David A Mankoff, MD, PhD

faculty photo
Gerd Muehllehner Professor of Radiology
Department: Radiology

Contact information
Division of Nuclear Medicine
Department of Radiology
Perelman School of Medicine, University of Pennsylvania
1 Donner, HUP
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-746-4062
Fax: 215-349-5843
Education:
B.S. (Physics)
Yale University, 1981.
M.D. (Medicine)
University of Pennsylvania, 1988.
Ph.D. (Bioengineering)
University of Pennsylvania, 1988.
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Description of Clinical Expertise

Nuclear Medicine/PET
Radionuclide Therapy
Thyroid Cancer

Description of Other Expertise

Susan G. Komen Scholar

Description of Research Expertise

Molecular Imaging
Breast Cancer
Quantitative Cancer Imaging and Image Analysis
Translational Clinical Trials

Selected Publications

Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL: A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. J Clin Invest 128(5): 2116-2126, 2018.

Peterson LM, O'Sullivan J, Wu QV, Novakova-Jiresova A, Jenkins I, Lee JH, Shields A, Montgomery S, Linden HM, Gralow JR, Gadi VK, Muzi M, Kinahan PE, Mankoff DA, Specht JM: Prospective study of serial (18)F-FDG PET and (18)F-fluoride ((18)F-NaF) PET to predict time to skeletal related events, time-to-progression, and survival in patients with bone-dominant metastatic breast cancer. J Nucl Med 59(12): 1823-1830, 2018.

Zhou, R., Pantel, A. R., Li, S., Lieberman, B. P., Ploessl, K., Choi, H., Blankemeyer, E., Lee, H., Kung, H. F., Mach, R. H., Mankoff, D. A.: [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer Res 77(6): 1476-1484, Mar 2017 Notes: Epub 2017 Feb 15.

Kurland BF, Peterson LM, Lee JH, Schubert EK, Currin ER, Link JM, Krohn KA, Mankoff DA, Linden HM: Estrogen receptor binding (18F-FES PET) and glycolytic activity (18F-FDG PET) predict progression-free survival on endocrine therapy in patients with ER+ nreast cancer. Clin Cancer Res 23(2): 407-415, 2017.

Sellmyer MA, Lee I, Hou C, Lieberman BP, Zeng C, Mankoff DA, Mach RH: Quantitative PET reporter gene imaging with [11C]trimethoprim. Mol Ther 25(1): 120-126, 2017.

Zhou R, Bagga P, Nath K, Hariharan H, Mankoff DA, Reddy R: Glutamate-weighted chemical exchange saturation transfer magnetic resonance imaging detects glutaminase inhibition in a mouse model of triple-negative breast cancer. Cancer Res 78(19): 5521-5526, 2018.

Mankoff DA, Farwell MD, Clark AS, Pryma DA: Making molecular imaging a clinical tool for precision oncology: A review. JAMA Oncol 3(5): 695-701, May 2017.

Gerstner ER, Zhang Z, Fink JR, Muzi M, Hanna L, Greco E, Prah M, Schmainda KM, Mintz A, Kostakoglu L, Eikman EA, Ellingson BM, Ratai EM, Sorensen AG, Barboriak DP, Mankoff DA; ACRIN 6684 Trial Group: ACRIN 6684: Assessment of tumor hypoxia in newly diagnosed glioblastoma using 18F-FMISO PET and MRI. Clin Cancer Res 22(20): 5079-5086, 2016.

Edmonds CE, Makvandi M, Lieberman BP, Xu K, Zeng C, Li S, Hou C, Lee H, Greenberg RA, Mankoff DA, Mach RH: [(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer. Am J Nucl Med Mol Imaging 6(1): 94-101, 2016.

Kostakoglu L, Duan F, Idowu MO, Jolles PR, Bear HD, Muzi M, Cormack J, Muzi JP, Pryma DA, Specht JM, Hovanessian-Larsen L, Miliziano J, Mallett S, Shields AF, Mankoff DA; ACRIN 668 Investigative Team: A phase II study of 3''-Deoxy-3''-18F-fluorothymidine PET in the assessment of early response of breast cancer to neoadjuvant chemotherapy: results from ACRIN 6688. J Nucl Med 56(11): 1681-9, 2015.

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Last updated: 12/29/2018
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