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Reynold A. Panettieri, Jr., MD

Reynold A. Panettieri, Jr., MD

faculty photo
Robert L. Mayock and David A. Cooper Professor of Pulmonary Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
University of Pennsylvania
125 South 31st Street
TRL Suite 1200
Philadelphia, PA 19104-3413
Office: (215) 573-9860
Fax: (215) 746-1224
Lab: (215) 746-2759
Education:
B.S. (Biology)
St. Joseph's University, Philadelphia, PA, 1979.
M.D. (Medicine)
University of Pennsylvania, 1983.
M.A. (Honorary)
University of Pennsylvania, 1998.
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Description of Research Expertise

Smooth muscle biology, airway remodeling, respiratory pharmacology and physiology

Description of Clinical Expertise

Asthma, chronic obstructive pulmonary disease, irreversible airway obstruction

Selected Publications

Sharma Amitabh, Menche Jörg, Huang Chris, Ort Tatiana, Zhou Xiaobo, Kitsak Maksim, Sahni Nidhi, Thibault Derek, Voung Linh, Guo Feng, Gulbahce Natali, Baribaud Frédéric, Tocker Joel, Dobrin Radu, Barnathan Elliot, Liu Hao, Panettieri Reynold A, Tantisira Kelan G, Qiu Weiliang, Raby Benjamin A, Silverman Edwin K, Vidal Marc, Weiss Scott T, Barabási Albert-László: A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes. Human molecular genetics 24(11): 3005-3020, June 2015.

McGeachie Michael J, Wu Ann C, Tse Sze Man, Clemmer George L, Sordillo Joanne, Himes Blanca E, Lasky-Su Jessica, Chase Robert P, Martinez Fernando D, Weeke Peter, Shaffer Christian M, Xu Hua, Denny Josh C, Roden Dan M, Panettieri Reynold A, Raby Benjamin A, Weiss Scott T, Tantisira Kelan G: CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies. The Journal of allergy and clinical immunology Page: Epub ahead of print, Jun 2015.

Koziol-White C, Zhang J, Dainty I, Miller-Larsson A, Panettieri RA Jr: A brief budesonide pretreatment has little effect on carbachol-induced bronchoconstriction, but significantly augments formoterol-induced bronchodilation of human small airways. American journal of respiratory and critical care medicine 191: A4118, May 2015.

An S, Tang WY, Ahn K, Mitzner W, Huang J, Kumar S, Biswal S, Panettieri RA Jr, Solway J, Liggett SB: Inflammation-independent regulation of airway smooth muscle mechanical properties in asthma. American journal of respiratory and critical care medicine 191: A2466, May 2015.

Jiang Z, Kokalari B, Koziol-White C, Jester W, Panettieri RA Jr, Haczku A: 20-hydroxyeicosatetraenoic acid (20-HETE) induces airway inflammation and hyperresponsiveness in mice. American journal of respiratory and critical care medicine 191: A5165, May 2015.

Jude JA, Ojiaku CA, Koziol-White C, Jester W, Cao G, Panettieri RA Jr: Cigarette smoke enhances carbachol-induced airway narrowing in human precision-cut human lung slices (hPCLS). American journal of respiratory and critical care medicine 191: A5002, May 2015.

Koziol-White C, Johnson M, Filer A, Ryan M, Panettieri RA Jr: CCL17 augments contractility and contractile pathways in human small airways and airway smooth muscle (ASM). American journal of respiratory and critical care medicine 191: A5187, May 2015.

Gupta MK, Asosingh K, Aronica M, Comhair SAA, Erzurum SC, Panettieri RA Jr, Naga Prasad SV: Loss of beta-adrenergic receptor resensitization in human airway smooth muscle cells from asthmatic patients. American journal of respiratory and critical care medicine 191: A3536, May 2015.

Ojiaku CA, Jude JA, Panettieri RA Jr : The role of NADPH oxidase isoforms and reactive oxygen species in human airway smooth muscle cell (HASMC) function. American journal of respiratory and critical care medicine 191: A3526, May 2015.

Huang J, Aisenberg W, Cruz R, Natarajan N, Oh JJ, Yong HM, Panettieri RA Jr, Liggett SB, Pluznick JL, An SS: Functional expression of the olfactory signaling system in human airway smooth muscle. American journal of respiratory and critical care medicine 191: A5594, May 2015.

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Last updated: 06/26/2015
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