Melpo Christofidou-Solomidou, PhD

faculty photo
Research Professor of Medicine
Department: Medicine

Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Office: (215) 573-9917
Fax: (215) 746-0376
Lab: (215)-573-9848
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
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Description of Research Expertise

The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.

Selected Publications

Shampa Chatterjee, Ralph A. Pietrofesa, Kyewon Park, Jian-Qin Tao, Alejandro Carabe-Fernandez, Abigail T. Berman, Constantinos Koumenis, Thais Sielecki, and Melpo Christofidou-Solomidou : LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks. International Journal of Molecular Sciences. MDPI, 20(176): 1-27, JAN 2019.

Dimitra Kokkinaki, Matthew Hoffman, Charikleia Kalliora, Anastasios Lymperopoulos, Anna Maria Lucchese, Sanantham Shanmughapriya, Ioannis Kyriazis, Dhanendra Tomar, Joon Young Park, Hong Wang, Xiao-Feng Yang, Muniswamy Madesh, Walter J. Koch, Melpo Christofidou-Solomidou and Konstantinos Drosatos: Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Journal of Molecular and Cellular Cardiology. Elsevier, XX(XX), JAN 2019.

Christofidou-Solomidou M, Pietrofesa R, Park K, Albelda SM, Serve K, Keil D, and Pfau J : Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Libby Amphibole Fiber-Induced Acute Inflammation in Mice. Toxicology and Applied Pharmacology IN REVIEW 2019.

Vladimir V. Shuvaev,Makan Khoshnejad,Katherine W. Pulsipher,Raisa Yu. Kiseleva, Evguenia Arguiri, Jasmina C. Cheung-Lau, Kathleen M. LeFort, Christofidou-Solomidou M, Radu V. Stan, Ivan J. Dmochowski, and Vladimir R. Muzykantov: Spatially controlled assembly of affinity ligand and enzyme cargo enables targeting ferritin nanocarriers to caveolae. Biomaterials 185: 348-359, SEPT 2018.

Zhou Bing, Yoshi Suzuki, Thomas Disanto, Samantha Rubin, Zachary Penfil, Melpo Christofidou-Solomidou, Edward Cantu: Application of Out of Body Lung Perfusion: Yesterday, Today and Tomorrow. Academic Radiology JULY 2018 Notes:

Pietrofesa RA, Chatterjee S, Park K, Arguiri E4, Albelda SM, Christofidou-Solomidou M.: Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner. Antioxidants (Basel) 7(3), MARCH 2018.

Mishra OP, Popov AV, Pietrofesa RA, Andrake M, Nakamaru-Ogiso E, and Christofidou-Solomidou M: Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Myeloperoxidase Activity in Inflammatory Cells. Biochim Biophys Acta MARCH 2018.

Thomas J. Goodwin, Melpo Christofidou-Solomidou: Oxidative Stress and Space Biology: An Organ-Based Approach. International Journal of Molecular Sciences. MDPI, Basel, Switzerland, 19: 959, MARCH 2018.

Shuvaev VV, Kiseleva RY, Arguiri E, Villa CH, Muro S, Christofidou-Solomidou M, Stan RV, Muzykantov VR.: Targeting superoxide dismutase to endothelial caveolae profoundly alleviates inflammation caused by endotoxin. Journal of Controlled Release 272: 1-8, FEB 2018.

Shireen Chikara, Sujan Mamidi, Avinash Sreedasyam, Kishore Chittem, Ralph Pietrofesa, Athena Zuppa, Ganesh Moorthy, Neil Dyer, Christofidou-Solomidou M, and Katie Reindl: Flaxseed Consumption Inhibits Chemically--Induced Lung Tumorigenesis and Alters Expression of Phase II Enzyme and Inflammatory Cytokines in A/J Mice. Cancer Prevention Research 11(1): 27-37, JAN 2018.

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Last updated: 01/22/2019
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