Jay Fitzgerald Dorsey, M.D., Ph.D.

faculty photo
Associate Professor of Radiation Oncology
Active Staff - Radiation Oncology, Chestnut Hill Hospital
Attending Physician, Hospital at the University of Pennsylvania
Attending Physician, Pennsylvania Hospital
Consulting Staff - Radiation Oncology, Phoenixville Hospital
Courtesy Staff - Radiation Oncology, Chester County Hospital
Contract Physician - Radiation Oncology, Philadelphia Veterans Medical Center
Active Staff - Radiation Oncology, Penn Medicine at Valley Forge
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
Bldg 421 SCTR 8-135
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 662-2428
Fax: (215) 349-5445
Education:
BSChE (Chemical Engineering)
University of Florida, 1995.
MSChE (Chemical Engineering)
University of South Florida, 1997.
M.D.
University of South Florida College of Medicine, 2003.
Ph.D.
University of South Florida (H. Lee Moffitt Cancer Research Institute), 2003.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

RESEARCH INTERESTS:
As a Physician-Scientist, I conduct brain tumor research and specialize in treatment of patients with intracranial malignancies. I have scientific expertise in the areas of signal transduction, molecular therapeutics, brain tumor biology, and radiation biology. As a translational researcher, I am actively involved in basic mechanistic studies, the application of in vivo imaging methods to preclinical studies in relevant biological models of cancer, and early phase clinical trials in intracranial malignancies. In a broad sense, my research focuses on understanding the underlying mechanisms whereby cancers demonstrate resistance to radiation and chemotherapy. This information will give us a framework to develop ways to target oncogenic pathways that lead to therapeutic resistance and identify potential molecular interventions that may reduce the normal tissue complications of radiation therapy. One research focus concerns the elucidation of mechanism(s) whereby the Integrated Stress Response (ISR) modulates death receptor expression, and leveraging this understanding therapeutically. A second area of focus is the identification and characterization of circulating tumor cells (CTCs) in the peripheral blood of cancer patients including those with primary brain tumors to gain prognostic and predictive information. Finally, my laboratory has an ongoing project focused on the application and preclinical testing of novel theranostic gold nanoparticle agents in the imaging and radiosensitization of tumors and overcoming challenges of therapeutic access through the blood brain barrier. This includes evaluation of the efficacy of novel radiotheranostic nanoparticle combinations in preclinical animal models and determination of timing, dosage, and in vivo mechanisms of anti-tumor action.

Description of Clinical Expertise

I am a board-certified radiation oncologist who specializes in the treatment of cancers of the central nervous system with conventional radiation, IMRT, proton, and stereotactic radiation. I am certified to perform gamma knife radiosurgery.

Selected Publications

Paul R, Dorsey JF, Fan Y: Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications. Pharmacol Ther. Sep 2021 Notes: doi: 10.1016/j.pharmthera.2021.107985. Epub ahead of print.

Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y: Multiblock Discriminant Analysis of Integrative 18F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 110(5): 1451-1465, Aug 2021 Notes: doi: 10.1016/j.ijrobp.2021.02.030. Epub 2021.

Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH, Gong Y, Fan Y.: Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nat Commun. 12(1), Jun 2021 Notes: doi: 10.1038/s41467-021-23832-3.

Jean-Baptiste SR, Feigenberg SJ, Dorsey JF, Kao GD: Personal and Prognostic: Tissue and Liquid Biomarkers of Radiotherapeutic Response in Non-Small Cell Lung Cancer. Semin Radiat Oncol. 31(2): 149-154, Apr 2021 Notes: doi:10.1016/j.semradonc.2020.11.002.

Teng CW, Amirshaghaghi A, Cho SS, Cai SS, De Ravin E, Singh Y, Miller J, Sheikh S, Delikatny E, Cheng Z, Busch TM, Dorsey JF, Singhal S, Tsourkas A, Lee JYK.: Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster. J Neurooncol. 2020 Sep 10. doi: 10.1007/s11060-020-03618-1. Online ahead of print. PMID: 32914293 2020.

Frick MA, Feigenberg SJ, Jean-Baptiste SR, Aguarin LA, Mendes A, Chinniah C, Swisher-McClure S, Berman A, Levin W, Cengel KA, Hahn SM, Dorsey JF, Simone CB 2nd, Kao GD.: Circulating Tumor Cells Are Associated with Recurrent Disease in Patients with Early-Stage Non-Small Cell Lung Cancer Treated with Stereotactic Body Radiotherapy. Clin Cancer Res. 2020 May 15;26(10):2372-2380. doi: 10.1158/1078-0432.CCR-19-2158. Epub 2020 Jan 22. PMID: 31969332 2020.

Jacob F, Salinas RD, Zhang DY, Nguyen PTT, Schnoll JG, Wong SZH, Thokala R, Sheikh S, Saxena D, Prokop S, Liu DA, Qian X, Petrov D, Lucas T, Chen HI, Dorsey JF, Christian KM, Binder ZA, Nasrallah M, Brem S, O'Rourke DM, Ming GL, Song H.: A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. Cell. 2020 Jan 9;180(1):188-204.e22. doi: 10.1016/j.cell.2019.11.036. Epub 2019 Dec 26. PMID: 31883794 2020.

Cho SS, Sheikh S, Teng CW, Georges J, Yang AI, De Ravin E, Buch L, Li C, Singh Y, Appelt D, Delikatny EJ, Petersson EJ, Tsourkas A, Dorsey J, Singhal S, Lee JYK.: Evaluation of Diagnostic Accuracy Following the Coadministration of Delta-Aminolevulinic Acid and Second Window Indocyanine Green in Rodent and Human Glioblastomas. Mol Imaging Biol. 2020 Oct;22(5):1266-1279. doi: 10.1007/s11307-020-01504-w. PMID: 32514886 2020.

Baumann BC, Lustig RA, Mazzoni S, Grady SM, O'Malley BW, Lee JYK, Newman JG, Schuster JM, Both S, Lin A, Dorsey JF, Alonso-Basanta M: A prospective clinical trial of proton therapy for chordoma and chondrosarcoma: Feasibility assessment. J Surg Oncol. May 2019.

Sheikh Saad, Saxena Deeksha, Tian Xiaobing, Amirshaghaghi Ahmad, Tsourkas Andrew, Brem Steven, Dorsey Jay F: An integrated stress response agent that modulates DR5 dependent TRAIL synergy reduces patient derived glioma stem cell viability. Molecular cancer research : MCR Jan 2019.

back to top
Last updated: 04/15/2022
The Trustees of the University of Pennsylvania