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John Plastaras, M.D., Ph.D.

John Plastaras, M.D., Ph.D.

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Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
TRC 4W
3400 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-615-3714
Fax: 215-349-8975
Education:
M.S. (Chemistry)
Emory University, 1994.
B.S. (Chemistry)
Emory University, 1994.
B.A. (Biology)
Emory University, 1994.
Ph.D. (Biochemistry)
Vanderbilt University, 2000.
M.D.
Vanderbilt University, 2002.
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Description of Research Expertise

1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" (ClinicalTrials.gov Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.

2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.

3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.

4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" (ClinicalTrials.gov Identifier: NCT01449864)

Description of Clinical Expertise

radiation therapy, lymphoma, gastroinstestinal cancer, proton radiotherapy, total body irradiation

Selected Publications

Fernandes Annemarie T, Apisarnthanarax Smith, Yin Lingshu, Zou Wei, Rosen Mark, Plastaras John P, Ben-Josef Edgar, Metz James M, Teo Boon-Keng: Comparative assessment of liver tumor motion using cine-magnetic resonance imaging versus 4-dimensional computed tomography. International journal of radiation oncology, biology, physics 91(5): 1034-40, Apr 2015.

Ojerholm E, Kirk M, Thompson R, Zhai A, Metz JM, Both S, Ben-Josef E, Plastaras JP : Pencil-beam scanning proton therapy for anal cancer: a dosimetric comparison with intensity-modulated radiotherapy. Acta Oncologica [Epub ahead of print], Mar 3 2015.

Datta J, McMillan MT, Ecker BL, Karakousis GC, Mamtani R, Plastaras JL, Giantonio BJ, Drebin JA, Dempsey DT, Fraker DL, Roses RE: Implications of Lymph Node Staging on Selection of Adjuvant Therapy for Gastric Cancer in the United States: A Propensity Score-Matched Analysis. Annals of Surgery 2015.

Gandhi SJ, Liang X, Ding X, Zhu TC, Ben-Josef E, Plastaras JP, Metz JM, Both S, Apisarnthanarax S: Clinical decision tool for optimal delivery of liver stereotactic body radiation therapy (SBRT): photons versus protons. Practical Radiation Oncology in press, 2015.

Zeng C, Plastaras JP, Tochner Z, White B, Hill-Kayser C, Hahn S, Both S: Proton pencil beam scanning for mediastinal lymphoma: the impact of interplay between target motion and beam scanning. Physics in Medicine and Biology 60: 3013-3029, 2015.

Datta J, McMillan MT, Shang EK, Mamtani R, Lewis RS Jr, Kelz RR, Teitelbaum U, Plastaras JL, Drebin JA, Fraker DL, Karakousis GC, Roses RE: Omission of Adjuvant Therapy Following Gastric Cancer Resection: Development of a Validated Risk Model. J Natl Compr Canc Netw 13(5): 531–541, 2015.

McMillan MT, Ojerholm E, Roses RE, Plastaras JP, Metz JM, Mamtani R, Karakousis GC, Fraker DL, Drebin JA, Stripp D, Ben-Josef E, Datta J: Adjuvant Radiotherapy Treatment Time Impacts Overall Survival in Gastric Cancer International Journal of Radiation Oncology, Biology, Physics 2015.

Landsburg DJ, Vogl DT, Plastaras JP, Stadtmauer EA: Melphalan/total body irradiation-conditioned myeloablative allogeneic hematopoietic cell transplantation for patients with primary plasma cell leukemia. Clinical Lymphoma, Myeloma & Leukemia 14(6): e225-8, Dec 2014.

Dionisi F, Avery S, Lukens JN, Ding X, Kralik J, Kirk M, Roses RE, Amichetti M, Metz JM, Plastaras JP: Proton therapy in adjuvant treatment of gastric cancer: planning comparison with advanced x-ray therapy and feasibility report Acta Oncologica 53(10): 1312-20, Oct 2014.

Bloch P and Plastaras JP: Dose Calculation for I131/ I124 Radioimmunoconjugates for Radioimmunotherapy. Austin Journal of Nuclear Medicine and Radiotherapy 1(1): 3, Sept 2014.

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Last updated: 05/21/2015
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