Melpo Christofidou-Solomidou, PhD
Research Professor of Medicine
Department: Medicine
Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Office: (215) 573-9917
Fax: (215) 746-0376
Lab: (215)-573-9848
Fax: (215) 746-0376
Lab: (215)-573-9848
Email:
melpo@mail.med.upenn.edu
melpo@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Synthetic flaxseed derivative helps heart function in septic mice
Penn Lung Center Faculty profile
3. Protect Yourself from Radiation with Flaxseeds
Researchers show synthetic flaxseed derivative helps heart function in septic mice
LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
Temple University Researchers Show Synthetic Flaxseed-Derived Antioxidant Improves Heart Function in Mice with Sepsis, Alleviating Cardiac Complications
4. This Inexpensive Omega-3 Source can Protect Against Radiation
LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors
5. Radiotherapy damage may be prevented by Flaxseed
2. Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
6. The little seed that can protect you from radiation damage
Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
Primary Work Website
Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
Synthetic flaxseed derivative helps heart function in septic mice
Search PubMed for articles
Synthetic flaxseed derivative helps heart function in septic mice
Penn Lung Center Faculty profile
3. Protect Yourself from Radiation with Flaxseeds
Researchers show synthetic flaxseed derivative helps heart function in septic mice
LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
Temple University Researchers Show Synthetic Flaxseed-Derived Antioxidant Improves Heart Function in Mice with Sepsis, Alleviating Cardiac Complications
4. This Inexpensive Omega-3 Source can Protect Against Radiation
LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors
5. Radiotherapy damage may be prevented by Flaxseed
2. Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
6. The little seed that can protect you from radiation damage
Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
Primary Work Website
Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
Synthetic flaxseed derivative helps heart function in septic mice
Education:
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Permanent linkB.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Description of Research Expertise
The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.Selected Publications
Shampa Chatterjee, Ralph A. Pietrofesa, Kyewon Park, Jian-Qin Tao, Alejandro Carabe-Fernandez, Abigail T. Berman, Constantinos Koumenis, Thais Sielecki, and Melpo Christofidou-Solomidou : LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks. International Journal of Molecular Sciences. MDPI, 20(176): 1-27, JAN 2019.Dimitra Kokkinaki, Matthew Hoffman, Charikleia Kalliora, Anastasios Lymperopoulos, Anna Maria Lucchese, Sanantham Shanmughapriya, Ioannis Kyriazis, Dhanendra Tomar, Joon Young Park, Hong Wang, Xiao-Feng Yang, Muniswamy Madesh, Walter J. Koch, Melpo Christofidou-Solomidou and Konstantinos Drosatos: Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Journal of Molecular and Cellular Cardiology. Elsevier, XX(XX), JAN 2019.
Christofidou-Solomidou M, Pietrofesa R, Park K, Albelda SM, Serve K, Keil D, and Pfau J : Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Libby Amphibole Fiber-Induced Acute Inflammation in Mice. Toxicology and Applied Pharmacology IN REVIEW 2019.
Vladimir V. Shuvaev,Makan Khoshnejad,Katherine W. Pulsipher,Raisa Yu. Kiseleva, Evguenia Arguiri, Jasmina C. Cheung-Lau, Kathleen M. LeFort, Christofidou-Solomidou M, Radu V. Stan, Ivan J. Dmochowski, and Vladimir R. Muzykantov: Spatially controlled assembly of affinity ligand and enzyme cargo enables targeting ferritin nanocarriers to caveolae. Biomaterials 185: 348-359, SEPT 2018.
Zhou Bing, Yoshi Suzuki, Thomas Disanto, Samantha Rubin, Zachary Penfil, Melpo Christofidou-Solomidou, Edward Cantu: Application of Out of Body Lung Perfusion: Yesterday, Today and Tomorrow. Academic Radiology JULY 2018 Notes: https://doi.org/10.1016/j.acra.2018.05.022.
Pietrofesa RA, Chatterjee S, Park K, Arguiri E4, Albelda SM, Christofidou-Solomidou M.: Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner. Antioxidants (Basel) 7(3), MARCH 2018.
Mishra OP, Popov AV, Pietrofesa RA, Andrake M, Nakamaru-Ogiso E, and Christofidou-Solomidou M: Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Myeloperoxidase Activity in Inflammatory Cells. Biochim Biophys Acta MARCH 2018.
Thomas J. Goodwin, Melpo Christofidou-Solomidou: Oxidative Stress and Space Biology: An Organ-Based Approach. International Journal of Molecular Sciences. MDPI, Basel, Switzerland, 19: 959, MARCH 2018.
Shuvaev VV, Kiseleva RY, Arguiri E, Villa CH, Muro S, Christofidou-Solomidou M, Stan RV, Muzykantov VR.: Targeting superoxide dismutase to endothelial caveolae profoundly alleviates inflammation caused by endotoxin. Journal of Controlled Release 272: 1-8, FEB 2018.
Shireen Chikara, Sujan Mamidi, Avinash Sreedasyam, Kishore Chittem, Ralph Pietrofesa, Athena Zuppa, Ganesh Moorthy, Neil Dyer, Christofidou-Solomidou M, and Katie Reindl: Flaxseed Consumption Inhibits Chemically--Induced Lung Tumorigenesis and Alters Expression of Phase II Enzyme and Inflammatory Cytokines in A/J Mice. Cancer Prevention Research 11(1): 27-37, JAN 2018.