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John C. Kucharczuk, M.D., FACS
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Carole and Stuart Potter Associate Professor in BRCA Clinical Care
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Active Surgeon, Presbyterian Medical Center, Philadelphia, PA, University of Pennsylvania
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Active Surgeon, Pennsylvania Hospital, Philadelphia, PA
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Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
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Member of Resident Work Hours Task Force, Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, PA
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Faculty Annual Giving Appeal Committee, University of Pennsylvania School of Medicine, Philadelphia, PA
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Chairman, Thoracic Oncology Service Line, Penn Medicine - University of Pennsylvania Health System
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Department: Surgery
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Contact information
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Division of Thoracic Surgery
3f Perelman School of Medicine, University of Pennsylvania
39 14th Floor South, PCAM
Philadelphia, PA 19104
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3f Perelman School of Medicine, University of Pennsylvania
39 14th Floor South, PCAM
Philadelphia, PA 19104
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Office: 2156624988
30 Fax: 2156156562
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30 Fax: 2156156562
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Links
98 University of Pennsylvania, Department of Surgery Web Site
73 The Cardiothoracic Surgery Network
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98 University of Pennsylvania, Department of Surgery Web Site
73 The Cardiothoracic Surgery Network
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Education:
21 8 BCE 21 (Chemical Engineering) c
3c Villanova University, Villanova, PA, 1987.
21 5 c
39 Georgetown University, College of Arts and Science, 12 Washington, DC 16 , 1988.
21 7 MD c
58 University of Pennsylvania School of Medicine, Philadelphia, PA, 1992.
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Permanent link21 8 BCE 21 (Chemical Engineering) c
3c Villanova University, Villanova, PA, 1987.
21 5 c
39 Georgetown University, College of Arts and Science, 12 Washington, DC 16 , 1988.
21 7 MD c
58 University of Pennsylvania School of Medicine, Philadelphia, PA, 1992.
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42 Trimodality Treatment for Esophgeal cancer-clinical trials
34 Quality Outcome Measures in Thoracic Surgery
31 Benchmarking Outcomes in Thoracic Surgery
21 Thoracic Surgery Education
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24 Surgery For Esophgeal Cancer
25 Surgery of Mediasinal Disease
34 Surgery for Pleural Disease and Mesothelioma
2b Minimally Invasive Thoracic Surgery
38 Repair and Management of Esophageal Perforations
50 Complex Sugical resections for locally advanced lung and esophgeal cancer
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Description of Research Expertise
43 Adjuvant Treatment for Lung cancer-clinical trials42 Trimodality Treatment for Esophgeal cancer-clinical trials
34 Quality Outcome Measures in Thoracic Surgery
31 Benchmarking Outcomes in Thoracic Surgery
21 Thoracic Surgery Education
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Description of Clinical Expertise
28 Surgery for Lung Cancer24 Surgery For Esophgeal Cancer
25 Surgery of Mediasinal Disease
34 Surgery for Pleural Disease and Mesothelioma
2b Minimally Invasive Thoracic Surgery
38 Repair and Management of Esophageal Perforations
50 Complex Sugical resections for locally advanced lung and esophgeal cancer
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Description of Other Expertise
2f4 Dr. Kucharczuk completed medical School, a general Surgery Residency and thoracic Surgery Training all at the University of Pennsylvania. His clinical and research interests focus on general thoracic surgery. He has expertise in the diagnosis and treatment of benign and malignant diseases of the chest including lung cancer, esophageal cancer, mesothelioma, and mediastinal tumors. He performs a high volume of traditional and minimally invasive thoracic surgical procedures at the Hospital of the University of Pennsylvania. He is an active member of the Thoracic Oncology Research Laboratory, serves as the educational coordinator for the Thoracic Surgery Service and is involved in a number of basic as well clinical research projects.e 29
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112 Kucharczuk JC, Kaiser LR: Flexible and rigid bronchoscopy. Robb & Smith's Operative Cardiac Surgery, Seventh Edition. Spray TL, Acker MA (eds.). Oxford, UK: Butterworth & Heineman Ltd. 2025 (in press).
