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John Plastaras, M.D., Ph.D.

John Plastaras, M.D., Ph.D.

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Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
TRC 4W
3400 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-615-3714
Fax: 215-349-8975
Education:
B.S. (Chemistry)
Emory University, 1994.
B.A. (Biology)
Emory University, 1994.
M.S. (Chemistry)
Emory University, 1994.
Ph.D. (Biochemistry)
Vanderbilt University, 2000.
M.D.
Vanderbilt University, 2002.
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Description of Research Expertise

1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" (ClinicalTrials.gov Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.

2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.

3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.

4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" (ClinicalTrials.gov Identifier: NCT01449864)

Description of Clinical Expertise

radiation therapy, lymphoma, gastroinstestinal cancer, proton radiotherapy, total body irradiation

Selected Publications

Fernandes Annemarie, Berman Abigail T, Mick Rosemarie, Both Stefan, Lelionis Kristi, Lukens John N, Ben-Josef Edgar, Metz James M, Plastaras John P: A Prospective Study of Proton Beam Reirradiation for Esophageal Cancer. International journal of radiation oncology, biology, physics 95(1): 483-7, May 2016.

Datta Jashodeep, McMillan Matthew T, Ruffolo Luis, Lowenfeld Lea, Mamtani Ronac, Plastaras John P, Dempsey Daniel T, Karakousis Giorgos C, Drebin Jeffrey A, Fraker Douglas L, Roses Robert E: Multimodality Therapy Improves Survival in Resected Early Stage Gastric Cancer in the United States. Annals of surgical oncology Apr 2016.

Zeng C, Plastaras JP, James P, Tochner Z, Hill-Kayser C, Hahn S, and Both S: Proton Pencil Beam Scanning for Mediastinal Lymphoma: Treatment Planning and Robustness Assessment. Acta Oncologica In Press, 2016 Notes: In Press.

Dhakal S, Advani R, Ballas LK, Dabaja BS, Flowers CR, Ha CS, Hoppe BS, Mendenhall NP, Metzger ML, Plastaras JP, Roberts KB, Shapiro R, Smith SM, Terezakis SA, Winkfield KM, Younes A, Constine LS: ACR Appropriateness Criteria® Hodgkin Lymphoma-Favorable Prognosis Stage I and II. American Journal of Clinical Oncology 2016.

Datta Jashodeep, McMillan Matthew T, Ecker Brett L, Karakousis Giorgos C, Mamtani Ronac, Plastaras John P, Giantonio Bruce J, Drebin Jeffrey A, Dempsey Daniel T, Fraker Douglas L, Roses Robert E: Implications of Lymph Node Staging on Selection of Adjuvant Therapy for Gastric Cancer in the United States: A Propensity Score-matched Analysis. Annals of surgery Jul 2015.

Gandhi SJ, Liang X, Ding X, Zhu TC, Ben-Josef E, Plastaras JP, Metz JM, Both S, Apisarnthanarax S: Clinical decision tool for optimal delivery of liver stereotactic body radiation therapy (SBRT): photons versus protons. Practical Radiation Oncology 5(4): 209-1, Jul-Aug 2015.

McMillan Matthew T, Ojerholm Eric, Roses Robert E, Plastaras John P, Metz James M, Mamtani Ronac, Karakousis Giorgos C, Fraker Douglas L, Drebin Jeffrey A, Stripp Diana, Ben-Josef Edgar, Datta Jashodeep: Adjuvant Radiation Therapy Treatment Time Impacts Overall Survival in Gastric Cancer. International journal of radiation oncology, biology, physics May 2015.

Datta Jashodeep, McMillan Matthew T, Shang Eric K, Mamtani Ronac, Lewis Russell S, Kelz Rachel R, Teitelbaum Ursina, Plastaras John P, Drebin Jeffrey A, Fraker Douglas L, Karakousis Giorgos C, Roses Robert E: Omission of adjuvant therapy after gastric cancer resection: development of a validated risk model. Journal of the National Comprehensive Cancer Network : JNCCN 13(5): 531-41, May 2015.

Fernandes Annemarie T, Apisarnthanarax Smith, Yin Lingshu, Zou Wei, Rosen Mark, Plastaras John P, Ben-Josef Edgar, Metz James M, Teo Boon-Keng: Comparative assessment of liver tumor motion using cine-magnetic resonance imaging versus 4-dimensional computed tomography. International journal of radiation oncology, biology, physics 91(5): 1034-40, Apr 2015.

Ojerholm E, Kirk M, Thompson R, Zhai A, Metz JM, Both S, Ben-Josef E, Plastaras JP : Pencil-beam scanning proton therapy for anal cancer: a dosimetric comparison with intensity-modulated radiotherapy. Acta Oncologica [Epub ahead of print], Mar 3 2015.

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Last updated: 08/23/2016
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