Bruce L. Levine, Ph.D.

faculty photo
Barbara and Edward Netter Professor in Cancer Gene Therapy
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Center for Cellular Immunotherapies
Smilow 8-114
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-746-1481
Education:
B.A. (Major-Biology, Minor-History)
The University of Pennsylvania , 1984.
Ph.D. (Immunology and Infectious Diseases)
The Johns Hopkins University, 1992.
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Description of Research Expertise

Immunology, Cell and Gene Therapy

Description of Other Expertise

Good Manufacturing Practices

Selected Publications

Diorio C, Shaw PA, Pequignot E, Orlenko A, Chen F, Aplenc R, Barrett DM, Bassiri H, Behrens E, DiNofia AM, Gonzalez V, Koterba N, Levine BL, Maude SL, Meyer NJ, Moore JH, Paessler M, Porter DL, Bush JL, Siegel DL, Davis MM, Zhang D, June CH, Grupp SA, Melenhorst JJ, Lacey SF, Weiss SL, Teachey DT. : Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children. Blood Advances 4(20): 5174-5183, October 2020.

Andrew H Ko, Alexander C Jordan, Evan Tooker, Simon F Lacey, Renee B Chang, Yan Li, Alan P Venook, Margaret Tempero, Lloyd Damon, Lawrence Fong, Mark H O'Hara, Bruce L Levine, J Joseph Melenhorst, Gabriela Plesa, Carl H June, Gregory L Beatty: Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer. Molecular Therapy July 2020 Notes: online ahead of print, DOI: 10.1016/j.ymthe.2020.07.017.

Mark D Stewart, Anne Keane, Lisa H Butterfield, Bruce L Levine, Bruce Thompson, Yuan Xu, Chris Ramsborg, Ann Lee, Michael Kalos, Chin Koerner, Timothy Moore, Ingrid Markovic, Laura Lasiter, Ramy Ibrahim, Jeffrey Bluestone, Ellen Sigal, Jeff Allen: Accelerating the development of innovative cellular therapy products for the treatment of cancer. Cytotherapy 22(5): 239-246, May 2020.

Noelle V Frey, Saar Gill, Elizabeth O Hexner, Stephen Schuster, Sunita Nasta, Alison Loren, Jakub Svoboda, Edward Stadtmauer, Daniel J Landsburg, Anthony Mato, Bruce L Levine, Simon F Lacey, Jan Joseph Melenhorst, Elizabeth Veloso, Avery Gaymon, Edward Pequignot, Xinhe Shan, Wei-Ting Hwang, Carl H June, David L Porter: Long-Term Outcomes From a Randomized Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells in Relapsed Chronic Lymphocytic Leukemia. Journal of Clinical Oncology April 2020 Notes: online ahead of print DOI: 10.1200/JCO.19.03237.

Stadtmauer Edward A, Fraietta Joseph A, Davis Megan M, Cohen Adam D, Weber Kristy L, Lancaster Eric, Mangan Patricia A, Kulikovskaya Irina, Gupta Minnal, Chen Fang, Tian Lifeng, Gonzalez Vanessa E, Xu Jun, Jung In-Young, Melenhorst J Joseph, Plesa Gabriela, Shea Joanne, Matlawski Tina, Cervini Amanda, Gaymon Avery L, Desjardins Stephanie, Lamontagne Anne, Salas-Mckee January, Fesnak Andrew, Siegel Donald L, Levine Bruce L, Jadlowsky Julie K, Young Regina M, Chew Anne, Hwang Wei-Ting, Hexner Elizabeth O, Carreno Beatriz M, Nobles Christopher L, Bushman Frederic D, Parker Kevin R, Qi Yanyan, Satpathy Ansuman T, Chang Howard Y, Zhao Yangbing, Lacey Simon F, June Carl H: CRISPR-engineered T cells in patients with refractory cancer. Science (New York, N.Y.) Feb 2020.

Frey Noelle V, Shaw Pamela A, Hexner Elizabeth O, Pequignot Edward, Gill Saar, Luger Selina M, Mangan James K, Loren Alison W, Perl Alexander E, Maude Shannon L, Grupp Stephan A, Shah Nirav N, Gilmore Joan, Lacey Simon F, Melenhorst Jos J, Levine Bruce L, June Carl H, Porter David L: Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 38(5): 415-422, Feb 2020.

Nobles Christopher L, Sherrill-Mix Scott, Everett John K, Reddy Shantan, Fraietta Joseph A, Porter David L, Frey Noelle, Gill Saar I, Grupp Stephan A, Maude Shannon L, Siegel Donald L, Levine Bruce L, June Carl H, Lacey Simon F, Melenhorst J Joseph, Bushman Frederic D: CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration. The Journal of clinical investigation 130(2): 673-685, Feb 2020.

Garfall Alfred L, Dancy Ehren K, Cohen Adam D, Hwang Wei-Ting, Fraietta Joseph A, Davis Megan M, Levine Bruce L, Siegel Don L, Stadtmauer Edward A, Vogl Dan T, Waxman Adam, Rapoport Aaron P, Milone Michael C, June Carl H, Melenhorst J Joseph: T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma. Blood advances 3(19): 2812-2815, Oct 2019.

Chong Elise A, Levine Bruce L, Grupp Stephan A, Davis Megan M, Siegel Don L, Maude Shannon L, Gladney Whitney L, Frey Noelle V, Porter David L, Hwang Wei-Ting, Chong Emeline R, June Carl H, Schuster Stephen J: CAR T cell viability release testing and clinical outcomes: is there a lower limit? Blood Sep 2019.

Wang Kan, Liu Y I, Li Junxuan, Wang Ben, Bishop Reid, White Chip, DAS Amritava, Levine Aaron D, Ho Linda, Levine Bruce L, Fesnak Andrew D: A multiscale simulation framework for the manufacturing facility and supply chain of autologous cell therapies. Cytotherapy Aug 2019.

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Last updated: 11/11/2020
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