William H. Peranteau, MD

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Associate Professor of Surgery at the Children's Hospital of Philadelphia
Active Surgeon, Pennsylvania Hospital, Philadelphia, PA
Active Surgeon, Children's Hospital of Philadelphia, Philadelphia, PA
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Member, Institute for Translational Medicine and Therapeutics (ITMAT), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Active Physician, Virtua Hospital, Voorhees, NJ
Adzick-McCausland Distinguished Chair in Fetal and Pediatric Surgery, Children's Hospital of Philadelphia, Philadelphia, PA (Inaugural chair holder)
Co-Director, The Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, PA
Department: Surgery

Contact information
Division of Pediatric General, Thoracic & Fetal Surgery
The Children's Hospital of Philadelphia
Center for Fetal Research
3615 Civic Center Blvd
Abramson Research Center, Rm 1116E
Philadelphia, PA 19104
Office: 215-590-2730
Fax: 215-590-4875
Lab: 215-590-4810
Education:
BA (molecular biology)
Princeton University, Princeton, NJ, 1997.
MD
University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.
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Description of Research Expertise

I have an interest in fetal development as it relates to the potential understanding of and fetal intervention for congenital anomalies. Specifically, I have had a deep interest and significant experience evaluating in utero hematopoietic stem cell transplantation in the murine and canine model. These studies provide interesting information and address basic questions on the development of the fetal hematopoietic niche. One of the main goals of my research is a better understanding of the barriers to successful allogeneic in utero bone marrow transplantation. Allogeneic in utero bone marrow transplantation would allow for nonmyeloablative unmatched transplants without the need for immunosuppression and thus holds significant clinical promise for the treatment of hemoglobinopathies, such as Sickle Cell disease.

Selected Publications

Bose SK, White B, Menon P, Teerdhala S, Li H, Zoltick P, Peranteau W: In utero base editing ameliorates musculoskeletal pathology in a mouse model of mucopolysaccharidosis type I. Presented at the American Pediatric Surgical Association (virtual) May 2021.

Palanki R, Peranteau WH, Mitchell MJ: Delivery technologies for in utero gene therapy. Advanced Drug Delivery Reviews 169: 51-62, Feb. 2021 Notes: Epub Nov. 9, 2020.

Bose SK, White B, Kashyap M, Li H, Zoltick PW, Peranteau WH: Fetal base editing ameliorates cardiac pathology in a mouse model of mucopolysaccharidosis type I. Presented at the Academic Surgical Congress (virtual) Feb. 2 2021.

Riley RS, Kashyap MV, Billingsley MM, White B, Alameh MG, Bose SK, Zoltick PW, Li H, Zhang R, Cheng AY, Weissman D, Peranteau WH*, Mitchell MJ*: Ionizable lipid nanoparticles for in utero mRNA delivery. Science Advances 7(3): eaba1028, Jan. 13 2021 Notes: * co-senior authors.

Moldenhauer JS, Soni S, Jatres J, Gebb J, Khalek N, Paidas Teefey C, Johnson MP, Flake AW, Hedrick HL, Peranteau WH, Heuer GG, Adzick NS: Open fetal surgical outcomes for myelomeningocele closure stratified by maternal body mass index in a large single-center cohort. Fetal Diagnosis & Therapy 47(12): 889-893, Dec. 2020 Notes: Epub Nov. 9, 2020.

Bose SK, White B, Kashyap M, Li H, Zoltick PW, Peranteau WH: Fetal base editing ameliorates cardiac pathology in a mouse model of mucopolysaccharidosis type I. Presented at the Massachusetts Chapter of the American College of Surgeons (virtual) Dec. 5 2020.

Sagar R, Almeida-Porada G, Blakemore K, Chan JK, Choolani M, Götherström C, Jaulent A, MacKenzie TC, Mattar C, Porada CD, Peranteau WH, Schneider H, Shaw SW, Waddington SN, Westgren M, David AL: Fetal and maternal safety considerations for in utero therapy clinical trials: iFeTiS consensus statement Molecular Therapy 28(11): 2316-2319, Nov. 4 2020 Notes: Epub Oct. 15, 2020.

McGovern Patrick E, Hornick Matthew A, Mejaddam Ali Y, Lawrence Kendall, Schupper Alexander J, Rossidis Avery C, Baumgarten Heron, Vossough Arastoo, Didier Ryne A, Kim Aimee, Partridge Emily A, Hwang Grace, Young Kathleen, Peranteau William H, Davey Marcus G, Flake Alan W: Neurologic outcomes of the premature lamb in an extrauterine environment for neonatal development. Journal of Pediatric Surgery 55(10): 2115-2123, Oct. 2020 Notes: Epub Jan. 8, 2020.

O'Connell AE, Guseh S, Lapteva L, Cummings CL, Wilkins-Haug L, Chan J, Peranteau WH, Almeida-Porada G, Kourembanas S: Gene and stem cell therapies for fetal care: A review. JAMA Pediatrics 174(10): 985-991, Oct. 1 2020 Notes: Epub June 29, 2020.

Riley RS, Kashyap M, Billingsley M, White, B, Zoltick, P, Cheng A, Zhang R, Peranteau W, Mitchell M: Engineering lipid nanoparticles for in utero mRNA delivery. Presented at the Biomedical Engineering Society, Remote Meeting Oct. 2020.

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Last updated: 04/19/2021
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