Bruce L. Levine, Ph.D.

faculty photo
Barbara and Edward Netter Professor in Cancer Gene Therapy
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Center for Cellular Immunotherapies
Smilow 8-114
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-746-1481
B.A. (Major-Biology, Minor-History)
The University of Pennsylvania , 1984.
Ph.D. (Immunology and Infectious Diseases)
The Johns Hopkins University, 1992.
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Description of Research Expertise

Immunology, Cell and Gene Therapy

Description of Other Expertise

Good Manufacturing Practices

Selected Publications

Nobles Christopher L, Sherrill-Mix Scott, Everett John K, Reddy Shantan, Fraietta Joseph A, Porter David L, Frey Noelle, Gill Saar I, Grupp Stephan A, Maude Shannon L, Siegel Donald L, Levine Bruce L, June Carl H, Lacey Simon F, Melenhorst J Joseph, Bushman Frederic D: CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration. The Journal of clinical investigation 130(2): 673-685, Feb 2020.

Frey Noelle V, Shaw Pamela A, Hexner Elizabeth O, Pequignot Edward, Gill Saar, Luger Selina M, Mangan James K, Loren Alison W, Perl Alexander E, Maude Shannon L, Grupp Stephan A, Shah Nirav N, Gilmore Joan, Lacey Simon F, Melenhorst Jos J, Levine Bruce L, June Carl H, Porter David L: Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 38(5): 415-422, Feb 2020.

Stadtmauer Edward A, Fraietta Joseph A, Davis Megan M, Cohen Adam D, Weber Kristy L, Lancaster Eric, Mangan Patricia A, Kulikovskaya Irina, Gupta Minnal, Chen Fang, Tian Lifeng, Gonzalez Vanessa E, Xu Jun, Jung In-Young, Melenhorst J Joseph, Plesa Gabriela, Shea Joanne, Matlawski Tina, Cervini Amanda, Gaymon Avery L, Desjardins Stephanie, Lamontagne Anne, Salas-Mckee January, Fesnak Andrew, Siegel Donald L, Levine Bruce L, Jadlowsky Julie K, Young Regina M, Chew Anne, Hwang Wei-Ting, Hexner Elizabeth O, Carreno Beatriz M, Nobles Christopher L, Bushman Frederic D, Parker Kevin R, Qi Yanyan, Satpathy Ansuman T, Chang Howard Y, Zhao Yangbing, Lacey Simon F, June Carl H: CRISPR-engineered T cells in patients with refractory cancer. Science (New York, N.Y.) Feb 2020.

Garfall Alfred L, Dancy Ehren K, Cohen Adam D, Hwang Wei-Ting, Fraietta Joseph A, Davis Megan M, Levine Bruce L, Siegel Don L, Stadtmauer Edward A, Vogl Dan T, Waxman Adam, Rapoport Aaron P, Milone Michael C, June Carl H, Melenhorst J Joseph: T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma. Blood advances 3(19): 2812-2815, Oct 2019.

Chong Elise A, Levine Bruce L, Grupp Stephan A, Davis Megan M, Siegel Don L, Maude Shannon L, Gladney Whitney L, Frey Noelle V, Porter David L, Hwang Wei-Ting, Chong Emeline R, June Carl H, Schuster Stephen J: CAR T cell viability release testing and clinical outcomes: is there a lower limit? Blood Sep 2019.

Wang Kan, Liu Y I, Li Junxuan, Wang Ben, Bishop Reid, White Chip, DAS Amritava, Levine Aaron D, Ho Linda, Levine Bruce L, Fesnak Andrew D: A multiscale simulation framework for the manufacturing facility and supply chain of autologous cell therapies. Cytotherapy Aug 2019.

Haas Andrew R, Tanyi Janos L, O'Hara Mark H, Gladney Whitney L, Lacey Simon F, Torigian Drew A, Soulen Michael C, Tian Lifeng, McGarvey Maureen, Nelson Anne Marie, Farabaugh Caitlin S, Moon Edmund, Levine Bruce L, Melenhorst J Joseph, Plesa Gabriela, June Carl H, Albelda Steven M, Beatty Gregory L: Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers. Molecular therapy : the journal of the American Society of Gene Therapy Jul 2019.

Cohen Adam D, Garfall Alfred L, Stadtmauer Edward A, Melenhorst J Joseph, Lacey Simon F, Lancaster Eric, Vogl Dan T, Weiss Brendan M, Dengel Karen, Nelson Annemarie, Plesa Gabriela, Chen Fang, Davis Megan M, Hwang Wei-Ting, Young Regina M, Brogdon Jennifer L, Isaacs Randi, Pruteanu-Malinici Iulian, Siegel Don L, Levine Bruce L, June Carl H, Milone Michael C: B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. The Journal of Clinical Investigation 130: 126397, Mar 2019.

Stein Andrew M, Grupp Stephan A, Levine John E, Laetsch Theodore W, Pulsipher Michael A, Boyer Michael W, August Keith J, Levine Bruce L, Tomassian Lori, Shah Sweta, Leung Mimi, Huang Pai-Hsi, Awasthi Rakesh, Mueller Karen Thudium, Wood Patricia A, June Carl H: Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells. CPT: pharmacometrics & systems pharmacology Mar 2019 Notes: ePub ahead of print doi: 10.1002/psp4.12388.

Harrison Richard P, Zylberberg Ezequiel, Ellison Simon, Levine Bruce L: Chimeric antigen receptor-T cell therapy manufacturing: modelling the effect of offshore production on aggregate cost of goods. Cytotherapy 21(2): 224-233, Feb 2019.

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Last updated: 04/13/2020
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