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Julia I-Ju Leu, Ph.D.

Julia I-Ju Leu, Ph.D.

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Research Assistant Professor of Genetics
Department: Genetics

Contact information
Perelman School of Medicine, University of Pennsylvania
Department of Genetics
520 Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
Office: 215-898-5033
Education:
B.S.
University of Washington, 1994.
Ph.D.
University of Pennsylvania , 2001.
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Selected Publications

Leu, J.I., Zhang, P., Murphy, M.E., Marmorstein, R., and George, D.L.: Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket. ACS Chem. Biol. 2014.

Zhang, P., Leu, J.I., Murphy, M.E., George, D.L., and Marmorstein, R.: Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate. PLoS One 9: e103518, 2014.

Leu, J.I., Murphy, M.E., and George, D.L. : The p53 codon 72 polymorphism modifies the cellular response to inflammatory challenge in the liver . Journal of Liver 2: 117, 2013.

Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, Zhang G, Herlyn M, Villanueva J, Dunbrack RL Jr, Yen T, George DL, and Murphy ME.: A modified HSP70 inhibitor shows broad activity as an anticancer agent. Molecular Cancer Research 11: 219-229, 2013.

Frank, A.K., Leu, J.I., Zhou, Y., Devarajan, K., Nedelko, T., Klein- Szanto, A., Hollstein, M., and Murphy, M.E.: The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation. Molecular and Cellular Biology 31: 1201-1213, 2011.

Leu, J.I., Pimkina, J., Pandey, P., Murphy, M.E. and George, D.L.: HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Molecular Cancer Research 9: 936-947, 2011.

Leu, J.I. Pimkina, J., Frank, A., Murphy M.E. and George, D.L.: A small molecule inhibitor of inducible heat shock protein 70. Molecular Cell 36: 15-27, 2009 Notes: Comment in: Galluzzi, L., Giordanetto, F., and Kroemer, G. Targeting HSP70 for cancer therapy. Molecular Cell 36: 176-177, 2009.

Leu, J.I. and George, D.L.: Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria. Genes and Development 21: 3095-3109, 2007 Notes: Comment in: Gough, N.R.: Protecting the Liver from Death. Sci. STKE, Vol. 2007, Issue 416: p. tw447, 2007. Guicciardi, M.E. and Gores, G.J.: Cell stress gives a red light to the mitochondrial cell death pathway. Science Signaling 1(7): pe9, 2008.

Leu, J.I., Dumont, P., Hafey, M., Murphy, M.E. and George, D.L.: Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nature Cell Biology 6: 443-450, 2004 Notes: Comment in: Perfettini, J.L., Kroemer, R.T., and Kroemer, G.: Fatal liaisons of p53 with Bax and Bak. Nature Cell Biology 6: 386-388, 2004.

Leu, J.I., Crissey, M.A. and Taub, R.: Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice. The Journal of Clinical Investigation 111: 129-139, 2003.

Leu, J.I., Crissey, M.A., Craig, L.E. and Taub, R.: Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation. Molecular and Cellular Biology 23: 1251-1259, 2003.

Dumont, P., Leu, J.I.*, Della Pietra AC 3rd, George, D.L. and Murphy, M.: The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nature Genetics 33: 357-365, 2003 Notes: *Co-first author. Comment in: Manfredi, J.J.: p53 and apoptosis: it's not just in the nucleus anymore. Molecular Cell 11: 552-554, 2003. Baptiste, N. and Prives, C.: p53 in the cytoplasm: a question of overkill? Cell 116: 487-489, 2004.

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Last updated: 09/13/2014
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