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Leslie M. Shaw, Ph.D.

Leslie M. Shaw, Ph.D.

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Hospital of the University of Pennsylvania
7.103 Founders Pavilion 3400 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-6575
Fax: (215) 662-7529
B.S. (Cum Laude, Chemistry)
LeMoyne College, Syracuse, New York, 1962.
Ph.D. (Biochemistry)
S.U.N.Y. at Upstate Medical Center, 1968.
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Description of Research Expertise

Development, validation and implementation of neurodegenerative diseases biomarkers in cerebrospinal fluid and plasma into treatment trials and clinical studies (eg, ADNI study; PPMI study). These studies include the use of manual and highly automated immunoassays and for amyloid beta(1-42) and for total tau the use of high sensitivity UPLC/tandem mass spectrometry. Multi-modal statistical analyses of these study data to address several questions including the diagnostic utilities of these biomarkers; assessments of the longitudinal trajectories of these biomarkers in AD, MCI and cognitively normal controls to assess the neuropathological changes over time in these individuals.

Description of Clinical Expertise

Measurement and interpretation of the toxicokinetics of drugs and toxins in patients affected by them. Interpretation of the pharmacokinetics of immunosuppressant maintenance medications in transplant patients.

Description of Other Expertise

Development and implementation of mass spectrometry-based methods for measuring small molecules of clinical utility including therapeutic drugs, toxins and special chemistry tests including 25-OH vitamin D.

Selected Publications

Durazzo TC, Korecka M, Trojanowski JQ, Weiner MW, O'Hara R, Ashford JW, Shaw LM, Alzheimer's Disease Neuroimaging Initiative. : Active Cigarette smoking in cognitively-normal elders and probable Alzheimer's Disease is associated with Elevated Cerebrospinal fluid Oxidative Stress biomarkers. J Alzheimers Dis. Jul 25 2016 Notes: EPub ahead of print.

Bjerke M, Andreasson U, Kuhlman J, Portelius E, Pannee J, Lewczuk P, Umek RM, Vanmechelen E, Vanderstichele H, Stoops E, Lewis J, Vandijck M, Kostanjevecki V, Jeromin A, Salamone SJ, Schmidt O, Matzen A, Madin K, Eichenlaub U, Bittner T, Shaw LM, Zegers I, Zetterberg H, Blennow K.: Assessing the commutability of reference material formats for the harmonization of amyloid-B measurements. Clin Chem Lab Med. 54(7), Jul 2016.

Kang JH, Mollenhauer B, Coffey CS, Toledo JB, Weintraub D, Galasko DR, Irwin DJ, Van Deerlin V, Chen-Plotkin AS, Caspell-Garcia C, Waligorska T, Taylor P, Shah N, Pan S, Zero P, Frasier M, Marek K, Kieburtz K, Jennings D, Tanner CM, Simuni T, Singleton A, Toga AW, Chowdhury S, Trojanowski JQ, Shaw LM; Parkinson's Progression Marker Initiative.: CSF Biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study. Acta Neuropathol. 131(6): 935-49, June 2016 Notes: EPub ahead of print - 2016/Mar 28.

Vilas D, Shaw LM, Taylor P, Berg D, Brockman K, Aasly J, Marras C, Pont-Sunyer C, Rios J, Marek K, Tolosa E.: Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers. Mov Disord. 31(6): 906-14, June 2016 Notes: EPub ahead of print - 2016/Apr 4.

Podlesniy P, Vilas D, Taylor P, Shaw LM, Tolosa E, Trullas R. : Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease. Neurobiol Dis. 94: 10-17, May 31 2016 Notes: EPub ahead of print.

Van Broeck B, Timmers M, Ramael S, Bogert J, Shaw LM, Mercken M, Slemmon J, Van Nueten L, Engelborghs S, Streffer JR. : Impact of frequent cerebrospinal fluid sampling on AB levels: systematic approach to elucidate influencing factors. Alzheimers Res Ther. 8(1), May 2016.

Kuhlmann J, Andreasson U, Pannee J, Bjerke M, Portelius E, Leinerbach A, Bittner T, Korecka M, Jenkins RG, Vanderstichele H, Stoops E, Lewczuk P, Shaw LM, Zegers I, Schimmel H, Zetterberg H, Blennow K, IFCC Working Group on Standarization of CSF Proteins (WG-CSF).: CSF AB1-42 - an excellent but complicated Alzheimer's biomarker - a route to standardization. Clin Chim Acta. EPub ahead of print. May 2016.

Abner EL, Jicha GA, Shaw LM, Trojanowski JQ, Goetzl EJ. : Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging. Ann Clin Transl Neurol. 3(5): 399-403, Apr 2016 Notes: eCollection 2016 May.

berger M, Nadler JW, Friedman A, McDonagh DL, Bennett ER, Cooter M, Qi W, Laskowitz DT, Ponnusamy V, Newman MF, Shaw LM, Warner DS, Matjew JP, James ML; MAD-PIA trial team. : The effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal fluid markers of Alzheimer's Disease: Results of a Randomized trial. J Alzheimers Dis. 52(4): 1299-310, Apr 2016.

Pannee J, Gobom J, Shaw LM, Korecka M, Chambers EE, Lame M, Jenkins R, Mylott W, Carrillo MC, Zegers I, Zetterberg H, Blennow K, Portelius E.: Round robin test on quantification of amyloid-B 1-42 in cerebrospinal fluid by mass spectrometry. Alzheimer's & Dementia 12(1): 55-9, Jan 2016 Notes: ePub ahead of print 2015/July 21.

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Last updated: 08/09/2016
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