Leslie M. Shaw, Ph.D.

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Hospital of the University of Pennsylvania
7.103 Founders Pavilion 3400 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-6575
Fax: (215) 662-7529
Education:
B.S. (Cum Laude, Chemistry)
LeMoyne College, Syracuse, New York, 1962.
Ph.D. (Biochemistry)
S.U.N.Y. at Upstate Medical Center, 1968.
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Description of Research Expertise

Development, validation and implementation of neurodegenerative diseases biomarkers in cerebrospinal fluid and plasma into treatment trials and clinical studies (eg, ADNI study; PPMI study). These studies include the use of manual and highly automated immunoassays and for amyloid beta(1-42) and for total tau the use of high sensitivity UPLC/tandem mass spectrometry. Multi-modal statistical analyses of these study data to address several questions including the diagnostic utilities of these biomarkers; assessments of the longitudinal trajectories of these biomarkers in AD, MCI and cognitively normal controls to assess the neuropathological changes over time in these individuals.

Description of Clinical Expertise

Measurement and interpretation of the toxicokinetics of drugs and toxins in patients affected by them. Interpretation of the pharmacokinetics of immunosuppressant maintenance medications in transplant patients.

Description of Other Expertise

Development and implementation of mass spectrometry-based methods for measuring small molecules of clinical utility including therapeutic drugs, toxins and special chemistry tests including 25-OH vitamin D.

Selected Publications

Mollenhauer B, Caspell-Garcia CJ, Coffey CS, Taylor P, Singleton A, Shaw LM, Tronjanowski JQ, Frasier M, Simuni T, Iranzo A, Oertal W, Siderowf A, Weintraub D, Seibyl J, Toga AW, Tanner CM, Kieburtz K, Chahine LM, Marek K, Galasko D for the PPMI Study.: Longitudunal Analyses of Cerebrospinal Fluid a-Synuclein in Prodromal and Early Parkinson's Disease. Movement Disorders 2019 - In Press Notes: DOI: 10.1002/mds.27806.

Kuhlmann J, Boulo S, Andreaasson U, Bjerke M, Pannee J, Charoud-Got J, Auclair G, Mazoua S, Trapman S, Schimmel H, Emons H, Florian D, Quaglia M, Portelius E, Korecka M, Shaw LM, Lame M, Chambers E, Vanderstitchele H, Stoops E, Leinenbach A, BIttner T, Jenkins RG, Kostanjavecki V, Lewczuk P, Zetterberg H, Zegers I, Blennow K. : The Certification of Amyloid B1-42 in CSF in ERM -DA480/IFCC, ERM - DA481/IFCC and ERM -DA482/IFCC. ERM - European Reference Materials. 2019 In Press.

Shaw LM, Hansson O, Manuilova E, Masters CL, Doecke JD, Li Q-X, Rutz S, Widmann M, Leinenbach A, Blennow K. : Method Comparison study of the Elecsys B-Amyloid (1-42) CSF Assay versus comparator assays and LC-MS/MS. Clinical Biochemistry. May 2019 Notes: https://doi.org/10.1016/j.clinbiochem.2019.05.006.

Lifke V, Kollmorgen G, Manuilova E, Oelschlaegel T, Hillringhaus L, Widmann M, Von Arnim CAF, Otto M, Christenson RH, Powers JL, Shaw LM, Hansson O, Doecke JD, Li Q-B, Teunissen C, Tumani H, Blennow K. : Elecsys Total-Tau and Phospho-Tau (181P) CSF Assays: Analytical performance of the novel, fully automated immunoasays for quantification of tau proteins in human cerebrospinal fluid. Clinical Biochemistry May 2019 Notes: https://doi.org/10.1016/j.clinbiochem.2019.05.005.

Berger M, Oyeyemi D, Olurinde MO, Whitson HE, Weinhold KJ, Woldorff MG, Lipsitz LA, Morett E, Giattino CM, Roberts KC, Zhou J, Bunning T, Ferrandino M, Scheri RP, Cooter M, Chan C, Cabeza R, Browndyke JN, Murdoch DM, Devinney MJ, Shaw LM, Cohen HJ, Mathew JP, and the INTUIT Investigators. : The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction. JAGS (Journal of American Geriatrics Society). 2019 Notes: DOI: 10.1111/jgs.15770.

Nho K, Kueider-Paisley A, Ahmad S, Mahmoudian-Dehkordi S, Arnold M, Risacher SL, Louie G, Blach C, Baillie R, Han X, Kastenmuller G, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy M, Van Duijn C, Saykin AJ, Kaddurah-Daouk R, for the Alzheimer's Disease Neuroimaging Initiative and the Alzheimer's Disease Metabolomics Consortium. : Association of Altered Liver Enzymes with Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers. JAMA Network Open. 2(7), 2019 Notes: DOI: 10.1001/jamanetworkopen.2019.7978.

Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagist W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ, and the Alzheimer's Disease Neuroimaging Initiative. : Understanding Disease progression and improving Alzheimer's Disease Clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & Dementia 15: 106-152, 2019 Notes: http://doi.org/10.1016/j.jalz.2018.08.005.

Phillips JS, Da Re F, Dratch L, Xie SX, Irwin DJ, McMillan CT, Vaishnavi SN, Ferrarese C, Lee EB, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. : Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiology of Aging. 63, 2018, in Press Notes: Available online ahead of print - November 21, 2017. https://doi.org/10.1016/j.neurobiolaging.2017.11.008.

Portelius E, Olsson B, Hoglund K, Cullen NC, Kvartsberg H, Andreasson U, Zetterberg H, Sandelius A, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, McBride J, Toledo JB, Trojanowski JQ, Blennow K. : Cerebrospinal Fluid Neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta Neuropathologica 2018, in Press Notes: https://doi.org/10.1007/s00401-018-1851.

Shaw LM, Arias J, Blennow K, Galasko D, Molinuevo JL, Salloway S, Schindler S, Carrillo MC, Hendrix JA, Ross A, Illes J, Ramus C, Fifer S. : Appropriate Use Criteria for Lumbar Puncture and Cerebrospinal Fluid Testing in the Diagnosis of Alzheimer's Disease. Alzheimer's and Dementia 2018, in Press.

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Last updated: 07/31/2019
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