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George Cotsarelis, M.D.
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Milton Bixler Hartzell Professor of Dermatology
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Director, University of Pennsylvania Hair and Scalp Clinic, University of Pennsylvania Health System
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Assistant Director, Edwin and Fannie Gray Hall Center for Human Appearance at the University of Pennsylvania Medical Center
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Director, Program on Epithelial Regeneration and Stem Cells, Penn Institute for Regenerative Medicine
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Chairman, Department of Dermatology, University of Pennsylvania Health System
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Department: Dermatology
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Graduate Group Affiliations
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Contact information
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1053 Biomedical Research Building
Philadelphia, PA 19104
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Philadelphia, PA 19104
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Education:
21 9 B.A. 22 (Bio Basis of Behavior) c
33 University of Pennsylvania, 1983.
21 9 M.D. 15 (Medicine) c
33 University of Pennsylvania, 1987.
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Permanent link21 9 B.A. 22 (Bio Basis of Behavior) c
33 University of Pennsylvania, 1983.
21 9 M.D. 15 (Medicine) c
33 University of Pennsylvania, 1987.
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15 hair follicle
10 wounding
d aging
12 skin cancer
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Description of Research Expertise
1b stem cells15 hair follicle
10 wounding
d aging
12 skin cancer
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Description of Clinical Expertise
18 alopecia1a 29
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174 Garza LA, Yang CC, Zhao T, Blatt HB, Lee M, He H, Stanton DC, Carrasco L, Spiegel JH, Tobias JW, Cotsarelis G: Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest 121(2): 613-22, Feb 2011.
11d Ito M, Liu Y, Yang Z, Nguyen J, Liang F, Morris R, Cotsarelis G: Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nature Medicine 11(12): 1351-4, Dec 2005.
140 Fan C, Luedtke MA, Prouty SM, Burrows M, Kollias N, Cotsarelis G: Characterization and quantification of wound-induced hair follicle neogenesis using in vivo confocal scanning laser microscopy. Skin Research and Technology 17(4): 387-97, Nov 2011.
fd Morris R, Liu Y, Marles L, Yang Z, Trempus C, Li S, Lin J, Sawicki J, Cotsarelis G: Capturing and profiling hair follicle stem cells. Nature Biotechnology 22(4): 411-17, Apr 2004.
17e Trempus CS, Morris RJ, Ehinger M, Elmore A, Bortner CD, Ito M, Cotsarelis G, Nijhof JG, Peckham J, Flagler N, Kissling G, Humble MM, King LC, Adams LD, Desai D, Amin S, Tennant RW: CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res 67(9): 4173-81, May 2007.
13a Trempus CS, Dang H, Humble MM, Wei SJ, Gerdes MJ, Morris RJ, Bortner CD, Cotsarelis G, Tennant RW : Comprehensive Microarray Transcriptome Profiling of CD34-Enriched Mouse Keratinocyte Stem Cells J Invest Dermatol 127(12): 2904-7, Dec 2007.
15e Endo M, Zoltick PW, Peranteau WH, Radu A, Muvarak N, Ito M, Yang Z, Cotsarelis G, Flake AW : Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral vector driven by the keratin 5 promoter. Mol Ther 16(1): 131-7, Jan 2008.
134 Lyle S, Christofidou-Solomidou M, Liu Y, Elder D, Albelda S, Cotsarelis G: The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Science 111(21): 3179-88, Nov 1998.
db Kantor J, Jay L, Brooks D, Cotsarelis G: Decreased serum ferritin is associated with alopecia in women. J Invest Dermatol 121(5): 985-8, Nov 2003.
f1 Liu Y, Lyle S, Solky B, Cotsarelis G : Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol 121(5): 985-8, Nov 2003.
11a Cotsarelis G, Sun T, Lavker R: Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis Cell 61(7): 1329-37, Jun 1990.
12c Cotsarelis G, Cheng SZ, Dong G, Sun T, Lavker R: Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 57(2): 201-09, Apr 1989.
