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Keith A. Cengel, M.D., Ph.D.
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Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
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Director, Photodynamic Therapy Program, University of Pennsylvania
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Vice-Chair, Data and Safety Monitoring Board, Abramson Cancer Center
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Executive Director, Penn Mesothelioma and Pleural Diseases Program
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Department: Radiation Oncology
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Contact information
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Smilow Center for Translational Research, Room 8-136
39 Univ of Pennsylvania, Perelman School of Medicine
43 3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
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39 Univ of Pennsylvania, Perelman School of Medicine
43 3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
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Office: 215-898-1035
32 Fax: 215-349-5445
32 Lab: 215-898-0838
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32 Fax: 215-349-5445
32 Lab: 215-898-0838
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Publications
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Education:
21 7 BS 19 (Biochemistry) c
43 University of Illinois at Urbana-Champaign, 1991.
21 7 BS 14 (Biology) c
43 University of Illinois at Urbana-Champaign, 1991.
21 7 MS 27 (Cellular/Molecular Biology) c
43 University of Illinois at Urbana-Champaign, 1993.
21 8 PhD 27 (Cellular/Molecular Biology) c
43 University of Illinois at Urbana-Champaign, 1998.
21 7 MD 14 (Medical) c
43 University of Illinois at Urbana-Champaign, 2001.
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Permanent link21 7 BS 19 (Biochemistry) c
43 University of Illinois at Urbana-Champaign, 1991.
21 7 BS 14 (Biology) c
43 University of Illinois at Urbana-Champaign, 1991.
21 7 MS 27 (Cellular/Molecular Biology) c
43 University of Illinois at Urbana-Champaign, 1993.
21 8 PhD 27 (Cellular/Molecular Biology) c
43 University of Illinois at Urbana-Champaign, 1998.
21 7 MD 14 (Medical) c
43 University of Illinois at Urbana-Champaign, 2001.
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1d8 1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine.
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101 2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors.
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f6 3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with cancers that are difficult to treat using current standard modalities.
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3f Radiation therapy for neuroendocrine and thoracic tumors
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Description of Research Expertise
24 RESEARCH INTERESTS:1d8 1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine.
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101 2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors.
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f6 3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with cancers that are difficult to treat using current standard modalities.
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Description of Clinical Expertise
25 Photodynamic Therapy3f Radiation therapy for neuroendocrine and thoracic tumors
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240 Feigenberg SJ, Costabile F, Tanes C, Bittinger K, O'Connor R, Agarwal D, Skoufos G, Salaris S, Hatzigeorgiou A, Kostopoulos N, Lloyd S, Friedes C, Chen L, Yegya-Raman N, Cengel K, Levin W, Valentić B, Quarton T, Shestov AA, Berman A, Bradley J, Maity A, Koumenis C, Ben-Josef E, Facciabene A.: Enhancing outcomes in medically inoperable early-stage NSCLC with gut-targeted antibiotics and stereotactic body radiotherapy: results from a randomized pilot study. J Immunother Cancer 13: e011356, Jul 2025.
16d Jenna Rocchetti 1, Nikhil Yegya-Raman 1, Michelle Iocolano 1, William P Levin 1, Keith A Cengel 1, Jeffrey Bradley 1, Steven J Feigenberg 1, Cole Friedes 2: Salvage thoracic reirradiation for recurrent non-small cell lung cancer: Clinical efficacy and the impact of consolidative immunotherapy. Radiother Oncol 1f July 2025.
1b9 Seyyedeh Azar Oliaei Motlagh 1, François Vander Stappen 2, Michele M Kim 1, Rudi Labarbe 2, Lucian Hotoiu 2, Arnaud Pin 2, Rasmus Nilsson 3, Erik Traneus 3, Keith A Cengel 1, Wei Zou 1, Boon-Keng Kevin Teo 1, Lei Dong 1, Eric S Diffenderfer 1: Verification of dose and dose rate for quality assurance of spread-out-Bragg-peak proton FLASH radiotherapy using machine log files. Med Phys 20 June 2025.
