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David A Mankoff, MD, PhD
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Matthew J. Wilson Professor of Research Radiology
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Active Medical Staff - Radiologist, Chester County Hospital
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Active Physician, Penn Presbyterian Medical Center
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Active Physician, Pennsylvania Hospital
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Attending, Department of Radiology, Hospital of the University of Pennsylvania
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Vice-Chair of Research, Department of Radiology, University of Pennsylvania
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Associate Director of Education and Research, Abramson Cancer Center
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Department: Radiology
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Graduate Group Affiliations
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- Bioengineering e
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Contact information
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Division of Nuclear Medicine
1f Department of Radiology
3f Perelman School of Medicine, University of Pennsylvania
15 1 Donner, HUP
35 3400 Spruce Street
Philadelphia, PA 19104
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1f Department of Radiology
3f Perelman School of Medicine, University of Pennsylvania
15 1 Donner, HUP
35 3400 Spruce Street
Philadelphia, PA 19104
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Office: 215-746-4062
32 Fax: 215-349-5843
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32 Fax: 215-349-5843
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Education:
21 9 B.S. 14 (Physics) c
28 Yale University, 1981.
21 a Ph.D. 1b (Bioengineering) c
33 University of Pennsylvania, 1988.
21 9 M.D. 15 (Medicine) c
33 University of Pennsylvania, 1988.
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Permanent link21 9 B.S. 14 (Physics) c
28 Yale University, 1981.
21 a Ph.D. 1b (Bioengineering) c
33 University of Pennsylvania, 1988.
21 9 M.D. 15 (Medicine) c
33 University of Pennsylvania, 1988.
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1c Radionuclide Therapy
15 Thyroid Cancer
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15 Breast Cancer
36 Quantitative Cancer Imaging and Image Analysis
24 Translational Clinical Trials
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Description of Clinical Expertise
25 Nuclear Medicine/PET1c Radionuclide Therapy
15 Thyroid Cancer
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Description of Other Expertise
26 Susan G. Komen Scholar65
Description of Research Expertise
22 Molecular Imaging15 Breast Cancer
36 Quantitative Cancer Imaging and Image Analysis
24 Translational Clinical Trials
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138 Zhou, R., Choi, H., Cao, J., Pantel, A., Gupta, M., Lee, H. S., Mankoff, D.: (18)F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models. J Nucl Med 64(1): 131-136, Jan 2023 Notes: DOI: 10.2967/jnumed.122.264152.
132 O'Brien, S. R., Edmonds, C. E., Lanzo, S. M., Weeks, J. K., Mankoff, D. A., Pantel, A. R.: (18)F-Fluoroestradiol: Current Applications and Future Directions. Radiographics 43(3): e220143, Mar 2023 Notes: DOI: 10.1148/rg.220143.
25c Pantel, A. R., Gitto, S. B., Makvandi, M., Kim, H., Medvedv, S., Weeks, J. K., Torigian, D. A., Hsieh, C. J., Ferman, B., Latif, N. A., Tanyi, J. L., Martin, L. P., Lanzo, S. M., Liu, F., Cao, Q., Mills, G. B., Doot, R. K., Mankoff, D. A., Mach, R. H., Lin, L. L., Simpkins, F.: [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study. Clin Cancer Res 29(8): 1515-1527, Apr 2023 Notes: DOI: 10.1158/1078-0432.CCR-22-1602.
20a Lee, I. K., Jacome, D. A., Cho, J. K., Tu, V., Young, A. J., Dominguez, T., Northrup, J. D., Etersque, J. M., Lee, H. S., Ruff, A., Aklilu, O., Bittinger, K., Glaser, L. J., Dorgan, D., Hadjiliadis, D., Kohli, R. M., Mach, R. H., Mankoff, D. A., Doot, R. K., Sellmyer, M. A.: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. J Clin Invest 132(18): e156679, Sept 2022 Notes: DOI: 10.1172/JCI156679.
19b Chitalia, R., Viswanath, V., Pantel, A. R., Peterson, L. M., Gastounioti, A., Cohen, E. A., Muzi, M., Karp, J., Mankoff, D. A., Kontos, D.: Functional 4-D clustering for characterizing intratumor heterogeneity in dynamic imaging: evaluation in FDG PET as a prognostic biomarker for breast cancer. Eur J Nucl Med Mol Imaging 2021.
177 Viswanath, V., Zhou, R., Lee, H., Li, S., Cragin, A., Doot, R. K., Mankoff, D. A., Pantel, A. R.: Kinetic Modeling of (18)F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism. J Nucl Med 62(8): 1154-1162, 2021.
