Bruce L. Levine, Ph.D.

faculty photo
Barbara and Edward Netter Professor in Cancer Gene Therapy
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Center for Cellular Immunotherapies
Smilow 8-114
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-746-1481
Education:
B.A. (Major-Biology, Minor-History)
The University of Pennsylvania , 1984.
Ph.D. (Immunology and Infectious Diseases)
The Johns Hopkins University, 1992.
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Description of Research Expertise

Immunology, Cell and Gene Therapy

Description of Other Expertise

Good Manufacturing Practices

Selected Publications

Schuster Stephen J, Svoboda Jakub, Chong Elise A, Nasta Sunita D, Mato Anthony R, Anak Özlem, Brogdon Jennifer L, Pruteanu-Malinici Iulian, Bhoj Vijay, Landsburg Daniel, Wasik Mariusz, Levine Bruce L, Lacey Simon F, Melenhorst Jan J, Porter David L, June Carl H: Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas. The New England journal of medicine Dec 2017 Notes: doi: 10.1056/NEJMoa1708566. [Epub ahead of print]

Tchou Julia, Zhao Yangbing, Levine Bruce L, Zhang Paul J, Davis Megan M, Melenhorst Jan Joseph, Kulikovskaya Irina, Brennan Andrea L, Liu Xiaojun, Lacey Simon F, Posey Avery D, Williams Austin D, So Alycia, Conejo-Garcia Jose R, Plesa Gabriela, Young Regina M, McGettigan Shannon, Campbell Jean, Pierce Robert H, Matro Jennifer M, DeMichele Angela M, Clark Amy S, Cooper Laurence J, Schuchter Lynn M, Vonderheide Robert H, June Carl H: Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer. Cancer immunology research 5(12): 1152-1161, Dec 2017.

Marcucci Katherine T, Jadlowsky Julie K, Hwang Wei-Ting, Suhoski-Davis Megan, Gonzalez Vanessa E, Kulikovskaya Irina, Gupta Minnal, Lacey Simon F, Plesa Gabriela, Chew Anne, Melenhorst J Joseph, Levine Bruce L, June Carl H: Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients. Molecular therapy : the journal of the American Society of Gene Therapy Oct 2017 Notes: DOI: http://dx.doi.org/10.1016/j.ymthe.2017.10.012.

Mueller Karen Thudium, Maude Shannon L, Porter David L, Frey Noelle, Wood Patricia, Han Xia, Waldron Edward, Chakraborty Abhijit, Awasthi Rakesh, Levine Bruce L, Melenhorst J Joseph, Grupp Stephan A, June Carl H, Lacey Simon F: Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia. Blood Sep 2017.

Donald M. O’Rourke, MacLean P. Nasrallah, Arati Desai, Jan J. Melenhorst, Keith Mansfield, Jennifer J. D. Morrissette, Maria Martinez-Lage, Steven Brem, Eileen Maloney, Angela Shen, Randi Isaacs, Suyash Mohan, Gabriela Plesa, Simon F. Lacey, Jean-Marc Navenot, Zhaohui Zheng, Bruce L. Levine, Hideho Okada, Carl H. June, Jennifer L. Brogdon and Marcela V. Maus: A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Science Translational Medicine 9(399): eaaa0984, July 2017.

Singh N, Hofmann TJ, Gershenson Z, Levine BL, Grupp SA, Teachey DT, Barrett DM: Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function. Cytotherapy 19(7): 867, July 2017.

Chong Elise A, Melenhorst J Joseph, Lacey Simon F, Ambrose David E, Gonzalez Vanessa, Levine Bruce L, June Carl H, Schuster Stephen J: PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR. Blood 129(8): 1039-1041, Feb 2017.

McKenna David H, Sumstad Darin, Kadidlo Diane M, Batdorf Bjorn, Lord Colin J, Merkel Sarah C, Koellner Christine M, Curtsinger Julie M, June Carl H, Riley James L, Levine Bruce L, Miller Jeffrey S, Brunstein Claudio G, Wagner John E, Blazar Bruce R, Hippen Keli L: Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials. Cytotherapy 19(2): 250-262, Nov 2016.

Lu Yunjie, Hippen Keli L, Lemire Amanda L, Gu Jian, Wang Weizhi, Ni Xuhao, Ranganathan Parvathi, Levine Bruce L, Riley James L, June Carl H, Turka Laurence A, Munn David H, Garzon Ramiro, Lu Ling, Blazar Bruce R: miR-146b antagomir treated human Tregs increase TRAF6-NFkB expression, suppressor function and GVHD inhibitory potency. Blood 128(10): 1424-35, Aug 2016.

Teachey David T, Lacey Simon F, Shaw Pamela A, Melenhorst J Joseph, Maude Shannon L, Frey Noelle, Pequignot Edward, Gonzalez Vanessa E, Chen Fang, Finklestein Jeffrey, Barrett David M, Weiss Scott L, Fitzgerald Julie C, Berg Robert A, Aplenc Richard, Callahan Colleen, Rheingold Susan R, Zheng Zhaohui, Rose-John Stefan, White Jason C, Nazimuddin Farzana, Wertheim Gerald, Levine Bruce L, June Carl H, Porter David L, Grupp Stephan A: Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia. Cancer discovery 6(6): 664-79, June 2016.

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Last updated: 03/16/2018
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