255 Gwendolyn M Cramer 1, Richard W Davis 4th 1, Emmanouil Papasavvas 2, Astero Klampatsa 3, Joann M Miller 1, Shirron Carter 1, Ruth Ikpe 1, Min Yuan 1, Sandy Widura 2, R Sonali Majumdar 2, Sally McNulty 1, Mary Putt 4, Andrew V Kossenkov 2, Luis J Montaner 2, Sunil Singhal 5, Edmund K Moon 3, Steven M Albelda 3, Keith A Cengel 1, Theresa M Busch 1: PD-1 Blockade Mitigates Surgery-Induced Immunosuppression and Increases the Efficacy of Photodynamic Therapy for Pleural Mesothelioma. Cancer Res Commun 5: 841-856, May 2025.
286 Ioannis I Verginadis 1, Anastasia Velalopoulou 1, Michele M Kim 1, Kyle Kim 1, Ioannis Paraskevaidis 1, Brett Bell 2, Seyyedeh Azar Oliaei Motlagh 1, Antoneta Karaj 3, Esha Banerjee 4, Giovanni Finesso 4, Charles-Antoine Assenmacher 4, Enrico Radaelli 4, Jiawei Lu 5, Yuewei Lin 5, Mary E Putt 3, Eric S Diffenderfer 1, Chandan Guha 2, Ling Qin 5, James M Metz 1, Amit Maity 1, Keith A Cengel 1, Constantinos Koumenis 1, Theresa M Busch 6: FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone. Radiother Oncol 20 April 2025.
17c Stalker M, Walker SL, Lebow E, Pai EL, Watts A, Hwang WT, Banihashemi A, Anderson E, Roshkovan L, Katz SI, Litzky L, Haas AR, Singhal S, Langer CJ, Cengel K, Marmarelis ME.: Incidence and Outcomes of Brain Metastasis in Pleural Mesothelioma in the Era of Immunotherapy. JTO Clin Res Rep 6: 100823, Mar 2025.
158 Hongjing Sun 1 2, Michele M Kim 1, Yi Hong Ong 1, Andreea Dimofte 1, Sunil Singhal 3, Theresa M Busch 1, Keith A Cengel 1, Timothy C Zhu 1: Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates. Photochem Photobiol 1f Jan 2025.
f6 Wang H, Yao L, Zhong L, Fang J, He Q, Busch TM, Cengel K, Qin L.: Marrow adipogenic lineage precursors (MALPs) facilitate bone marrow recovery after chemotherapy. Bone 2025.
140 Cengel KA, Belal Z, Kim MM, Hagan S, Camps S, Kalinin A, Hsue W, Diffenderfer E, Garonna A, Tschabrunn C.: Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system. Clin Transl Radiat Oncol 51: 100904, Dec 2024.
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Selected Publications
168 Friberg AM, Tan HS, Diffenderfer ES, Verginadis I, Kim MM, Cengel K, Wiersma R, Dong L, Koumenis C, Teo BK, Zou W.: Physicochemical indication of the FLASH effect from shoot-through proton pencil beam scanning parameters delivered under ultra-high dose rates. Phys Med Biol 70, Aug 2025.240 Feigenberg SJ, Costabile F, Tanes C, Bittinger K, O'Connor R, Agarwal D, Skoufos G, Salaris S, Hatzigeorgiou A, Kostopoulos N, Lloyd S, Friedes C, Chen L, Yegya-Raman N, Cengel K, Levin W, Valentić B, Quarton T, Shestov AA, Berman A, Bradley J, Maity A, Koumenis C, Ben-Josef E, Facciabene A.: Enhancing outcomes in medically inoperable early-stage NSCLC with gut-targeted antibiotics and stereotactic body radiotherapy: results from a randomized pilot study. J Immunother Cancer 13: e011356, Jul 2025.
