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Ravi K Amaravadi, MD

Ravi K Amaravadi, MD

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-201
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-662-7402
Fax: 215-349-8550
Education:
BA (Biochemistry )
Columbia University , 1996.
MD (Medicine)
Johns Hopkins University , 2000.
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Description of Research Expertise

Autophagy, Mechanisms of Cell Death, Developmental Therapeutics

Description of Clinical Expertise

Phase I and Phase II Clinical Trials
Melanoma

Selected Publications

Kong Jianping, Whelan Kelly A, Laczkó Dorottya, Dang Brendan, Caro Monroig Angeliz, Soroush Ali, Falcone John, Amaravadi Ravi K, Rustgi Anil K, Ginsberg Gregory G, Falk Gary W, Nakagawa Hiroshi, Lynch John P: Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress. Molecular carcinogenesis 55(11): 1526-1541, Nov 2016.

Zhang Gao, Frederick Dennie T, Wu Lawrence, Wei Zhi, Krepler Clemens, Srinivasan Satish, Chae Young Chan, Xu Xiaowei, Choi Harry, Dimwamwa Elaida, Ope Omotayo, Shannan Batool, Basu Devraj, Zhang Dongmei, Guha Manti, Xiao Min, Randell Sergio, Sproesser Katrin, Xu Wei, Liu Jephrey, Karakousis Giorgos C, Schuchter Lynn M, Gangadhar Tara C, Amaravadi Ravi K, Gu Mengnan, Xu Caiyue, Ghosh Abheek, Xu Weiting, Tian Tian, Zhang Jie, Zha Shijie, Liu Qin, Brafford Patricia, Weeraratna Ashani, Davies Michael A, Wargo Jennifer A, Avadhani Narayan G, Lu Yiling, Mills Gordon B, Altieri Dario C, Flaherty Keith T, Herlyn Meenhard: Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. The Journal of clinical investigation 126(5): 1834-56, May 2016.

Budina-Kolomets Anna, Webster Marie R, Leu Julia I-Ju, Jennis Matthew, Krepler Clemens, Guerrini Anastasia, Kossenkov Andrew V, Xu Wei, Karakousis Giorgos, Schuchter Lynn, Amaravadi Ravi K, Wu Hong, Yin Xiangfan, Liu Qin, Lu Yiling, Mills Gordon B, Xu Xiaowei, George Donna L, Weeraratna Ashani T, Murphy Maureen E: HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer research 76(9): 2720-30, May 2016.

Twyman-Saint Victor C, Rech A, Maity A, Rengan R, Pauken K, Stelekati E, Xu B, Dada H, Odiorizzi P, Herati R, Mansfield K, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma D, Xu X, Feldman M, Gangadhar T, Hahn S, Wherry JE, Vonderheide R, Benci J, Minn A. : Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer. Nature Mar 2015 Notes: [Epub ahead of print]

Amaravadi RK, Schilder RJ, Martin LP, Levin M, Graham MA, Weng DE, Adjei AA.: A Phase 1 Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma. Molecular Cancer Therapeutics Sept 2015.

Amaravadi RK, Hamilton KE, Ma X, Piao S, Portillo AD, Nathanson KL, Carlino MS, Long GV, Puzanov I, Xu X, Morrissette JJ, Tsai KY, Flaherty KT, Sosman JA, Goodman GR, McArthur GA, Rustgi AK, Metz DC, Schuchter LM, Chapman PB, Sepulveda AR.: Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors. Clinical Cancer Research Jul 2015.

Flaherty KT, Hamilton BK, Rosen MA, Amaravadi RK, Schuchter LM, Gallagher M, Chen H, Sehgal C, O'Dwyer PJ. : Phase I/II Trial of Imatinib and Bevacizumab in Patients With Advanced Melanoma and Other Advanced Cancers. The Oncologist June 2015.

Wang T, Xiao M, Ge Y, Krepler C, Belser E, Lopez-Coral A, Xu X, Zhang G, Azuma R, Liu Q, Liu R, Li L, Amaravadi RK, Xu W, Karakousis GC, Gangadhar TC, Schuchter LM, Lieu M, Khare S, Halloran MB, Herlyn M, Kaufman RE: BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth. Clin Cancer Res. Jan epub 2015.

Krayya A, Piao S, Xu G, Zhang G, Gimotty PG, Xu X, Amaravadi RK**, Speicher DW**. **Co-senior authors.: Identification of secreted proteins that reflect autophagy dynamics with tumor cells Autophagy 11(1): 60-74, Jan 2 2015.

Puzanov I, Amaravadi RK, McArthur GA, Flaherty KT, Chapman PB, Sosman JA, Ribas A, Shackleton M, Hwu P, Chmielowski B, Nolop KB, Lin PS, Kim KB.: Long-term outcome in BRAF(V600E) melanoma patients treated with vemurafenib: Patterns of disease progression and clinical management of limited progression. European Journal of Cancer 51(11): 1435-43, 2015.

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Last updated: 12/05/2016
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