Edward J. (Jim) Delikatny, Ph.D.
Edward J. (Jim) Delikatny, Ph.D.
Research Associate Professor of Radiology
Department: Radiology
Graduate Group Affiliations
Contact information
University of Pennsylvania,
Department of Radiology,
B6-Blockley Hall,
423 Guardian Drive
Philadelphia, PA 19104
Department of Radiology,
B6-Blockley Hall,
423 Guardian Drive
Philadelphia, PA 19104
Office: (215) 746-7386
Fax: (215) 573-2113
Fax: (215) 573-2113
Email:
delikatn@mail.med.upenn.edu
delikatn@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Pharmacological Sciences graduate group faculty webpage.
Department of Radiology webpage
Department of Radiology, Laboratory of Molecular Imaging
Search PubMed for articles
Pharmacological Sciences graduate group faculty webpage.
Department of Radiology webpage
Department of Radiology, Laboratory of Molecular Imaging
Education:
B.S. (Chemistry/Environmental Studies)
University of Winnipeg, 1978.
Ph.D. (Physical Chemistry)
University of British Columbia, 1987.
Permanent linkB.S. (Chemistry/Environmental Studies)
University of Winnipeg, 1978.
Ph.D. (Physical Chemistry)
University of British Columbia, 1987.
Description of Research Expertise
Research Interest Summary:The main interest of this group is the non invasive detection of lipid metabolic changes in response to anticancer drugs and differentiation therapy using magnetic resonance spectroscopy and MRI and optical imaging. Changes in lipid metabolites are monitored using 1H, 13C and 31P MR spectroscopy in perfused cell systems and in in vivo tumor models to determine potential biochemical markers for the detection of tumors and their early response to therapy. Changes in metabolite levels are correlated with information obtained from near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ.
A number of molecular imaging projects are active in the laboratory including the design, characterization and implementation of optical contrast agents for the detection of phospholipase, choline kinase and matrix metalloproteinase activity, and development of MR methods and contrast agents for detection of apoptosis and noninvasive detection of fatty liver and early stages of liver disease.
Description of Other Expertise
MR spectroscopy, MR imaging, NIR optical imaging, anticancer drugs, lipid metabolism, cancer pharmacologySelected Publications
Milkevitch M, Beardsley NJ, Delikatny EJ: Phenylbutyrate induces apoptosis and lipid accumulations via a peroxisome proliferator-activated receptor gamma-dependent pathway NMR in Biomedicine in press, 2009.Corbin IR, Furth EE, Pickup S, Siegelman ES, Delikatny EJ: In vivo assessment of hepatic triglycerides in murine non-alcoholic fatty liver disease using magnetic resonance spectroscopy. Biochimica et Biophysica Acta 1791(8): 757-63, Aug 2009.
Lee SC, Delikatny EJ, Poptani H, Pickup S, Glickson JD: In vivo (1)H MRS of WSU-DLCL2 human non-Hodgkin's lymphoma xenografts: response to rituximab and rituximab plus CHOP. NMR in Biomedicine 22(3): 259-65, Apr 2009.
Magnitsky S, Vite CH, Delikatny EJ, Pickup S, Wehrli S, Wolfe JH, Poptani H: Magnetic resonance spectroscopy of the occipital cortex and the cerebellar vermis distinguishes individual cats affected with alpha-mannosidosis from normal cats. NMR in Biomedicine Sep 2009.
Chawla S, Kim S, Loevner LA, Quon H, Wang S, Mutale F, Weinstein G, Delikatny EJ, Poptani H: Proton and phosphorous MR spectroscopy in squamous cell carcinomas of the head and neck. Academic Radiology Jul 2009.
Milkevitch M, Jeitner TM, Beardsley NJ, Delikatny, E.J: Lovastatin enhances phenylbutyrate-induced MR-visible lipid metabolites but not apoptosis in DU145 human prostate cells. Biochimica Biophysica Acta 1771: 1166-1176, 2007.
Delikatny, E.J, Watzl JQY: Application of 2D magnetic resonance spectroscopy to the study of human biopsies. Modern Magnetic Resonance, Part 2: Applications in Medical and Pharmaceutical Sciences. G.A. Webb (eds.). Page: 1001-1011, 2007.
Jeitner, T.M., Delikatny, E.J., Ahlqvst, J. Capper, H.R. and Cooper, A.J.L.: Mechanism for the inhibition of transglutaminase 2 by cystamine. Biochemical Pharmacology 69: 961-970, 2005.
Delikatny, E.J., and Poptani, H. : MR techniques for in vivo molecular and cellular imaging. Radiologic Clinics of North America. A. Alavi (eds.). W.B. Saunders Co., Philadelphia, 43: 205-220, 2005.
Milkevitch, M., Shim, H., Pilatus, U., Pickup, S., Wehrle, J.P., Samid, D., Poptani, H., Glickson, J.D. and Delikatny, E.J. : Increases in NMR visible lipid and glycerophosphocholine during phenylbutyrate-induced apoptosis in human prostate cancer cells. Biochimica Biophysica Acta 1734: 1-12, May 2005.
Sathasivam N., Brammah S., Wright LC., Delikatny EJ.: Inhibition of tetraphenylphosphonium-induced NMR-visible lipid accumulation in human breast cells by chlorpromazine. Biochimica et Biophysica Acta 1633(3): 149-60, Sep 22 2003.
Poptani, H., Bansal, N., Jenkins, W.T., Blessington, D., Mancuso, A., Nelson, D.S., Feldman, M., Delikatny, E.J., Chance, B. and Glickson, J.D. : Cyclophosphamide treatment modifies tumor oxygenation and glycolytic rates of RIF-1 tumors: 13C MRS, Eppendorf electrode and redox scanning. Cancer Research 63: 8813-8820, 2003.
Delikatny EJ., Cooper WA., Brammah S., Sathasivam N., Rideout DC.: Nuclear magnetic resonance-visible lipids induced by cationic lipophilic chemotherapeutic agents are accompanied by increased lipid droplet formation and damaged mitochondria. Cancer Research 62(5): 1394-400, Mar 1 2002.
Delikatny EJ., van Holst Pellekaan CJ., King NJ.: Autologous lymphocyte-monocyte co-culture increases NMR-visible and cytoplasmic lipids in the absence of increased markers of lymphocyte activation. Biochimica et Biophysica Acta 1533(3): 243-54, Oct 31 2001.
Cooper WA., Bartier WA., Rideout DC., Delikatny EJ.: 1H NMR visible lipids are induced by phosphonium salts and 5-fluorouracil in human breast cancer cells. Magnetic Resonance in Medicine 45(6): 1001-10, Jun 2001.
Wright LC., Obbink KL., Delikatny EJ., Santangelo RT., Sorrell TC.: The origin of 1H NMR-visible triacylglycerol in human neutrophils. Highfatty acid environments result in preferential sequestration of palmitic acid into plasma membrane triacylglycerol. European Journal of Biochemistry 267(1): 68-78, Jan 2000.
Jeitner TM., Delikatny EJ., Bartier WA., Capper HR., Hunt NH.: Inhibition of drug-naive and -resistant leukemia cell proliferation by low molecular weight thiols. Biochemical Pharmacology 55(6): 793-802, Mar 15 1998.
Roman SK., Jeitner TM., Hancock R., Cooper WA., Rideout DC., Delikatny EJ.: Induction of magnetic resonance-visible lipid in a transformed human breast cell line by tetraphenylphosphonium chloride. International Journal of Cancer 73(4): 570-9, Nov 14 1997.