Keith A. Cengel, M.D., Ph.D.

faculty photo
Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Smilow Center for Translational Research, Room 8-136
Univ of Pennsylvania, Perelman School of Medicine
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
Office: 215-898-1035
Fax: 215-349-5445
Lab: 215-898-0838
Education:
BS (Biochemistry)
University of Illinois at Urbana-Champaign, 1991.
BS (Biology)
University of Illinois at Urbana-Champaign, 1991.
MS (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1993.
PhD (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1998.
MD (Medical)
University of Illinois at Urbana-Champaign, 2001.
Permanent link
 
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Description of Research Expertise

RESEARCH INTERESTS:
1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine.

2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors.

3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with cancers that are difficult to treat using current standard modalities.

Description of Clinical Expertise

Photodynamic Therapy
Radiation therapy for neuroendocrine and thoracic tumors

Selected Publications

Luna José Marcio, Chao Hann-Hsiang, Shinohara Russel T, Ungar Lyle H, Cengel Keith A, Pryma Daniel A, Chinniah Chidambaram, Berman Abigail T, Katz Sharyn I, Kontos Despina, Simone Charles B, Diffenderfer Eric S: Machine learning highlights the deficiency of conventional dosimetric constraints for prevention of high-grade radiation esophagitis in non-small cell lung cancer treated with chemoradiation. Clinical and translational radiation oncology 22: 69-75, May 2020.

Cramer Gwendolyn, Lewis Robert, Gymarty Ashley, Hagan Sarah, Mickler Michela, Evans Sydney, Punekar Salman R, Shuman Lee, Simone Charles B, Hahn Stephen M, Busch Theresa M, Fraker Douglass, Cengel Keith A: Preclinical Evaluation of Cetuximab and Benzoporphyrin Derivative-Mediated Intraperitoneal Photodynamic Therapy in a Canine Model. Photochemistry and photobiology Mar 2020 Notes: doi: 10.1111/php.13247.

Busch Theresa M, Cengel Keith A, Zhu Timothy C: In Memoriam Jarod C. Finlay, PhD. Photochemistry and photobiology 96(2): 218, Mar 2020.

Cramer Gwendolyn M, Sandell Meo Julia, Finlay Jarod C, Zhu Timothy C, Busch Theresa M, Cengel Keith A: In vivo Spectroscopic Evaluation of the Intraperitoneal Cavity in Canines. Photochemistry and photobiology Feb 2020 Notes: doi: 10.1111/php.13226.

Dupre Pamela J, Ong Yi Hong, Friedberg Joseph, Singhal Sunil, Carter Shirron, Simone Charles B, Finlay Jarod C, Zhu Timothy C, Cengel Keith A, Busch Theresa M: Light Fluence Rate and Tissue Oxygenation (S O ) Distributions Within the Thoracic Cavity of Patients Receiving Intraoperative Photodynamic Therapy for Malignant Pleural Mesothelioma. Photochemistry and photobiology Feb 2020 Notes: doi: 10.1111/php.13224.

Kim Michele M, Zhu Timothy C, Ong Yi Hong, Finlay Jarod C, Dimofte Andreea, Singhal Sunil, Glatstein Eli, Cengel Keith A: Infrared navigation system for light dosimetry during pleural photodynamic therapy. Physics in medicine and biology Feb 2020 Notes: doi: 10.1088/1361-6560/ab7632.

Frick Melissa A, Feigenberg Steven J, Jean-Baptiste Samuel R, Aguarin Louise A, Mendes Amberly, Chinniah Chimbu, Swisher-McClure Sam, Berman Abigail, Levin William, Cengel Keith A, Hahn Stephen M, Dorsey Jay F, Simone Charles B, Kao Gary D: Circulating Tumor Cells Are Associated with Recurrent Disease in Patients with Early-stage Non-small Cell Lung Cancer Treated with Stereotactic Body Radiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research Jan 2020.

Diffenderfer Eric S, Verginadis Ioannis I, Kim Michele M, Shoniyozov Khayrullo, Velalopoulou Anastasia, Goia Denisa, Putt Mary, Hagan Sarah, Avery Stephen, Teo Kevin, Zou Wei, Lin Alexander, Swisher-McClure Samuel, Koch Cameron, Kennedy Ann R, Minn Andy, Maity Amit, Busch Theresa M, Dong Lei, Koumenis Costas, Metz James, Cengel Keith A: Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System. International journal of radiation oncology, biology, physics 106(2): 440-448, 02 2020.

Barsky, A. R., Kim, M. M., Williams, G. R., Lally, B. E., Ingram, W. S., Cengel, K. A., Feigenberg, S. J.: Proton-Beam Therapy: At the Heart of Cardiac Dose-Sparing in Mediastinal Radiotherapy for Thymic Carcinoma. J Thorac Oncol 15(7): 1240-1242, 2020.

Barsky, A. R., Ahern, C. A., Venigalla, S., Verma, V., Anstadt, E. J., Wright, C. M., Ludmir, E. B., Berlind, C. G., Lindsay, W. D., Grover, S., Cengel, K. A., Simone, C. B., 2nd: Gender-based Disparities in Receipt of Care and Survival in Malignant Pleural Mesothelioma. Clin Lung Cancer 2020.

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Last updated: 07/07/2020
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