Nilam S. Mangalmurti, MD
Nilam S. Mangalmurti, MD
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine
Contact information
1016 A Abramson Research Center
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 2155734590
Fax: 2155734469
Lab: 2155735973
Fax: 2155734469
Lab: 2155735973
Email:
nspatel@mail.med.upenn.edu
nspatel@mail.med.upenn.edu
Education:
BA (Biology and South Asian Studies)
University of Pennsylvania, 1998.
MD (Medicine)
Temple University School of Medicine, 2002.
Permanent linkBA (Biology and South Asian Studies)
University of Pennsylvania, 1998.
MD (Medicine)
Temple University School of Medicine, 2002.
Description of Clinical Expertise
Dr. Mangalmurti serves as an attending physician for the Medical Intensive Care Unit and the Procedure and Resuscitation Service at the Hospital of the University of Pennsylvania. Dr. Mangalmurti’s clinical interests include acute lung injury and the management of the critically ill patient.Description of Research Expertise
Dr. Mangalmurti’s research interests include lung inflammation, erythrocyte-endothelial interactions and the role of red cell transfusions in altering the lung inflammatory response to injury. She is interested in how the formation of novel red cell antigens during erythrocyte storage can alter cell-cell interactions and augment lung injury in vivo. The primary focus of the lab has been examining the role of the Receptor for Advanced Glycation End-Products (RAGE),a multi-ligand receptor that is highly expressed in the lung and may perpetuate lung inflammation following transfusion. Dr. Mangalmurti’s research seeks to advance our understanding of how the red cell “storage lesion” may adversely affect susceptible transfusion recipients.Selected Publications
Mangalmurti NS, Friedman JL, Wang LC, Stolz DB, Muthukumaran G, Siegel DL, Schmidt AM, Lee JS, Albelda SM: The Receptor for Advanced Glycation End Products Mediates Lung Endothelial Activation by RBCs. Am J Physiol Lung Cell Mol Physiol December 2012.Mangalmurti NS, Friedman JL, Wang LC, Sun J, Siegel DL, Lee JS, Albelda SM. : “Banked RBCs Induce the Expression of the Receptor for Advanced Glycation Endproducts (RAGE) on Lung Endothelial Cells” American Thoracic Society May 2012 Notes: Selected for poster discussion.
Shah RJ, Bellamy SL, Lee JC, Cantu E, Diamond JM, Mangalmurti N, Kawut, SM, Ware LB, Christie JD: Early plasma soluble Receptor for Advanced Glycation End Product levels are associated with bronchiolitis obliterans syndrome. American Journal of Transplantation 2012 Notes: in press.
Cheng Guanjun, Wang Liang-Chuan S, Fridlender Zvi G, Cheng Guang-Shing, Chen Bei, Mangalmurti Nilam S, Saloura Vassiliki, Yu Zaifang, Kapoor Veena, Mozdzanowska Krystyna, Moon Edmund, Sun Jing, Kreindler James L, Cohen Noam A, Caton Andrew J, Erikson Jan, Albelda Steven M: Pharmacologic activation of the innate immune system to prevent respiratory viral infections. American Journal of Respiratory Cell and Molecular Biology 45(3): 480-8, Sep 2011.
Mangalmurti NS, Friedman JL, Wang LC, Sun J, Albelda SM.: The Receptor for Advanced Glycation Endproducts (RAGE) is expressed on Lung Endothelial Cells and is Inducible by Banked RBCs. University of Pennsylvania Respiration Research Retreat June 2011 Notes: Selected for oral presentation.
Zhao Y, Mangalmurti NS, Xiong Z, Prakash B, Stolz DB, Lee JS.: Chemokine Endocytosis by P. vivax Malaria Receptor Duffy Antigen is Predominantly Mediated Through Macropinocytosis in Endothelial Cells. American Thoracic Society International Conference May 2011 Notes: Poster.
Xiong Z, Cavaretta J, Stolz DB, Mangalmurti NS, Triulzi D, Gladwin MT, Lee JS.: Erythroid Microparticles from Stored RBC Units Elicit TNF-a response in Macrophages. American Thoracic Society International Conference May 2011 Notes: Selected for poster discussion.
Yani Zhao, Nilam Mangalmurti, Zeyu Xiong, Bharat Prakash, Fengli Guo, Donna B. Stolz, and Janet S. Lee: DARC-mediated CXCL1 endocytosis is caveolin-1 independent and occurs through a macropinocytosis-like process in endothelial cells. Plos One. PMID 22216333. 2011.
Mangalmurti Nilam S, Chatterjee Shampa, Cheng Guanjun, Andersen Emily, Mohammed Aishat, Siegel Donald L, Schmidt Ann Marie, Albelda Steven M, Lee Janet S: Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products. Transfusion 50(11): 2353-61, Nov 2010.
Mangalmurti NS, Cheng G, Mohammed A, Lee JS, Albelda SM. : Activation of Pulmonary Endothelial Cells by banked RBCs and LPS. American Thoracic Society International Conference May 2010 Notes: Poster.