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Ian A. Blair, Ph.D.

Ian A. Blair, Ph.D.

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A.N. Richards Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
854 Biomedical Research Building II/III
University of Pennsylvania School of Medicine
Center for Cancer Pharmacology
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office: (215) 573-9880
Fax: (215) 573-9889
Education:

Cambridge Grammar School for Boys, United Kingdom , 1960.

Prince of Wales School, Nairobi, Kenya, 1963.
B.Sc. ((Special) Chemistry, ARCS)
Imperial College of Science and Technology, University of London, United Kingdom, 1968.
Ph.D.
Imperial College of Science and Technology, University of London, United Kingdom, 1971.
MRSC (Organic Chemistry)
Adelaide University, Australia, 1972.
ARACI
Australian National University, 1977.
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Description of Research Expertise

Oxidative stress, carcinogenesis, cardiovascular disease, and neurodegenerative disease
Oxidative stress results in damage to lipids through the formation of lipid hydroperoxides. Our laboratory is involved in determining the factors that control lipid hydroperoxide-mediated damage to DNA, and proteins. We are also characterizing the lesions in these macromolecules using novel mass spectrometry methodology, determining how the lesions affect proliferation and apoptosis using model in vitro systems, and assessing how such processes can be prevented using novel pharmacological agents. We also have a program in biomarker discovery and analysis, which is focused on metabolomic and proteomic biomarkers of smoking, pancreatic cancer, breast cancer, and neurodegenerative diseases. This involves the use of quantitative stable isotope dilution liquid chromatography-mass spectrometry methodology. We recently implement the use of stable isotope dilution by essential nutrients in cell culture (SILEC) as a method for analyzing important Krebs cycle coenzyme A-thioesters. This has made it possible to examine the effects of chemicals and disease on mitochondrial dysfunction.

Selected Publications

Pinney SE, Mesaros CA, Snyder NW, Busch CM, Xiao R, Aijaz S, Ijaz N, Blair IA, Manson JM. : Second trimester amniotic fluid bisphenol a concentration is associated with decreased birth weight in term infants. Reprod Toxicol. 67: 1-9, November 2017 Notes: pii: S0890-6238(16)30403-8. doi: 10.1016/j.reprotox.2016.11.007. [Epub ahead of print]

Mesaros C, Weng L and Blair IA. : “Chapter 12: Biomarkers of respose to asbestos exposure.” In Current Cancer Research: Asbestos and Mesothelioma. Testa, Joseph R (eds.). Springer International Publishing AG, Page: 259-277, May 2017.

Xu R, Mesaros C, Weng L, Snyder NW, Vachani A, Blair IA, Hwang WT: Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure. Biomark Med. MAY 2017 Notes: doi: 10.2217/bmm-2017-0087. [Epub ahead of print]

Schick SF, Blount BC, Jacob P 3rd, Saliba NA, Bernert JT, El Hellani A, Jatlow P, Pappas RS, Wang L, Foulds J, Ghosh A, Hecht SS, Gomez JC, Martin JR, Mesaros C, Srivastava S, St Helen G, Tarran R, Lorkiewicz PK, Blair IA, Kimmel HL, Doerschuk CM, Benowitz NL, Bhatnagar A. : Biomarkers of Exposure to New and Emerging Tobacco and Nicotine Delivery Products. Am J Physiol Lung Cell Mol Physiol. MAY 2017.

Angelin A, Gil-de-Gómez L, Dahiya S, Jiao J, Guo L, Levine MH, Wang Z, Quinn WJ 3rd, Kopinski PK, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Laskin BL, Baur JA, Blair IA, Wallace DC, Hancock WW, Beier UH: Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Cell Metab. APRIL 2017.

Huang M, Mesaros C, Hackfeld LC, Hodge RP, Zang T, Blair IA, Penning TM: Potential Metabolic Activation of a Representative C4-Alkylated Polycyclic Aromatic Hydrocarbon Retene (1-Methyl-7-isopropyl-phenanthrene) Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells. Chem Res Toxicol 30(4): 1093-1101, APRIL 2017.

Bagley SJ, Vitale S, Zhang S, Aggarwal C, Evans TL, Alley EW, Cohen RB, Langer CJ, Blair IA, Vachani A, Whitehead AS: Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer. Clin Lung Cancer(2), e143-e149, March 2017.

Carrer A, Parris JLD, Trefely S, Henry RA, Montgomery DC, Torres AM, Viola JM, Kuo Y-M, Blair IA, MeierJL, Andrews AJ, Snyder NW, and Wellen KE: Impact of High Fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels. J Biol Chem 292(8): 3312-3322, February 2017.

Mesaros C, Arroyo AD, Blair IA, Snyder NW: Coenzyme A thioester formation of 11- and 15-oxo-eicosatetraenoic acid. Prostaglandins Other Lipid Mediat 130: 1-7, February 2017.

Kulkarni RA, Worth AJ, Zengeya TT, Shrimp JH, Garlick JM, Roberts AM, Montgomery DC, Sourbier C, Gibbs BK, Mesaros C, Tsai YC, Das S, Chan KC, Zhou M, Andresson T, Weissman AM, Linehan WM, Blair IA, Snyder NW, Meier JL. : Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling. Cell Chem Biol. 24(2): 231-242, February 2017.

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Last updated: 06/01/2017
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