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John Plastaras, M.D., Ph.D.

John Plastaras, M.D., Ph.D.

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Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
TRC 4W
3400 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-615-3714
Fax: 215-349-8975
Education:
B.S. (Chemistry)
Emory University, 1994.
B.A. (Biology)
Emory University, 1994.
M.S. (Chemistry)
Emory University, 1994.
Ph.D. (Biochemistry)
Vanderbilt University, 2000.
M.D.
Vanderbilt University, 2002.
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Description of Research Expertise

1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" (ClinicalTrials.gov Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.

2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.

3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.

4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" (ClinicalTrials.gov Identifier: NCT01449864)

Description of Clinical Expertise

radiation therapy, lymphoma, gastroinstestinal cancer, proton radiotherapy, total body irradiation

Selected Publications

Lukens JN, Nasta SD, Fram B, Glatstein E, Plastaras JP: Outcomes Following Involved Field Radiation Therapy (IFRT) with or without Rituximab in Patients with Early Stage Low-Grade Non-Hodgkin's Lymphoma (NHL) Staged with CT and PETwith CT and PET. American Journal of Clinical Oncology 37(1): 35-40, February 2014.

Berman AT, Both S, Sharkoski T, Goldrath K, Tochner Z, Apisarnthanarax S, Metz JM, Plastaras JP : Proton Reirradiation of Recurrent Rectal Cancer: Dosimetric Comparsion, Toxicities, and Preliminary Outcomes. International Journal of Particle Therapy in press, 2014.

Whaley JT, Fernandes AT, Sackmann R, Plastaras JP, Teo B-K, Grover S, Perini RF, Metz JM, Pryma DA, Apisarnthanarax S: Clinical utility of integrated positron emission tomography/computed tomography imaging in the clinical management and radiation treatment planning of locally advanced rectal cancer. Practical Radiation Oncology in press, 2014.

Thompson RF, Myeker S, Zhai H, Both S, Apisarnthanarax S, Metz JM, Plastaras JP, Ben-Josef E: A Dosimetric Comparison of Proton and Photon Therapy in Unresectable Cancers of the Head of Pancreas. Medical Physics in press, 2014.

K. Wang, N. Vapiwala, C. Deville, J. P. Plastaras, V. Bui, V. Bar Ad, Z. Tochner, S. Both: The Impact of Stool and Gas Volume on Intrafraction Prostate Motion in Patients Undergoing Radiotherapy with Daily Endorectal Balloon Radiotherapy and Oncology in press, 2014.

Dionisi F, Avery S, Lukens JN, Ding X, Kralik J, Kirk M, Roses RE, Amichetti M, Metz JM, Plastaras JP: Proton therapy in adjuvant treatment of gastric cancer: planning comparison with advanced x-ray therapy and feasibility report Acta Oncologica in press, 2014.

Geiger GA, Kim MB, Xanthopoulos EP, Pryma DA, Grover S, Plastaras JP, Langer CJ, Simone CB 2nd, Rengan R: Stage Migration in Planning PET/CT Scans in Patients Due to Receive Radiotherapy for Non-Small-Cell Lung Cancer. Clin Lung Cancer 13: S1525-7304, Oct 2013

Patel V, Buckstein M, Perini R, Hill-Kayser C, Svoboda J, Plastaras JP: CT and PET/CT surveillance after combined modality treatment of supradiaphragmatic Hodgkin Lymphoma: a clinical and economic perspective. Leukemia and Lymphoma 54(10): 2168-76, Oct 2013.

Joshua A. Jones, MD, Vatsal B. Patel, BA, , Ursina Teitelbaum, MD, John P. Plastaras, MD, PhD: Diffusely metastatic digital papillary adenocarcinoma eleven years after initial presentation treated with palliative chemotherapy and radiotherapy. J Clin Oncol 31(22): e386-9, Aug [Epub 2013 Jun 24] 2013.

Wojcieszynski AP, Berman AT, Wan F, Plastaras JP, Metz JM, Mitra N, Apisarnthanarax S: The impact of radiation therapy sequencing on survival and cardiopulmonary mortality in the combined modality treatment of patients with esophageal cancer. Cancer 119(11): 1976-84, Jun 2013.

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Last updated: 06/24/2014
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