Edward J. (Jim) Delikatny, Ph.D.

faculty photo
Research Professor of Radiology
Member, Abramson Cancer Center, University of Pennsylvania
Member, Institute for Translational Medicine & Therapeutics (ITMAT), University of Pennsylvania
Director, Optical Bioluminescence Sub-Core, Small Animal Imaging Facility, University of Pennsylvania
Member, Institute of Medicine & Engineering, University of Pennsylvania
Director, Small Animal Imaging Facility , University of Pennsylvania
Director of Translational Research, Center for Precision Surgery, University of Pennsylvania
Department: Radiology
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
317 Anatomy Chemistry Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-3105
Education:
B.Sc. (Chemistry/Environmental Studies)
University of Winnipeg, 1978.
Ph.D. (Physical Chemistry)
University of British Columbia, 1987.
Permanent link
 
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Description of Research Expertise

Research Interest Summary:
The main interest of this group is the non invasive detection of metabolic changes that occur during tumor development and in response to anticancer drugs in models of human breast cancer. We employ a number of imaging modalities that include near infrared fluorescence optical imaging, MRI and MRS, PET and Cerenkov imaging. We have an active program in the design, synthesis and characterization of NIR optical contrast agents for the detection of phospholipase and choline kinase expression and activity in tumors and for the detection of pH and redox changes in the tumor microenvironment. Changes in lipid metabolite levels are monitored using MRS to determine potential biochemical markers for the detection of tumors and their early response to therapy and correlated with near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ. We are pioneering the development of Cerenkov imaging by creating novel radiolabeled probes suitable for determining both location and function using dual PET and optical imaging.

Description of Other Expertise

NIR optical imaging, contrast agent design, fluorescence guided surgery, MR spectroscopy, MR imaging, Cerenkov imaging, anticancer drugs, lipid metabolism, cancer pharmacology

Selected Publications

Hsu JC, Barragan D, Tward AE, Hajfathalian M, Amirshaghaghi A, Mossburg KJ, Rosario-Berríos DN, Bouché M, Andrianov AK, Delikatny EJ, Cormode DP: A biodegradable "one-For-all" nanoparticle for multimodality imaging and enhanced photothermal treatment of breast cancer Adv Healthc Mater 13(8): e2303018, Mar 2024 Notes: doi: 10.1002/adhm.202303018.

Kennedy GT, Azari FS, Chang A, Chang A, Bou-Samra P, Desphande C, Delikatny EJ, Eruslanov E, Kucharczuk JC, Rice DC, Singhal S: A pH-Activatable nanoprobe labels diverse histologic subtypes of human lung cancer during resection. Mol Imaging Biol 25(5): 824-833, Oct 2023 Notes: doi: 10.1007/s11307-023-01853-2.

Azari F, Zhang K, Kennedy G, Bou-Samra P, Chang A, Nadeem B, Chang A, Galandarova A, Ibrahimli A, Karimov Z, Din A, Kucharczuk J, Doraid J, Pechet T, Delikatny E, Singhal S.: Prospective validation of tumor folate receptor expression density with the association of pafolacianine fluorescence during intraoperative molecular imaging-guided lung cancer resections. Eur J Nucl Med Mol Imaging 50(8): 2453-2465, Jul 2023.

Azari F, Kennedy GT, Chang A, Nadeem B, Bou-Samra P, Chang A, Segil A, Bernstein E, Sullivan NT, Eruslanov E, Delikatny J, Singhal S: Sodium multivitamin transporter-targeted fluorochrome facilitates enhanced metabolic evaluation of tumors through Coenzyme-R dependent intracellular signaling pathways. Mol Imaging Biol 25(3): 569-585, Jun 2023 Notes: doi:10.1007/s11307-022-01792-4.

Bhaduri S, Kelly CL, Lesbats C, Sharkey J, Ressel L, Mukherjee S, Platt MD, Delikatny EJ, Poptani H: Metabolic changes in glioblastomas in response to choline kinase inhibition: In vivo MRS in rodent models: In vivo MRS in rodent models. NMR Biomed 36(3): e4855, Mar 2023.

Kennedy GT, Azari FS, Bernstein E, Deshpande C, Kucharczuk JC, Delikatny EJ, Singhal S : Three-dimensional near-infrared specimen mapping can identify the distance from the tumor to the surgical margin during resection of pulmonary ground glass opacities Mol Imaging Biol 25(1): 203-211, Feb 2023 Notes: doi:10.1007/s11307-022-01750-0.

Azari, F., Kennedy, G., Zhang, K., Bernstein, E., Chang, A., Nadeem, B., Segil, A., Desphande, C., Delikatny, J., Kucharczuk, J., and Singhal, S.: Effects of light-absorbing carbons in intraoperative molecular imaging-guided lung cancer resections. Mol Imaging Biol 25(1), Feb 2023 Notes: https://doi.org/10.1007/s11307-021-01699-6.

Kennedy, G. T., Azari, F. S., Bernstein, E., Desphande, C., Din, A., Marfatia, I., Kucharczuk, J. C., Delikatny, E. J., Low, P. S., and Singhal, S. : 3D Specimen Mapping Expedites Frozen Section Diagnosis of Nonpalpable Ground Glass Opacities. The Annals of Thoracic Surgery 114(6): 2115-2123, Dec 2022 Notes: https://doi.org/10.1016/j.athoracsur.2021.09.069.

Azari F, Kennedy G, Chang A, Nadeem B, Sullivan N, Marfatia I, Din A, Desphande C, Kucharczuk J, Delikatny EJ, Singhal S.: Presence of non-Newtonian fluid in invasive pulmonary mucinous adenocarcinomas impacts fluorescence during intraoperative molecular imaging of lung cancer. Eur J Nucl Med Mol Imaging 49(13), Nov 2022.

Kennedy G.T., Holt D., Azari F.S., Bernstein E., Nadeem B., Chang A., Sullivan N.T., Segil A., Deshpande C., Bensen E., Santini, Jr J.T., Kucharczuk J.C., Delikatny E.J., Bogyo M., Egan A.J.M., Bradley C.W., Eruslanov E., Lickliter J.D., Wright G. and Singhal S. : A cathepsin targeted quenched activity-based probe facilitates enhanced detection of human tumors during resection. Clinical Cancer Research 28(17): 3279-3741, Sep 2022.

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Last updated: 06/13/2024
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