Allan I. Pack, M.B.Ch.B., Ph.D.
Allan I. Pack, M.B.Ch.B., Ph.D.
John Miclot Professor
Department: Medicine
Graduate Group Affiliations
Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Fax: 215-746-4814
Email:
PACK@MAIL.MED.UPENN.EDU
PACK@MAIL.MED.UPENN.EDU
Publications
Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
Permanent linkM.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
Description of Research Expertise
Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.Selected Publications
Grandner, M.A., Patel, N.P., Gehrman, P.R., Perlis, M.L., and Pack, A.I.: Problems associated with short sleep: bridging the gap between laboratory and epidemiological studies. Sleep Medicine Reviews 14(4): 239-247, 2010.Mackiewicz, M., Zimmerman, J.E., Shockley, K.R., Churchill, G.A., and Pack, A.I.: What are microarrays teaching us about sleep? Trends in Molecular Medicine 15(2): 79-87, 2009.
Arnardottir, E.S., Mackiewicz, M., Gislason, T., Teff, K.L. and Pack, A.I.: Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep 32(4): 447-470, 2009.
Brennick, M.J., Pack, A.I., Ko, K., Kim, E., Pickup, S., Maislin, G., and Schwab, R.J.: Altered upper airway and soft tissue structures in the New Zealand obese mouse. American Journal of Respiratory and Critical Care Medicine 179: 158-169, 2009.
Pack, A.I. and Gislason, T.: Obstructive sleep apnea and cardiovascular disease: a perspective and future directions. Progress in Cardiovascular Diseases 51(5): 434-451, 2009.
Gurubhagavatula, I., Nkwuo, J.E., Maislin, G., Pack, A.I.: Estimated cost of crashes in commercial drivers supports screening and treatment of obstructive sleep apnea. Accident Analysis and Prevention 40: 104-115, 2008.
Zimmerman, J.E., Raizen, D.M., Maycock, M.H., Maislin, G., and Pack, A.I.: A video method to study Drosophila sleep. Sleep 31(11): 1587-1598, 2008.
Pack, A.I., Platt, A.B., and Pien, G.W.: Does untreated obstructive sleep apnea lead to death? Sleep 31(8): 1067-1068, 2008.
Trojanowski, J.Q., Hendricks, J.C., Jedrziewski, K., Johnson, F.B., Michel, K.E., Hess, R.S., Cancro, M.P., Sleeper, M.M., Pignolo, R., Teff, K.L., Aguirre, G.D., Lee, V.M-Y., Lawler, D.F., Pack, A.I., Davies, P.F.: Exploring human/animal intersections: converging lines of evidence in comparative models of aging. Alzheimer's & Dementia 4: 1-5, 2008.
Hackney, J.E., Weaver, T.E., and Pack, A.I.: Health literacy and sleep disorders: a review. Sleep Medicine Reviews 12(2): 143-151, 2008.