Allan I. Pack, M.B.Ch.B., Ph.D., FRCP

faculty photo
John Miclot Professor
Department: Medicine
Graduate Group Affiliations

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Selected Publications

Varendh, M., Andersson, M., Bjornsdottir, E., Arnardottir, E.S., Gislason, T., Pack, A.I, Hrubos-Strom, H., Johannisson A. and Juliusson, S. : PAP treatment in patients with OSA does not induce long-term nasal obstruction. Journal of Sleep Research Sep 2018 Notes: Sep 28:e12768. doi: 10.1111/jsr.12768. [Epub ahead of print]

Naidoo, N., Zhu, J., Galante, R.J., Lian, J., Strus, E., Lee, A., Keenan, B.T., and Pack, A.I.: Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior. Neurobiology of Aging 69: 10-25, Sep 2018.

Magalang, U.J., Johns, J.N., Wood, K.A., Mindel, J.W., Lim, D.C., Bittencourt, L.R., Chen, N.H., Cistulli, P.A., Gislason, T., Arnardottir, E.S., Penzel, T., Tufik, S. and Pack, A.I.: Home sleep apnea testing: comparison of manual and automated scoring across international sleep centers. Sleep and Breathing Sep 2018 Notes: 2018 Sep 10. doi: 10.1007/s11325-018-1715-6. [Epub ahead of print]

van Hees, V.T., Sabia, S., Jones, S.E., Wood, A.R., Anderson, K.N., Kivimaki, M., Frayling, T.M., Pack, A.I., Bucan, M., Trenell, M.I., Mazzotti, D.R., Gehrman, P.R., Singh-Manoux, B.A. and Weedon, M.N.: Estimating sleep parameters using an accelerometer without sleep diary. Scientific Reports 8(1): 12975, Aug 2018.

Feng, Y., Keenan, B.T., Wang, S., Leinwand, S., Wiemken, A., Pack, A.I. and Schwab R.J.: Dynamic upper airway imaging during wakefulness in obese subjects with and without sleep apnea. American Journal of Respiratory and Critical Care Medicine Jul 2018 Notes: doi: 10.1164/rccm.201711-2171OC. [Epub ahead of print]

Mazzotti, D.R., Lim, D.C., Sutherland, K., Bittencourt, L., Mindel, J.W., Magalang, U., Pack, A.I., de Chazal, P. and Penzel, T.: Opportunities for utilizing polysomnography signals to characterize obstructive sleep apnea subtypes and severity. Physiological Measurement 39(9): 09TR01, Jul 26 2018 Notes: doi: 10.1088/1361-6579/aad5fe.

Pak, V.M., Mazzotti, D.R., Keenan, B.T., Hirotsu, C., Gehrman, P., Bittencourt, L., Pack, A.I. and Tufik, S.: Candidate gene analysis in the Sao Paulo Epidemiological Sleep Study (EPISONO) shows an association of variant in PDE4D and sleepiness. Sleep Medicine 47: 106-112, Jul 2018.

Perron, I.J., Keenan, B.T., Chellappa, K., Lahens, N.F., Yohn, N.L., Shockley, K.R., Pack, A.I. and Veasey, S.C.: Dietary challenges differentially affect activity and sleep/wake behavior in mus musculus: isolating independent associations with diet/energy balance and body weight. PLoS One 13(5): e0196743, May 10 2018.

Pak, V.M., Dai, F., Keenan, B.T., Gooneratne, N.S. and Pack, A.I.: Lower plasma choline levels are associated with sleepiness symptoms. Sleep Medicine 44: 89-96, Apr 2018.

Kim, J., Keenan, B.T., Lim, D.C., Lee, S.K., Pack, A.I. and Shin, C.: Symptom-based subgroups of Koreans with obstructive sleep apnea. Journal of Clinical Sleep Medicine 14(3): 437-443, Mar 15 2018.

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Last updated: 11/08/2018
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