In Memoriam

Joel S. Bennett, M.D.

faculty photo
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Hematology-Oncology
421 Curie Boulevard/6160
Philadelphia, PA 19104
Office: (215) 573-3280
Fax: (215) 573-7039
B.S. (Pre-med)
University of Michigan , 1963.
M.D. (Medicine (Cum laude)
University of Michigan, 1967.
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Description of Research Expertise

Integrin function is essential for normal platelet adhesion and aggregation and participates i n the formation of the arterial thrombi that are responsible for heart attacks and strokes. The activation state of platelet integrins is regulated by platelet agonists, but the structural basis for this regulation is not known. Our studies indicate that helix-helix interactions involving the transmembrane and membrane-proximal cytoplasmic domain segments play an essential role in regulating the function of both beta 1 and beta 3 integrins. The current focus of the laboratory is to use biophysical and molecular biologic techniques to characterize these interactions in detail and to use this information to design potential anti-thrombotic agents.

Description of Clinical Expertise

General Hematology, Internal Medicine, Hemostasis, and Thrombosis

Selected Publications

Litvinov, R.I., Mravic, M., Zhu, H., Weisel, J.W., DeGrado, W.F., and Bennett, J.S.: Unique transmembrane domain interactions differentially modulate integrin avb3 and aIIbb3 function. Proc. Natl. Acad. Sci. U.S.A. 116: 11195-12300, 2019.

Tan, S.K., Fong, K.P., Polizzi, N.F., Sternisha, A., Slusky, J.S.G., Yoon, K., DeGrado, W.F., and Bennett, J.S.: Modulating integrin aIIbb3 activity through mutagenesis of allosterically regulated inter-subunit contacts. Biochemistry 58: 3251-3259, 2019.

Mravic, M., Hu, H., Lu, Z., Bennett, J.S., Sanders, C.R., Orr, A.W., and DeGrado, W.F.: De novo designed transmembrane peptides activating the 51 integrin. Protein : De novo designed transmembrane peptides activating the 51 integrin. Protein Engineering, Design & Selection. 2018.

Kononova, O., Litvinov, R.I., Blokhin, D.S., Klochkov, V.V., Weisel, J.W., Bennett, J.S., Barsegov, V.: Mechanistic basis for the binding of RGD- and AGDV-peptides to the platelet integrin IIb3. Biochemistery 56, 2017.

Bennett, J.S.: Are anti-platelet agents beneficial in Essential Thrombocythemia? Maybe yes, probably no. Ann. Int. Med. 167: 206-207, 2017.

Bennett, J.S.: Clinical dilemma: Experts make the call. ASH Clinical News. 3(05): 34, 2017.

Bennett, J.S. : IIb3 (GPIIb/IIIa) structure and function. Platelets in Thrombotic and Non-Thrombotic Disorders. Gresele, P., Lopez, J.A., Kleiman, N.S., and Page, C.P., eds.) (eds.). Springer, Switzerland, 2: 99-109, 2017.

Höök, P., Litvinov, R.I., Kim, O.V., Xu, S., Bennett, J.S., Alber, M.S., and Weisel, J.W: Strong binding of platelet integrin IIb3 to fibrin clots: Potential target to destabilize thrombi. Scientific Reports 7, 2017.

Huntington, S.F., O’Hara, M.O., and Bennett, J.S: Platelet disorders: clinical and laboratory evaluation. Non-Malignant Hematology: Expert Clinical Perspective Ragni, M., Connors, J.M., and Abutalib, S., eds. (eds.). Springer, Switzerland, Page: 171-184, 2016.

Fong, F.P., Zhu, H., Span, L.M., Moore, D.T., Yoon, K., Tamura, R., Yin, H.H., DeGrado, W.F., and Bennett, J.S.: Directly activating IIb3 initiates outside-in signaling by causing IIb3 clustering. J. Bio. Chem/ 291, 2016.

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Last updated: 11/03/2020
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