Allan I. Pack, M.B.Ch.B., Ph.D., FRCP
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
Description of Research ExpertiseDr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs three training grants from the National Institutes of Health.
Description of Clinical ExpertiseDr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).
Selected PublicationsRizzatti, F.G., Mazzotti, D.R., Mindel, J., Maislin, G., Keenan, B.T., Bittencourt, L., Chen. N.H., Cistulli, P.A., McArdle, N., Pack, F.M., Singh, B., Sutherland, K., Benediktsdottir, B., Fietze, I., Gislason, T., Lim, D.C., Penzel, T., Sanner, B., Han, F., Li, Q.Y., Schwab, R., Tufik, S., Pack, A.I. and Magalang, U.J.: Defining extreme phenotypes of obstructive sleep apnea across international sleep centers. Chest Page: pii: S0012-3692(20)30680-2, Apr 2020 Notes: doi: 10.1016/j.chest.2020.03.055.
Wang, S.H., Keenan, B.T., Wiemken, A., Zang, Y., Staley, B., Sarwer, D.B., Torigian, D.A., Williams, N., Pack, A.I. and Schwab, R.J.: Effect of weight loss on upper airway anatomy and the apnea-hypopnea index. The importance of tongue fat. American Journal of Respiratory and Critical Care Medicine 201(6): 718-727, Mar 2020.
Lim, D.C., Mazzotti, D., Sutherland, K., Mindel, J., Kim, J, Cistulli, P., Magalang, Y., Pack, A., de Chazal, P. and Penzel, T.: Reinventing polysomnography in the age of precision medicine. Sleep Medicine Reviews 52: 101313, Mar 2020 Notes: doi: 10.1016/j.smrv.2020.101313.
Keenan, B.T., Galante, R.J., Lian, J., Simecek, P., Gatti, D.M., Zhang, L., Lim, D.C., Svenson, K.L., Churchill, G.A. and Pack, A.I.: High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains. Sleep Feb 2020 Notes: pii: zsz278. doi: 10.1093/sleep/zsz278.
Keenan, B.T., Kirchner, H.L., Veatch, O.J., Borthwick, K.M., Davenport, V.A., Feemster, J.C., Gendy, M., Gossard, T.R., Pack, F.M., Sirikulvadhana, L., Teigen, L.N., Timm, P.C., Malow, B.A., Morgenthaler, T.I., Zee, P.C., Pack, A.I., Robishaw, J.D., and Derose, S.F.: Multisite validation of a simple electronic health record algorithm for identifying diagnosed obstructive sleep apnea. Journal of Clinical Sleep Medicine 16(2): 175-183, Feb 2020.
Yaeger, A., Keenan, B.T., Cash, N.R., Parham, T., Deo, R., Frankel, D.S., Schaller, R.D., Santangeli, P., Nazarian, S., Supple, G.E., Arkles, J., Kumareswaran, R., Hyman, M.C., Riley, M.P., Garcia, F.C., Lin, D., Epstein, A.E., Callans, D.J., Mora, J.I., Amaro, A., Schwab, R., Pack, A., Marchlinski, F.E. and Dixit, S.: Impact of a nurse-led limited risk factor modification program on arrhythmia outcomes in patients with atrial fibrillation undergoing catheter ablation. Journal of Cardiovascular Electrophysiology 31(2): 423-431, Feb 2020.
Kuna, S.T., Townsend, R.R., Keenan, B.T., Maislin, D., Gislason, T., Benediktsdottir, B., Gudmundsdottir, S., Arnardottir, E.S., Sifferman, A., Staley, B., Pack, F.M., Guo, X., Schwab, R.J., Maislin, G., Chirinos, J.A. and Pack, A.I.: Blood pressure response to treatment of obese vs non-obese adults with sleep apnea. Journal of Clinical Hypertension 21(10): 1580-1590, Oct 2019.
Varendh, M., Andersson, M., Bjornsdottir, E., Arnardottir, E.S., Gislason, T., Pack, A.I, Hrubos-Strom, H., Johannisson A. and Juliusson, S. : PAP treatment in patients with OSA does not induce long-term nasal obstruction. Journal of Sleep Research 28(5): e12768, Oct 2019 Notes: doi: 10.1111/jsr.12768.
Sarantopoulou, D., Tang, S.Y., Ricciotti, E., Lahens, N.F., Lekkas, D., Schug, J., Guo, X.S., Paschos, G.K., FitzGerald, G.A., Pack, A.I. and Grant, G.R.: Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input. Scientific Reports 9(1): 13477, Sep 2019.
Guo, X., Keena, B.T., Sarantopoulou, D., Lim, D.C., Lian, J., Grant. G.R. and Pack, A.I.: Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex. Aging Cell Page: e13021, Sep 2019.