Ravi K Amaravadi, MD

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
8 BRB - Room 852
Philadelphia, PA 19104
Office: 215-769-5159
Education:
BA (Biochemistry )
Columbia University , 1996.
MD (Medicine)
Johns Hopkins University , 2000.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Autophagy, Mechanisms of Cell Death, Developmental Therapeutics

Description of Clinical Expertise

Phase I and Phase II Clinical Trials
Melanoma

Selected Publications

Parekh Vishwas, Sobanko Joseph, Miller Christopher J, Karakousis Giorgos, Xu Wei, Letrero Richard, Elenitsas Rosalie, Xu Xiaowei, Elder David E, Amaravadi Ravi, Schuchter Lynn M, Nathanson Katherine L, Wilson Melissa A, Chu Emily Y: NRAS Q61R and BRAF G466A mutations in atypical melanocytic lesions newly arising in advanced melanoma patients treated with vemurafenib. Journal of cutaneous pathology 46(3): 190-194, Mar 2019.

Rebecca Vito W, Nicastri Michael C, Fennelly Colin, Chude Cynthia I, Barber-Rotenberg Julie S, Ronghe Amruta, McAfee Quentin, McLaughlin Noel P, Zhang Gao, Goldman Aaron R, Ojha Rani, Piao Shengfu, Noguera-Ortega Estela, Martorella Alessandra, Alicea Gretchen M, Lee Jennifer J, Schuchter Lynn M, Xu Xiaowei, Herlyn Meenhard, Marmorstein Ronen, Gimotty Phyllis A, Speicher David W, Winkler Jeffrey D, Amaravadi Ravi K: PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. Cancer discovery 9(2): 220-229, Feb 2019.

Haas Naomi B, Appleman Leonard J, Stein Mark, Redlinger Maryann, Wilks Melissa, Xu Xiaowei, Onorati Angelique, Kalavacharla Anusha, Kim Taehyong, Zhen Chao Jie, Kadri Sabah, Segal Jeremy P, Gimotty Phyllis A, Davis Lisa E, Amaravadi Ravi K: Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research Jan 2019.

Ojha Rani, Leli Nektaria M, Onorati Angelique, Piao Shengfu, Verginadis Ioannis I, Tameire Feven, Rebecca Vito W, Chude Cynthia I, Murugan Sengottuvelan, Fennelly Colin, Noguera-Ortega Estela, Liu Shujing, Xu Xiaowei, Krepler Clemens, Xiao Min, Xu Wei, Wei Zhi, Frederick Dennie T, Boland Genevieve, Mitchell Tara C, Karakousis Giorgos C, Schuchter Lynn M, Flaherty Keith T, Zhang Gao, Herlyn Meenhard, Koumenis Constantinos, Amaravadi Ravi K: ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma. Cancer discovery Dec 2018.

Baquero Pablo, Dawson Amy, Mukhopadhyay Arunima, Kuntz Elodie M, Mitchell Rebecca, Olivares Orianne, Ianniciello Angela, Scott Mary T, Dunn Karen, Nicastri Michael C, Winkler Jeffrey D, Michie Alison M, Ryan Kevin M, Halsey Christina, Gottlieb Eyal, Keaney Erin P, Murphy Leon O, Amaravadi Ravi K, Holyoake Tessa L, Helgason G Vignir: Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia Sep 2018.

Kugel Curtis H, Douglass Stephen M, Webster Marie R, Kaur Amanpreet, Liu Qin, Yin Xiangfan, Weiss Sarah A, Darvishian Farbod, Al-Rohil Rami N, Ndoye Abibatou, Behera Reeti, Alicea Gretchen M, Ecker Brett L, Fane Mitchell, Allegrezza Michael J, Svoronos Nikolaos, Kumar Vinit, Wang Daniel Y, Somasundaram Rajasekharan, Hu-Lieskovan Siwen, Ozgun Alpaslan, Herlyn Meenhard, Conejo-Garcia Jose R, Gabrilovich Dmitry, Stone Erica L, Nowicki Theodore S, Sosman Jeffrey, Rai Rajat, Carlino Matteo S, Long Georgina V, Marais Richard, Ribas Antoni, Eroglu Zeynep, Davies Michael A, Schilling Bastian, Schadendorf Dirk, Xu Wei, Amaravadi Ravi K, Menzies Alexander M, McQuade Jennifer L, Johnson Douglas B, Osman Iman, Weeraratna Ashani T: Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations. Clinical cancer research : an official journal of the American Association for Cancer Research Jun 2018.

Echevarría-Vargas Ileabett M, Reyes-Uribe Patricia I, Guterres Adam N, Yin Xiangfan, Kossenkov Andrew V, Liu Qin, Zhang Gao, Krepler Clemens, Cheng Chaoran, Wei Zhi, Somasundaram Rajasekharan, Karakousis Giorgos, Xu Wei, Morrissette Jennifer Jd, Lu Yiling, Mills Gordon B, Sullivan Ryan J, Benchun Miao, Frederick Dennie T, Boland Genevieve, Flaherty Keith T, Weeraratna Ashani T, Herlyn Meenhard, Amaravadi Ravi, Schuchter Lynn M, Burd Christin E, Aplin Andrew E, Xu Xiaowei, Villanueva Jessie: Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma. EMBO molecular medicine 10(5), May 2018.

Zhang Gao, Wu Lawrence W, Mender Ilgen, Barzily-Rokni Michal, Hammond Marc R, Ope Omotayo, Cheng Chaoran, Vasilopoulos Themistoklis, Randell Sergio, Sadek Norah, Beroard Aurelie, Xiao Min, Tian Tian, Tan Jiufeng, Saeed Umar, Sugarman Eric, Krepler Clemens, Brafford Patricia A, Sproesser Katrin, Murugan Sengottuvelan, Somasundaram Rajasekharan, Garman Bradley, Wubbenhorst Bradley, Woo Jonathan, Yin Xiangfan, Liu Qin, Frederick Dennie T, Miao Benchun, Xu Wei, Karakousis Giorgos C, Xu Xiaowei, Schuchter Lynn M, Mitchell Tara C, Kwong Lawrence N, Amaravadi Ravi K, Lu Yiling, Boland Genevieve, Wei Zhi, Nathanson Katherine L, Herbig Utz, Mills Gordon B, Flaherty Keith T, Herlyn Meenhard, Shay Jerry W: Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research Mar 2018.

Monteleon Christine L, Agnihotri Tanvir, Dahal Ankit, Liu Mingen, Rebecca Vito W, Beatty Gregory L, Amaravadi Ravi K, Ridky Todd W: Lysosomes Support the Degradation, Signaling, and Mitochondrial Metabolism Necessary for Human Epidermal Differentiation. The Journal of investigative dermatology Mar 2018.

Yam Clinton, Xu Xiaowei, Davies Michael A, Gimotty Phyllis A, Morrissette Jennifer J D, Tetzlaff Michael T, Wani Khalida M, Liu Shujing, Deng Wanleng, Buckley Meghan, Zhao Jianhua, Amaravadi Ravi K, Haas Naomi B, Kudchadkar Ragini R, Pavlick Anna C, Sosman Jeffrey A, Tawbi Hussein, Walker Luke, Schuchter Lynn M, Karakousis Giorgos C, Gangadhar Tara C: A Multicenter Phase I Study Evaluating Dual PI3K and BRAF Inhibition with PX-866 and Vemurafenib in Patients with Advanced BRAF V600-Mutant Solid Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 24(1): 22-32, Jan 2018.

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Last updated: 02/14/2019
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