Perelman School of Medicine/ Faculty Search/ Bruce L. Levine

Bruce L. Levine, Ph.D.

Barbara and Edward Netter Associate Professor in Cancer Gene Therapy

Department: Pathology and Laboratory Medicine

Contact information

M6.40 Maloney Building
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104-4268

Office: (215)-573-6788
Fax: 215-615-4718

Links
Clinical Cell and Vaccine Production Facility, Bruce Levine, Ph.D., Director
Abramson Family Cancer Research Institute, Bruce Levine, Ph.D. Biography and research description

Education:
B.A. (Major-Biology, Minor-History)
The University of Pennsylvania , 1984.
Ph.D. (Immunology and Infectious Diseases)
The Johns Hopkins University, 1992.

Permanent link

Perelman School of Medicine > Faculty > Search

Description of Research Expertise

Immunology, Cell and Gene Therapy

Description of Other Expertise

Good Manufacturing Practices

Selected Publications

Grupp, SA, Kalos, M, Barrett, D, Aplenc, R, Porter, DL, Rheingold, SR, Teachey, DT, Chew, A, Hauck, B, Wright, JF, Milone, MC, Levine, BL, June, CH: Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia. New England Journal of Medicine 368(16): 1509-18, April 2013 Notes: doi: 10.1056/NEJMoa1215134. Epub 2013 Mar 25.

Kumar AJ, Hexner EO, Frey NV, Luger SM, Loren AW, Reshef R, Boyer J, Smith J, Stadtmauer EA, Levine BL, June CH, Porter DL, Goldstein SC: A Pilot Study of Prophylactic Ex Vivo Co-Stimulated Donor Leukocyte Infusions After Reduced Intensity Conditioned Allogeneic Stem Cell Transplantation. Biology of Blood and Marrow Transplant April 2013 Notes: 2013 Apr 28. doi:pii: S1083-8791(13)00189-4. 10.1016/j.bbmt.2013.04.021. [Epub ahead of print]

Fowler DH, Mossoba ME, Steinberg SM, Halverson DC, Stroncek D, Khuu HM, Hakim FT, Castiello L, Sabatino M, Leitman SF, Mariotti J, Gea-Banacloche JC, Sportes C, Hardy NM, Hickstein DD, Pavletic SZ, Rowley S, Goy A, Donato M, Korngold R, Pecora A, Levine BL, June CH, Gress RE, Bishop MR: Phase II clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation. Blood February 2013 Notes: ePub ahead of print, doi: 10.1182/blood-2012-08-446872.

Kandalaft, LE, Powell Jr., DJ, Chiang, CL, Tanyi, J, Kim, S, Bosch, M, Montone, K, Mick, R, Torigian, DA, Levine, BL, June, CH, Coukos, G: Autologous Lysate-pulsed Dendritic Cell Vaccination Followed by Adoptive Transfer of Vaccine-primed Ex Vivo Costimulated T-cells in Recurrent Ovarian Cancer Oncoimmunology 2(1): 1-9, January 2013 Notes: eLocation ID: e22664.

Maier D, Brennan AL, Jiang S, Binder-Scholl GK, Lee G, Plesa G, Zheng Z, Cotte J, Carpenito C, Wood T, Spratt SK, Ando D, Gregory P, Holmes M, Perez EE, Riley JL, Carroll R, June CH, Levine BL: Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease Targeted Disruption of the HIV Co-Receptor CCR5. Human Gene Therapy January 2013 Notes: Epub ahead of print.

Grupp SA, Luning Prak E, Boyer J, McDonald KR, Shusterman S, Thompson E, Callahan C, Jawad A, Levine BL, June CH, Sullivan KE: Adoptive Transfer of Autologous T cells Improves T Cell Repertoire Diversity and Long Term B cell Function in Pediatric Patients with Neuroblastoma. Clinical Cancer Research 18(24): 6732-41, December 15 2012 Notes: doi: 10.1158/1078-0432.CCR-12-1432. Epub 2012 Oct 23.

Tebas P, Stein D, Binder-Scholl G, Mukherjee R, Brady T, Rebello T, Humeau L, Kalos M, Papasavvas E, Montaner LJ, Schullery D, Shaheen F, Brennan AL, Zheng Z, Cotte J, Slepushkin V, Veloso E, Mackley A, Hwang WT, Aberra F, Zhan J, Boyer J, Collman RG, Bushman FD, Levine BL, June CH: Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long anti-sense to HIV. Blood December 20 2012 Notes: Epub ahead of print.

Scholler J, Brady TL, Binder-Scholl G, Hwang WT, Plesa G, Hege KM, Vogel AN, Kalos M, Riley JL, Deeks SG, Mitsuyasu RT, Bernstein WB, Aronson NE, Levine BL, Bushman FD, June CH: Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Science Translational Medicine 4(132): 132ra53, May 2012.

Sharma A, Koldovsky U, Xu S, Mick R, Roses R, Fitzpatrick E, Weinstein S, Nisenbaum H, Levine BL, Fox K, Zhang P, Koski G, Czerniecki BJ: HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ. Cancer January 2012 Notes: doi: 10.1002/cncr.26734. [Epub ahead of print]

Hardy NM, Fellowes V, Rose JJ, Odom J, Pittaluga S, Steinberg SM, Blacklock-Schuver B, Avila DN, Memon S, Kurlander RJ, Khuu HM, Stetler-Stevenson M, Mena E, Dwyer AJ, Levine BL, June CH, Reshef R, Vonderheide RH, Gress RE, Fowler DH, Hakim FT, Bishop MR: Costimulated tumor-infiltrating lymphocytes are a feasible and safe alternative donor cell therapy for relapse after allogeneic stem cell transplantation. Blood January 2012 Notes: Epub ahead of print.