1d9 Wang W, Scholes D, Roy M, Singhal S, Kucharczuk J, Jarrar D, Predina J, Pechet T, Sun L, Singh AP, Cohen RB, Langer CJ, Aggarwal C, Marmarelis ME: EMBER-Lung: Electronic medical record boosting molecular testing in early stage NSCLC. Journal of Clinical Oncology 43(16 Suppl), June 2025 Notes: Presented at the 2025 American Society of Clinical Oncology Annual Meeting I, ASCO, Chicago, IL, May 2025.
175 Krupp K, Leung G, Simon C, Kucharczuk J, Predina J, Hashimoto DA: Per oral transthoracic rendezvous for endoscopic closure of persistent gastropleural fistula that failed surgical management. VideoGIE 10(5 Suppl): S5, May 2025 Notes: Presented at Digestive Disease Week 2025, San Diego, CA, May 2025.
f3 Soegaard Ballester JM, Kucharczuk JC: Esophageal-pericardial and esophageal-atrial fistulae. Thoracic Surgery Clinics 34(4): 395-403, Nov. 2024 Notes: Epub June 28, 2024.
18f Bou-Samra P, Chang A, Guo E, Azari F, Kennedy G, Din A, Pechet T, Jarrar D, Kucharczuk J, Predina J, Delikatny J, Low PS, Singhal S: Histology and lung nodule fluorescence in intraoperative molecular imaging with pafolacianine. Annals of Thoracic Surgery Short Reports 2(3): 432-437, Mar. 5 2024 Notes: eCollection Sept. 2024.
246 Simone CB, Yegya-Raman N, Manjunath S, Verma V, Shabason JE, Xu L, Cengel KA, Levin WP, Berman AT, Christodouleas JP, Aggarwal C, Cohen RB, Langer CJ, Pechet TT, Singal S, Kucharczuk JC, Rengan R, Feigenberg SJ: Prospective feasibility and phase I/II trial of preoperative proton beam therapy with concurrent chemotherapy for resectable stage IIIA or superior sulcus non-small cell lung cancer. International Journal of Radiation Oncology Biology Physics 117(3): 683-689, Nov. 1 2023 Notes: Epub May 17, 2023.
1d9 Azari F, Kennedy G, Bou-Samra P, Din A, Zhang K, Chang A, Ibrahimli A, Galandarova A, Kucharczuk J, Singhal S: First in human prospective validation of intraoperative artificial intelligence guided diagnosis of indeterminate lung nodules. Journal of Thoracic Oncology 18(11 Suppl): S137, Nov. 2023 Notes: Abstract MA11.03; Presented at the 2023 World Conference on Lung Cancer, Singapore, Sept. 2023.
17f Kennedy GT, Azari FS, Chang A, Chang A, Bou-Samra P, Desphande C, Delikatny EJ, Eruslanov E, Kucharczuk JC, Rice DC, Singhal S: A pH-activatable nanoprobe labels diverse histologic subtypes of human lung cancer during resection. Molecular Imaging & Biology 25(5): 824-832, Oct. 2023 Notes: Epub Sept. 11, 2023.
17a Azari F, Kennedy GT, Chang A, Bernstein E, Nadeem B, Pèlegrin A, Cailler F, Sullivan NT, Kucharczuk J, Singhal S: Glycoprotein receptor CEACAM5-targeted intraoperative molecular imaging tracer in non-small cell lung cancer. Annals of Thoracic Surgery 116(3): 631-641, Sept. 2023 Notes: Epub May 27, 2022.
