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Jay Fitzgerald Dorsey, M.D., Ph.D.
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Associate Professor of Radiation Oncology
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Attending Physician, Hospital of the University of Pennsylvania
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Attending Physician, Pennsylvania Hospital
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Courtesy Staff - Radiation Oncology, Chester County Hospital
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Contract Physician - Radiation Oncology, Philadelphia Veterans Medical Center
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Active Staff - Radiation Oncology, Penn Medicine at Valley Forge
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Department: Radiation Oncology
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Graduate Group Affiliations
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- Bioengineering e
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Contact information
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Department of Radiation Oncology
2d Perelman Center for Advanced Medicine
1b Bldg 421 SCTR 8-135
39 3400 Civic Center Blvd
Philadelphia, PA 19104
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2d Perelman Center for Advanced Medicine
1b Bldg 421 SCTR 8-135
39 3400 Civic Center Blvd
Philadelphia, PA 19104
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Office: (215) 662-2428
34 Fax: (215) 349-5445
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34 Fax: (215) 349-5445
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Publications
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Links
df Search PubMed for articles
80 Department of Radiation Oncology, University of Pennsylvania
53 Dorsey Lab Website
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df Search PubMed for articles
80 Department of Radiation Oncology, University of Pennsylvania
53 Dorsey Lab Website
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Education:
21 a BSChE 21 (Chemical Engineering) c
2e University of Florida, 1995.
21 a MSChE 21 (Chemical Engineering) c
34 University of South Florida, 1997.
21 a Ph.D. c
5f University of South Florida (H. Lee Moffitt Cancer Research Institute), 2003.
21 9 M.D. c
48 University of South Florida College of Medicine, 2003.
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Permanent link21 a BSChE 21 (Chemical Engineering) c
2e University of Florida, 1995.
21 a MSChE 21 (Chemical Engineering) c
34 University of South Florida, 1997.
21 a Ph.D. c
5f University of South Florida (H. Lee Moffitt Cancer Research Institute), 2003.
21 9 M.D. c
48 University of South Florida College of Medicine, 2003.
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182 Dr. Dorsey also serves as a standing member of the K99/R00 transition to independence NIH study section and is the PI and Director of (NIH R25-funded undergraduate research pipeline program) SUPERS@PENN program which seeks to introduce the next generation of biomedical scientists to undergraduate research in oncology/medical physics/bioengineering/radiology/radiation biology.
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b1 He has published in journals such as Cancer Research, Cell, Nature Communications, Nature Cancer, ACS Nano, Int J Radiat Oncol Biol Phys., and Molecular Cancer Research.
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6e His work has been funded by ASCO, RSNA, Burroughs Wellcome Fund, and the National Institutes of Health.
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cf His medical training and experience include an internship in Internal Medicine, ABR-sponsored Holman Research Pathway residency in Radiation Oncology at the Hospital of the University of Pennsylvania.
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Description of Research Expertise
2a4 Jay Dorsey, MD, PhD has been continuously funded by the NIH for the past decade. He has expertise in genomics, precision medicine, circulating tumor material/liquid biopsy, molecular diagnostics, cancer biomarkers, nanoparticle therapeutics, preclinical tumor models, and clinical trials. His lab focuses on translational-facing research that explores areas of brain tumor biology, biomarkers of resistance/sensitivity to radiation and chemotherapies and identification of predictive/prognostic single-cell biomarkers of solid tumors, including GBM, lung and melanoma. He is Co-Leader of the Abramson Cancer Center's RadOnc Translational Center of Excellence.8
182 Dr. Dorsey also serves as a standing member of the K99/R00 transition to independence NIH study section and is the PI and Director of (NIH R25-funded undergraduate research pipeline program) SUPERS@PENN program which seeks to introduce the next generation of biomedical scientists to undergraduate research in oncology/medical physics/bioengineering/radiology/radiation biology.
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b1 He has published in journals such as Cancer Research, Cell, Nature Communications, Nature Cancer, ACS Nano, Int J Radiat Oncol Biol Phys., and Molecular Cancer Research.
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6e His work has been funded by ASCO, RSNA, Burroughs Wellcome Fund, and the National Institutes of Health.
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Description of Clinical Expertise
22b Jay Dorsey, MD, PhD is a University of Pennsylvania/Penn Medicine-trained Radiation Oncologist, physician, and scientist at the Perelman Center for Advanced Medicine and Smilow Center for Translational Research. He is a tenured Associate Professor at the University of Pennsylvania, where he has clinical expertise in treating primary and metastatic (lung, breast, skin, GI) tumors of the central nervous system. He is ABR board-certified in Radiation Oncology and trained and certified in Gamma Knife stereotactic precision radiosurgery.8
cf His medical training and experience include an internship in Internal Medicine, ABR-sponsored Holman Research Pathway residency in Radiation Oncology at the Hospital of the University of Pennsylvania.
