Allan I. Pack, M.B.Ch.B., Ph.D., FRCP

faculty photo
John Miclot Professor
Department: Medicine
Graduate Group Affiliations

Contact information
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs three training grants from the National Institutes of Health.

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Selected Publications

Yaeger, A., Keenan, B.T., Cash, N.R., Parham, T., Deo, R., Frankel, D.S., Schaller, R.D., Santangeli, P., Nazarian, S., Supple, G.E., Arkles, J., Kumareswaran, R., Hyman, M.C., Riley, M.P., Garcia, F.C., Lin, D., Epstein, A.E., Callans, D.J., Mora, J.I., Amaro, A., Schwab, R., Pack, A., Marchlinski, F.E. and Dixit, S.: Impact of a nurse-led limited risk factor modification program on arrhythmia outcomes in patients with atrial fibrillation undergoing catheter ablation. Journal of Cardiovascular Electrophysiology 31(2): 423-431, Feb 2020.

Keenan, B.T., Galante, R.J., Lian, J., Simecek, P., Gatti, D.M., Zhang, L., Lim, D.C., Svenson, K.L., Churchill, G.A. and Pack, A.I.: High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains. Sleep 2020 Notes: pii: zsz278. doi: 10.1093/sleep/zsz278.

Lim, D.C., Mazzotti, D., Sutherland, K., Mindel, J., Kim, J, Cistulli, P., Magalang, Y., Pack, A., de Chazal, P. and Penzel, T.: Reinventing polysomnography in the age of precision medicine. Sleep Medicine Reviews 2020.

Kuna, S.T., Townsend, R.R., Keenan, B.T., Maislin, D., Gislason, T., Benediktsdottir, B., Gudmundsdottir, S., Arnardottir, E.S., Sifferman, A., Staley, B., Pack, F.M., Guo, X., Schwab, R.J., Maislin, G., Chirinos, J.A. and Pack, A.I.: Blood pressure response to treatment of obese vs non-obese adults with sleep apnea. Journal of Clinical Hypertension 21(10): 1580-1590, Oct 2019.

Varendh, M., Andersson, M., Bjornsdottir, E., Arnardottir, E.S., Gislason, T., Pack, A.I, Hrubos-Strom, H., Johannisson A. and Juliusson, S. : PAP treatment in patients with OSA does not induce long-term nasal obstruction. Journal of Sleep Research 28(5): e12768, Oct 2019 Notes: doi: 10.1111/jsr.12768.

Sarantopoulou, D., Tang, S.Y., Ricciotti, E., Lahens, N.F., Lekkas, D., Schug, J., Guo, X.S., Paschos, G.K., FitzGerald, G.A., Pack, A.I. and Grant, G.R.: Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input. Scientific Reports 9(1): 13477, Sep 2019.

Guo, X., Keena, B.T., Sarantopoulou, D., Lim, D.C., Lian, J., Grant. G.R. and Pack, A.I.: Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex. Aging Cell Page: e13021, Sep 2019.

Mazzotti, D.R., Keenan, B.T., Lim, D.C., Gottlieb, D.J., Kim, J. and Pack A.I.: Symptom subtypes of obstructive sleep apnea predict incidence of cardiovascular outcomes. American Journal of Respiratory and Critical Care Medicine 200(4): 493-506, Aug 2019.

Sutherland, K., Keenan, B.T., Bittencourt, L., Chen, N.H., Gislason, T., Leinwand, S., Magalang, U.J., Maislin, G., Mazzotti, D.R., McArdle, N., Mindel, J., Pack, A.I., Penzel, T., Singh, B., Tufik, S., Schwab, R.J., Cistulli, P.A. and SAGIC Investigators: A global comparison of anatomic risk factors and their relationship to obstructive sleep apnea severity in clinical samples. Journal of Clinical Sleep Medicine 15(4): 629-639, Apr 2 2019.

Chang, Y., Xu, L., Han, F., Keenan, B.T., Kneeland-Szanto, E., Zhang, R., Zhang, W., Yu, Y., Zuo, Y., Pack, A.I. and Kuna, S.T.: Validation of the Nox-T3 portable monitor for diagnosis of obstructive sleep apnea in patients with chronic obstructive pulmonary disease. Journal of Clinical Sleep Medicine 15(4): 587-596, Apr 2019.

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Last updated: 02/20/2020
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