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Perelman School of Medicine at the University of Pennsylvania Advanced Search

George Cotsarelis, M.D.

George Cotsarelis, M.D.

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Milton Bixler Hartzell Professor of Dermatology
Department: Dermatology
Graduate Group Affiliations

Contact information
1053 Biomedical Research Building
Philadelphia, PA 19104
Education:
B.A. (Bio Basis of Behavior)
University of Pennsylvania, 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
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Description of Research Expertise

stem cells
hair follicle
wounding
aging
skin cancer

Description of Clinical Expertise

alopecia

Selected Publications

Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S.E. Cotsarelis, G. : Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 447: 316-321, 2007.

Garza, L.A., Yang, C.C., Zhao, T., Blatt, H.B., Lee, M., He, H., Stanton, D.C., Carrasco, L., Spiegel, J.H., Tobias, J.W,, Cotsarelis, G.: Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest 121(2): 613-622, February 2011.

*Ito, M., *Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R., Cotsarelis, G. *equal contributors: Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nature Medicine 11: 1351-1354, 2005.

Fan, C., Luedtke, M.A., Prouty, S.M., Burrows, M., Kollias, N., Cotsarelis, G.: Characterization and quantification of wound-induced hair follicule neogenesis using in vivo confocal scanning laser microscopy. Skin Research and Technology 17(4): 387-97, November 2011.

*Morris, R., *Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J., Sawicki, J., Cotsarelis, G. *equal contributors: Capturing and profiling hair follicle stem cells. Nature Biotechnology 22: 411-417, 2004.

Trempus, C.S., Morris, R.J., Ehinger, M., Elmore, A., Bortner, C.D., Ito, M., Cotsarelis, G., Nijhof, J.G., Peckham, J., Flagler, N., Kissling, G., Humble, M.M., King, L.C., Adams, L.D., Desai, D., Amin, S., Tennant, R.W.: CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res 67: 4173-81, 2007.

Trempus, C.S., Dang, H., Humble, M.M., Wei, S.J., Gerdes, M.J., Morris, R.J., Bortner, C.D., Cotsarelis, G., Tennant, R.W. : Comprehensive Microarray Transcriptome Profiling of CD34-Enriched Mouse Keratinocyte Stem Cells. J Invest Dermatol 127: 2904-7, 2007.

Endo, M., Zoltick, P.W., Peranteau, W.H., Radu, A., Muvarak, N., Ito, M., Yang, Z., Cotsarelis, G., Flake, A.W. : Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral vector driven by the keratin 5 promoter. Mol Ther 16: 131-7, 2008.

Lyle, S., Christofidou-Solomidou, M., Liu, Y., Elder, D., Albelda, S., Cotsarelis, G. : The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Science 111: 3179-3188, 1998.

Kantor, J., Jay, L., Brooks, D., Cotsarelis, G.: Decreased Serum Ferritin is Associated with Alopecia in Women. J Invest Dermatol 121: 963-968, 2003.

Liu, Y., Lyle, S., Solky, B., Cotsarelis, G. : Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol 121: 985-988, 2003.

Cotsarelis, G., Sun, T., Lavker, R. : Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61: 1329-1337, 1990.

Cotsarelis, G., Cheng, S.-Z., Dong, G., Sun, T., Lavker, R.: Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 57: 201-209, 1989.

Trempus, C., Morris, R., Bortner, C., Cotsarelis, G., Faircloth, R., Reece, J., Tennant, W. : Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol 120: 501-511, 2003.

Xu, X., Lyle, S., Liu, Y., Solky, B., Cotsarelis, G.: Differential expression of cyclin D1 in the human hair follicle. Am J Pathol 163: 969-978, 2003.

Hanakawa, Y., Li, H., Lin, C., Stanley, J.R., Cotsarelis, G.: Desmogleins 1 and 3 in the companion layer anchor mouse anagen hair to the follicle. J Invest Dermatol 123(5): 817-822, December 2004.

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Last updated: 11/19/2014
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