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William H. Peranteau, MD

William H. Peranteau, MD

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Assistant Professor of Surgery
Department: Surgery

Contact information
Division of Pediatric General, Thoracic and Fetal Surgery
The Children's Hospital of Philadelphia
34th Street & Civic Center Boulevard
5th Floor, Wood Center
Philadelphia, PA 19104
Office: 215-590-2730
Fax: 215-590-4875
Education:
BA (molecular biology)
Princeton University, Princeton, NJ, 1997.
MD
University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.
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Description of Research Expertise

I have an interest in fetal development as it relates to the potential understanding of and fetal intervention for congenital anomalies. Specifically, I have had a deep interest and significant experience evaluating in utero hematopoietic stem cell transplantation in the murine and canine model. These studies provide interesting information and address basic questions on the development of the fetal hematopoietic niche. One of the main goals of my research is a better understanding of the barriers to successful allogeneic in utero bone marrow transplantation. Allogeneic in utero bone marrow transplantation would allow for nonmyeloablative unmatched transplants without the need for immunosuppression and thus holds significant clinical promise for the treatment of hemoglobinopathies, such as Sickle Cell disease.

Selected Publications

Peranteau WH, Havens JM, Harrington S, Gates JD: Re-establishing surgical care at Port-au-Prince General Hospital, Haiti. Journal of the American College of Surgeons 211(1): 126-30, July 2010.

Endo M, Henriques-Coelho T, Zoltick P W, Stitelman D H, Peranteau W H, Radu A, Flake A W: The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors. Gene Therapy 17(1): 61-71, Jan. 2010.

Peranteau WH, Heaton TE, Gu Y, Volk SW, Bauer TR, Alcorn K, Tuschong LM, Johnson MP, Hickstein DD, Flake AW: Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency model. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation 15(3): 293-305, Mar. 2009.

Peranteau WH, Zhang L, Muvarak N, Badillo AT, Radu A, Zoltick PW, Liechty KW: IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation. Journal of Investigative Dermatology 128(7): 1852-60, July 2008.

Laje P, Peranteau WH, Flake AW: Repair of indirect inguinal hernias by "laparoscopic joining of the edges". Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 18(3): 280-2, June 2008.

Badillo AT, Peranteau WH, Heaton TE, Quinn C, Flake AW: Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease. British Journal of Haematology 141(2): 224-34, Apr. 2008.

Endo M, Zoltick PW, Peranteau WH, Radu A, Muvarak N, Ito M, Yang Z, Cotsarelis G, Flake AW: Efficient in vivo targeting of epidermal stem cells by early gestational intra-amniotic injection of lentiviral vector driven by the keratin 5 promoter. Molecular Therapy: The Journal of the American Society of Gene Therapy 16(1): 131-7, Jan. 2008.

Peranteau WH, Merchant AM, Hedrick HL, Liechty KW, Howell LJ, Flake AW, Wilson RD, Johnson MP, Bebbington MW, Adzick NS: Prenatal course and postnatal management of peripheral bronchial atresia: Association with congenital cystic adenomatoid malformation of the lung. Fetal Diagnosis and Therapy 24(3): 190-196, 2008.

Sabatino DE, Mackenzie TC, Peranteau W, Edmonson S, Campagnoli C, Liu Y, Flake AW, High KA: Persistent expression of hF.IX after tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice. Molecular Therapy: The Journal of the American Society of Gene Therapy 15(9): 1677-1685, Sept. 2007.

Peranteau WH, Endo M, Adibe OO, Flake AW: Evidence for an immune barrier after in utero hematopoietic-cell transplantation. Blood 109(3): 1331-1333, Feb. 2007.

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Last updated: 01/17/2013
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