Allan I. Pack, M.B.Ch.B., Ph.D., FRCP

faculty photo
John Miclot Professor
Fellow, Institute on Aging, University of Pennsylvania, Philadelphia, PA
Member, Institute for Neurological Sciences, University of Pennsylvania, Philadelphia, PA
Member, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
Member, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA
Assistant Dean and Director of Global Sleep Programs, Perelman School of Medicine, University of Pennsylvaia
Director of Research Training, Division of Sleep Medicine/Department of Medicine, University of Pennsylvania, Philadelphia, PA
Department: Medicine
Graduate Group Affiliations

Contact information
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs three training grants from the National Institutes of Health.

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Selected Publications

Matura, L.A., Fargo, J.D., Boyle, K., Fritz, J.S., Smith, K.A., Mazurek, J.A., Archer-Chicko, C.L., Palevsky, H.I., Pack, A.I., Somers, M.S., and Kawut, S.M.: Symptom phenotypes in pulmonary arterial hypertension: The PAH “symptome” Pulmonary Circulation 12(3): e12135, Jul 1 2022.

Reynor, A., McArdle, N., Shenoy, B., Dhaliwal, S.S., Rea, S.C., Walsh, J., Eastwood, P.R., Maddison, K., Hillman, D.R., Ling, I., Keenan, B.T., Maislin, G., Magalang, U., Pack, A.I., Mazzotti, D.R., Lee, C.H., and Singh, B.: Continuous positive airway pressure and adverse cardiovascular events in obstructive sleep apnea: Are participants of randomized trials representative of sleep clinic patients? Sleep 45(4): zsab264, Apr 2022.

Holfinger, S.J., Lyons, M.M., Keenen, B.T., Mazzotti, D.R., Mindel, J., Maislin, G., Cistulli, P.A., Sutherland, K., McArdle, N., Singh, B., Chen, N.H., Gislason, T., Penzel, T., Han, F., Li, Q.Y., Schwab, R., Pack, A.I., and Magalang, U.J.: Diagnostic performance of machine learning-derived OSA prediction tools in large clinical and community-based samples. Chest 161(3): 807-817, Mar 2022.

Keenan, B.T., Magalang, U.J., Mazzotti, D.R., McArdle, N., Gislason, T., Singh, B., Maislin, G., and Pack, A.I.: Obstructive sleep apnea symptom subtypes and cardiovascular risk: conflicting evidence to an important question. American Journal of Respiratory and Critical Care Medicine 205(6): 729-730, Mar 2022.

Mazzotti, D.R., Keenan, B.T., Thorarinsdottir, E.H., Gislason, T., Pack, A.I., and Sleep Apnea Global Interdisciplinary Consortium: Is the Epworth Sleepiness Scale sufficient to identify the excessively sleepy subtype of OSA? Chest 161(2): 557-561, Feb 2022.

Geuther, B., Chen, M., Galante, R.J., Han, O., Lian, J., George, J., Pack, A.I., and Kumar, V.: High-throughput visual assessment of sleep stages in mice using machine learning. Sleep 45(2): zsab260, Feb 2022.

Younes, M., Gerardy, B., Pack, A.I., Kuna, S.T., Castro-Diehl, C., and Redline, S.: Sleep architecture based on sleep depth and propensity: patterns in different demographics and sleep disorders and association with health outcomes. Sleep Page: zsac059, 2022.

Keenan, B.T., Galante, R.J., Lian, J., Zhang, L., Guo, X., Veatch, O.J., Chesler, E.J., O’Brien, W.T., Svenson, K.L., Churchill, G.A., and Pack, A.I.: The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice. Current Biology 31(23): 5238-5248, Dec 2021.

Thorarinsdottir, E.H., Janson, C., Aspelund, T., Benediktsdottir, B., Juliusson, S., Gislason, T., Kuna, S.T., Pack, A.I., and Keenan, B.T.: Different components of excessive daytime sleepiness and the change with positive airway pressure in obstructive sleep apnea patients – results from the Icelandic Sleep Apnea Cohort (ISAC). Journal of Sleep Research Page: e13528, Dec 2021.

Laharnar, N., Herberger, S., Prochnow L, Chen N., Cistulli, P.A., Pack, A.I., Schwab, R., Keenan, B.T., Mazzotti, D.R., Fietze, I., and Penzel, T.: Simple and unbiased OSA prescreening: introduction of a new morphologic OSA prediction score. Nature and Science of Sleep 13: 2039-2049, Nov 2021.

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Last updated: 10/28/2022
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