16d Jenna Rocchetti 1, Nikhil Yegya-Raman 1, Michelle Iocolano 1, William P Levin 1, Keith A Cengel 1, Jeffrey Bradley 1, Steven J Feigenberg 1, Cole Friedes 2: Salvage thoracic reirradiation for recurrent non-small cell lung cancer: Clinical efficacy and the impact of consolidative immunotherapy. Radiother Oncol 1f July 2025.
1b9 Seyyedeh Azar Oliaei Motlagh 1, François Vander Stappen 2, Michele M Kim 1, Rudi Labarbe 2, Lucian Hotoiu 2, Arnaud Pin 2, Rasmus Nilsson 3, Erik Traneus 3, Keith A Cengel 1, Wei Zou 1, Boon-Keng Kevin Teo 1, Lei Dong 1, Eric S Diffenderfer 1: Verification of dose and dose rate for quality assurance of spread-out-Bragg-peak proton FLASH radiotherapy using machine log files. Med Phys 20 June 2025.
255 Gwendolyn M Cramer 1, Richard W Davis 4th 1, Emmanouil Papasavvas 2, Astero Klampatsa 3, Joann M Miller 1, Shirron Carter 1, Ruth Ikpe 1, Min Yuan 1, Sandy Widura 2, R Sonali Majumdar 2, Sally McNulty 1, Mary Putt 4, Andrew V Kossenkov 2, Luis J Montaner 2, Sunil Singhal 5, Edmund K Moon 3, Steven M Albelda 3, Keith A Cengel 1, Theresa M Busch 1: PD-1 Blockade Mitigates Surgery-Induced Immunosuppression and Increases the Efficacy of Photodynamic Therapy for Pleural Mesothelioma. Cancer Res Commun 5: 841-856, May 2025.
286 Ioannis I Verginadis 1, Anastasia Velalopoulou 1, Michele M Kim 1, Kyle Kim 1, Ioannis Paraskevaidis 1, Brett Bell 2, Seyyedeh Azar Oliaei Motlagh 1, Antoneta Karaj 3, Esha Banerjee 4, Giovanni Finesso 4, Charles-Antoine Assenmacher 4, Enrico Radaelli 4, Jiawei Lu 5, Yuewei Lin 5, Mary E Putt 3, Eric S Diffenderfer 1, Chandan Guha 2, Ling Qin 5, James M Metz 1, Amit Maity 1, Keith A Cengel 1, Constantinos Koumenis 1, Theresa M Busch 6: FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone. Radiother Oncol 20 April 2025.
17c Stalker M, Walker SL, Lebow E, Pai EL, Watts A, Hwang WT, Banihashemi A, Anderson E, Roshkovan L, Katz SI, Litzky L, Haas AR, Singhal S, Langer CJ, Cengel K, Marmarelis ME.: Incidence and Outcomes of Brain Metastasis in Pleural Mesothelioma in the Era of Immunotherapy. JTO Clin Res Rep 6: 100823, Mar 2025.
158 Hongjing Sun 1 2, Michele M Kim 1, Yi Hong Ong 1, Andreea Dimofte 1, Sunil Singhal 3, Theresa M Busch 1, Keith A Cengel 1, Timothy C Zhu 1: Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates. Photochem Photobiol 1f Jan 2025.
f6 Wang H, Yao L, Zhong L, Fang J, He Q, Busch TM, Cengel K, Qin L.: Marrow adipogenic lineage precursors (MALPs) facilitate bone marrow recovery after chemotherapy. Bone 2025.
140 Cengel KA, Belal Z, Kim MM, Hagan S, Camps S, Kalinin A, Hsue W, Diffenderfer E, Garonna A, Tschabrunn C.: Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system. Clin Transl Radiat Oncol 51: 100904, Dec 2024.
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