Julia I-Ju Leu, Ph.D.
Julia I-Ju Leu, Ph.D.
Research Assistant Professor of Genetics
Department: Genetics
Contact information
University of Pennsylvania School of Medicine
Department of Genetics
520 Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
Department of Genetics
520 Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
Office: 215-898-5033
Email:
leu@mail.med.upenn.edu
leu@mail.med.upenn.edu
Education:
B.S.
University of Washington, 1994.
Ph.D.
University of Pennsylvania , 2001.
Permanent linkB.S.
University of Washington, 1994.
Ph.D.
University of Pennsylvania , 2001.
Selected Publications
Leu, J.I., Pimkina, J., Pandey, P., Murphy, M.E. and George, D.L.: HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Molecular Cancer Research 9: 936-947, 2011.Frank, A.K., Leu, J.I., Zhou, Y., Devarajan, K., Nedelko, T., Klein- Szanto, A., Hollstein, M., and Murphy, M.E.: The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation. Molecular and Cellular Biology 31: 1201-1213, 2011.
Leu, J.I. Pimkina, J., Frank, A., Murphy M.E. and George, D.L.: A small molecule inhibitor of inducible heat shock protein 70. Molecular Cell 36: 15-27, 2009. Notes: Comment in: Galluzzi, L., Giordanetto, F., and Kroemer, G. Targeting HSP70 for cancer therapy. Molecular Cell 36: 176-177, 2009.
Leu, J.I. and George, D.L.: Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria. Genes and Development 21: 3095-3109, 2007. Notes: Comment in: Gough, N.R.: Protecting the Liver from Death. Sci. STKE, Vol. 2007, Issue 416: p. tw447, 2007. Guicciardi, M.E. and Gores, G.J.: Cell stress gives a red light to the mitochondrial cell death pathway. Science Signaling 1(7): pe9, 2008.
Leu, J.I., Dumont, P., Hafey, M., Murphy, M.E. and George, D.L.: Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nature Cell Biology 6: 443-450, 2004. Notes: Comment in: Perfettini, J.L., Kroemer, R.T., and Kroemer, G.: Fatal liaisons of p53 with Bax and Bak. Nature Cell Biology 6: 386-388, 2004.
Dumont, P., Leu, J.I.*, Della Pietra AC 3rd, George, D.L. and Murphy, M.: The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nature Genetics 33: 357-365, 2003. Notes: *Co-first author. Comment in: Manfredi, J.J.: p53 and apoptosis: it's not just in the nucleus anymore. Molecular Cell 11: 552-554, 2003. Baptiste, N. and Prives, C.: p53 in the cytoplasm: a question of overkill? Cell 116: 487-489, 2004.
Leu, J.I., Crissey, M.A. and Taub, R.: Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice. The Journal of Clinical Investigation 111: 129-139, 2003.
Leu, J.I., Crissey, M.A., Craig, L.E. and Taub, R.: Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation. Molecular and Cellular Biology 23: 1251-1259, 2003.
Macias-Silva, M., Li ,W., Leu, J.I., Crissey, M.A. and Taub, R. : Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration. Journal of Biological Chemistry 277: 28483-28490, 2002.
Leu, J.I., Crissey, M.A., Leu, J.P., Ciliberto, G. and Taub, R.: Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury. Molecular and Cellular Biology 21: 414-424, 2001.