Aili L. Lazaar, MD

faculty photo
Adjunct Associate Professor of Medicine
Department: Medicine

Contact information
Penn Medicine University City
3737 Market Street
10th floor
Philadelphia, PA 19104-4318
Office: 215-662-8766
Fax: 215-243-5265
A.B. (Biochemistry)
Harvard University, 1982.
M.D. (Medicine)
New York University, 1986.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Phase I-II clinical trials in COPD, critical care, pulmonary hypertension

Description of Clinical Expertise

Asthma, COPD, COPD clinical trials

Selected Publications

Esther CR, Lazaar AL, Bordonali E, Qaqish B, Boucher RC: Elevated airway purines in chronic obstructive pulmonary disease. Chest 140(4): 954-960, 2011.

Lazaar AL, Sweeney LE, MacDonald AJ, Alexis NE, Chen C, Deans A, Tal-Singer R: SB-656933, a novel CXCR2 selective antagonist, inhibits ex-vivo neutrophil activation and ozone-induced airway inflammation in humans. British Journal of Clinical Pharmacology 72(2): 282-293, 2011.

Singh D, Petavy F, Macdonald AJ, Lazaar A and O`Connor BJ: The inhaled phosphodiesterase 4 inhibitor GSK256066 inhibits allergen challenge responses in asthma. Respiratory Research 11(1): 26, 2010.

Kim JH, Van Biesen C, Lazaar AL: VEGF alters tracheal ring force generation in a rho-dependent manner. Am J Respir Crit Care Med 169: A445, 2004.

Kazi AS, Lotfi S, Krymskaya VP, Lazaar AL. : Vascular endothelial growth factor (VEGF) up regulates fibronectin and matrix metalloproteinase-2 (MMP-2) secretion by human airway smooth muscle cells. Am J Respir Crit Care Med 167: A689, 2003.

Goncharova EA, Goncharov DA, Panettieri RA, Lazaar AL, Krymskaya VP. : VEGF stimulates proliferation and migration of LAM-derived cells. Am J Respir Crit Care Med 167: A953, 2003.

Kim JH, Ammit AJ, Puré E, Lazaar AL. : Hyaluronan activates NF-kB and induces IL-6 by human airway smooth muscle cells. Am J Respir Crit Care Med 167: A690, 2003.

Lazaar AL, Panettieri RA: Airway Smooth Muscle: An Immunomodulatory Cell? Therapeutic Targets in Airway Inflammation. Eissa NT, Huston DP (eds.). Marcel Dekker, Inc., New York 177: 767-780, 2003.

Lazaar AL, Albelda SM, Pilewski JM, Brennan B, Pure E, Panettieri RA Jr.: T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. Journal of Experimental Medicine 180(3): 807-16, Sep 1 1994.

back to top
Last updated: 10/24/2017
The Trustees of the University of Pennsylvania