Ravi K Amaravadi, MD

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
8 BRB - Room 852
Philadelphia, PA 19104
Office: 215-769-5159
Education:
BA (Biochemistry )
Columbia University , 1996.
MD (Medicine)
Johns Hopkins University , 2000.
Permanent link
 
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Description of Research Expertise

Autophagy, Mechanisms of Cell Death, Developmental Therapeutics

Description of Clinical Expertise

Phase I and Phase II Clinical Trials
Melanoma

Selected Publications

Sanseviero Emilio, O'Brien Erin M, Karras Jenna R, Shabaneh Tamer B, Aksoy Bulent Arman, Xu Wei, Zheng Cathy, Yin Xiangfan, Xu Xiaowei, Karakousis Giorgos C, Amaravadi Ravi K, Nam Brian, Turk Mary Jo, Hammerbacher Jeff, Rubinstein Mark P, Schuchter Lynn M, Mitchell Tara C, Liu Qin, Stone Erica L: Anti-CTLA-4 Activates Intratumoral NK Cells and Combined with IL15/IL15Rα Complexes Enhances Tumor Control. Cancer immunology research 7(8): 1371-1380, Aug 2019.

Song Yun, Tieniber Andrew D, Gimotty Phyllis A, Mitchell Tara C, Amaravadi Ravi K, Schuchter Lynn M, Fraker Douglas L, Karakousis Giorgos C: Survival Outcomes of Patients with Clinical Stage III Melanoma in the Era of Novel Systemic Therapies. Annals of surgical oncology Jul 2019.

Karasic Thomas B, O'Hara Mark H, Loaiza-Bonilla Arturo, Reiss Kim A, Teitelbaum Ursina R, Borazanci Erkut, De Jesus-Acosta Ana, Redlinger Colleen, Burrell Jessica A, Laheru Daniel A, Von Hoff Daniel D, Amaravadi Ravi K, Drebin Jeffrey A, O'Dwyer Peter J: Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial. JAMA oncology 5(7): 993-998, Jul 2019.

Tameire Feven, Verginadis Ioannis I, Leli Nektaria Maria, Polte Christine, Conn Crystal S, Ojha Rani, Salas Salinas Carlo, Chinga Frank, Monroy Alexandra M, Fu Weixuan, Wang Paul, Kossenkov Andrew, Ye Jiangbin, Amaravadi Ravi K, Ignatova Zoya, Fuchs Serge Y, Diehl J Alan, Ruggero Davide, Koumenis Constantinos: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nature cell biology 21(7): 889-899, Jul 2019.

Parekh Vishwas, Sobanko Joseph, Miller Christopher J, Karakousis Giorgos, Xu Wei, Letrero Richard, Elenitsas Rosalie, Xu Xiaowei, Elder David E, Amaravadi Ravi, Schuchter Lynn M, Nathanson Katherine L, Wilson Melissa A, Chu Emily Y: NRAS Q61R and BRAF G466A mutations in atypical melanocytic lesions newly arising in advanced melanoma patients treated with vemurafenib. Journal of cutaneous pathology 46(3): 190-194, Mar 2019.

Rebecca Vito W, Nicastri Michael C, Fennelly Colin, Chude Cynthia I, Barber-Rotenberg Julie S, Ronghe Amruta, McAfee Quentin, McLaughlin Noel P, Zhang Gao, Goldman Aaron R, Ojha Rani, Piao Shengfu, Noguera-Ortega Estela, Martorella Alessandra, Alicea Gretchen M, Lee Jennifer J, Schuchter Lynn M, Xu Xiaowei, Herlyn Meenhard, Marmorstein Ronen, Gimotty Phyllis A, Speicher David W, Winkler Jeffrey D, Amaravadi Ravi K: PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. Cancer discovery 9(2): 220-229, Feb 2019.

Haas Naomi B, Appleman Leonard J, Stein Mark, Redlinger Maryann, Wilks Melissa, Xu Xiaowei, Onorati Angelique, Kalavacharla Anusha, Kim Taehyong, Zhen Chao Jie, Kadri Sabah, Segal Jeremy P, Gimotty Phyllis A, Davis Lisa E, Amaravadi Ravi K: Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research Jan 2019.

Khan Omar, Giles Josephine R, McDonald Sierra, Manne Sasikanth, Ngiow Shin Foong, Patel Kunal P, Werner Michael T, Huang Alexander C, Alexander Katherine A, Wu Jennifer E, Attanasio John, Yan Patrick, George Sangeeth M, Bengsch Bertram, Staupe Ryan P, Donahue Greg, Xu Wei, Amaravadi Ravi K, Xu Xiaowei, Karakousis Giorgos C, Mitchell Tara C, Schuchter Lynn M, Kaye Jonathan, Berger Shelley L, Wherry E John: TOX transcriptionally and epigenetically programs CD8 T cell exhaustion. Nature 571(7764): 211-218, 07 2019.

Ojha Rani, Leli Nektaria M, Onorati Angelique, Piao Shengfu, Verginadis Ioannis I, Tameire Feven, Rebecca Vito W, Chude Cynthia I, Murugan Sengottuvelan, Fennelly Colin, Noguera-Ortega Estela, Liu Shujing, Xu Xiaowei, Krepler Clemens, Xiao Min, Xu Wei, Wei Zhi, Frederick Dennie T, Boland Genevieve, Mitchell Tara C, Karakousis Giorgos C, Schuchter Lynn M, Flaherty Keith T, Zhang Gao, Herlyn Meenhard, Koumenis Constantinos, Amaravadi Ravi K: ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma. Cancer discovery Dec 2018.

Baquero Pablo, Dawson Amy, Mukhopadhyay Arunima, Kuntz Elodie M, Mitchell Rebecca, Olivares Orianne, Ianniciello Angela, Scott Mary T, Dunn Karen, Nicastri Michael C, Winkler Jeffrey D, Michie Alison M, Ryan Kevin M, Halsey Christina, Gottlieb Eyal, Keaney Erin P, Murphy Leon O, Amaravadi Ravi K, Holyoake Tessa L, Helgason G Vignir: Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia Sep 2018.

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Last updated: 09/30/2019
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