Keith A. Cengel, M.D., Ph.D.
Univ of Pennsylvania, Perelman School of Medicine
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
University of Illinois at Urbana-Champaign, 1991.
University of Illinois at Urbana-Champaign, 1991.
MS (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1993.
PhD (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1998.
University of Illinois at Urbana-Champaign, 2001.
Description of Research ExpertiseRESEARCH INTERESTS:
1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine.
2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors.
3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with cancers that are difficult to treat using current standard modalities.
Description of Clinical ExpertisePhotodynamic Therapy
Radiation therapy for neuroendocrine and thoracic tumors
Selected PublicationsZhu Timothy C, Ong Yihong, Kim Michele M, Liang Xing, Finlay Jarod C, Dimofte Andreea, Simone Nd Charles B, Friedberg Joseph S, Busch Theresa M, Glatstein Eli, Cengel Keith A: Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH-mediated Pleural Photodynamic Therapy (pPDT). Photochemistry and photobiology Sep 2019.
Chinniah Chimbu, Aguarin Louise, Cheng Phillip, Decesaris Cristina, Cutillo Alicia, Berman Abigail T, Frick Melissa, Doucette Abigail, Cengel Keith A, Levin William, Hahn Stephen, Dorsey Jay F, Simone Charles B, Kao Gary D: Early Detection of Recurrence in Patients With Locally Advanced Non-Small-Cell Lung Cancer via Circulating Tumor Cell Analysis. Clinical lung cancer 20(5): 384-390.e2, Sep 2019.
Berger Ian, Cengel Keith A, Simone Charles B, Alley Evan W, Roshkovan Leonid, Haas Andrew R, Patel Akash M, Khalid Urooj, Culligan Melissa J, McNulty Sally, Singhal Sunil, Friedberg Joseph S, Katz Sharyn I: Lymphangitic carcinomatosis: A common radiographic manifestation of local failure following extended pleurectomy/decortication in patients with malignant pleural mesothelioma. Lung cancer (Amsterdam, Netherlands) 132: 94-98, Jun 2019.
Kim Michele, Irmen Peyton, Shoniyozov Khayrullo, Verginadis Ioannis I, Cengel Keith A, Koumenis Costas, Metz James M, Dong Lei, Diffenderfer Eric: Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research. Physics in medicine and biology May 2019.
Luna José Marcio, Chao Hann-Hsiang, Diffenderfer Eric S, Valdes Gilmer, Chinniah Chidambaram, Ma Grace, Cengel Keith A, Solberg Timothy D, Berman Abigail T, Simone Charles B: Predicting radiation pneumonitis in locally advanced stage II-III non-small cell lung cancer using machine learning. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 133: 106-112, Apr 2019.
Cramer Gwendolyn, Shin Michael, Hagan Sarah, Katz Sharyn I, Simone Charles B, Busch Theresa M, Cengel Keith A: Modeling Epidermal Growth Factor Inhibitor-mediated Enhancement of Photodynamic Therapy Efficacy Using 3D Mesothelioma Cell Culture. Photochemistry and photobiology 95(1): 397-405, Jan 2019.
Predina Jarrod D, Newton Andrew D, Corbett Christopher, Xia Leilei, Shin Michael, Sulfyok Lydia Frenzel, Okusanya Olugbenga T, Cengel Keith A, Haas Andrew, Litzky Leslie, Kucharczuk John C, Singhal Sunil: A Clinical Trial of TumorGlow to Identify Residual Disease During Pleurectomy and Decortication. The Annals of thoracic surgery 107(1): 224-232, Jan 2019.
Schonewolf Caitlin A, Heskel Marina, Doucette Abigail, Singhal Sunil, Frick Melissa A, Xanthopoulos Eric P, Corradetti Michael N, Friedberg Joseph S, Pechet Taine T, Christodouleas John P, Levin William, Berman Abigail, Cengel Keith A, Verma Vivek, Hahn Stephen M, Kucharczuk John C, Rengan Ramesh, Simone Charles B: Five-year Long-term Outcomes of Stereotactic Body Radiation Therapy for Operable Versus Medically Inoperable Stage I Non-small-cell Lung Cancer: Analysis by Operability, Fractionation Regimen, Tumor Size, and Tumor Location. Clinical lung cancer 20(1): e63-e71, Jan 2019.
Davis Richard W, Snyder Emma, Miller Joann, Carter Shirron, Houser Cassandra, Klampatsa Astero, Albelda Steven M, Cengel Keith A, Busch Theresa M: Luminol Chemiluminescence Reports Photodynamic Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy. Photochemistry and photobiology 95(1): 430-438, Jan 2019.
Rice Stephanie R, Li Yun R, Busch Theresa M, Kim Michele M, McNulty Sally, Dimofte Andrea, Zhu Timothy C, Cengel Keith A, Simone Charles B: A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma. Photochemistry and photobiology 95(1): 411-418, Jan 2019.