Melpo Christofidou-Solomidou, PhD
Research Professor of Medicine
Department: Medicine
Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Office: (215) 573-9917
Fax: (215) 746-0376
Lab: (215)-573-9848
Fax: (215) 746-0376
Lab: (215)-573-9848
Email:
melpo@mail.med.upenn.edu
melpo@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
Primary Work Website
3. Protect Yourself from Radiation with Flaxseeds
Synthetic flaxseed derivative helps heart function in septic mice
4. This Inexpensive Omega-3 Source can Protect Against Radiation
Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
Penn Lung Center Faculty profile
6. The little seed that can protect you from radiation damage
Synthetic flaxseed derivative helps heart function in septic mice
2. Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
Researchers show synthetic flaxseed derivative helps heart function in septic mice
ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors
LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
5. Radiotherapy damage may be prevented by Flaxseed
Temple University Researchers Show Synthetic Flaxseed-Derived Antioxidant Improves Heart Function in Mice with Sepsis, Alleviating Cardiac Complications
Search PubMed for articles
Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
Primary Work Website
3. Protect Yourself from Radiation with Flaxseeds
Synthetic flaxseed derivative helps heart function in septic mice
4. This Inexpensive Omega-3 Source can Protect Against Radiation
Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
Penn Lung Center Faculty profile
6. The little seed that can protect you from radiation damage
Synthetic flaxseed derivative helps heart function in septic mice
2. Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
Researchers show synthetic flaxseed derivative helps heart function in septic mice
ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors
LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
5. Radiotherapy damage may be prevented by Flaxseed
Temple University Researchers Show Synthetic Flaxseed-Derived Antioxidant Improves Heart Function in Mice with Sepsis, Alleviating Cardiac Complications
Education:
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Permanent linkB.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Description of Research Expertise
The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.Selected Publications
Mishra OP, Popov AV, Pietrofesa RA, Hwang WT, Andrake M, Nakamaru-Ogiso E, Christofidou-Solomidou M: Radiation activates myeloperoxidase (MPO) to generate active chlorine species (ACS) via a dephosphorylation mechanism - inhibitory effect of LGM2605. Biochim Biophys Acta Gen Subj. FEB 2020 Notes: doi: 10.1016/j.bbagen.2020.129548.Cameron H. Flayer, Erik D. Larson, Anjali Joseph, Sean Kao, Wenxiu Qu, Austin Van Haren, Christopher M. Royer, Thais Sielecki, Melpo Christofidou-Solomidou, Angela Haczku: Protective effect of LGM2605 on ozone-induced inflammation and hyperreactivity in rhesus macaques. J Allergy Clin Immunol 145(1): 312-323, JAN 2020.
Jacovides CL, Ahmed S, Suto Y, Paris AJ, Leone R, Weber M, Johnson VE, Christofidou-Solomidou M, Kaplan LJ, Smith DH, Holena DN, Schwab CW, Pascual JL: An inflammatory pulmonary insult post-traumatic brain injury worsens subsequent spatial learning and neurological outcomes. J. Trauma Acute Care Surg 87(3): 552-558, JUNE 2019.
Christofidou-Solomidou M, Pietrofesa R, Park K, Albelda SM, Serve K, Keil D, and Pfau J : Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Libby Amphibole Fiber-Induced Acute Inflammation in Mice. Toxicology and Applied Pharmacology 375: 81-93, April 2019.
Shampa Chatterjee, Ralph A. Pietrofesa, Kyewon Park, Jian-Qin Tao, Alejandro Carabe-Fernandez, Abigail T. Berman, Constantinos Koumenis, Thais Sielecki, and Melpo Christofidou-Solomidou : LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks. International Journal of Molecular Sciences. MDPI, 20(176): 1-27, JAN 2019.
Dimitra Kokkinaki, Matthew Hoffman, Charikleia Kalliora, Anastasios Lymperopoulos, Anna Maria Lucchese, Sanantham Shanmughapriya, Ioannis Kyriazis, Dhanendra Tomar, Joon Young Park, Hong Wang, Xiao-Feng Yang, Muniswamy Madesh, Walter J. Koch, Melpo Christofidou-Solomidou and Konstantinos Drosatos: Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Journal of Molecular and Cellular Cardiology. Elsevier, 127: 232-245, JAN 2019.
Ralph A. Pietrofesa, Shampa Chatterjee, Sandra Pastorino, Haining Yang, Steven M. Albelda, and Christofidou-Solomidou M: The Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells. International Journal of Molecular Sciences IN REVIEW 2019.
Vladimir V. Shuvaev,Makan Khoshnejad,Katherine W. Pulsipher,Raisa Yu. Kiseleva, Evguenia Arguiri, Jasmina C. Cheung-Lau, Kathleen M. LeFort, Christofidou-Solomidou M, Radu V. Stan, Ivan J. Dmochowski, and Vladimir R. Muzykantov: Spatially controlled assembly of affinity ligand and enzyme cargo enables targeting ferritin nanocarriers to caveolae. Biomaterials 185: 348-359, SEPT 2018.
Zhou Bing, Yoshi Suzuki, Thomas Disanto, Samantha Rubin, Zachary Penfil, Melpo Christofidou-Solomidou, Edward Cantu: Application of Out of Body Lung Perfusion: Yesterday, Today and Tomorrow. Academic Radiology 26(3): 404-411, JULY 2018 Notes: https://doi.org/10.1016/j.acra.2018.05.022.
Pietrofesa RA, Chatterjee S, Park K, Arguiri E4, Albelda SM, Christofidou-Solomidou M.: Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner. Antioxidants (Basel) 7(3), MARCH 2018.