6): 1364-1375, Feb 2020.
Jacovides CL, Ahmed S, Suto Y, Paris AJ, Leone R, Weber M, Johnson VE, Christofidou-Solomidou M, Kaplan LJ, Smith DH, Holena DN, Schwab CW, Pascual JL: An inflammatory pulmonary insult post-traumatic brain injury worsens subsequent spatial learning and neurological outcomes. J. Trauma Acute Care Surg 87(3): 552-558, JUN 2019.
Christofidou-Solomidou M, Pietrofesa R, Park K, Albelda SM, Serve K, Keil D, and Pfau J : Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Libby Amphibole Fiber-Induced Acute Inflammation in Mice. Toxicology and Applied Pharmacology 375: 81-93, Apr 2019.
Shampa Chatterjee, Ralph A. Pietrofesa, Kyewon Park, Jian-Qin Tao, Alejandro Carabe-Fernandez, Abigail T. Berman, Constantinos Koumenis, Thais Sielecki, and Melpo Christofidou-Solomidou : LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks. International Journal of Molecular Sciences. MDPI, 20(176): 1-27, JAN 2019.
Cameron H. Flayer, Erik D. Larson, Anjali Joseph, Sean Kao, Wenxiu Qu, Austin Van Haren, Christopher M. Royer, Thais Sielecki, Melpo Christofidou-Solomidou, Angela Haczku: Protective effect of LGM2605 on ozone-induced inflammation and hyperreactivity in rhesus macaques. J Allergy Clin Immunol 145(1): 312-323, JAN 2019.
Dimitra Kokkinaki, Matthew Hoffman, Charikleia Kalliora, Anastasios Lymperopoulos, Anna Maria Lucchese, Sanantham Shanmughapriya, Ioannis Kyriazis, Dhanendra Tomar, Joon Young Park, Hong Wang, Xiao-Feng Yang, Muniswamy Madesh, Walter J. Koch, Melpo Christofidou-Solomidou and Konstantinos Drosatos: Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Journal of Molecular and Cellular Cardiology. Elsevier, 127: 232-245, JAN 2019.
Vladimir V. Shuvaev,Makan Khoshnejad,Katherine W. Pulsipher,Raisa Yu. Kiseleva, Evguenia Arguiri, Jasmina C. Cheung-Lau, Kathleen M. LeFort, Christofidou-Solomidou M, Radu V. Stan, Ivan J. Dmochowski, and Vladimir R. Muzykantov: Spatially controlled assembly of affinity ligand and enzyme cargo enables targeting ferritin nanocarriers to caveolae. Biomaterials 185: 348-359, SEP 2018.