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Reynold A. Panettieri, Jr., MD

Reynold A. Panettieri, Jr., MD

faculty photo
Robert L. Mayock and David A. Cooper Professor of Pulmonary Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
University of Pennsylvania
125 South 31st Street
TRL Suite 1200
Philadelphia, PA 19104-3413
Office: (215) 573-9860
Fax: (215) 746-1224
Lab: (215) 746-2759
Education:
B.S. (Biology)
St. Joseph's University, Philadelphia, PA, 1979.
M.D. (Medicine)
University of Pennsylvania, 1983.
M.A. (Honorary)
University of Pennsylvania, 1998.
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Description of Research Expertise

Smooth muscle biology, airway remodeling, respiratory pharmacology and physiology

Description of Clinical Expertise

Asthma, chronic obstructive pulmonary disease, irreversible airway obstruction

Selected Publications

Marozkina Nadzeya V, Wang Xin-Qun, Stsiapura Vitali, Fitzpatrick Anne, Carraro Silvia, Hawkins Gregory A, Bleecker Eugene, Meyers Deborah, Jarjour Nizar, Fain Sean B, Wenzel Sally, Busse William, Castro Mario, Panettieri Reynold A, Moore Wendy, Lewis Stephen J, Palmer Lisa A, Altes Talissa, de Lange Eduard E, Erzurum Serpil, Teague W Gerald, Gaston Benjamin: Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. The European respiratory journal Page: Epub ahead of print, Oct 2014.

Columbo Michele, Panettieri Reynold A, Rohr Albert S: Asthma in the elderly: a study of the role of vitamin D. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 10(1): 48, Sep 2014.

Brightling Christopher E, Bleecker Eugene R, Panettieri Reynold A, Bafadhel Mona, She Dewei, Ward Christine K, Xu Xiao, Birrell Claire, van der Merwe René: Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study. The Lancet. Respiratory medicine Page: Epub ahead of print, Sep 2014.

Morgan Sarah J, Deshpande Deepak A, Tiegs Brian C, Misior Anna M, Yan Huandong, Hershfeld Alena V, Rich Thomas C, Panettieri Reynold A, An Steven S, Penn Raymond B: Beta-agonist-mediated relaxation of airway smooth muscle is PKA-dependent. The Journal of biological chemistry 289(33): 23065-23074, Aug 2014.

Balenga Nariman A, Jester William, Jiang Meiqi, Panettieri Jr Reynold A, Druey Kirk M: Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation. The Journal of allergy and clinical immunology 134(2): 451-459, Aug 2014.

Dileepan Mythili, Jude Joseph A, Rao Savita P, Walseth Timothy F, Panettieri Reynold A, Subramanian Subbaya, Kannan Mathur S: MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN/AKT in human airway smooth muscle cells. Respiratory research 15: 107, Aug 2014.

Himes Blanca E, Jiang Xiaofeng, Wagner Peter, Hu Ruoxi, Wang Qiyu, Klanderman Barbara, Whitaker Reid M, Duan Qingling, Lasky-Su Jessica, Nikolos Christina, Jester William, Johnson Martin, Panettieri Reynold A, Tantisira Kelan G, Weiss Scott T, Lu Quan: RNA-Seq Transcriptome Profiling Identifies CRISPLD2 as a Glucocorticoid Responsive Gene that Modulates Cytokine Function in Airway Smooth Muscle Cells. PloS one 9(6): e99625, June 2014.

Hu Ruoxi, Pan Wenchi, Fedulov Alexey V, Jester William, Jones Matthew R, Weiss Scott T, Panettieri Reynold A, Tantisira Kelan, Lu Quan: MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28(5): 2347-2357, May 2014.

Koziol-White CJ, Strong P, Ito K, Rapeport G, Gern JE, Panettieri RA Jr : Rhinovirus 16 (RV16) induced mediator release, but not airway hyper-responsiveness, from human small airways is modulated by the narrow spectrum kinase inhibitor RV1088. American journal of respiratory and critical care medicine 189: A3532, May 2014.

Koziol-White CJ, Zhao HJ, Vakkalanka S, Panettieri RA Jr: The novel PI3Kdelta/gammma inhibitor, RP6503, differentially modulates mediator release from human precision cut lung slices (hPCLS) and human airway smooth muscle (hASM) in response to TNFα and IFNgamma stimulation. American journal of respiratory and critical care medicine 189: A5319, May 2014.

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Last updated: 12/11/2014
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