Edward J. (Jim) Delikatny, Ph.D.

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Research Professor of Radiology
Member, Abramson Cancer Center, University of Pennsylvania
Member, Institute for Translational Medicine & Therapeutics (ITMAT), University of Pennsylvania
Director, Optical Bioluminescence Sub-Core, Small Animal Imaging Facility, University of Pennsylvania
Member, Institute of Medicine & Engineering, University of Pennsylvania
Director, Small Animal Imaging Facility , University of Pennsylvania
Director of Translational Research, Center for Precision Surgery, University of Pennsylvania
Department: Radiology
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
317 Anatomy Chemistry Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-3105
B.Sc. (Chemistry/Environmental Studies)
University of Winnipeg, 1978.
Ph.D. (Physical Chemistry)
University of British Columbia, 1987.
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Description of Research Expertise

Research Interest Summary:
The main interest of this group is the non invasive detection of metabolic changes that occur during tumor development and in response to anticancer drugs in models of human breast cancer. We employ a number of imaging modalities that include near infrared fluorescence optical imaging, MRI and MRS, PET and Cerenkov imaging. We have an active program in the design, synthesis and characterization of NIR optical contrast agents for the detection of phospholipase and choline kinase expression and activity in tumors and for the detection of pH and redox changes in the tumor microenvironment. Changes in lipid metabolite levels are monitored using MRS to determine potential biochemical markers for the detection of tumors and their early response to therapy and correlated with near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ. We are pioneering the development of Cerenkov imaging by creating novel radiolabeled probes suitable for determining both location and function using dual PET and optical imaging.

Description of Other Expertise

MR spectroscopy, MR imaging, NIR optical imaging, Cerenkov imaging, contrast agent design, anticancer drugs, lipid metabolism, cancer pharmacology

Selected Publications

Azari F, Kennedy G, Chang A, Nadeem B, Sullivan N, Marfatia I, Din A, Desphande C, Kucharczuk J, Delikatny EJ, Singhal S.: Presence of non-Newtonian fluid in invasive pulmonary mucinous adenocarcinomas impacts fluorescence during intraoperative molecular imaging of lung cancer. Eur J Nucl Med Mol Imaging 49(13), Nov 2022.

Kennedy G.T., Holt D., Azari F.S., Bernstein E., Nadeem B., Chang A., Sullivan N.T., Segil A., Deshpande C., Bensen E., Santini, Jr J.T., Kucharczuk J.C., Delikatny E.J., Bogyo M., Egan A.J.M., Bradley C.W., Eruslanov E., Lickliter J.D., Wright G. and Singhal S. : A cathepsin targeted quenched activity-based probe facilitates enhanced detection of human tumors during resection. Clinical Cancer Research 28(17): 3279-3741, Sep 2022.

Bhaduri S, Lesbats C, Sharkey J, Kelly CL, Mukherjee S, Taylor A, Delikatny EJ, Kim SG, Poptani H.: Assessing Tumour Haemodynamic Heterogeneity and Response to Choline Kinase Inhibition Using Clustered Dynamic Contrast Enhanced MRI Parameters in Rodent Models of Glioblastoma. Cancers 14(5): 1223, Feb 2022.

Kennedy GT, Azari FS, Bernstein E, Deshpande C, Kucharczuk JC, Delikatny EJ, Singhal S. : Three-Dimensional Near-Infrared Specimen Mapping Can Identify the Distance from the Tumor to the Surgical Margin During Resection of Pulmonary Ground Glass Opacities Moleculat Imaging and Biology (in press) 2022.

Kennedy G.T., Azari F.S., Nadeem B., Chang A., Segil A., Bernstein E., Deshpande C., Kucharczuk J.C., Delikatny E.J. and Singhal S. : Preclinical evaluation of a novel quenched activity-based near-infrared probe for intraoperative molecular imaging of esophageal cancer. Molecular Imaging (in press) 2022.

Azari F.S., Kennedy G.T., Chang A., Nadeem B., Segil A., Bernstein E., Sullivan N.T., Eruslanov E., Delikatny E.J. and Singhal S.: Sodium multivitamin transporter-targeted fluorochrome facilitates enhanced metabolic evaluation of tumors through Coenzyme-R dependent intracellular signaling pathways. European Journal of Nuclear Medicine and Molecular Imaging (in press) 2022.

Azari, F., Kennedy, G., Zhang, K., Bernstein, E., Chang, A., Nadeem, B., Segil, A., Desphande, C., Delikatny, J., Kucharczuk, J., and Singhal, S.: Effects of light-absorbing carbons in intraoperative molecular imaging-guided lung cancer resections. Molecular Imaging and Biology (in press) 2022 Notes: 10.1007/s11307-021-01699-6. Advance online publication. https://doi.org/10.1007/s11307-021-01699-6.

Bhaduri S, Kelly CL, Lesbats C, Sharkey J, Ressel L, Mukherjee S, Platt MD, Delikatny EJ, Poptani H: Metabolic changes in glioblastomas in response to choline kinase inhibition: In vivo MRS in rodent models: In vivo MRS in rodent models. NMR Biomed (in press) 2022.

Rubtsova, N.I., Hart, M.C., Arroyo, A.D., Osharovich, S.A., Liebov, B.K., Miller, J., Yuan, M., Cochran, J.M., Chong, S., Yodh, A.G., Busch, T.M., Delikatny, E.J., Anikeeva, N., and Popov, A.V. : NIR fluorescent imaging and photodynamic therapy with a novel theranostic phospholipid probe for triple-negative breast cancer cells. Bioconjugate Chemistry 18(32): 1852-1863, Aug 2021 Notes: doi:10.1021/acs.bioconjchem.1c00295.

Bryski, M.G., Frenzel-Sulyok, L.G., Delikatny, E.J., Deshpande, C., Litzky, L.A., and Singhal, S.. : Molecular imaging can identify the location to perform a frozen biopsy during intraoperative frozen section consultation. PLoS One 16(6): e0252731, Jun 2021.

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Last updated: 08/08/2023
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