12f Trempus C, Morris R, Bortner C, Cotsarelis G, Faircloth R, Reece J, Tennant W : Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol 120(4): 501-11, Apr 2003.
db Xu X, Lyle S, Liu Y, Solky B, Cotsarelis G: Differential expression of cyclin D1 in the human hair follicle. Am J Pathol 163(3): 969-78, Sep 2003.
fc Hanakawa Y, Li H, Lin C, Stanley JR, Cotsarelis G: Desmogleins 1 and 3 in the companion layer anchor mouse anagen hair to the follicle. J Invest Dermatol 123(5): 817-22, Dec 2004.
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Selected Publications
ff Ito M, Yang Z, Andl T, Cui C, Kim N, Millar SE, Cotsarelis G: Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 447(7142): 316-21, May 2007.174 Garza LA, Yang CC, Zhao T, Blatt HB, Lee M, He H, Stanton DC, Carrasco L, Spiegel JH, Tobias JW, Cotsarelis G: Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest 121(2): 613-22, Feb 2011.
11d Ito M, Liu Y, Yang Z, Nguyen J, Liang F, Morris R, Cotsarelis G: Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nature Medicine 11(12): 1351-4, Dec 2005.
140 Fan C, Luedtke MA, Prouty SM, Burrows M, Kollias N, Cotsarelis G: Characterization and quantification of wound-induced hair follicle neogenesis using in vivo confocal scanning laser microscopy. Skin Research and Technology 17(4): 387-97, Nov 2011.
fd Morris R, Liu Y, Marles L, Yang Z, Trempus C, Li S, Lin J, Sawicki J, Cotsarelis G: Capturing and profiling hair follicle stem cells. Nature Biotechnology 22(4): 411-17, Apr 2004.
17e Trempus CS, Morris RJ, Ehinger M, Elmore A, Bortner CD, Ito M, Cotsarelis G, Nijhof JG, Peckham J, Flagler N, Kissling G, Humble MM, King LC, Adams LD, Desai D, Amin S, Tennant RW: CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res 67(9): 4173-81, May 2007.
13a Trempus CS, Dang H, Humble MM, Wei SJ, Gerdes MJ, Morris RJ, Bortner CD, Cotsarelis G, Tennant RW : Comprehensive Microarray Transcriptome Profiling of CD34-Enriched Mouse Keratinocyte Stem Cells J Invest Dermatol 127(12): 2904-7, Dec 2007.
15e Endo M, Zoltick PW, Peranteau WH, Radu A, Muvarak N, Ito M, Yang Z, Cotsarelis G, Flake AW : Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral vector driven by the keratin 5 promoter. Mol Ther 16(1): 131-7, Jan 2008.
134 Lyle S, Christofidou-Solomidou M, Liu Y, Elder D, Albelda S, Cotsarelis G: The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Science 111(21): 3179-88, Nov 1998.
db Kantor J, Jay L, Brooks D, Cotsarelis G: Decreased serum ferritin is associated with alopecia in women. J Invest Dermatol 121(5): 985-8, Nov 2003.
f1 Liu Y, Lyle S, Solky B, Cotsarelis G : Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol 121(5): 985-8, Nov 2003.
11a Cotsarelis G, Sun T, Lavker R: Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis Cell 61(7): 1329-37, Jun 1990.
12c Cotsarelis G, Cheng SZ, Dong G, Sun T, Lavker R: Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 57(2): 201-09, Apr 1989.
12f Trempus C, Morris R, Bortner C, Cotsarelis G, Faircloth R, Reece J, Tennant W : Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol 120(4): 501-11, Apr 2003.
db Xu X, Lyle S, Liu Y, Solky B, Cotsarelis G: Differential expression of cyclin D1 in the human hair follicle. Am J Pathol 163(3): 969-78, Sep 2003.
fc Hanakawa Y, Li H, Lin C, Stanley JR, Cotsarelis G: Desmogleins 1 and 3 in the companion layer anchor mouse anagen hair to the follicle. J Invest Dermatol 123(5): 817-22, Dec 2004.
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