Julie I-Ju Leu, PhD
Research Associate Professor of Genetics
Department: Genetics
Contact information
Perelman School of Medicine, University of Pennsylvania
Department of Genetics
540-5 Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
Department of Genetics
540-5 Clinical Research Building
415 Curie Blvd
Philadelphia, PA 19104
Office: 215-898-5033
Email:
leu@pennmedicine.upenn.edu
leu@pennmedicine.upenn.edu
Education:
B.S. (Cell and Molecular Biology)
University of Washington, 1994.
Ph.D. (Cell and Molecular Biology)
University of Pennsylvania , 2001.
Permanent linkB.S. (Cell and Molecular Biology)
University of Washington, 1994.
Ph.D. (Cell and Molecular Biology)
University of Pennsylvania , 2001.
Selected Publications
IGVF Consortium: Deciphering the impact of genomic variation on function. Nature 633: 47-57, 2024.Stieg, D.C., Casey, K., Karisetty, B.C., Leu, J.I., Larkin, F., Vogel, P., Madzo, J., Murphy, M.E.: The Ashkenazi-Centric G334R Variant of TP53 is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model. Mol Cell Biol. 8: 1-15, 2024.
Indeglia, A., Leung, J.C., Miller, S.A., Leu, J.I., Dougherty, J.F., Clarke, N.L., Kirven, N.A., Shao, C., Ke, L., Lovell, S., Barnoud, T., Lu, D.Y., Lin, C., Kannan, T., Battaile, K.P., Yang, T.H.L., Batista Oliva, I., Claiborne, D.T., Vogel, P., Liu, L., Liu, Q., Nefedova, Y., Cassel, J., Auslander, N., Kossenkov, A.V., Karanicolas, J., Murphy, M.E.: An African-specific variant of TP53 reveals PADI4 as a regulator of p53-mediated tumor suppression. Cancer Discovery 13(7): 1696-1719, 2023.
Leung, J.C., Leu, J.I., Indeglia, A., Kannan, T., Clarke, N.L., Kirven, N.A., Dweep, H., Garlick, D., Barnoud, T., Kossenkov, A.V., George, D.L., Murphy, M.E.: Common activities and predictive gene signature identified for genetic hypomorphs of TP53. Proc. Natl. Acad. Sci. USA. 120(7): e2212940120, 2023.
Leu, J.I., Murphy, M.E., George, D.L.: Targeting ErbB3 and Cellular NADPH/NADP+ Abundance Sensitizes Cutaneous Melanomas to Ferroptosis Inducers. ACS Chemical Biology 17(5): 1038-1044, 2022.
Murphy, M., Leung, J., Leu, J., Indeglia, A., Clarke, N., Kannan, T., Kirven, N., Barnoud, T., Kossenkov, A., George, D.L.: The genetics of tumor suppression by p53. The FASEB Journal 2022 Notes: https://doi.org/10.1096/fasebj.2022.36.S1.0I212.
Leu, J.I., Murphy, M.E., George, D.L.: P53 regulates cellular redox state, ferroptosis and metabolism. Molecular & Cellular Oncology 8(2): 1877076, 2021.
Parris, J.L.D., Barnoud, T., Leu, J.I., Leung, J.C., Ma, W., Kirven, N.A., Poli, A.N.R., Kossenkov, A.V., Liu, Q., Salvino, J.M., George, D.L., Weeraratna, A.T., Chen, Q., Murphy, M.E.: HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS mutant melanoma. Cancer Research Communications. 1: 17-29, 2021.
Singh, K.S., Leu*, J.I., Barnoud, T., Vonteddu, P., Gnanapradeepan, K., Lin, C., Liu, Q., Barton, J.C., Kossenkov, A.V., George, D.L., Murphy, M.E., Dotiwala, F.: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Nature Communications 11(1): 473, 2020. Notes: *Co-first author.
Barnoud, T., Leung*, J.C., Leu*, J.I., Basu*, S., Poli*, A.N.R., Parris, J.L.D., Indeglia, A., Martynyuk, T., Good, M., Gnanapradeepan, K., Sanseviero, E., Moeller, R., Tang, H.Y., Cassel, J., Kossenkov, A.V., Liu, Q., Speicher, D.W., Gabrilovich, D.I., Salvino, J.M., George, D.L., Murphy, M.E.: A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors. Cancer Research. 80(23): 5270-5281, 2020. Notes: *Equal contribution.