Aili L. Lazaar, MD
Adjunct Associate Professor of Medicine (Pulmonary, Allergy and Critical Care)
Department: Medicine
Contact information
Penn Medicine University City
3737 Market Street
10th floor
Philadelphia, PA 19104-4318
3737 Market Street
10th floor
Philadelphia, PA 19104-4318
Office: 215-662-8766
Fax: 215-243-5265
Fax: 215-243-5265
Education:
A.B. (Biochemistry)
Harvard University, 1982.
M.D. (Medicine)
New York University, 1986.
Permanent linkA.B. (Biochemistry)
Harvard University, 1982.
M.D. (Medicine)
New York University, 1986.
Description of Research Expertise
Phase I-II clinical trials (COPD, critical care, pulmonary hypertension, respiratory viral infection, Hepatitis B)Description of Clinical Expertise
Asthma, COPD, COPD clinical trialsSelected Publications
Esther CR, Lazaar AL, Bordonali E, Qaqish B, Boucher RC: Elevated airway purines in chronic obstructive pulmonary disease. Chest 140(4): 954-960, 2011.Lazaar AL, Sweeney LE, MacDonald AJ, Alexis NE, Chen C, Deans A, Tal-Singer R: SB-656933, a novel CXCR2 selective antagonist, inhibits ex-vivo neutrophil activation and ozone-induced airway inflammation in humans. British Journal of Clinical Pharmacology 72(2): 282-293, 2011.
Singh D, Petavy F, Macdonald AJ, Lazaar A and O`Connor BJ: The inhaled phosphodiesterase 4 inhibitor GSK256066 inhibits allergen challenge responses in asthma. Respiratory Research 11(1): 26, 2010.
Kim JH, Van Biesen C, Lazaar AL: VEGF alters tracheal ring force generation in a rho-dependent manner. Am J Respir Crit Care Med 169: A445, 2004.
Kazi AS, Lotfi S, Krymskaya VP, Lazaar AL. : Vascular endothelial growth factor (VEGF) up regulates fibronectin and matrix metalloproteinase-2 (MMP-2) secretion by human airway smooth muscle cells. Am J Respir Crit Care Med 167: A689, 2003.
Goncharova EA, Goncharov DA, Panettieri RA, Lazaar AL, Krymskaya VP. : VEGF stimulates proliferation and migration of LAM-derived cells. Am J Respir Crit Care Med 167: A953, 2003.
Kim JH, Ammit AJ, Puré E, Lazaar AL. : Hyaluronan activates NF-kB and induces IL-6 by human airway smooth muscle cells. Am J Respir Crit Care Med 167: A690, 2003.
Lazaar AL, Panettieri RA: Airway Smooth Muscle: An Immunomodulatory Cell? Therapeutic Targets in Airway Inflammation. Eissa NT, Huston DP (eds.). Marcel Dekker, Inc., New York 177: 767-780, 2003.
Lazaar AL, Albelda SM, Pilewski JM, Brennan B, Pure E, Panettieri RA Jr.: T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. Journal of Experimental Medicine 180(3): 807-16, Sep 1 1994.