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Joel S. Bennett, M.D.

Joel S. Bennett, M.D.

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Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Hematology-Oncology
421 Curie Boulevard/6160
Philadelphia, PA 19104
Office: (215) 573-3280
Fax: (215) 573-7039
B.S. (Pre-med)
University of Michigan , 1963.
M.D. (Medicine (Cum laude)
University of Michigan, 1967.
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Description of Research Expertise

Integrin function is essential for normal platelet adhesion and aggregation and participates i n the formation of the arterial thrombi that are responsible for heart attacks and strokes. The activation state of platelet integrins is regulated by platelet agonists, but the structural basis for this regulation is not known. Our studies indicate that helix-helix interactions involving the transmembrane and membrane-proximal cytoplasmic domain segments play an essential role in regulating the function of both beta 1 and beta 3 integrins. The current focus of the laboratory is to use biophysical and molecular biologic techniques to characterize these interactions in detail and to use this information to design potential anti-thrombotic agents.

Selected Publications

Litvinov RI, Barsegov V, Schissler AJ, Fisher AR, Bennett JS, Weisel JW, Shuman H: Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force. Biophys J 100(1): 165-173, 2011.

Donald JE, Zhu H, Litvinov, RI, DeGrado WF, Bennett JS: Identification of interacting hotspots in the beta3 integrin stalk. J Biol Chem 285(49): 38658-38665, 2010.

Metcalf DG, Moore DT, Wu Y, Kielec JM, Molnar K, Valentine KG, Wand AJ, Bennett JS, Degrado WF: NMR analysis of the {alpha}IIb{beta}3 cytoplasmic interaction suggests a mechanism for integrin regulation. Proc Natl Acad Sci USA 107(52): 22481-22486, 2010.

Berger BW, Kulp DW, Span LM, DeGrado JL, Billings PC, Senes A, Bennett JS, DeGrado WF: Consensus motif for integrin transmembrane helix association. Proc Natl Acad Sci USA 107(2): 703-708, 2010.

Bennett JS: Ask the hematologist. The Hematologist, ASH News and Reports 2010 Notes: http://www.hematology.org/Publications/Hematologist/2010/4963.aspx.

Abrams CS, Shattil SJ, Bennett JS: Acquired qualitative platelet disorders (Chapter 122). Williams' Hematology, Eighth Edition. Lichtman MA, Kipps TJ, Seligsohn U, Kaushansky K, Prchal JT (eds.). McGraw-Hill Publishing, 2010 Notes: ISBN-13 / EAN: 9780071621519.

Friedewald VE, Bennett JS, Christo JP, Pool JL, Scheiman JM, Simon LS, Strand V, White WB, Williams GW, Roberts WC: AJC Editor's consensus: Selective and nonselective nonsteroidal anti-inflammatory drugs and cardiovascular risk. Am J Cardiol 106: 873-884, 2010.

Chopra SS, Stroud DM, Watanabe H, Bennett JS, Burns CG, Wells KS, Yang T, Zhong TP, Roden DM: Voltage-gated sodium channels are required for heart development in zebrafish. Circulation Res 106: 1342-1350, 2010.

Zhu H, Metcalf DG, Streu CN, Billings PC, Degrado WF, Bennett JS: Specificity for homooligomer versus heterooligomer formation in integrin transmembrane helices. J Molec Biol 401: 882-891, 2010.

Bennett JS and Moore DT: Regulation of platelet beta 3 integrins. Haematologica 95: 1049-1051, 2010.

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Last updated: 03/21/2014
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