Ravi K Amaravadi, MD

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
8 BRB - Room 852
Philadelphia, PA 19104
Office: 215-769-5159
Education:
BA (Biochemistry )
Columbia University , 1996.
MD (Medicine)
Johns Hopkins University , 2000.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Autophagy, Mechanisms of Cell Death, Developmental Therapeutics

Description of Clinical Expertise

Phase I and Phase II Clinical Trials
Melanoma

Selected Publications

Song Yun, Straker Richard J, Xu Xiaowei, Elder David E, Gimotty Phyllis A, Huang Alexander C, Mitchell Tara C, Amaravadi Ravi K, Schuchter Lynn M, Karakousis Giorgos C: Neoadjuvant Versus Adjuvant Immune Checkpoint Blockade in the Treatment of Clinical Stage III Melanoma. Annals of surgical oncology Jan 2020.

Webster Marie R, Fane Mitchell E, Alicea Gretchen M, Basu Subhasree, Kossenkov Andrew V, Marino Gloria E, Douglass Stephen M, Kaur Amanpreet, Ecker Brett L, Gnanapradeepan Keerthana, Ndoye Abibatou, Kugel Curtis, Valiga Alexander, Palmer Jessica, Liu Qin, Xu Xiaowei, Morris Jessicamarie, Yin Xiangfan, Wu Hong, Xu Wei, Zheng Cathy, Karakousis Giorgos C, Amaravadi Ravi K, Mitchell Tara C, Almeida Filipe V, Xiao Min, Rebecca Vito W, Wang Ying-Jie, Schuchter Lynn M, Herlyn Meenhard, Murphy Maureen E, Weeraratna Ashani T: Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma. Molecular cell Dec 2019.

Cechakova Lucie, Ondrej Martin, Pavlik Vojtech, Jost Petr, Cizkova Dana, Bezrouk Ales, Pejchal Jaroslav, Amaravadi Ravi K, Winkler Jeffrey D, Tichy Ales: A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299. International journal of molecular sciences 20(23), Nov 2019.

Santiago-O'Farrill Janice M, Weroha S John, Hou Xiaonan, Oberg Ann L, Heinzen Ethan P, Maurer Matthew J, Pang Lan, Rask Philip, Amaravadi Ravi K, Becker Sarah E, Romero Ignacio, Rubio Ma Jesús, Matias-Guiu Xavier, Santacana Maria, Llombart-Cussac Antonio, Poveda Andrés, Lu Zhen, Bast Robert C: Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models. Cancer Nov 2019.

Sanseviero Emilio, O'Brien Erin M, Karras Jenna R, Shabaneh Tamer B, Aksoy Bulent Arman, Xu Wei, Zheng Cathy, Yin Xiangfan, Xu Xiaowei, Karakousis Giorgos C, Amaravadi Ravi K, Nam Brian, Turk Mary Jo, Hammerbacher Jeff, Rubinstein Mark P, Schuchter Lynn M, Mitchell Tara C, Liu Qin, Stone Erica L: Anti-CTLA-4 Activates Intratumoral NK Cells and Combined with IL15/IL15Rα Complexes Enhances Tumor Control. Cancer immunology research 7(8): 1371-1380, Aug 2019.

Song Yun, Tieniber Andrew D, Gimotty Phyllis A, Mitchell Tara C, Amaravadi Ravi K, Schuchter Lynn M, Fraker Douglas L, Karakousis Giorgos C: Survival Outcomes of Patients with Clinical Stage III Melanoma in the Era of Novel Systemic Therapies. Annals of surgical oncology Jul 2019.

Karasic Thomas B, O'Hara Mark H, Loaiza-Bonilla Arturo, Reiss Kim A, Teitelbaum Ursina R, Borazanci Erkut, De Jesus-Acosta Ana, Redlinger Colleen, Burrell Jessica A, Laheru Daniel A, Von Hoff Daniel D, Amaravadi Ravi K, Drebin Jeffrey A, O'Dwyer Peter J: Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial. JAMA oncology 5(7): 993-998, Jul 2019.

Tameire Feven, Verginadis Ioannis I, Leli Nektaria Maria, Polte Christine, Conn Crystal S, Ojha Rani, Salas Salinas Carlo, Chinga Frank, Monroy Alexandra M, Fu Weixuan, Wang Paul, Kossenkov Andrew, Ye Jiangbin, Amaravadi Ravi K, Ignatova Zoya, Fuchs Serge Y, Diehl J Alan, Ruggero Davide, Koumenis Constantinos: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nature cell biology 21(7): 889-899, Jul 2019.

Parekh Vishwas, Sobanko Joseph, Miller Christopher J, Karakousis Giorgos, Xu Wei, Letrero Richard, Elenitsas Rosalie, Xu Xiaowei, Elder David E, Amaravadi Ravi, Schuchter Lynn M, Nathanson Katherine L, Wilson Melissa A, Chu Emily Y: NRAS Q61R and BRAF G466A mutations in atypical melanocytic lesions newly arising in advanced melanoma patients treated with vemurafenib. Journal of cutaneous pathology 46(3): 190-194, Mar 2019.

Rebecca Vito W, Nicastri Michael C, Fennelly Colin, Chude Cynthia I, Barber-Rotenberg Julie S, Ronghe Amruta, McAfee Quentin, McLaughlin Noel P, Zhang Gao, Goldman Aaron R, Ojha Rani, Piao Shengfu, Noguera-Ortega Estela, Martorella Alessandra, Alicea Gretchen M, Lee Jennifer J, Schuchter Lynn M, Xu Xiaowei, Herlyn Meenhard, Marmorstein Ronen, Gimotty Phyllis A, Speicher David W, Winkler Jeffrey D, Amaravadi Ravi K: PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. Cancer discovery 9(2): 220-229, Feb 2019.

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Last updated: 02/14/2020
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