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Julia I-Ju Leu, Ph.D.

Julia I-Ju Leu, Ph.D.

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Research Assistant Professor of Genetics
Department: Genetics

Contact information
Perelman School of Medicine, University of Pennsylvania
Department of Genetics
520 Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
Office: 215-898-5033
Education:
B.S.
University of Washington, 1994.
Ph.D.
University of Pennsylvania , 2001.
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Perelman School of Medicine > Faculty > Search

Selected Publications

Leu JI*, Zhang P, Murphy ME, Marmorstein R, George DL: Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket. ACS Chemical Biology 9: 2508-2516, 2014. Notes: *Co-corresponding author.

Zhang P, Leu JI*, Murphy ME, George DL, Marmorstein R: Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate. PLoS One 9: e103518, 2014. Notes: *Co-corresponding author.

Leu JI*, Murphy ME, George DL: The p53 codon 72 polymorphism modifies the cellular response to inflammatory challenge in the liver. Journal of Liver 2: 117, 2013. Notes: Corresponding author.

Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, Zhang G, Herlyn M, Villanueva J, Dunbrack RL Jr, Yen T, George DL, Murphy ME: A modified HSP70 inhibitor shows broad activity as an anticancer agent. Molecular Cancer Research 11: 219-229, 2013.

Frank AK, Leu JI, Zhou Y, Devarajan K, Nedelko T, Klein-Szanto A, Hollstein M, Murphy ME: The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation. Molecular and Cellular Biology 31: 1201-1213, 2011.

Leu JI*, Pimkina J, Pandey P, Murphy ME, George DL: HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells Molecular Cancer Research 9: 936-947, 2011. Notes: *Co-corresponding author.

Leu JI, Pimkina J, Frank A, Murphy ME, George DL: A small molecule inhibitor of inducible heat shock protein 70. Molecular Cell 36: 15-27, 2009. Notes: Preview: Galluzzi L, Giordanetto F, Kroemer G: Targeting HSP70 for cancer therapy. Molecular Cell 36:176-177, 2009.

Leu JI, George DL: Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria. Genes and Development 21: 3095-3109, 2007. Notes: Editors' Choice: Gough NR: Protecting the Liver from Death. Science STKE Vol. 2007, Issue 416, p. tw447, 2007. Perspectives: Guicciardi ME, Gores GJ: Cell stress gives a red light to the mitochondrial cell death pathway. Science Signaling 1:pe9, 2008.

Leu JI, Dumont P, Hafey M, Murphy ME, George DL: Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nature Cell Biology 6: 443-450, 2004. Notes: News and Views: Perfettini JL, Kroemer RT, Kroemer G: Fatal liaisons of p53 with Bax and Bak. Nature Cell Biology 6:386-388, 2004.

Leu JI, Crissey MA, Taub R: Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice. Journal of Clinical Investigation 111: 129-139, 2003.

Leu JI, Crissey MA, Craig LE, Taub R: Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation. Molecular and Cellular Biology 23: 1251-1259, 2003.

Dumont P, Leu JI*, Della Pietra AC 3rd, George DL, Murphy M: The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nature Genetics 33: 357-365, 2003. Notes: *Co-first author. Previews: Manfredi JJ: p53 and apoptosis: it's not just in the nucleus anymore. Molecular Cell 11:552-554, 2003. Baptiste N, Prives C: p53 in the cytoplasm: a question of overkill? Cell 116:487-489, 2004.

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Last updated: 04/20/2015
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