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Bruce L. Levine, Ph.D.

Bruce L. Levine, Ph.D.

faculty photo
Barbara and Edward Netter Professor in Cancer Gene Therapy
Department: Pathology and Laboratory Medicine

Contact information
M6.40 Maloney Building
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104-4268
Office: (215)-614-0309
Fax: 215-615-4718
Education:
B.A. (Major-Biology, Minor-History)
The University of Pennsylvania , 1984.
Ph.D. (Immunology and Infectious Diseases)
The Johns Hopkins University, 1992.
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Description of Research Expertise

Immunology, Cell and Gene Therapy

Description of Other Expertise

Good Manufacturing Practices

Selected Publications

Rapoport AP, Stadtmauer EA, Binder-Scholl GK, Goloubeva O, Vogl DT, Lacey SF, Badros AZ, Garfall A, Weiss B, Finklestein J, Kulikovskaya I, Sinha SK, Kronsberg S, Gupta M, Bond S, Melchiori L, Brewer JE, Bennett AD, Gerry AB, Pumphrey NJ, Williams D, Tayton-Martin HK, Ribeiro L, Holdich T, Yanovich S, Hardy N, Yared J, Kerr N, Philip S, Westphal S, Siegel DL, Levine BL, Jakobsen BK, Kalos M, June CH: NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma. Nature Medicine July 2015 Notes: doi:10.1038/nm.3910.

Zsiros E, Duttagupta P, Dangaj D, Li H, Frank R, Garrabrant T, Hagemann IS, Levine BL, June CH, Zhang L, Wang E, Marincola FM, Bedognetti D, Powell DJ Jr, Tanyi J, Feldman MD, Kandalaft LE, Coukos G.: The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy. Clinical Cancer Research 21(12): 2840-50, June 2015 Notes: DOI: 10.1158/1078-0432.CCR-14-2777

Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, Mahnke YD, Melenhorst JJ, Rheingold SR, Shen A, Teachey DT, Levine BL, June CH, Porter DL, Grupp SA: Chimeric antigen receptor T cells for sustained remissions in leukemia. New England Journal of Medicine 371(16): 1507-17, October 2014 Notes: doi: 10.1056/NEJMoa1407222.

Rapoport, AP, Aqui, NA, Stadtmauer, EA, Vogl, DT, Xu, YY, Kalos, M, Cai, L, Fang, H-B, Weiss, BM, Badros, A, Yanovich, S, Akpek, G, Cross, A, Mann, A, Philip, S, Kerr, N, Brennen, A, Zheng, Z, Ruehl, K, Milliron, T, Strome, SE, Salazar, AM, Levine, BL, June, CH: Combination immunotherapy after ASCT for multiple myeloma (MM) using MAGE-A3/Poly-ICLC immunizations followed by vaccine-primed and costimulated autologous T-Cells. Clinical Cancer Research 20(5): 1355, March 2014.

Tebas Pablo, Stein David, Tang Winson W, Frank Ian, Wang Shelley Q, Lee Gary, Spratt S Kaye, Surosky Richard T, Giedlin Martin A, Nichol Geoff, Holmes Michael C, Gregory Philip D, Ando Dale G, Kalos Michael, Collman Ronald G, Binder-Scholl Gwendolyn, Plesa Gabriela, Hwang Wei-Ting, Levine Bruce L, June Carl H: Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. The New England Journal of Medicine 370(10): 901-10, Mar 2014.

Beatty Gregory L, Haas Andrew R, Maus Marcela V, Torigian Drew A, Soulen Michael C, Plesa Gabriela, Chew Anne, Zhao Yangbing, Levine Bruce L, Albelda Steven M, Kalos Michael, June Carl H: Mesothelin-specific Chimeric Antigen Receptor mRNA-Engineered T cells Induce Anti-Tumor Activity in Solid Malignancies. Cancer immunology research 2(2): 112-120, Feb 2014.

Beatty, G.L., Haas, A.R., Maus, M.V., Torigian, D.A., Soulen, M.C., Zhao, Y., Levine, B.L., Albelda, S.M., Kalos, M., June, C.H.: Mesothelin-specific Chimeric Antigen Receptor mRNA-Engineered T cells Induce Anti-Tumor Activity in Solid Malignancies. Cancer Immunology Research 2(2): 1-9, December 2013 Notes: DOI: 10.1158/2326-6066.CIR-13-0170.

Cameron, BJ, Gerry, AB, Dukes, J, Harper, JV, Kannan, V, Bianchi, FC, Grand, F, Brewer, JE, Gupta, M, Plesa, G, Bossi, G, Vuidepot, A, Powlesland, AS, Legg, A, Adams, KJ, Bennett, AD, Pumphrey, NJ, Williams, DD, Binder-Scholl, G, Kulikovskaya, I, Levine, BL, Riley, JL, Varela-Rohena, A, Stadtmauer, EA, Rapoport, AP, Linette, GP, June, CH, Hassan, NJ, Kalos, M, Jakobsen, BK: Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells. Science Translational Medicine 5(197): 197ra103, August 2013.

Maus MV, Haas AR, Beatty GL, Albelda SM, Levine BL, Liu X, Zhao Y, Kalos M, June CH: T cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer Immunology Research 1(1): 26-31, July 2013 Notes: doi: 10.1158/2326-6066.CIR-13-0006.

Kumar AJ, Hexner EO, Frey NV, Luger SM, Loren AW, Reshef R, Boyer J, Smith J, Stadtmauer EA, Levine BL, June CH, Porter DL, Goldstein SC: Pilot Study of Prophylactic Ex Vivo Co-Stimulated Donor Leukocyte Infusions After Reduced Intensity Conditioned Allogeneic Stem Cell Transplantation. Biology of Blood and Marrow Transplant 19(7): 1094–1101, July 2013 Notes: 2013 Apr 28. doi:pii: S1083-8791(13)00189-4. 10.1016/j.bbmt.2013.04.021. [Epub ahead of print]

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Last updated: 08/26/2015
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