14d Pantel, A. R., Viswanath, V., Daube-Witherspoon, M. E., Dubroff, J. G., Muehllehner, G., Parma, M. J., Pryma, D. A., Schubert, E. K., Mankoff, D. A., Karp, J. S.: PennPET Explorer: Human Imaging on a Whole-Body Imager. J Nucl Med 61(1): 144-151, 2020.
165 McDonald, E. S., Doot, R. K., Pantel, A. R., Farwell, M. D., Mach, R. H., Maxwell, K. N., Mankoff, D. A.: Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. JAMA Oncol April 2020.
17c Elmi, A., Makvandi, M., Weng, C. C., Hou, C., Clark, A. S., Mach, R. H., Mankoff, D. A.: Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [(18)F]FLT and [(18)F]ISO-1 PET/CT. Clin Cancer Res 25(10): 3063-3073, 2019.
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Selected Publications
1b7 Mankoff, D., Balogova, S., Dunnwald, L., Dehdashti, F., DeVries, E., Evangelista, L., Van Kruchten, M., Vaz, S. C., Fowler, A., Linden, H., Ulaner, G. A.: Summary: SNMMI Procedure Standard/EANM Practice Guideline for Estrogen Receptor Imaging of Patients with Breast Cancer Using 16alpha-[(18)F]Fluoro-17beta-Estradiol PET. J Nucl Med 65(2): 221-223, 2024.138 Zhou, R., Choi, H., Cao, J., Pantel, A., Gupta, M., Lee, H. S., Mankoff, D.: (18)F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models. J Nucl Med 64(1): 131-136, Jan 2023 Notes: DOI: 10.2967/jnumed.122.264152.
132 O'Brien, S. R., Edmonds, C. E., Lanzo, S. M., Weeks, J. K., Mankoff, D. A., Pantel, A. R.: (18)F-Fluoroestradiol: Current Applications and Future Directions. Radiographics 43(3): e220143, Mar 2023 Notes: DOI: 10.1148/rg.220143.
25c Pantel, A. R., Gitto, S. B., Makvandi, M., Kim, H., Medvedv, S., Weeks, J. K., Torigian, D. A., Hsieh, C. J., Ferman, B., Latif, N. A., Tanyi, J. L., Martin, L. P., Lanzo, S. M., Liu, F., Cao, Q., Mills, G. B., Doot, R. K., Mankoff, D. A., Mach, R. H., Lin, L. L., Simpkins, F.: [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study. Clin Cancer Res 29(8): 1515-1527, Apr 2023 Notes: DOI: 10.1158/1078-0432.CCR-22-1602.
20a Lee, I. K., Jacome, D. A., Cho, J. K., Tu, V., Young, A. J., Dominguez, T., Northrup, J. D., Etersque, J. M., Lee, H. S., Ruff, A., Aklilu, O., Bittinger, K., Glaser, L. J., Dorgan, D., Hadjiliadis, D., Kohli, R. M., Mach, R. H., Mankoff, D. A., Doot, R. K., Sellmyer, M. A.: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. J Clin Invest 132(18): e156679, Sept 2022 Notes: DOI: 10.1172/JCI156679.
19b Chitalia, R., Viswanath, V., Pantel, A. R., Peterson, L. M., Gastounioti, A., Cohen, E. A., Muzi, M., Karp, J., Mankoff, D. A., Kontos, D.: Functional 4-D clustering for characterizing intratumor heterogeneity in dynamic imaging: evaluation in FDG PET as a prognostic biomarker for breast cancer. Eur J Nucl Med Mol Imaging 2021.
177 Viswanath, V., Zhou, R., Lee, H., Li, S., Cragin, A., Doot, R. K., Mankoff, D. A., Pantel, A. R.: Kinetic Modeling of (18)F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism. J Nucl Med 62(8): 1154-1162, 2021.
14d Pantel, A. R., Viswanath, V., Daube-Witherspoon, M. E., Dubroff, J. G., Muehllehner, G., Parma, M. J., Pryma, D. A., Schubert, E. K., Mankoff, D. A., Karp, J. S.: PennPET Explorer: Human Imaging on a Whole-Body Imager. J Nucl Med 61(1): 144-151, 2020.
165 McDonald, E. S., Doot, R. K., Pantel, A. R., Farwell, M. D., Mach, R. H., Maxwell, K. N., Mankoff, D. A.: Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. JAMA Oncol April 2020.
17c Elmi, A., Makvandi, M., Weng, C. C., Hou, C., Clark, A. S., Mach, R. H., Mankoff, D. A.: Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [(18)F]FLT and [(18)F]ISO-1 PET/CT. Clin Cancer Res 25(10): 3063-3073, 2019.
2c