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Perelman School of Medicine at the University of Pennsylvania Advanced Search

Joel S. Bennett, M.D.

Joel S. Bennett, M.D.

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Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Hematology-Oncology
814 BRB II/III
421 Curie Boulevard/6160
Philadelphia, PA 19104
Office: (215) 573-3280
Fax: (215) 573-7039
Education:
B.S. (Pre-med)
University of Michigan , 1963.
M.D. (Medicine (Cum laude)
University of Michigan, 1967.
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Description of Research Expertise

Integrin function is essential for normal platelet adhesion and aggregation and participates i n the formation of the arterial thrombi that are responsible for heart attacks and strokes. The activation state of platelet integrins is regulated by platelet agonists, but the structural basis for this regulation is not known. Our studies indicate that helix-helix interactions involving the transmembrane and membrane-proximal cytoplasmic domain segments play an essential role in regulating the function of both beta 1 and beta 3 integrins. The current focus of the laboratory is to use biophysical and molecular biologic techniques to characterize these interactions in detail and to use this information to design potential anti-thrombotic agents.

Selected Publications

Moore, D.T., Nygren, P., Jo, H., Boesze-Battaglia, K., Bennett, J.S., and DeGrado, W.F.: Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid environment. Proc. Natl. Acad. Sci. U.S.A. 109: 793-798, 2012.

Hook, K.M. and Bennett, J.S.: Glycoprotein IIb/IIIa Antagonists. Handbook of Experimental Pharmacology Series, Anti-platelet Agents. Page: 199-223, 2012 Notes: doi: 10.1007/978-3-642-29423-5-8.

Borza, C.M., Su, Y., Chen, X., Yu, L., Mont, S., Chetyrkin, S., Vozlyan, P., Hudson, B.G., Billings, P.C., Jo, H., Bennett, J.S., DeGrado, W.F., Eckes, B., Zent, R., and Pozzi, A.: Inhibition of integrin α2β1 ameliorates glomerular injury. J. Am. Soc. Nephrol. 23: 1027-1038, 2012.

Litvinov, R.I., Mekler, A., Shuman, H., Bennett, J.S., Barsegov, V., and Weisel, J.W. : Resolving two-dimensional kinectics of the integrin αIIbβ3-fibrinogen interactions using Binding-Unbinding Correlation Spectroscopy. J. Biol. Chem. 287: 35275-35285, 2012.

Sun, J.E, Vranic, J., Composto, R.J., Streu, C., Billings, P.C., Bennett, J.S., Weisel, J.W. : Bimolecular integrin-ligand interactions quantified using peptide-functionalized dextran-coated microparticles. Integr Biol (Camb) 4: 84-92, 2012.

Litvinov RI, Barsegov V, Schissler AJ, Fisher AR, Bennett JS, Weisel JW, Shuman H: Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force. Biophys J 100(1): 165-173, 2011.

Bennett, J.S.: ¿Como Se LLAMA? Blood 118: 487-488, 2011.

Shandler, S.J., Korendovych, I.V., Moore, D.T., Smith-Dupont, K.B., Streu, C.N., Litvinov, R.I., Billings, P.C., Gai, F., Bennett, J.S., and DeGrado, W.F.: Computational design of a β-peptide that targets transmembrane helices. J. Am. Chem. Soc. 133: 12378-12381, 2011.

Donald JE, Zhu H, Litvinov, RI, DeGrado WF, Bennett JS: Identification of interacting hotspots in the beta3 integrin stalk. J Biol Chem 285(49): 38658-38665, 2010.

Bennett JS and Moore DT: Perspective: Regulation of platelet beta 3 integrins. Haematologica 95: 1049-1051, 2010.

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Last updated: 04/22/2014
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