Allan I. Pack, M.B.Ch.B., Ph.D., FRCP

faculty photo
John Miclot Professor
Department: Medicine
Graduate Group Affiliations

Contact information
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs three training grants from the National Institutes of Health.

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Selected Publications

Guo, X., Gao, X., Keenan, B.T., Zhu, J., Sarantopoulou, D., Lian, J., Galante, R.J., Grant, G.R., and Pack, A.I.: RNA-seq analysis of galaninergic neurons from ventrolateral preoptic nucleus identifies expression changes between sleep and wake BMC Genomics 21(1): 633, Sep 2020.

Rizzatti, F.G., Mazzotti, D.R., Mindel, J., Maislin, G., Keenan, B.T., Bittencourt, L., Chen. N.H., Cistulli, P.A., McArdle, N., Pack, F.M., Singh, B., Sutherland, K., Benediktsdottir, B., Fietze, I., Gislason, T., Lim, D.C., Penzel, T., Sanner, B., Han, F., Li, Q.Y., Schwab, R., Tufik, S., Pack, A.I. and Magalang, U.J.: Defining extreme phenotypes of obstructive sleep apnea across international sleep centers. Chest 158(3): 1187-1197, Sep 2020.

Veatch, O.J., Bauer, C.R., Keenan, B.T., Josyula, N.S., Mazzotti, D.R., Bagai, K., Malow, B.A., Robishaw, J.D., Pack, A.I. and Pendergrass, S.A.: Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records. BMC Medical Genomics 13(1): 105, Jul 2020 Notes: doi: 10.1186/s12920-020-00755-4.

Xu, L., Keenan, B.T., Weimken, A.S., Chi, L., Staley, B., Wang, Z., Wang, J., Benedikstdottir, B., Juliusson, S., Pack, A.I., Gislason, T. and Schwab, R.J.: Differences in three-dimensional upper airway anatomy between Asian and European patients with obstructive sleep apnea. Sleep 43(5): zsz273, May 2020 Notes: Nov 18. pii: zsz273. doi: 10.1093/sleep/zsz273.

Keenan, B.T., Galante, R.J., Lian, J., Simecek, P., Gatti, D.M., Zhang, L., Lim, D.C., Svenson, K.L., Churchill, G.A. and Pack, A.I.: High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains. Sleep 43(5): zsz278, May 2020 Notes: pii: zsz278. doi: 10.1093/sleep/zsz278.

Lim, D.C., Mazzotti, D., Sutherland, K., Mindel, J., Kim, J, Cistulli, P., Magalang, Y., Pack, A., de Chazal, P. and Penzel, T.: Reinventing polysomnography in the age of precision medicine. Sleep Medicine Reviews 52: 101313, Mar 2020 Notes: doi: 10.1016/j.smrv.2020.101313.

Wang, S.H., Keenan, B.T., Wiemken, A., Zang, Y., Staley, B., Sarwer, D.B., Torigian, D.A., Williams, N., Pack, A.I. and Schwab, R.J.: Effect of weight loss on upper airway anatomy and the apnea-hypopnea index. The importance of tongue fat. American Journal of Respiratory and Critical Care Medicine 201(6): 718-727, Mar 2020.

Yaeger, A., Keenan, B.T., Cash, N.R., Parham, T., Deo, R., Frankel, D.S., Schaller, R.D., Santangeli, P., Nazarian, S., Supple, G.E., Arkles, J., Kumareswaran, R., Hyman, M.C., Riley, M.P., Garcia, F.C., Lin, D., Epstein, A.E., Callans, D.J., Mora, J.I., Amaro, A., Schwab, R., Pack, A., Marchlinski, F.E. and Dixit, S.: Impact of a nurse-led limited risk factor modification program on arrhythmia outcomes in patients with atrial fibrillation undergoing catheter ablation. Journal of Cardiovascular Electrophysiology 31(2): 423-431, Feb 2020.

Keenan, B.T., Kirchner, H.L., Veatch, O.J., Borthwick, K.M., Davenport, V.A., Feemster, J.C., Gendy, M., Gossard, T.R., Pack, F.M., Sirikulvadhana, L., Teigen, L.N., Timm, P.C., Malow, B.A., Morgenthaler, T.I., Zee, P.C., Pack, A.I., Robishaw, J.D., and Derose, S.F.: Multisite validation of a simple electronic health record algorithm for identifying diagnosed obstructive sleep apnea. Journal of Clinical Sleep Medicine 16(2): 175-183, Feb 2020.

Lyons, M.M., Bhatt, N.Y., Pack, A.I. and Magalang, U.J.: Global burden of sleep disordered breathing and its implications. Respirology 25(7): 690-702, 2020.

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Last updated: 10/28/2020
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