Keith A. Cengel, MD, PhD
Keith A. Cengel, MD, PhD
Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology
Contact information
3620 Hamilton Walk
Department of Radiation Oncology
180 G John Morgan Building
Philadelphia, PA 19104
Department of Radiation Oncology
180 G John Morgan Building
Philadelphia, PA 19104
Office: 215-898-1035
Fax: 215-349-5445
Fax: 215-349-5445
Email:
keith.cengel@uphs.upenn.edu
keith.cengel@uphs.upenn.edu
Publications
Education:
BS (Biochemistry)
University of Illinois at Urbana-Champaign, 1991.
MS (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1993.
PhD (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1998.
MD
University of Illinois at Urbana-Champaign, 2001.
Permanent linkBS (Biochemistry)
University of Illinois at Urbana-Champaign, 1991.
MS (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1993.
PhD (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1998.
MD
University of Illinois at Urbana-Champaign, 2001.
Description of Research Expertise
1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine.2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors.
3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with pleural and peritoneal malignancies.
Description of Clinical Expertise
Photodynamic TherapyRadiation therapy for neuroendocrine and thoracic tumors
Selected Publications
Fishbein, L, Bonner, L, Torigian, DA, Nathanson, KL, Cohen, DL, Pryma, D, Cengel, KA : External Beam Radiation Therapy (EBRT) for Patients with Malignant Pheochromocytoma and Non-Head and Neck Paraganglioma: Combination with 131I-MIBG. Horm Metab Res In Press, 2012.Friedberg, JS, Culligan, M, Sterman, J, Stevenson, J, Glatstein, E, Hahn, SM, Cengel, KA: Radical Pleurectomy and Intraoperative Photodynamic Therapy for Malignant Pleural Mesothelioma. Ann Thor Surg In Press, 2012.
Cengel, KA, Punekar, S, Diffenderfer, ES, Gridley, D, Wroe, A, Weissman, D, Kennedy AR: Skin Toxicity of Solar Particle Event Radiation: Dependence on Dose-Distribution Rather than Particle Identity. NASA Human Research Program Meeting, Houston, TX 2012.
York, J, McDaniel, A, Blevins, N, Guillet, R. Allison, S, Cengel, KA, Freund, GG: Individually Ventilated Cages Cause Chronic Low-Grade Hypoxia Impacting Mice Hematologically and Behaviorally. Brain Behav Immun In Press, 2012.
Simone, CB, Friedberg, JS, Cengel, KA: Photodynamic Therapy for Pleural Malignancies. Handbook of Photomedicine. Hamblin, MR, Sharma SK (eds.). Taylor & Francis, In Press, 2012.
Simone CB, Friedberg JS, Glatstein E, Stevenson JP, Sterman DH, Hahn SM, Cengel KA: Photodynamic Therapy for the Treatment of Non-Small Cell Lung Cancer. J Thorac Dis 4: 63-75, 2012.
Allen Aaron M, Pawlicki Todd, Dong Lei, Fourkal Eugene, Buyyounouski Mark, Cengel Keith, Plastaras John, Bucci Mary K, Yock Torunn I, Bonilla Luisa, Price Robert, Harris Eleanor E, Konski Andre A: An Evidence Based Review of Proton Beam Therapy: The Report of ASTRO's Emerging Technology Committee. Radiother Oncol 103: 8-11, 2012.
Cengel, K, Yendamuri, S, Demmy, T, Culligan, M, Schofield, M, Smith, D, Punekar, S, Sterman, D, Stevenson, J, Busch, T Glatstein, E, Hahn, S, Friedberg, J : Qualitative And Quantitative Differences in the Toxicity Of HPPH-Mediated PDT with a 24 Versus 48-Hour Drug Light Interval: Moving from the Bedside to the Bench and Back. SPIE Photonics West, San Francisco, CA 2012.
Wilson, JM, Diffenderfer, ES, Sanzari, JK, Yee, S, Seykora, JT, Maks, C, Ware, JH, Litt, HI, Reetz, JA, McDonough, J, Weissman, D, Kennedy, AR, Cengel, KA : Acute Biological Effects of Simulating the Whole Body Radiation Dose Distribution from a Solar Particle Event Using a Porcine Model. Rad Res 176: 649-659, 2011.
Christofidou-Solomidou, M, Tyagi, S, Tan, K-S, Hagan, S, Pietrofesa, R, Dukes, F, Arguiri, E, Heitjan, DF, Solomides, CC, Cengel, KA.: Dietary Flaxseed Administered Post-Thoracic Radiation Treatment Improves Survival and Mitigates Radiation-Induced Pneumonopathy in Mice. BMC Cancer 11: 269, 2011.
| Protocol | Title | Status |
|---|---|---|
| 806831 | UPCC 02507 A Phase I Trial of Photodynamic Therapy with HPPH in Patients with Pleural Malignancy | Recruiting |