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Edward J. (Jim) Delikatny, Ph.D.

Edward J. (Jim) Delikatny, Ph.D.

faculty photo
Research Associate Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
University of Pennsylvania,
Department of Radiology,
317 Anatomy Chemistry Buliding
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-3105
Fax: (215) 573-2113
Education:
B.S. (Chemistry/Environmental Studies)
University of Winnipeg, 1978.
Ph.D. (Physical Chemistry)
University of British Columbia, 1987.
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Description of Research Expertise

Research Interest Summary:
The main interest of this group is the non invasive detection of lipid metabolic changes in response to anticancer drugs and differentiation therapy using magnetic resonance spectroscopy and MRI and optical imaging. Changes in lipid metabolites are monitored using 1H, 13C and 31P MR spectroscopy in perfused cell systems and in in vivo tumor models to determine potential biochemical markers for the detection of tumors and their early response to therapy. Changes in metabolite levels are correlated with information obtained from near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ.

A number of molecular imaging projects are active in the laboratory including the design, characterization and implementation of optical contrast agents for the detection of phospholipase, choline kinase and matrix metalloproteinase activity, and development of MR methods and contrast agents for detection of apoptosis and noninvasive detection of fatty liver and early stages of liver disease.

Description of Other Expertise

MR spectroscopy, MR imaging, NIR optical imaging, anticancer drugs, lipid metabolism, cancer pharmacology

Selected Publications

Lee, S.-C., Poptani, H., Delikatny, E.J., Pickup, S., Mellon, E.A., Reddy, R. and Glickson, J.D. : NMR metabolic and physiological markers of therapeutic response. Advances in Experimental Medicine and Biology 701, 2011.

Popov AV, Mawn TM, Kim S, Zheng G, Delikatny E J: Design and synthesis of phospholipase C and A2-activatable near-infrared fluorescent smart probes. Bioconjugate Chemistry 21(10): 1724-7, Oct 2010.

Lee SC, Poptani H, Pickup S, Jenkins WT, Kim S, Koch CJ, Delikatny E J, Glickson JD: Early detection of radiation therapy response in non-Hodgkin's lymphoma xenografts by in vivo 1H magnetic resonance spectroscopy and imaging. NMR in Biomedicine 23(6): 624-32, Jul 2010.

Milkevitch M, Beardsley NJ, Delikatny E J: Phenylbutyrate induces apoptosis and lipid accumulations via a peroxisome proliferator-activated receptor gamma-dependent pathway. NMR in Biomedicine 23(5): 473-9, Jun 2010.

Magnitsky S, Vite CH, Delikatny E J, Pickup S, Wehrli S, Wolfe JH, Poptani H: Magnetic resonance spectroscopy of the occipital cortex and the cerebellar vermis distinguishes individual cats affected with alpha-mannosidosis from normal cats. NMR in Biomedicine 23(1): 74-9, Jan 2010.

Mellon EA, Lee SC, Pickup S, Kim S, Goldstein SC, Floyd TF, Poptani H, Delikatny E J, Reddy R, Glickson JD: Detection of lactate with a hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner: Application to tumors and muscle ischemia. Magnetic Resonance in Medicine 62(6): 1404-13, Dec 2009.

Chawla S, Kim S, Loevner LA, Quon H, Wang S, Mutale F, Weinstein G, Delikatny EJ, Poptani H.: Proton and phosphorous MR spectroscopy in squamous cell carcinomas of the head and neck. Academic Radiology 16(11): 1366-72, Nov 2009.

Corbin IR, Furth EE, Pickup S, Siegelman ES, Delikatny EJ: In vivo assessment of hepatic triglycerides in murine non-alcoholic fatty liver disease using magnetic resonance spectroscopy. Biochimica et Biophysica Acta 1791(8): 757-63, Aug 2009.

Lee SC, Delikatny EJ, Poptani H, Pickup S, Glickson JD: In vivo (1)H MRS of WSU-DLCL2 human non-Hodgkin's lymphoma xenografts: response to rituximab and rituximab plus CHOP. NMR in Biomedicine 22(3): 259-65, Apr 2009.

Huang M.Q., Pickup S., Nelson D.S., Qiao H., Xu H.N., Li L.Z., Zhou R., Delikatny E.J., Poptani H., Glickson J.D.: Monitoring response to chemotherapy of non-Hodgkin's lymphoma xenografts by T(2)-weighted and diffusion-weighted MRI. NMR in Biomedicine 21(10): 1021-9, Nov 2008.

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Last updated: 01/14/2014
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