Nilam S. Mangalmurti, MD

faculty photo
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 2155739918
Fax: 2155734469
Education:
BA (Biology and South Asian Studies)
University of Pennsylvania, 1998.
MD (Medicine)
Temple University School of Medicine, 2002.
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Description of Clinical Expertise

Dr. Mangalmurti serves as an attending physician for the Medical Intensive Care Unit and the Procedure and Resuscitation Service at the Hospital of the University of Pennsylvania. Dr. Mangalmurti’s clinical interests include acute lung injury and the management of the critically ill patient.

Description of Research Expertise

My research interests stem from my clinical interest in sepsis and lung injury. Our lab investigates how red blood cells and lung endothelium modulate innate immune responses. Our current research aims to understand the mechanisms of the programmed cell death pathway necroptosis in lung endothelium and the role of danger signals released during necroptosis in the development of lung injury. We have also focused on defining the immunomodulatory properties of RBCs and their role in the development of lung injury. Our lab utilizes murine models, human cell culture models, patient samples and dynamic microfluidic models of RBC-induced endothelial injury in order to understand how perturbations of normal RBC and endothelial function contribute to lung inflammation and injury.

Selected Publications

Hotz JM, Qing D, Shashaty Michael GS, Zhang P, Faust H, Sondheimer N , Rivella S, Worthen GS, Mangalmurti, NS.: RBCs homeostatically bind mtDNA through TLR9 to maintain quiescence and prevent lung injury. American Journal of Respiratory and Critical Care Medicine 197(4): 470-480, February 2018.

Jeongyun Seo1, David Conegliano1, Megan Farrell, Minseon Cho, Xueting Ding, Thomas Seykora, Danielle Qing, Nilam S. Mangalmurti, Dongeun Huh : A microengineered model of RBC transfusion-induced pulmonary vascular injury. Scientific Reports 7(1): 3413, June 2017.

Shashaty MGS, Reilly JP, Sims C, Holena DN, Qing D, Meyer NJ, Lanken PN, Feldman HI, Christie JD, Mangalmurti NS : Plasma levels of receptor interacting protein kinase-3 (RIP3), an essential mediator of necroptosis, are associated with acute kidney injury in critically ill trauma patients. Shock 46(2): 139-143, Aug 2016.

Qing D,Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS.: RBCs Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation. American Journal of Respiratory and Critical Care Medicine 190(11): 1243-54, December 2014.

Mangalmurti NS, Friedman JL, Wang LC, Stolz DB, Muthukumaran G, Siegel DL, Schmidt AM, Lee JS, Albelda SM: The Receptor for Advanced Glycation End Products Mediates Lung Endothelial Activation by RBCs. Am J Physiol Lung Cell Mol Physiol 304(4): 250-63, February 2013.

Mangalmurti Nilam S, Chatterjee Shampa, Cheng Guanjun, Andersen Emily, Mohammed Aishat, Siegel Donald L, Schmidt Ann Marie, Albelda Steven M, Lee Janet S: Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products. Transfusion 50(11): 2353-61, Nov 2010.

Mangalmurti Nilam S, Xiong Zeyu, Hulver Mei, Ranganathan Mrunalini, Liu Xiang Hong, Oriss Timothy, Fitzpatrick Meghan, Rubin Marc, Triulzi Darrell, Choi Augustine, Lee Janet S: Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood 113(5): 1158-66, Jan 2009.

Christie JD, Shah CV, Kawut SM, Mangalmurti N, Lederer DJ, Sonett JR, Ahya VN, Palmer SM, Wille K, Lama V, Shah PD, Shah A, Weinacker A, Deutschman CS, Kohl BA, Demissie E, Bellamy S, Ware LB: Plasma Levels of Receptor for Advanced Glycation End-Products (sRAGE), Blood Transfusion, and Risk Of Primary Graft Dysfunction. American Journal of Respiratory and Critical Care Medicine 180(10): 1010-1015, November 2009.

Yani Zhao, Nilam Mangalmurti, Zeyu Xiong, Bharat Prakash, Fengli Guo, Donna B. Stolz, and Janet S. Lee: DARC-mediated CXCL1 endocytosis is caveolin-1 independent and occurs through a macropinocytosis-like process in endothelial cells. Plos One 6(12), December 2011.

Reilly JP, Anderson BJ, Mangalmurti NS, Nguyen TD, Holena DN, Wu Q, Nguyen ET, Reilly MP, Lanken PN, Christie JD, Meyer NJ, Shashaty MGS: The ABO histo-blood group and acute kidney injury in critically ill trauma and sepsis patients. Clinical Journal of the American Society of Nephrology. 10(11): 1911-1920, Nov 2015

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Last updated: 03/09/2018
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