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Selected Publications
10c Kucharczuk JC, Kaiser LR: Bronchoplastic procedures. Robb & Smith's Operative Cardiac Surgery, Seventh Edition. Spray TL, Acker MA (eds.). Oxford, UK: Butterworth & Heineman Ltd. 2025 (in press).112 Kucharczuk JC, Kaiser LR: Flexible and rigid bronchoscopy. Robb & Smith's Operative Cardiac Surgery, Seventh Edition. Spray TL, Acker MA (eds.). Oxford, UK: Butterworth & Heineman Ltd. 2025 (in press).
1d9 Wang W, Scholes D, Roy M, Singhal S, Kucharczuk J, Jarrar D, Predina J, Pechet T, Sun L, Singh AP, Cohen RB, Langer CJ, Aggarwal C, Marmarelis ME: EMBER-Lung: Electronic medical record boosting molecular testing in early stage NSCLC. Journal of Clinical Oncology 43(16 Suppl), June 2025 Notes: Presented at the 2025 American Society of Clinical Oncology Annual Meeting I, ASCO, Chicago, IL, May 2025.
175 Krupp K, Leung G, Simon C, Kucharczuk J, Predina J, Hashimoto DA: Per oral transthoracic rendezvous for endoscopic closure of persistent gastropleural fistula that failed surgical management. VideoGIE 10(5 Suppl): S5, May 2025 Notes: Presented at Digestive Disease Week 2025, San Diego, CA, May 2025.
f3 Soegaard Ballester JM, Kucharczuk JC: Esophageal-pericardial and esophageal-atrial fistulae. Thoracic Surgery Clinics 34(4): 395-403, Nov. 2024 Notes: Epub June 28, 2024.
18f Bou-Samra P, Chang A, Guo E, Azari F, Kennedy G, Din A, Pechet T, Jarrar D, Kucharczuk J, Predina J, Delikatny J, Low PS, Singhal S: Histology and lung nodule fluorescence in intraoperative molecular imaging with pafolacianine. Annals of Thoracic Surgery Short Reports 2(3): 432-437, Mar. 5 2024 Notes: eCollection Sept. 2024.
246 Simone CB, Yegya-Raman N, Manjunath S, Verma V, Shabason JE, Xu L, Cengel KA, Levin WP, Berman AT, Christodouleas JP, Aggarwal C, Cohen RB, Langer CJ, Pechet TT, Singal S, Kucharczuk JC, Rengan R, Feigenberg SJ: Prospective feasibility and phase I/II trial of preoperative proton beam therapy with concurrent chemotherapy for resectable stage IIIA or superior sulcus non-small cell lung cancer. International Journal of Radiation Oncology Biology Physics 117(3): 683-689, Nov. 1 2023 Notes: Epub May 17, 2023.
1d9 Azari F, Kennedy G, Bou-Samra P, Din A, Zhang K, Chang A, Ibrahimli A, Galandarova A, Kucharczuk J, Singhal S: First in human prospective validation of intraoperative artificial intelligence guided diagnosis of indeterminate lung nodules. Journal of Thoracic Oncology 18(11 Suppl): S137, Nov. 2023 Notes: Abstract MA11.03; Presented at the 2023 World Conference on Lung Cancer, Singapore, Sept. 2023.
17f Kennedy GT, Azari FS, Chang A, Chang A, Bou-Samra P, Desphande C, Delikatny EJ, Eruslanov E, Kucharczuk JC, Rice DC, Singhal S: A pH-activatable nanoprobe labels diverse histologic subtypes of human lung cancer during resection. Molecular Imaging & Biology 25(5): 824-832, Oct. 2023 Notes: Epub Sept. 11, 2023.
17a Azari F, Kennedy GT, Chang A, Bernstein E, Nadeem B, Pèlegrin A, Cailler F, Sullivan NT, Kucharczuk J, Singhal S: Glycoprotein receptor CEACAM5-targeted intraoperative molecular imaging tracer in non-small cell lung cancer. Annals of Thoracic Surgery 116(3): 631-641, Sept. 2023 Notes: Epub May 27, 2022.
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