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John Plastaras, M.D., Ph.D.

John Plastaras, M.D., Ph.D.

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Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
TRC 4W
3400 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-615-3714
Fax: 215-349-8975
Education:
B.A. (Biology)
Emory University, 1994.
B.S. (Chemistry)
Emory University, 1994.
M.S. (Chemistry)
Emory University, 1994.
Ph.D. (Biochemistry)
Vanderbilt University, 2000.
M.D.
Vanderbilt University, 2002.
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Description of Research Expertise

1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" (ClinicalTrials.gov Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.

2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.

3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.

4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" (ClinicalTrials.gov Identifier: NCT01449864)

Description of Clinical Expertise

radiation therapy, lymphoma, gastroinstestinal cancer, proton radiotherapy, total body irradiation

Selected Publications

Bloch P and Plastaras JP: Dose Calculation for I131/ I124 Radioimmunoconjugates for Radioimmunotherapy. Austin Journal of Nuclear Medicine and Radiotherapy 1(1): 3, Sept 2014.

Lukens JN, Nasta SD, Fram B, Glatstein E, Plastaras JP: Outcomes Following Involved Field Radiation Therapy (IFRT) with or without Rituximab in Patients with Early Stage Low-Grade Non-Hodgkin's Lymphoma (NHL) Staged with CT and PETwith CT and PET. American Journal of Clinical Oncology 37(1): 35-40, February 2014.

Berman AT, Both S, Sharkoski T, Goldrath K, Tochner Z, Apisarnthanarax S, Metz JM, Plastaras JP : Proton Reirradiation of Recurrent Rectal Cancer: Dosimetric Comparsion, Toxicities, and Preliminary Outcomes. International Journal of Particle Therapy 1(1): 3, 2014.

Whaley JT, Fernandes AT, Sackmann R, Plastaras JP, Teo B-K, Grover S, Perini RF, Metz JM, Pryma DA, Apisarnthanarax S: Clinical utility of integrated positron emission tomography/computed tomography imaging in the clinical management and radiation treatment planning of locally advanced rectal cancer. Practical Radiation Oncology in press, 2014.

Thompson RF, Myeker S, Zhai H, Both S, Apisarnthanarax S, Metz JM, Plastaras JP, Ben-Josef E: A Dosimetric Comparison of Proton and Photon Therapy in Unresectable Cancers of the Head of Pancreas. Medical Physics in press, 2014.

K. Wang, N. Vapiwala, C. Deville, J. P. Plastaras, V. Bui, V. Bar Ad, Z. Tochner, S. Both: The Impact of Stool and Gas Volume on Intrafraction Prostate Motion in Patients Undergoing Radiotherapy with Daily Endorectal Balloon Radiotherapy and Oncology in press, 2014.

Dionisi F, Avery S, Lukens JN, Ding X, Kralik J, Kirk M, Roses RE, Amichetti M, Metz JM, Plastaras JP: Proton therapy in adjuvant treatment of gastric cancer: planning comparison with advanced x-ray therapy and feasibility report Acta Oncologica in press, 2014.

Nagle SJ, Chong EA, Chekol S, Shah NN, Nasta SD, Glatstein E, Plastaras JP, Torigian D, Schuster SJ, Svoboda J: The Role of FDG-PET Imaging as a Prognostic Marker of Outcome in Primary Mediastinal B-Cell Lymphoma. Cancer Medicine in press, 2014.

Landsburg DJ, Vogl DT, Plastaras JP, Stadtmauer EA: Melphalan/total body irradiation-conditioned myeloablative allogeneic hematopoietic cell transplantation for patients with primary plasma cell leukemia. Clinical Lymphoma, Myeloma & Leukemia in press, 2014.

Geiger GA, Kim MB, Xanthopoulos EP, Pryma DA, Grover S, Plastaras JP, Langer CJ, Simone CB 2nd, Rengan R: Stage Migration in Planning PET/CT Scans in Patients Due to Receive Radiotherapy for Non-Small-Cell Lung Cancer. Clin Lung Cancer 13: S1525-7304, Oct 2013

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Last updated: 12/15/2014
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