David A Mankoff, MD, PhD

faculty photo
Gerd Muehllehner Professor of Radiology
Department: Radiology

Contact information
Division of Nuclear Medicine
Department of Radiology
Perelman School of Medicine
1 Donner, HUP
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-3687
Fax: 215-349-5843
B.S. (Physics)
Yale University, 1981.
Ph.D. (Bioengineering)
University of Pennsylvania, 1988.
M.D. (Medicine)
University of Pennsylvania, 1988.
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Description of Clinical Expertise

Nuclear Medicine/PET
Radionuclide Therapy
Thyroid Cancer

Description of Other Expertise

Susan G. Komen Scholar

Description of Research Expertise

Molecular Imaging
Breast Cancer
Quantitative Cancer Imaging and Image Analysis
Translational Clinical Trials

Selected Publications

Makvandi, M., Pantel, A., Schwartz, L., Schubert, E., Xu, K., Hsieh, C. J., Hou, C., Kim, H., Weng, C. C., Winters, H., Doot, R., Farwell, M. D., Pryma, D. A., Greenberg, R. A., Mankoff, D. A., Simpkins, F., Mach, R. H., Lin, L. L.: A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. J Clin Invest 128(5): 2116-2126, 2018.

Peterson, L. M., O'Sullivan, J., Wu, Q. V., Novakova-Jiresova, A., Jenkins, I., Lee, J. H., Shields, A., Montgomery, S., Linden, H. M., Gralow, J. R., Gadi, V. K., Muzi, M., Kinahan, P. E., Mankoff, D. A., Specht, J. M.: Prospective study of serial (18)F-FDG PET and (18)F-fluoride ((18)F-NaF) PET to predict time to skeletal related events, time-to-progression, and survival in patients with bone-dominant metastatic breast cancer. J Nucl Med 2018.

Zhou, R., Pantel, A. R., Li, S., Lieberman, B. P., Ploessl, K., Choi, H., Blankemeyer, E., Lee, H., Kung, H. F., Mach, R. H., Mankoff, D. A.: [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer Res 77(6): 1476-1484, Mar 2017 Notes: Epub 2017 Feb 15.

Kurland, B. F., Peterson, L. M., Lee, J. H., Schubert, E. K., Currin, E. R., Link, J. M., Krohn, K. A., Mankoff, D. A., Linden, H. M.: Estrogen Receptor Binding (18F-FES PET) and Glycolytic Activity (18F-FDG PET) Predict Progression-Free Survival on Endocrine Therapy in Patients with ER+ Breast Cancer. Clin Cancer Res 23(2): 407-415, Jan 2017 Notes: Epub 2016 Jun 24.

Sellmyer, M. A., Lee, I., Hou, C., Lieberman, B. P., Zeng, C., Mankoff, D. A., Mach, R. H.: Quantitative PET Reporter Gene Imaging with [11C]Trimethoprim. Mol Ther 25(1): 120-126, Jan 2017 Notes: Epub 2017 Jan 4.

Zhou, R., Bagga, P., Nath, K., Hariharan, H., Mankoff, D. A., Reddy, R.: Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer. Cancer Res 78(19): 5521-5526, 2018.

Mankoff, D. A., Farwell, M. D., Clark, A. S., Pryma, D. A.: Making Molecular Imaging a Clinical Tool for Precision Oncology: A Review. JAMA Oncol 3(5): 695-701, May 2017.

Gerstner, E. R., Zhang, Z., Fink, J. R., Muzi, M., Hanna, L., Greco, E., Prah, M., Schmainda, K. M., Mintz, A., Kostakoglu, L., Eikman, E. A., Ellingson, B. M., Ratai, E. M., Sorensen, A. G., Barboriak, D. P., Mankoff, D. A., Acrin Trial Group: ACRIN 6684: Assessment of Tumor Hypoxia in Newly Diagnosed Glioblastoma Using 18F-FMISO PET and MRI. Clin Cancer Res 22(20): 5079-5086, Oct 2016 Notes: Epub 2016 May 16.

Edmonds, C. E., Makvandi, M., Lieberman, B. P., Xu, K., Zeng, C., Li, S., Hou, C., Lee, H., Greenberg, R. A., Mankoff, D. A., Mach, R. H.: [(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer. Am J Nucl Med Mol Imaging 6(1): 94-101, Jan 2016 Notes: eCollection 2016.

Kostakoglu, L., Duan, F., Idowu, M. O., Jolles, P. R., Bear, H. D., Muzi, M., Cormack, J., Muzi, J. P., Pryma, D. A., Specht, J. M., Hovanessian-Larsen, L., Miliziano, J., Mallett, S., Shields, A. F., Mankoff, D. A., Acrin Investigative Team: A Phase II Study of 3''-Deoxy-3''-18F-Fluorothymidine PET in the Assessment of Early Response of Breast Cancer to Neoadjuvant Chemotherapy: Results from ACRIN 6688. J Nucl Med 56(11): 1681-9, Nov 2015 Notes: Epub 2015 Sep 10.

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Last updated: 11/19/2018
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