Ravi K Amaravadi, MD

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
8 BRB - Room 852
Philadelphia, PA 19104
Office: 215-769-5159
Education:
BA (Biochemistry )
Columbia University , 1996.
MD (Medicine)
Johns Hopkins University , 2000.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Autophagy, Mechanisms of Cell Death, Developmental Therapeutics

Description of Clinical Expertise

Phase I and Phase II Clinical Trials
Melanoma

Selected Publications

Marie R Webster, Mitchell E Fane, Gretchen M Alicea, Subhasree Basu, Andrew V Kossenkov, Gloria E Marino, Stephen M Douglass, Amanpreet Kaur, Brett L Ecker, Keerthana Gnanapradeepan, Abibatou Ndoye, Curtis Kugel, Alexander Valiga, Jessica Palmer, Qin Liu, Xiaowei Xu, Jessicamarie Morris, Xiangfan Yin, Hong Wu, Wei Xu, Cathy Zheng, Giorgos C Karakousis, Ravi K Amaravadi, Tara C Mitchell, Filipe V Almeida, Min Xiao, Vito W Rebecca, Ying-Jie Wang, Lynn M Schuchter, Meenhard Herlyn, Maureen E Murphy, Ashani T Weeraratna. : Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma. Mol Cell. 77(3): 681, Feb 6 2020.

Janice M Santiago-O'Farrill, S John Weroha, Xiaonan Hou, Ann L Oberg, Ethan P Heinzen, Matthew J Maurer, Lan Pang, Philip Rask, Ravi K Amaravadi, Sarah E Becker, Ignacio Romero, Ma Jesús Rubio, Xavier Matias-Guiu, Maria Santacana, Antonio Llombart-Cussac, Andrés Poveda, Zhen Lu, Robert C Bast Jr. : Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models. Cancer 126(4): 894-907, Feb 15 2020.

Marie R Webster, Mitchell E Fane, Gretchen M Alicea, Subhasree Basu, Andrew V Kossenkov, Gloria E Marino, Stephen M Douglass, Amanpreet Kaur, Brett L Ecker, Keerthana Gnanapradeepan, Abibatou Ndoye, Curtis Kugel, Alexander Valiga, Jessica Palmer, Qin Liu, Xiaowei Xu, Jessicamarie Morris, Xiangfan Yin, Hong Wu, Wei Xu, Cathy Zheng, Giorgos C Karakousis, Ravi K Amaravadi, Tara C Mitchell, Filipe V Almeida, Min Xiao, Vito W Rebecca, Ying-Jie Wang, Lynn M Schuchter, Meenhard Herlyn, Maureen E Murphy, Ashani T Weeraratna. : Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma. Mol Cell. 77(3): 681, Feb 2020.

Yun Song, Richard J Straker, Xiaowei Xu, David E Elder, Phyllis A Gimotty, Alexander C Huang, Tara C Mitchell, Ravi K Amaravadi, Lynn M Schuchter, Giorgos C Karakousis. : Neoadjuvant Versus Adjuvant Immune Checkpoint Blockade in the Treatment of Clinical Stage III Melanoma. Ann Surg Oncol. Jan 2 2020 Notes: doi: 10.1245/s10434-019-08174-1. [Online ahead of print]

Yun Song, Andrew D Tieniber, Phyllis A Gimotty, Tara C Mitchell, Ravi K Amaravadi, Lynn M Schuchter, Douglas L Fraker, Giorgos C Karakousis. : Survival Outcomes of Patients with Clinical Stage III Melanoma in the Era of Novel Systemic Therapies. Ann Surg Oncol. 26(13): 4621-4630, Dec 2019.

Lucie Cechakova, Martin Ondrej, Vojtech Pavlik, Petr Jost, Dana Cizkova, Ales Bezrouk, Jaroslav Pejchal, Ravi K Amaravadi, Jeffrey D Winkler, Ales Tichy. : A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299. Int J Mol Sci. 20(23): pii: E5881, Nov 23 2019.

Emilio Sanseviero, Erin M O'Brien, Jenna R Karras, Tamer B Shabaneh, Bulent Arman Aksoy, Wei Xu, Cathy Zheng, Xiangfan Yin, Xiaowei Xu, Giorgos C Karakousis, Ravi K Amaravadi, Brian Nam, Mary Jo Turk, Jeff Hammerbacher, Mark P Rubinstein, Lynn M Schuchter, Tara C Mitchell, Qin Liu, Erica L Stone. : Anti-CTLA-4 Activates Intratumoral NK Cells and Combined with IL15/IL15Rα Complexes Enhances Tumor Control. Cancer Immunol Res. 7(8): 1371-1380, Aug 2019.

Feven Tameire, Ioannis I Verginadis, Nektaria Maria Leli, Christine Polte, Crystal S Conn, Rani Ojha, Carlo Salas Salinas, Frank Chinga, Alexandra M Monroy, Weixuan Fu, Paul Wang, Andrew Kossenkov, Jiangbin Ye, Ravi K Amaravadi, Zoya Ignatova , Serge Y Fuchs, J Alan Diehl, Davide Ruggero, Constantinos Koumenis. : ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nat Cell Biol. 21(7): 889-899, Jul 2019.

Thomas B Karasic, Mark H O'Hara, Arturo Loaiza-Bonilla, Kim A Reiss, Ursina R Teitelbaum, Erkut Borazanci, Ana De Jesus-Acosta, Colleen Redlinger, Jessica A Burrell, Daniel A Laheru, Daniel D Von Hoff, Ravi K Amaravadi, Jeffrey A Drebin, Peter J O'Dwyer. : Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial. JAMA Oncol. 5(7): 993-998, Jul 2019.

Omar Khan, Josephine R Giles, Sierra McDonald, Sasikanth Manne, Shin Foong Ngiow, Kunal P Patel, Michael T Werner, Alexander C Huang, Katherine A Alexander, Jennifer E Wu, JohnAttanasio, Patrick Yan, Sangeeth M George, Bertram Bengsch, Ryan P Staupe, Greg Donahue, Wei Xu, Ravi K Amaravadi, Xiaowei Xu, Giorgos C Karakousis, Tara C Mitchell, Lynn M Schuchter, Jonathan Kaye, Shelley L Berger, E John Wherry. : TOX transcriptionally and epigenetically programs CD8 T cell exhaustion. Nature 571(7764): 211-218, Jul 2019.

back to top
Last updated: 05/29/2020
The Trustees of the University of Pennsylvania