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Joel S. Bennett, M.D.

Joel S. Bennett, M.D.

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Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Hematology-Oncology
814 BRB II/III
421 Curie Boulevard/6160
Philadelphia, PA 19104
Office: (215) 573-3280
Fax: (215) 573-7039
Education:
B.S. (Pre-med)
University of Michigan , 1963.
M.D. (Medicine (Cum laude)
University of Michigan, 1967.
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Description of Research Expertise

Integrin function is essential for normal platelet adhesion and aggregation and participates i n the formation of the arterial thrombi that are responsible for heart attacks and strokes. The activation state of platelet integrins is regulated by platelet agonists, but the structural basis for this regulation is not known. Our studies indicate that helix-helix interactions involving the transmembrane and membrane-proximal cytoplasmic domain segments play an essential role in regulating the function of both beta 1 and beta 3 integrins. The current focus of the laboratory is to use biophysical and molecular biologic techniques to characterize these interactions in detail and to use this information to design potential anti-thrombotic agents.

Description of Clinical Expertise

General Hematology, Internal Medicine, Hemostasis, and Thrombosis

Selected Publications

Bennett, J.S.: Clinical dilemma: Experts make the call. ASH Clinical News 1(1), October 2014.

Bennett, J.S.: Inside Blood: Platelet αIIbβ3 activation. Blood Page: in press, 2014.

Bennett, J.S.: Chapter 22: Overview of megakaryocyte and platelet biology. Hemostasis and Thrombosis: Basic Principles and Clinical Practice Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S., and White, G.C. II (eds.). Lippincott, Williams & Wilkins, 6th Edition: 341-348, 2013.

Bennett, J.S. and Abrams, C.S.: Chapter 60: Differential diagnosis of thrombocytopenia. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S., and White, G.C. II (eds.). Lippincott, Williams & Wilkins, 6th Edition: 757-762, 2013.

Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S., and White, G.C. II: Chapter 1: The field of hemostasis and thrombosis: Selected translational achievements Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S., and White, G.C. II (eds.). Lippincott, Williams & Wilkins, 6th Edition: 3-10, 2013.

White, G.C. II, Marder, V.J., Shulman, S., Aird, W.C., and Bennett, J.S.: Chapter 8: Overview of basic coagulation and fibrinolysis. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S., and White, G.C. II (eds.). Lippincott, Williams & Wilkins, 6th Edition, 2013.

Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S., and White, G.C. II: Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Textbook. Lippincott, Williams & Wilkins, 6th Edition, 2013.

Marder, V.J. and Bennett, J.S.: Chapter 115: Overview of special clinical groups. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S., and White, G.C. II (eds.). Lippincott, Williams & Wilkins, 6th Edition: 1379, 2013.

Rao, A.K. and Bennett, J.S.: : Chapter 66: Acquired disorders of platelet function. Hemostasis and Thrombosis: Basic Principles and Clinical Practice Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S., and White, G.C. II (eds.). Lippincott, Williams & Wilkins, 6th Edition: 820-828, 2013.

Bennett, J.S.: Chapter 59: Overview of acquired and inherited clinical platelet disorders. Hemostasis and Thrombosis: Basic Principles and Clinical Practice Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S., and White, G.C. II (eds.). Lippincott, Williams & Wilkins, 6th Edition: 751-756, 2013.

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Last updated: 11/12/2014
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