Edward J. (Jim) Delikatny, Ph.D.

faculty photo
Research Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
University of Pennsylvania,
Department of Radiology,
317 Anatomy Chemistry Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-3105
Education:
B.Sc. (Chemistry/Environmental Studies)
University of Winnipeg, 1978.
Ph.D. (Physical Chemistry)
University of British Columbia, 1987.
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Description of Research Expertise

Research Interest Summary:
The main interest of this group is the non invasive detection of metabolic changes that occur during tumor development and in response to anticancer drugs in models of human breast cancer. We employ a number of imaging modalities that include near infrared fluorescence optical imaging, MRI and MRS, PET and Cerenkov imaging. We have an active program in the design, synthesis and characterization of NIR optical contrast agents for the detection of phospholipase and choline kinase expression and activity in tumors and for the detection of pH and redox changes in the tumor microenvironment. Changes in lipid metabolite levels are monitored using MRS to determine potential biochemical markers for the detection of tumors and their early response to therapy and correlated with near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ. We are pioneering the development of Cerenkov imaging by creating novel radiolabeled probes suitable for determining both location and function using dual PET and optical imaging.

Description of Other Expertise

MR spectroscopy, MR imaging, NIR optical imaging, Cerenkov imaging, contrast agent design, anticancer drugs, lipid metabolism, cancer pharmacology

Selected Publications

Liebov, B.K., Arroyo, A.D., Rubtsova, N.I., Osharovich, S.A., Delikatny, E.J. and Popov, A.V.: Nonprotecting group synthesis of a phospholipase C activatable probe with an azo-free quencher. ACS Omega 30(3): 6867-6873, Jun 2018.

Buljan, V.A., Graeber, M.B., Holsinger, R.M.D., Brown, D., Hambly, B.D., Delikatny, E.J., Vuletic, V.R., Krebs, X.N., Tomas, I.B., Bohorquez-Florez, J.J., Liu, G.J. and Banati, R.B.: Calcium-axonemal microtubuli interactions underlie mechanism(s) of primary cilia morphological changes. J. Biol. Phys. 44(1): 53-80, Mar 2018.

Kall, S.L., Delikatny, E.J. and Lavie. A.: Identification of a unique inhibitor-binding Site on Choline Kinase α. Biochemistry 57(8): 1316-1325, Feb 2018.

Predina, J.D., Newton, A.D., Keating, J., Barbosa, E.M. Jr, Okusanya, O., Xia, L., Dunbar, A., Connolly, C., Baldassari, M.P., Mizelle, J., Delikatny, E.J., Kucharczuk, J.C., Deshpande, C., Kularatne, S.A., Low, P., Drebin, J. and Singhal S.: Intraoperative molecular imaging combined with Positron Emission Tomography improves surgical management of peripheral malignant pulmonary nodules. Annals of Surgery 266(3): 479-488, Sep 2017.

Kachur, A.V., Arroyo, A.D., Bryan, N.W., Saylor, S.J., Popov, A.V. and Delikatny, E.J.: Synthesis of pH indicators for Cerenkov imaging by electrophilic substitution of bromine by fluorine in an aromatic system. Journal of Fluorine Chemistry 200: 146-152, Aug 2017.

Arlauckas, S.P., Kumar, M., Popov, A.V., Poptani, H. and Delikatny, E.J.: Near infrared fluorescent imaging of choline kinase alpha expression and inhibition in breast tumors. Oncotarget 8(10): 16518-30, Feb 2017.

Keating, J., Newton, A., Venegas, O., Nims, S., Zeh, R., Predina, J., Deshpande, C., Kucharczuk, J., Nie, S., Delikatny, E.J. and Singhal, S.: Near-infrared intraoperative molecular imaging can locate metastases to the lung. Ann. Thorac. Surg. 103(2): 390-398, Feb 2017.

Karunamuni, R., Naha, P.C., Lau, K.C., Al-Zaki, A., Popov, A.V., Delikatny, E.J., Tsourkas, A.T., Cormode, D.A., and Maidment, A.D.A.: Development of silica-encapsulated silver nanoparticles as contrast agents intended for dual-energy mammography. European Radiology 26(9): 3301-9, Sep 2016.

Kalogiannis, M., Delikatny, E.J. and Jeitner, T.M.: Serotonin as a putative scavenger of hypohalous acid in the brain. Biochimica Biophysica Acta - Molecular Basis of Disease 1862(4): 651-661, Apr 2016.

Chiorazzo, M.G., Bloch, N.B., Popov, A.V. and Delikatny, E.J.: Synthesis and evaluation of cytosolic phospholipase A2 activatable fluorophores for cancer imaging. Bioconjugate Chemistry 26(12): 2360-2370, Dec 2015.

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Last updated: 09/20/2018
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