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Ian A. Blair, Ph.D.

Ian A. Blair, Ph.D.

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A.N. Richards Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
854 Biomedical Research Building II/III
University of Pennsylvania School of Medicine
Center for Cancer Pharmacology
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office: (215) 573-9880
Fax: (215) 573-9889

Cambridge Grammar School for Boys, United Kingdom , 1960.

Prince of Wales School, Nairobi, Kenya, 1963.
B.Sc. ((Special) Chemistry, ARCS)
Imperial College of Science and Technology, University of London, United Kingdom, 1968.
Imperial College of Science and Technology, University of London, United Kingdom, 1971.
MRSC (Organic Chemistry)
Adelaide University, Australia, 1972.
Australian National University, 1977.
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Description of Research Expertise

Oxidative stress, carcinogenesis, cardiovascular disease, and neurodegenerative disease
Oxidative stress results in damage to lipids through the formation of lipid hydroperoxides. Our laboratory is involved in determining the factors that control lipid hydroperoxide-mediated damage to DNA, and proteins. We are also characterizing the lesions in these macromolecules using novel mass spectrometry methodology, determining how the lesions affect proliferation and apoptosis using model in vitro systems, and assessing how such processes can be prevented using novel pharmacological agents. We also have a program in biomarker discovery and analysis, which is focused on metabolomic and proteomic biomarkers of smoking, pancreatic cancer, breast cancer, and neurodegenerative diseases. This involves the use of quantitative stable isotope dilution liquid chromatography-mass spectrometry methodology. We recently implement the use of stable isotope dilution by essential nutrients in cell culture (SILEC) as a method for analyzing important Krebs cycle coenzyme A-thioesters. This has made it possible to examine the effects of chemicals and disease on mitochondrial dysfunction.

Selected Publications

Pinney SE, Mesaros CA, Snyder NW, Busch CM, Xiao R, Aijaz S, Ijaz N, Blair IA, Manson JM. : Second trimester amniotic fluid bisphenol a concentration is associated with decreased birth weight in term infants. Reprod Toxicol. 67: 1-9, November 2017 Notes: pii: S0890-6238(16)30403-8. doi: 10.1016/j.reprotox.2016.11.007. [Epub ahead of print]

Mesaros C, Weng L and Blair IA. : “Chapter 12: Biomarkers of respose to asbestos exposure.” In Current Cancer Research: Asbestos and Mesothelioma. In Current Cancer Research: Asbestos and Mesothelioma. Testa, Joseph R (eds.). Springer International Publishing AG, Page: 259-277, May 2017.

Bagley SJ, Vitale S, Zhang S, Aggarwal C, Evans TL, Alley EW, Cohen RB, Langer CJ, Blair IA, Vachani A, Whitehead AS: Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer. Clin Lung Cancer(2), e143-e149, March 2017.

Carrer A, Parris JLD, Trefely S, Henry RA, Montgomery DC, Torres AM, Viola JM, Kuo Y-M, Blair IA, MeierJL, Andrews AJ, Snyder NW, and Wellen KE: Impact of High Fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels. J Biol Chem 292(8): 3312-3322, February 2017.

Mesaros C, Arroyo AD, Blair IA, Snyder NW: Coenzyme A thioester formation of 11- and 15-oxo-eicosatetraenoic acid. Prostaglandins Other Lipid Mediat 130: 1-7, February 2017.

Kulkarni RA, Worth AJ, Zengeya TT, Shrimp JH, Garlick JM, Roberts AM, Montgomery DC, Sourbier C, Gibbs BK, Mesaros C, Tsai YC, Das S, Chan KC, Zhou M, Andresson T, Weissman AM, Linehan WM, Blair IA, Snyder NW, Meier JL. : Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling. Cell Chem Biol. 24(2): 231-242, February 2017.

Zang T, Tamae D, Mesaros C, Wang Q, Huang M, Blair IA, Penning TM: Quantitation of Nine Hydroxy-Androgens and Their Conjugates in Human Serum by Stable Isotope Dilution Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry. J Steroid Biochem Mol Biol. 165(Pt B): 342-355, January 2017.

Mesaros C, Blair IA.: Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease. Clin Proteom 13:20. eCollection, October 2016

Frey AJ, Wang Q, Busch C, Feldman D, Bottalico L, Mesaros CA, Blair IA, Vachani A, Snyder NW. : Validation of highly sensitive simultaneous targeted and untargeted analysis of keto-steroids by Girard P derivatization and stable isotope dilution-liquid chromatography-high resolution mass spectrometry. Steroids 116: 60-66, October 2016.

Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ, Wellen KE. : ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. Cell Rep. 17(4): 1037-1052, October 2016.

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Last updated: 05/23/2017
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