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111 Zhang D, Cleveland AH, Krimitza E, Han K, Yi C, Stout AL, Zou W, Dorsey JF, Gong Y, Fan Y.: Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy. Nat Protoc 2024.
161 Yang F, Akhtar MN, Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, Fuchs SY, Koumenis C, Lathia JD, Mitchell MJ, Gong Y, Fan Y.: An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Sci Adv 2024.
7b Paul R, Dorsey JF, Fan Y: Cell plasticity, senescence, and quiescence in d5 cancer stem cells: Biological and therapeutic implications. Pharmacol Ther. Mar 2022 Notes: PMID: 34480963 PMCID: PMC8844041 (available on 2023-03-01) DOI: 10.1016/j.pharmthera.2021.107985.
e3 Paul R, Dorsey JF, Fan Y.: Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications. Pharmacol Ther 2022.
13d Yang AI, Mensah-Brown KG, Shekhtman EF, Kvint S, Wathen CA, Hitti FL, Alonso-Basanta M, Avery SM, Dorsey JF, Y K Lee J.: Gamma Knife radiosurgery for trigeminal neuralgia provides greater pain relief at higher dose rates. J Radiosurg SBRT 2022.
79 Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, 19f Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y: Multiblock Discriminant Analysis of Integrative 18F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 110(5): 1451-1465, Aug 2021 Notes: doi: 10.1016/j.ijrobp.2021.02.030. Epub 2021.
1d7 Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y.: Multiblock Discriminant Analysis of Integrative (18)F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys 110: 1451-1465, Aug 2021.
1c8 Mathilde Bouché, Yuxi C Dong, Saad Sheikh, Kimberly Taing, Deeksha Saxena, Jessica C Hsu, Minna H Chen, Ryan D Salinas, Hongjun Song, Jason A Burdick, Jay Dorsey, David P Cormode: Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel. ACS Biomater Sci Eng. Jul 2021 Notes: PMID: 34160196 PMCID: PMC8411482 DOI: 10.1021/acsbiomaterials.1c00385.
76 Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh a8 SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH, Gong Y, Fan Y.: Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 65 and CD40. Nat Commun. 12(1), Jun 2021 Notes: doi: 10.1038/s41467-021-23832-3.
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Selected Publications
18c Dastgheyb SS, Dreyfuss AD, LaRiviere MJ, Mohiuddin JJ, Baumann BC, Shabason J, Lustig RA, Dorsey JF, Lin A, Grady SM, O'Malley BW, Lee JYK, Newman JG, Schuster JM, Alonso-Basanta M.: A Prospective Phase I/II Clinical Trial of High-Dose Proton Therapy for Chordomas and Chondrosarcomas. Adv Radiat Oncol 9: 101456, Feb 2024.111 Zhang D, Cleveland AH, Krimitza E, Han K, Yi C, Stout AL, Zou W, Dorsey JF, Gong Y, Fan Y.: Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy. Nat Protoc 2024.
161 Yang F, Akhtar MN, Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, Fuchs SY, Koumenis C, Lathia JD, Mitchell MJ, Gong Y, Fan Y.: An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Sci Adv 2024.
7b Paul R, Dorsey JF, Fan Y: Cell plasticity, senescence, and quiescence in d5 cancer stem cells: Biological and therapeutic implications. Pharmacol Ther. Mar 2022 Notes: PMID: 34480963 PMCID: PMC8844041 (available on 2023-03-01) DOI: 10.1016/j.pharmthera.2021.107985.
e3 Paul R, Dorsey JF, Fan Y.: Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications. Pharmacol Ther 2022.
13d Yang AI, Mensah-Brown KG, Shekhtman EF, Kvint S, Wathen CA, Hitti FL, Alonso-Basanta M, Avery SM, Dorsey JF, Y K Lee J.: Gamma Knife radiosurgery for trigeminal neuralgia provides greater pain relief at higher dose rates. J Radiosurg SBRT 2022.
79 Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, 19f Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y: Multiblock Discriminant Analysis of Integrative 18F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 110(5): 1451-1465, Aug 2021 Notes: doi: 10.1016/j.ijrobp.2021.02.030. Epub 2021.
1d7 Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y.: Multiblock Discriminant Analysis of Integrative (18)F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys 110: 1451-1465, Aug 2021.
1c8 Mathilde Bouché, Yuxi C Dong, Saad Sheikh, Kimberly Taing, Deeksha Saxena, Jessica C Hsu, Minna H Chen, Ryan D Salinas, Hongjun Song, Jason A Burdick, Jay Dorsey, David P Cormode: Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel. ACS Biomater Sci Eng. Jul 2021 Notes: PMID: 34160196 PMCID: PMC8411482 DOI: 10.1021/acsbiomaterials.1c00385.
76 Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh a8 SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH, Gong Y, Fan Y.: Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 65 and CD40. Nat Commun. 12(1), Jun 2021 Notes: doi: 10.1038/s41467-021-23832-3.
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