Melpo Christofidou-Solomidou, PhD
Melpo Christofidou-Solomidou, PhD
Research Professor of Medicine
Department: Medicine
Contact information
University of Pennsylvania, Department of Medicine
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Pulmonary, Allergy and Critical Care Division
3450 Hamilton Walk,
Edward J. Stemmler Hall, Office Suite 227
Philadelphia, PA 19104-6118
Office: (215) 573-9917
Fax: (215) 746-0376
Lab: (215)-573-9848
Fax: (215) 746-0376
Lab: (215)-573-9848
Email:
melpo@mail.med.upenn.edu
melpo@mail.med.upenn.edu
Links
Penn Lung Center Faculty profile
6. The little seed that can protect you from radiation damage
Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
4. This Inexpensive Omega-3 Source can Protect Against Radiation
LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
Primary Work Website
The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
2. Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors
5. Radiotherapy damage may be prevented by Flaxseed
3. Protect Yourself from Radiation with Flaxseeds
Penn Lung Center Faculty profile
6. The little seed that can protect you from radiation damage
Chemical and Engineering News, Vol 94, Issue 47, pp. 32-34; COVER STORIES: THE GLOBAL MENACE OF ASBESTOS: University of Pennsylvania program addresses aspects from environmental containment to health effects
4. This Inexpensive Omega-3 Source can Protect Against Radiation
LignaMed, LLC is a drug development company with a fast track strategy to market approval and an early exit. The company’s initial product, LGM-2605, will be utilized to reduce side effects of radiation exposure.
Primary Work Website
The Greater Philadelphia Alliance for Capital and Technologies (PACT), Philadelphia region’s premier technology and life sciences trade association, has recognized LignaMed as “2015 Company to Watch” as part of the 22nd consecutive Enterprise Awards.
LignaMed, LLC, announced today that the company was awarded a $5.2 million dollar contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
2. Penn Study Shows an Ancient Crop Effective in Protecting Against a 21st Century Hazard
Nutrition Frontiers e-newsletter, Volume 5, Issue 3, 2014 : Research update: what's new in basic science Flaxseed Modulates miRNA in Irradiated and Nonirradiated Murine Lungs
ANTICANCER ACTIVITY FOUND IN HERBAL ADDITIVES OF ANCIENT ALCOHOLIC BEVERAGES: Penn Museum and Penn Medicine Research Collaboration Yields First Promising Evidence for Efficacy of Medicinal Compounds Once Employed by Our Ancestors
5. Radiotherapy damage may be prevented by Flaxseed
3. Protect Yourself from Radiation with Flaxseeds
Education:
B.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Permanent linkB.S. (Biology)
State University of New York at Stony Brook, Long Island, New York, 1983.
M.S. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1987.
Ph.D. (Cell Biology)
Rhenish Friedrich Wilhelm’s University, Bonn, Germany, 1991.
Description of Research Expertise
The theme of Dr. Christofidou-Solomidou's research is pulmonary inflammation and cell adhesion molecule regulation/expression. Projects involve the development of oxidant-induced acute and chronic lung injury animal models for the study of diseases such as ARDS, sepsis, radiation induced pneumonitis/fibrosis, and oxygen toxicity. Specific projects focus on the development of antioxidant methodologies such as immune conjugates for the targeting of anti-oxidant enzymes such as Catalase and Superoxide Dismutase to the pulmonary endothelium using antibodies to endothelial antigens. Recent work extends to the use of dietary alternative antioxidant agents such as curcumin, flaxseed or phenolic compounds in ameliorating acute and chronic oxidative lung disease.Selected Publications
Mohanty SK, Gonneau C, Salamatipour A, Pietrofesa RA, Casper B, Christofidou-Solomidou M and Willenbring JW: Siderophore-mediated iron removal from chrysotile: Implications on asbestos toxicity reduction and bioremediation. Journal of Hazardous Materials 341: 290-296, JUL 2018.Mishra OP, Popov AV, Pietrofesa RA, Andrake M, Nakamaru-Ogiso E, and Christofidou-Solomidou M: Synthetic Secoisolariciresinol Diglucoside (LGM2605) Inhibits Myeloperoxidase Activity in Inflammatory Cells. Biochim Biophys Acta IN REVIEW 2018.
Vladimir V. Shuvaev, Makan Khoshnejad, Katherine W. Pulsipher,Raisa Yu. Kiseleva, Evguenia Arguiri, Christofidou-Solomidou M, Radu V. Stan, Ivan J. Dmochowski, and Vladimir R. Muzykantov: Caveolar Targeting and Anti-inflammatory Effect of Ferritin Nanocarriers with Spatially Controlled Configuration of Affinity Ligand and Enzymatic Cargo. Journal of Controlled Release IN REVIEW 2018.
Ralph A. Pietrofesa, Shampa Chatterjee, Sandra Pastorino, Haining Yang, Steven M. Albelda, and Christofidou-Solomidou M: The Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells. International Journal of Molecular Sciences IN REVIEW 2018.
Ralph A. Pietrofesa, Shampa Chatterjee, Anastasia Velalopoulou, Cynthia Koziol-White, Raymond Pannetieri, and Christofidou-Solomidou M: The Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) prevents proton radiation damage in human lung-an ex vivo study. International Journal of Molecular Sciences IN REVIEW 2018.
Slava Rom, Viviana Zuluaga-Ramirez, Nancy Lee Reichenbach, Michelle A Erickson, Malika Winfield, Sachin Gajghate, Christofidou-Solomidou M: Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: Implications for neuroinflammation. Journal of Neuroinflammation IN REVIEW 2018.
Shireen Chikara, Sujan Mamidi, Avinash Sreedasyam, Kishore Chittem, Christofidou-Solomidou M, and Katie M. Reindl: Flaxseed Consumption Inhibits NNK-Induced Lung Tumorigenesis and Modulates Phase II Enzyme and Inflammatory Cytokine Gene Expression in A/J Mice. Cancer Research IN REVIEW 2018.
Christofidou-Solomidou M, Ralph A. Pietrofesa, Evguenia Arguiri, Constantinos Koumenis, and Robert Segal: Radiation mitigating properties of intranasally administered KL4 surfactant in a murine model of radiation –induced lung damage. Radiation Research Sept 2017.
Ralph A. Pietrofesa, Patrick Woodruff, Wei-Ting Hwang, Priyal Patel, Shampa Chatterjee, Steven M. Albelda and Christofidou-Solomidou M: The Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammasome Activation in Murine Macrophages. Oxidative Medicine and Cellular Longevity ID 3795238, Sept 2017.
Shireen Chikara, Kaitlin Lindsey, Harsharan Dhillon, Sujan Mamidi, Jeffrey Kittilson, Christofidou-Solomidou M, and Katie M. Reindl: Enterolactone induces G1-phase cell cycle arrest in non-small cell lung cancer cells. Nutrition and Cancer 69(4): 652-662, MAY 2017.